SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2r26'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_1
(ESTROGEN RECEPTOR)		 2r26 CITRATE SYNTHASE
(Thermoplasma
acidophilum) 		5 / 12 THR A 211
ALA A 213
LEU A 217
LEU A 197
ILE A 353
 None
 1.21A 1errA-2r26A:
undetectable		 1errA-2r26A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA502_1
(YKOF)		 2r26 CITRATE SYNTHASE
(Thermoplasma
acidophilum) 		4 / 6 ALA A 180
LEU A 183
ILE A 182
SER A 343
 None
 1.03A 1sbrA-2r26A:
undetectable
1sbrB-2r26A:
undetectable		 1sbrA-2r26A:
17.97
1sbrB-2r26A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F6D_A_ACRA996_1
(GLUCOAMYLASE GLU1)		 2r26 CITRATE SYNTHASE
(Thermoplasma
acidophilum) 		5 / 7 HIS A 222
ASN A 315
ASP A 269
THR A 337
GLY A 223
 CMC  A 701 ( 3.7A)
CMC  A 701 (-3.0A)
None
None
CMC  A 701 (-3.5A)
 1.30A 2f6dA-2r26A:
undetectable		 2f6dA-2r26A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0G_A_LEUA1887_0
(AMINOACYL-TRNA
SYNTHETASE)		 2r26 CITRATE SYNTHASE
(Thermoplasma
acidophilum) 		4 / 8 MET A 177
TYR A 156
ASP A  47
TYR A 324
 None
 1.14A 2v0gA-2r26A:
undetectable		 2v0gA-2r26A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_B_ACTB1463_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 2r26 CITRATE SYNTHASE
(Thermoplasma
acidophilum) 		4 / 7 VAL A 345
ILE A 128
ALA A 124
GLY A 347
 None
 0.77A 2xrzB-2r26A:
undetectable		 2xrzB-2r26A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA602_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 2r26 CITRATE SYNTHASE
(Thermoplasma
acidophilum) 		4 / 7 ASN A  84
ALA A 102
ALA A 101
ALA A 105
 None
 0.89A 3a2qA-2r26A:
undetectable		 3a2qA-2r26A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_D_NCAD192_0
(NICOTINAMIDASE)		 2r26 CITRATE SYNTHASE
(Thermoplasma
acidophilum) 		5 / 11 PHE A 160
LEU A 161
PHE A 165
TYR A 139
LEU A 339
 None
 1.44A 3o94D-2r26A:
undetectable		 3o94D-2r26A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_E_9PLE1_1
(CYTOCHROME P450 2A13)		 2r26 CITRATE SYNTHASE
(Thermoplasma
acidophilum) 		4 / 8 PHE A  81
ALA A  85
ALA A 104
THR A 211
 None
 1.07A 3t3sE-2r26A:
undetectable		 3t3sE-2r26A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_A_9PLA501_1
(CYTOCHROME P450 2E1)		 2r26 CITRATE SYNTHASE
(Thermoplasma
acidophilum) 		4 / 6 LEU A 161
PHE A 329
THR A 135
LEU A 181
 None
 0.94A 3t3zA-2r26A:
undetectable		 3t3zA-2r26A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_B_9PLB501_1
(CYTOCHROME P450 2E1)		 2r26 CITRATE SYNTHASE
(Thermoplasma
acidophilum) 		4 / 6 LEU A 161
PHE A 329
THR A 135
LEU A 181
 None
 1.00A 3t3zB-2r26A:
undetectable		 3t3zB-2r26A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_D_9PLD501_1
(CYTOCHROME P450 2E1)		 2r26 CITRATE SYNTHASE
(Thermoplasma
acidophilum) 		4 / 6 LEU A 161
PHE A 329
THR A 135
LEU A 181
 None
 0.99A 3t3zD-2r26A:
undetectable		 3t3zD-2r26A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKA_A_SAMA400_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H)		 2r26 CITRATE SYNTHASE
(Thermoplasma
