SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2r1d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)		 2r1d NEUREXIN-1-BETA
(Rattus
norvegicus) 		5 / 8 ILE A 122
TYR A 127
LEU A  80
VAL A  81
LEU A  95
 None
 1.47A 2w98B-2r1dA:
undetectable		 2w98B-2r1dA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2r1d NEUREXIN-1-BETA
(Rattus
norvegicus) 		5 / 12 ILE A 122
ASP A 144
SER A 183
ILE A  69
LEU A  95
 None
 1.05A 4dfrA-2r1dA:
undetectable		 4dfrA-2r1dA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EXS_B_X8ZB301_1
(BETA-LACTAMASE NDM-1)		 2r1d NEUREXIN-1-BETA
(Rattus
norvegicus) 		4 / 8 VAL A 143
TRP A 146
ASN A 123
HIS A 128
 None
 0.90A 4exsB-2r1dA:
undetectable		 4exsB-2r1dA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_1
(PROTEASE)		 2r1d NEUREXIN-1-BETA
(Rattus
norvegicus) 		5 / 12 GLY A  70
ILE A 169
VAL A 104
VAL A 192
ILE A 167
 None
 0.95A 4q5mA-2r1dA:
undetectable		 4q5mA-2r1dA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 2r1d NEUREXIN-1-BETA
(Rattus
norvegicus) 		5 / 12 ILE A 122
ASP A 144
SER A 183
ILE A  69
LEU A  95
 None
 1.08A 4qi9A-2r1dA:
undetectable		 4qi9A-2r1dA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DHB_A_BEZA202_0
(HEPATITIS A VIRUS
CELLULAR RECEPTOR 2)		 2r1d NEUREXIN-1-BETA
(Rattus
norvegicus) 		4 / 6 PHE A 161
ARG A 134
ASN A 188
ASP A  65
 None
 1.29A 6dhbA-2r1dA:
undetectable		 6dhbA-2r1dA:
18.61