SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2r1f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_1
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 2r1f PREDICTED
AMINODEOXYCHORISMATE
LYASE
(Escherichia
coli) 		4 / 7 TYR A 142
THR A 286
SER A 213
GLN A 126
 None
 1.38A 1eiiA-2r1fA:
undetectable		 1eiiA-2r1fA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_D_SAMD200_0
(METHIONINE REPRESSOR)		 2r1f PREDICTED
AMINODEOXYCHORISMATE
LYASE
(Escherichia
coli) 		5 / 12 HIS A 297
GLY A 195
ALA A 295
LEU A 200
PRO A 201
 CD  A 341 (-3.6A)
None
None
None
None
 1.14A 1mjqC-2r1fA:
undetectable
1mjqD-2r1fA:
0.9		 1mjqC-2r1fA:
20.90
1mjqD-2r1fA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_J_SAMJ200_0
(METHIONINE REPRESSOR)		 2r1f PREDICTED
AMINODEOXYCHORISMATE
LYASE
(Escherichia
coli) 		5 / 12 HIS A 297
GLY A 195
ALA A 295
LEU A 200
PRO A 201
 CD  A 341 (-3.6A)
None
None
None
None
 1.14A 1mjqI-2r1fA:
undetectable
1mjqJ-2r1fA:
0.9		 1mjqI-2r1fA:
20.90
1mjqJ-2r1fA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMJ_A_ACRA1001_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 2r1f PREDICTED
AMINODEOXYCHORISMATE
LYASE
(Escherichia
coli) 		5 / 12 ASN A 171
ASP A 140
ARG A 128
ASP A 174
ALA A 176
 None
 0.89A 2qmjA-2r1fA:
undetectable		 2qmjA-2r1fA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_A_DVAA8_0
(GRAMICIDIN A)		 2r1f PREDICTED
AMINODEOXYCHORISMATE
LYASE
(Escherichia
coli) 		3 / 3 VAL A 115
TRP A 162
TRP A 166
 None
 1.42A 2xdcA-2r1fA:
undetectable
2xdcB-2r1fA:
undetectable		 2xdcA-2r1fA:
11.59
2xdcB-2r1fA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_A_DVAA8_0
(GRAMICIDIN A)		 2r1f PREDICTED
AMINODEOXYCHORISMATE
LYASE
(Escherichia
coli) 		3 / 3 VAL A 115
TRP A 166
TRP A 162
 None
 1.45A 2xdcA-2r1fA:
undetectable
2xdcB-2r1fA:
undetectable		 2xdcA-2r1fA:
11.59
2xdcB-2r1fA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_B_DVAB8_0
(GRAMICIDIN A)		 2r1f PREDICTED
AMINODEOXYCHORISMATE
LYASE
(Escherichia
coli) 		3 / 3 TRP A 162
VAL A 115
TRP A 166
 None
 1.44A 2xdcA-2r1fA:
undetectable
2xdcB-2r1fA:
undetectable		 2xdcA-2r1fA:
11.59
2xdcB-2r1fA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_B_DVAB8_0
(GRAMICIDIN A)		 2r1f PREDICTED
AMINODEOXYCHORISMATE
LYASE
(Escherichia
coli) 		3 / 3 TRP A 166
VAL A 115
TRP A 162
 None
 1.41A 2xdcA-2r1fA:
undetectable
2xdcB-2r1fA:
undetectable		 2xdcA-2r1fA:
11.59
2xdcB-2r1fA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_D_DVAD8_0
(GRAMICIDIN A)		 2r1f PREDICTED
AMINODEOXYCHORISMATE
LYASE
(Escherichia
coli) 		3 / 3 TRP A 166
VAL A 115
TRP A 162
 None
 0.91A 2xdcC-2r1fA:
undetectable
2xdcD-2r1fA:
undetectable		 2xdcC-2r1fA:
11.59
2xdcD-2r1fA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_F_DVAF8_0
(GRAMICIDIN A)		 2r1f PREDICTED
AMINODEOXYCHORISMATE
LYASE
(Escherichia
coli) 		3 / 3 TRP A 166
VAL A 115
TRP A 162
 None
 0.97A 2xdcE-2r1fA:
undetectable
2xdcF-2r1fA:
undetectable		 2xdcE-2r1fA:
11.59
2xdcF-2r1fA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_A_DVAA8_0