acidophilum) 		5 / 12 THR A 316
GLY A 259
GLY A 261
HIS A 262
PHE A 275
 OAA  A 501 ( 4.9A)
CMC  A 701 (-3.3A)
CMC  A 701 (-3.2A)
OAA  A 501 ( 4.0A)
None
 1.04A 3tkaA-2r26A:
undetectable		 3tkaA-2r26A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA1_A_08YA600_1
(CYTOCHROME P450 3A4)		 2r26 CITRATE SYNTHASE
(Thermoplasma
acidophilum) 		5 / 12 ASP A 317
ILE A 327
THR A 316
PHE A 160
ALA A  95
 CMC  A 701 (-2.7A)
None
OAA  A 501 ( 4.9A)
None
None
 1.30A 3ua1A-2r26A:
undetectable		 3ua1A-2r26A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_1
(PUTATIVE REGULATORY
PROTEIN)		 2r26 CITRATE SYNTHASE
(Thermoplasma
acidophilum) 		3 / 3 TYR A  68
MET A 177
LEU A 342
 None
 0.84A 3vw1D-2r26A:
undetectable		 3vw1D-2r26A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQE_B_DXCB1079_0
(PROTEIN PRGI, CELL
INVASION PROTEIN
SIPD)		 2r26 CITRATE SYNTHASE
(Thermoplasma
acidophilum) 		5 / 11 PRO A 190
SER A 192
GLN A  51
THR A 185
GLN A 349
 OAA  A 501 (-4.0A)
OAA  A 501 ( 4.9A)
None
None
None
 1.44A 3zqeA-2r26A:
0.0
3zqeB-2r26A:
0.0		 3zqeA-2r26A:
21.77
3zqeB-2r26A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_1
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 2r26 CITRATE SYNTHASE
(Thermoplasma
acidophilum) 		3 / 3 TYR A  56
ASP A 122
ASP A 118
 None
 0.74A 4a6eA-2r26A:
undetectable		 4a6eA-2r26A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_C_MIYC392_1
(TETX2 PROTEIN)		 2r26 CITRATE SYNTHASE
(Thermoplasma
acidophilum) 		5 / 12 TYR A 324
VAL A 345
ILE A 128
GLN A  51
ILE A  50
 None
 1.45A 4a99A-2r26A:
undetectable
4a99C-2r26A:
undetectable		 4a99A-2r26A:
22.59
4a99C-2r26A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_A_DM2A1106_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2r26 CITRATE SYNTHASE
(Thermoplasma
acidophilum) 		5 / 11 PHE A 329
PHE A 165
ASN A 162
LEU A 161
THR A 170
 None
 1.39A 4dx7A-2r26A:
1.5		 4dx7A-2r26A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 2r26 CITRATE SYNTHASE
(Thermoplasma
acidophilum) 		4 / 7 ILE A 251
ASP A 301
GLY A 303
PHE A 307
 None
None
None
CMC  A 701 ( 4.3A)
 0.93A 4iqqA-2r26A:
undetectable		 4iqqA-2r26A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 2r26 CITRATE SYNTHASE
(Thermoplasma
acidophilum) 		4 / 7 TYR A 313
ASP A 317
GLY A 259
PHE A 260
 None
CMC  A 701 (-2.7A)
CMC  A 701 (-3.3A)
None
 0.82A 4iqqA-2r26A:
undetectable		 4iqqA-2r26A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 2r26 CITRATE SYNTHASE
(Thermoplasma
acidophilum) 		4 / 7 TYR A 313
ASP A 317
GLY A 259
PHE A 260
 None
CMC  A 701 (-2.7A)
CMC  A 701 (-3.3A)
None
 0.81A 4iqqB-2r26A:
undetectable		 4iqqB-2r26A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 2r26 CITRATE SYNTHASE
(Thermoplasma
acidophilum) 		4 / 8 ILE A 251
ASP A 301
GLY A 303
PHE A 307
 None
None
None
CMC  A 701 ( 4.3A)
 0.85A 4iqqD-2r26A:
undetectable		 4iqqD-2r26A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 2r26 CITRATE SYNTHASE
(Thermoplasma
acidophilum) 		4 / 8 TYR A 313
ASP A 317
GLY A 259
PHE A 260
 None
CMC  A 701 (-2.7A)
CMC  A 701 (-3.3A)
