SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2r1h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FIQ_C_SALC1335_1
(XANTHINE OXIDASE)		 2r1h HEMOGLOBIN SUBUNIT
BETA-4
(Oncorhynchus
mykiss) 		4 / 8 LEU B  71
THR B  84
LEU B  88
ALA B 141
 None
None
HEM  B 148 ( 4.6A)
None
 0.87A 1fiqC-2r1hB:
undetectable		 1fiqC-2r1hB:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2r1h HEMOGLOBIN SUBUNIT
BETA-4
(Oncorhynchus
mykiss) 		5 / 12 VAL B 138
LEU B 142
LEU B 135
VAL B  67
GLY B  70
 None
HEM  B 148 (-4.7A)
EDO  B2775 ( 4.8A)
HEM  B 148 ( 4.0A)
HEM  B 148 ( 4.3A)
 1.09A 3rr3C-2r1hB:
undetectable		 3rr3C-2r1hB:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2r1h HEMOGLOBIN SUBUNIT
BETA-4
(Oncorhynchus
mykiss) 		5 / 12 VAL B 138
LEU B 142
LEU B 135
VAL B  67
GLY B  70
 None
HEM  B 148 (-4.7A)
EDO  B2775 ( 4.8A)
HEM  B 148 ( 4.0A)
HEM  B 148 ( 4.3A)
 1.08A 3rr3D-2r1hB:
undetectable		 3rr3D-2r1hB:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_1
(GLYCINE
N-METHYLTRANSFERASE)		 2r1h HEMOGLOBIN SUBUNIT
BETA-4
(Oncorhynchus
mykiss) 		3 / 3 LEU B  96
HIS B  92
MET B  91
 HEM  B 148 (-4.2A)
HEM  B 148 (-3.4A)
HEM  B 148 (-3.7A)
 0.94A 3thrD-2r1hB:
undetectable		 3thrD-2r1hB:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_2
(ANCESTRAL STEROID
RECEPTOR 2)		 2r1h HEMOGLOBIN SUBUNIT
ALPHA-4
HEMOGLOBIN SUBUNIT
BETA-4
(Oncorhynchus
mykiss) 		4 / 8 TRP A  14
MET A  64
VAL B 112
PHE A 118
 None
 1.03A 4ltwA-2r1hA:
undetectable		 4ltwA-2r1hA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2r1h HEMOGLOBIN SUBUNIT
BETA-4
(Oncorhynchus
mykiss) 		5 / 12 ILE B 110
VAL B 114
LEU B 118
GLY B  13
LEU B  71
 None
 0.94A 4o1zA-2r1hB:
undetectable		 4o1zA-2r1hB:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_C_IPHC101_0
(INSULIN)		 2r1h HEMOGLOBIN SUBUNIT
ALPHA-4
(Oncorhynchus
mykiss) 		5 / 11 CYH A  70
LEU A  81
LEU A 133
ALA A 136
LEU A   2
 None
 1.05A 4p65C-2r1hA:
undetectable
4p65D-2r1hA:
undetectable
4p65J-2r1hA:
undetectable
4p65L-2r1hA:
undetectable		 4p65C-2r1hA:
10.94
4p65D-2r1hA:
22.08
4p65J-2r1hA:
22.08
4p65L-2r1hA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_E_IPHE101_0
(INSULIN)		 2r1h HEMOGLOBIN SUBUNIT
ALPHA-4
(Oncorhynchus
mykiss) 		5 / 11 CYH A  70
LEU A  81
LEU A 133
ALA A 136
LEU A   2
 None
 1.01A 4p65E-2r1hA:
undetectable
4p65F-2r1hA:
undetectable
4p65J-2r1hA:
undetectable
4p65L-2r1hA:
undetectable		 4p65E-2r1hA:
10.94
4p65F-2r1hA:
22.08
4p65J-2r1hA:
22.08
4p65L-2r1hA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 2r1h HEMOGLOBIN SUBUNIT
ALPHA-4
(Oncorhynchus
mykiss) 		5 / 12 MET A  64
ILE A  67
VAL A  94
LEU A  33
LEU A  29
 None
HEM  A 143 (-4.9A)
HEM  A 143 ( 4.7A)
None
None
 1.42A 4qztA-2r1hA:
undetectable		 4qztA-2r1hA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA305_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 2r1h HEMOGLOBIN SUBUNIT
ALPHA-4
(Oncorhynchus
mykiss) 		4 / 6 LEU A 106
LEU A 102
ILE A  63
MET A  64
 None
HEM  A 143 (-4.2A)
HEM  A 143 ( 4.6A)
None
 0.89A 4ww7A-2r1hA:
undetectable		 4ww7A-2r1hA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_A_IPHA101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 2r1h HEMOGLOBIN SUBUNIT
ALPHA-4
(Oncorhynchus
mykiss) 		4 / 4 CYH A  70
LEU A  81
LEU A 133
ALA A 136
 None
 1.14A 5hpuA-2r1hA:
undetectable
5hpuB-2r1hA:
undetectable		 5hpuA-2r1hA:
10.94
5hpuB-2r1hA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_A_FUAA1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 2r1h HEMOGLOBIN SUBUNIT
ALPHA-4
(Oncorhynchus
mykiss) 		4 / 5 ILE A  17
ILE A 122
HIS A 123
VAL A 126
 None
 0.44A 5jmnA-2r1hA:
undetectable		 5jmnA-2r1hA:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWY_A_YNUA1101_0
(MINERALOCORTICOID
RECEPTOR)		 2r1h HEMOGLOBIN SUBUNIT
ALPHA-4
(Oncorhynchus
mykiss) 		5 / 12 LEU A 130
LEU A 133
ALA A 136
SER A  85
LEU A  84
 None
None
None
None
HEM  A 143 (-4.7A)
 1.16A 5mwyA-2r1hA:
undetectable		 5mwyA-2r1hA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 2r1h HEMOGLOBIN SUBUNIT
BETA-4
(Oncorhynchus
mykiss) 		5 / 12 VAL B  67
PHE B 134
VAL B 114
LEU B 135
VAL B 138
 HEM  B 148 ( 4.0A)
None
None
EDO  B2775 ( 4.8A)
None
 1.09A 5tudD-2r1hB:
undetectable		 5tudD-2r1hB:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B54_A_OAQA302_0
(SULFOTRANSFERASE)		 2r1h HEMOGLOBIN SUBUNIT
ALPHA-4
(Oncorhynchus
mykiss) 		5 / 12 ILE A  63
LEU A  81
LEU A  29
THR A  39
LEU A  33
 HEM  A 143 ( 4.6A)
None
None
HEM  A 143 ( 4.3A)
None
 1.15A 6b54A-2r1hA:
undetectable		 6b54A-2r1hA:
19.67