(VAL-GRAMICIDIN A)		 2r1f PREDICTED
AMINODEOXYCHORISMATE
LYASE
(Escherichia
coli) 		3 / 3 VAL A 115
TRP A 162
TRP A 166
 None
 1.40A 2y5mA-2r1fA:
undetectable
2y5mB-2r1fA:
undetectable		 2y5mA-2r1fA:
11.59
2y5mB-2r1fA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_A_DVAA8_0
(VAL-GRAMICIDIN A)		 2r1f PREDICTED
AMINODEOXYCHORISMATE
LYASE
(Escherichia
coli) 		3 / 3 VAL A 115
TRP A 166
TRP A 162
 None
 1.45A 2y5mA-2r1fA:
undetectable
2y5mB-2r1fA:
undetectable		 2y5mA-2r1fA:
11.59
2y5mB-2r1fA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_F_DVAF8_0
(VAL-GRAMICIDIN A)		 2r1f PREDICTED
AMINODEOXYCHORISMATE
LYASE
(Escherichia
coli) 		3 / 3 TRP A 166
VAL A 115
TRP A 162
 None
 0.91A 2y5mE-2r1fA:
undetectable
2y5mF-2r1fA:
undetectable		 2y5mE-2r1fA:
11.59
2y5mF-2r1fA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_A_DVAA8_0
(VAL-GRAMICIDIN A)		 2r1f PREDICTED
AMINODEOXYCHORISMATE
LYASE
(Escherichia
coli) 		3 / 3 VAL A 115
TRP A 162
TRP A 166
 None
 1.41A 2y6nA-2r1fA:
undetectable
2y6nB-2r1fA:
undetectable		 2y6nA-2r1fA:
11.59
2y6nB-2r1fA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_A_DVAA8_0
(VAL-GRAMICIDIN A)		 2r1f PREDICTED
AMINODEOXYCHORISMATE
LYASE
(Escherichia
coli) 		3 / 3 VAL A 115
TRP A 166
TRP A 162
 None
 1.45A 2y6nA-2r1fA:
undetectable
2y6nB-2r1fA:
undetectable		 2y6nA-2r1fA:
11.59
2y6nB-2r1fA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_B_DVAB8_0
(VAL-GRAMICIDIN A)		 2r1f PREDICTED
AMINODEOXYCHORISMATE
LYASE
(Escherichia
coli) 		3 / 3 TRP A 162
VAL A 115
TRP A 166
 None
 1.45A 2y6nA-2r1fA:
undetectable
2y6nB-2r1fA:
undetectable		 2y6nA-2r1fA:
11.59
2y6nB-2r1fA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_B_DVAB8_0
(VAL-GRAMICIDIN A)		 2r1f PREDICTED
AMINODEOXYCHORISMATE
LYASE
(Escherichia
coli) 		3 / 3 TRP A 166
VAL A 115
TRP A 162
 None
 1.40A 2y6nA-2r1fA:
undetectable
2y6nB-2r1fA:
undetectable		 2y6nA-2r1fA:
11.59
2y6nB-2r1fA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_D_DVAD8_0
(VAL-GRAMICIDIN A)		 2r1f PREDICTED
AMINODEOXYCHORISMATE
LYASE
(Escherichia
coli) 		3 / 3 TRP A 166
VAL A 115
TRP A 162
 None
 0.92A 2y6nC-2r1fA:
undetectable
2y6nD-2r1fA:
undetectable		 2y6nC-2r1fA:
11.59
2y6nD-2r1fA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_F_DVAF8_0
(VAL-GRAMICIDIN A)		 2r1f PREDICTED
AMINODEOXYCHORISMATE
LYASE
(Escherichia
coli) 		3 / 3 TRP A 166
VAL A 115
TRP A 162
 None
 0.91A 2y6nE-2r1fA:
undetectable
2y6nF-2r1fA:
undetectable		 2y6nE-2r1fA:
11.59
2y6nF-2r1fA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2r1f PREDICTED
AMINODEOXYCHORISMATE
LYASE
(Escherichia
coli) 		4 / 5 LEU A 137
GLN A 147
THR A 144
THR A 173
 None
 1.11A 2zj0B-2r1fA:
undetectable		 2zj0B-2r1fA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2r1f PREDICTED
AMINODEOXYCHORISMATE
LYASE
(Escherichia
coli) 		4 / 4 LEU A 137
GLN A 147
THR A 144
THR A 173
 None
 1.10A 2zj0D-2r1fA:
undetectable		 2zj0D-2r1fA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_B_ADNB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2r1f PREDICTED