None
 0.82A 4iqqD-2r26A:
undetectable		 4iqqD-2r26A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 2r26 CITRATE SYNTHASE
(Thermoplasma
acidophilum) 		4 / 7 THR A 135
ALA A  95
ALA A  97
THR A 337
 None
 1.02A 4qw0K-2r26A:
undetectable		 4qw0K-2r26A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 2r26 CITRATE SYNTHASE
(Thermoplasma
acidophilum) 		4 / 7 THR A 135
ALA A  95
ALA A  97
THR A 337
 None
 1.01A 4qw0Y-2r26A:
undetectable		 4qw0Y-2r26A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 2r26 CITRATE SYNTHASE
(Thermoplasma
acidophilum) 		4 / 7 ALA A 272
TYR A 265
VAL A  37
GLU A  38
 None
 1.11A 5ecnA-2r26A:
undetectable		 5ecnA-2r26A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA302_1
(CHITOSANASE)		 2r26 CITRATE SYNTHASE
(Thermoplasma
acidophilum) 		4 / 7 ARG A  31
THR A  22
TYR A 265
GLY A  28
 None
 1.13A 5hwaA-2r26A:
undetectable		 5hwaA-2r26A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K50_C_ACTC1403_0
(L-THREONINE
3-DEHYDROGENASE)		 2r26 CITRATE SYNTHASE
(Thermoplasma
acidophilum) 		4 / 4 MET A 325
SER A 326
VAL A 323
GLY A 321
 None
 1.37A 5k50C-2r26A:
0.0		 5k50C-2r26A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 2r26 CITRATE SYNTHASE
(Thermoplasma
acidophilum) 		4 / 6 TYR A 313
ASP A 317
GLY A 259
PHE A 260
 None
CMC  A 701 (-2.7A)
CMC  A 701 (-3.3A)
None
 0.86A 5nooC-2r26A:
undetectable		 5nooC-2r26A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 2r26 CITRATE SYNTHASE
(Thermoplasma
acidophilum) 		4 / 8 ILE A 251
ASP A 301
GLY A 303
PHE A 307
 None
None
None
CMC  A 701 ( 4.3A)
 0.87A 5nooD-2r26A:
undetectable		 5nooD-2r26A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 2r26 CITRATE SYNTHASE
(Thermoplasma
acidophilum) 		4 / 8 TYR A 313
ASP A 317
GLY A 259
PHE A 260
 None
CMC  A 701 (-2.7A)
CMC  A 701 (-3.3A)
None
 0.85A 5nooD-2r26A:
undetectable		 5nooD-2r26A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_1
(CYTOCHROME P450 3A4)		 2r26 CITRATE SYNTHASE
(Thermoplasma
acidophilum) 		5 / 12 ASP A 317
ILE A 327
THR A 316
PHE A 160
ALA A  95
 CMC  A 701 (-2.7A)
None
OAA  A 501 ( 4.9A)
None
None
 1.29A 5vcgA-2r26A:
0.0		 5vcgA-2r26A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2r26 CITRATE SYNTHASE
(Thermoplasma
acidophilum) 		3 / 3 GLN A 232
TRP A 245
VAL A 242
 None
 1.06A 6auuA-2r26A:
undetectable		 6auuA-2r26A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HXI_B_ACTB706_0
(SUCCINYL-COA LIGASE
(ADP-FORMING)
SUBUNIT ALPHA)		 2r26 CITRATE SYNTHASE
(Thermoplasma
acidophilum) 		4 / 5 HIS A 187
ARG A 271
PHE A 340
ARG A 344
 OAA  A 501 (-3.8A)
OAA  A 501 (-3.1A)
OAA  A 501 ( 4.6A)
OAA  A 501 (-2.7A)
 0.68A 6hxiB-2r26A:
15.2		 6hxiB-2r26A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HXI_D_ACTD703_0
(SUCCINYL-COA LIGASE
(ADP-FORMING)
SUBUNIT ALPHA)		 2r26 CITRATE SYNTHASE
(Thermoplasma
acidophilum) 		5 / 5 HIS A 187
ARG A 271
ASP A 317
PHE A 340
ARG A 344
 OAA  A 501 (-3.8A)
OAA  A 501 (-3.1A)
CMC  A 701 (-2.7A)
OAA  A 501 ( 4.6A)
OAA  A 501 (-2.7A)
 0.70A 6hxiD-2r26A:
16.8		 6hxiD-2r26A:
21.56