SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2r1y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DSD_C_DVAC2_0 (ACTINOMYCIN D)	2r1y	FAB, ANTIBODY FRAGMENT (IGG1K), HEAVY CHAIN (Mus musculus)	4 / 4	THR B 115 PRO B 145 THR B 114 PRO B 116	None	1.29A	1dsdC-2r1yB: undetectable	1dsdC-2r1yB: 13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DSD_C_DVAC8_0 (ACTINOMYCIN D)	2r1y	FAB, ANTIBODY FRAGMENT (IGG1K), HEAVY CHAIN (Mus musculus)	4 / 4	THR B 115 PRO B 145 THR B 114 PRO B 116	None	1.29A	1dsdC-2r1yB: undetectable	1dsdC-2r1yB: 13.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5MTH_A_ACTA302_0 (ANTIBODY FAB HEAVY CHAIN)	2r1y	FAB, ANTIBODY FRAGMENT (IGG1K), HEAVY CHAIN (Mus musculus)	5 / 5	SER B 110 ALA B 112 PHE B 144 LEU B 168 ASP B 171	None	0.37A	5mthA-2r1yB: 28.7	5mthA-2r1yB: 70.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X6Y_A_SAMA902_1 (MRNA CAPPING ENZYME P5)	2r1y	FAB, ANTIBODY FRAGMENT (IGG1K), HEAVY CHAIN (Mus musculus)	3 / 3	TYR B 32 ASP B 95 ASP B 97	None	0.83A	5x6yA-2r1yB: undetectable	5x6yA-2r1yB: 14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIW_D_LOCD503_1 (TUBULIN ALPHA-1B CHAIN TUBULIN BETA CHAIN)	2r1y	FAB, ANTIBODY FRAGMENT (IGG1K), HEAVY CHAIN (Mus musculus)	3 / 3	SER B 201 ALA B 196 VAL B 195	None	0.53A	5xiwC-2r1yB: undetectable	5xiwC-2r1yB: 16.07

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1DSD_C_DVAC2_0","ACTINOMYCIN D","2r1y","FAB, ANTIBODY FRAGMENT (IGG1K), HEAVY CHAIN","Mus musculus",4,"THR B 115;PRO B 145;THR B 114;PRO B 116","None","1.29A","1dsdC-2r1yB:undetectable","1dsdC-2r1yB:13.33"],["1DSD_C_DVAC8_0","ACTINOMYCIN D","2r1y","FAB, ANTIBODY FRAGMENT (IGG1K), HEAVY CHAIN","Mus musculus",4,"THR B 115;PRO B 145;THR B 114;PRO B 116","None","1.29A","1dsdC-2r1yB:undetectable","1dsdC-2r1yB:13.33"],["5MTH_A_ACTA302_0","ANTIBODY FAB HEAVY CHAIN","2r1y","FAB, ANTIBODY FRAGMENT (IGG1K), HEAVY CHAIN","Mus musculus",5,"SER B 110;ALA B 112;PHE B 144;LEU B 168;ASP B 171","None","0.37A","5mthA-2r1yB:28.7","5mthA-2r1yB:70.27"],["5X6Y_A_SAMA902_1","MRNA CAPPING ENZYME P5","2r1y","FAB, ANTIBODY FRAGMENT (IGG1K), HEAVY CHAIN","Mus musculus",3,"TYR B  32;ASP B  95;ASP B  97","None","0.83A","5x6yA-2r1yB:undetectable","5x6yA-2r1yB:14.81"],["5XIW_D_LOCD503_1","TUBULIN ALPHA-1B CHAIN;TUBULIN BETA CHAIN","2r1y","FAB, ANTIBODY FRAGMENT (IGG1K), HEAVY CHAIN","Mus musculus",3,"SER B 201;ALA B 196;VAL B 195","None","0.53A","5xiwC-2r1yB:undetectable","5xiwC-2r1yB:16.07"]]