AMINODEOXYCHORISMATE
LYASE
(Escherichia
coli) 		4 / 5 LEU A 137
GLN A 147
THR A 144
THR A 173
 None
 1.10A 3ce6B-2r1fA:
undetectable		 3ce6B-2r1fA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_D_9PLD1_1
(CYTOCHROME P450 2A13)		 2r1f PREDICTED
AMINODEOXYCHORISMATE
LYASE
(Escherichia
coli) 		4 / 8 PHE A 306
PHE A 316
PHE A 232
ALA A 229
 GOL  A 350 (-3.8A)
None
GOL  A 350 (-4.8A)
None
 0.89A 3t3sD-2r1fA:
undetectable		 3t3sD-2r1fA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_A_NCTA501_1
(CYTOCHROME P450 2A13)		 2r1f PREDICTED
AMINODEOXYCHORISMATE
LYASE
(Escherichia
coli) 		4 / 7 PHE A 306
PHE A 316
PHE A 232
ALA A 229
 GOL  A 350 (-3.8A)
None
GOL  A 350 (-4.8A)
None
 0.84A 4ejgA-2r1fA:
undetectable		 4ejgA-2r1fA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_B_NCTB501_1
(CYTOCHROME P450 2A13)		 2r1f PREDICTED
AMINODEOXYCHORISMATE
LYASE
(Escherichia
coli) 		4 / 8 PHE A 306
PHE A 316
PHE A 232
ALA A 229
 GOL  A 350 (-3.8A)
None
GOL  A 350 (-4.8A)
None
 0.92A 4ejgB-2r1fA:
undetectable		 4ejgB-2r1fA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2O_B_CLQB1079_0
(SAPOSIN-B)		 2r1f PREDICTED
AMINODEOXYCHORISMATE
LYASE
(Escherichia
coli) 		3 / 3 MET A  93
GLU A  97
LEU A 101
 None
 0.76A 4v2oB-2r1fA:
undetectable		 4v2oB-2r1fA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2r1f PREDICTED
AMINODEOXYCHORISMATE
LYASE
(Escherichia
coli) 		4 / 7 LEU A 279
THR A 273
THR A 244
THR A 210
 None
 0.96A 4z91F-2r1fA:
undetectable
4z91G-2r1fA:
undetectable
4z91H-2r1fA:
undetectable
4z91I-2r1fA:
undetectable
4z91J-2r1fA:
undetectable		 4z91F-2r1fA:
20.61
4z91G-2r1fA:
20.61
4z91H-2r1fA:
20.61
4z91I-2r1fA:
20.61
4z91J-2r1fA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2r1f PREDICTED
AMINODEOXYCHORISMATE
LYASE
(Escherichia
coli) 		4 / 7 THR A 136
LEU A 137
THR A 173
LEU A 149
 None
 0.81A 4z91F-2r1fA:
undetectable
4z91G-2r1fA:
undetectable
4z91H-2r1fA:
undetectable
4z91I-2r1fA:
undetectable
4z91J-2r1fA:
undetectable		 4z91F-2r1fA:
20.61
4z91G-2r1fA:
20.61
4z91H-2r1fA:
20.61
4z91I-2r1fA:
20.61
4z91J-2r1fA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)		 2r1f PREDICTED
AMINODEOXYCHORISMATE
LYASE
(Escherichia
coli) 		5 / 9 ALA A 285
VAL A 209
ALA A 212
SER A 213
GLY A 288
 None
None
None
None
CD  A   1 ( 4.5A)
 1.26A 6bklA-2r1fA:
undetectable
6bklB-2r1fA:
undetectable
6bklC-2r1fA:
undetectable
6bklD-2r1fA:
undetectable		 6bklA-2r1fA:
6.49
6bklB-2r1fA:
6.49
6bklC-2r1fA:
6.49
6bklD-2r1fA:
6.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA820_0
(GEPHYRIN)		 2r1f PREDICTED
AMINODEOXYCHORISMATE
LYASE
(Escherichia
coli) 		4 / 5 GLU A 116
PRO A 287
THR A 286
MET A 185
 CD  A   1 (-3.3A)
None
None
None
 1.43A 6fgdA-2r1fA:
undetectable		 6fgdA-2r1fA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_B_LLLB301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2r1f PREDICTED
AMINODEOXYCHORISMATE
LYASE
(Escherichia
coli) 		4 / 7 ASP A 122
ARG A 119
TYR A 142
GLU A 158
 None
 1.33A 6mn5B-2r1fA:
undetectable		 6mn5B-2r1fA:
15.75