SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2r17'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2r17 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 35
(Homo
sapiens) 		4 / 7 LEU C 589
LEU C 630
ILE C 632
MET C 638
 None
 0.93A 2qqdA-2r17C:
undetectable
2qqdE-2r17C:
undetectable		 2qqdA-2r17C:
9.40
2qqdE-2r17C:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2r17 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 35
(Homo
sapiens) 		4 / 5 ILE C 560
THR C 567
PHE C 534
TYR C 537
 None
 1.21A 3em0A-2r17C:
undetectable		 3em0A-2r17C:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA3_L_ACTL301_0
(C2095 HEAVY CHAIN
C2095 LIGHT CHAIN)		 2r17 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 35
(Homo
sapiens) 		3 / 3 PRO C 755
ASN C 767
HIS C 771
 None
 1.03A 4ma3H-2r17C:
undetectable
4ma3L-2r17C:
undetectable		 4ma3H-2r17C:
19.80
4ma3L-2r17C:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2r17 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 35
(Homo
sapiens) 		5 / 12 LEU C 579
PHE C 584
GLY C 587
ALA C 591
PHE C 606
 None
 1.12A 4retA-2r17C:
undetectable		 4retA-2r17C:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y1D_D_DVAD5_0
(CYCLIC HEXAPEPTIDE
CYC[NDPOPPKID]
INTEGRASE)		 2r17 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 35
(Homo
sapiens) 		3 / 3 GLU C 597
LYS C 555
ASN C 598
 None
 0.78A 4y1dA-2r17C:
undetectable
4y1dD-2r17C:
undetectable		 4y1dA-2r17C:
18.92
4y1dD-2r17C:
4.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_1_BEZ1801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2r17 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 35
(Homo
sapiens) 		3 / 3 LEU C 571
PHE C 584
ILE C 572
 None
 0.66A 5dzk1-2r17C:
undetectable
5dzkF-2r17C:
undetectable
5dzkM-2r17C:
undetectable		 5dzk1-2r17C:
12.50
5dzkF-2r17C:
23.10
5dzkM-2r17C:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2r17 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 35
(Homo
sapiens) 		5 / 12 ILE C 723
TYR C 727
VAL C 696
ALA C 703
ALA C 707
 None
 1.08A 5n0oB-2r17C:
undetectable		 5n0oB-2r17C:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2r17 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 35
(Homo
sapiens) 		3 / 3 SER C 679
HIS C 675
TYR C 729
 None
 1.01A 5y2tA-2r17C:
undetectable		 5y2tA-2r17C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NCS_A_ACTA303_0
(N-ACETYLNEURAMINIC
ACID (SIALIC ACID)
SYNTHETASE)		 2r17 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 35
(Homo
sapiens) 		3 / 3 ILE C 568
THR C 567
PRO C 580
 None
 0.58A 6ncsA-2r17C:
undetectable		 6ncsA-2r17C:
23.51