SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2r1v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_A_ADNA2001_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 2r1v DJ-1
(Homo
sapiens) 		4 / 7 GLU A  15
ALA A 129
ASN A  76
ALA A 107
 None
 1.01A 2ejfA-2r1vA:
undetectable		 2ejfA-2r1vA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAT_A_CLMA301_0
(XENOBIOTIC
ACETYLTRANSFERASE)		 2r1v DJ-1
(Homo
sapiens) 		3 / 3 GLY A 120
TYR A 139
SER A 121
 None
 0.67A 2xatA-2r1vA:
undetectable		 2xatA-2r1vA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_A_ADNA1301_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 2r1v DJ-1
(Homo
sapiens) 		4 / 7 GLU A  15
ALA A 129
ASN A  76
ALA A 107
 None
 0.94A 2zgwA-2r1vA:
undetectable		 2zgwA-2r1vA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_B_ADNB1302_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 2r1v DJ-1
(Homo
sapiens) 		4 / 6 GLU A  15
ALA A 129
ASN A  76
ALA A 107
 None
 0.96A 2zgwB-2r1vA:
undetectable		 2zgwB-2r1vA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Y_A_ROCA201_2
(HIV-1 PROTEASE)		 2r1v DJ-1
(Homo
sapiens) 		5 / 9 LEU A 101
GLY A 108
ILE A 105
VAL A  69
ILE A 102
 None
 1.11A 3d1yB-2r1vA:
undetectable		 3d1yB-2r1vA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 2r1v DJ-1
(Homo
sapiens) 		5 / 10 ILE A 105
LEU A 166
VAL A 169
VAL A 181
LEU A 185
 None
 1.03A 3gwxA-2r1vA:
undetectable		 3gwxA-2r1vA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 2r1v DJ-1
(Homo
sapiens) 		5 / 12 ALA A 104
ILE A 102
LEU A  82
ILE A  91
LEU A  58
 None
 1.15A 3k2hB-2r1vA:
undetectable		 3k2hB-2r1vA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 2r1v DJ-1
(Homo
sapiens) 		6 / 12 ALA A 106
PRO A 109
THR A 110
GLY A  78
GLY A  74
LEU A  77
 None
 1.50A 5c0oG-2r1vA:
3.3		 5c0oG-2r1vA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2r1v DJ-1
(Homo
sapiens) 		4 / 5 ALA A  14
PRO A  22
GLY A 174
LEU A 153
 None
 0.99A 5eslA-2r1vA:
undetectable		 5eslA-2r1vA:
17.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6E5Z_A_CCSA106_0
(PROTEIN/NUCLEIC ACID
DEGLYCASE DJ-1)		 2r1v DJ-1
(Homo
sapiens) 		10 / 10 GLU A  18
GLY A  74
GLY A  75
ASN A  76
ILE A 105
ALA A 107
PRO A 109
THR A 125
HIS A 126
GLY A 157
 None
 0.23A 6e5zA-2r1vA:
39.7		 6e5zA-2r1vA:
99.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6E5Z_A_CCSA106_0
(PROTEIN/NUCLEIC ACID
DEGLYCASE DJ-1)		 2r1v DJ-1
(Homo
sapiens) 		6 / 10 GLU A  18
GLY A  75
ALA A 107
THR A 125
HIS A 126
GLY A 157
 None
 1.11A 6e5zA-2r1vA:
39.7		 6e5zA-2r1vA:
99.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA414_0
(AROMATIC
PEROXYGENASE)		 2r1v DJ-1
(Homo
sapiens) 		4 / 5 VAL A 146
PRO A  22
MET A  26
VAL A   8
 None
 1.29A 6ekzA-2r1vA:
undetectable		 6ekzA-2r1vA:
18.60