SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2r2d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_A_PPFA410_1
(PHOSPHONOACETATE
HYDROLASE)		 2r2d ZN-DEPENDENT
HYDROLASES
(Agrobacterium
fabrum) 		4 / 5 ASP A 213
HIS A 259
HIS A 111
HIS A 116
 ZN  A 277 (-2.0A)
ZN  A 277 (-3.2A)
ZN  A 278 ( 3.2A)
ZN  A 277 ( 3.2A)
 1.20A 1ei6A-2r2dA:
undetectable		 1ei6A-2r2dA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3003_0
(BETA-CARBONIC
ANHYDRASE)		 2r2d ZN-DEPENDENT
HYDROLASES
(Agrobacterium
fabrum) 		4 / 8 ASP A 213
VAL A 211
HIS A 116
GLY A 258
 ZN  A 277 (-2.0A)
None
ZN  A 277 ( 3.2A)
None
 0.98A 1ekjA-2r2dA:
undetectable
1ekjB-2r2dA:
undetectable		 1ekjA-2r2dA:
22.22
1ekjB-2r2dA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ITU_B_CILB452_1
(RENAL DIPEPTIDASE)		 2r2d ZN-DEPENDENT
HYDROLASES
(Agrobacterium
fabrum) 		5 / 12 HIS A 191
HIS A 111
ASP A 115
VAL A  43
PRO A  42
 ZN  A 278 ( 3.2A)
ZN  A 278 ( 3.2A)
PO4  A 279 (-2.9A)
None
None
 1.33A 1ituB-2r2dA:
undetectable		 1ituB-2r2dA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U72_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 2r2d ZN-DEPENDENT
HYDROLASES
(Agrobacterium
fabrum) 		5 / 12 LEU A 112
SER A 110
ASN A 186
LEU A 184
ARG A 176
 None
 1.35A 1u72A-2r2dA:
undetectable		 1u72A-2r2dA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0I_A_BEZA990_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 2r2d ZN-DEPENDENT
HYDROLASES
(Agrobacterium
fabrum) 		4 / 8 ASP A 115
ASP A 213
HIS A 116
SER A  44
 PO4  A 279 (-2.9A)
ZN  A 277 (-2.0A)
ZN  A 277 ( 3.2A)
None
 1.05A 2q0iA-2r2dA:
12.9		 2q0iA-2r2dA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0J_B_BEZB500_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 2r2d ZN-DEPENDENT
HYDROLASES
(Agrobacterium
fabrum) 		5 / 11 ASP A 115
HIS A 116
HIS A 191
ASP A 213
HIS A 259
 PO4  A 279 (-2.9A)
ZN  A 277 ( 3.2A)
ZN  A 278 ( 3.2A)
ZN  A 277 (-2.0A)
ZN  A 277 (-3.2A)
 0.62A 2q0jB-2r2dA:
12.7		 2q0jB-2r2dA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 2r2d ZN-DEPENDENT
HYDROLASES
(Agrobacterium
fabrum) 		4 / 6 PHE A   6
GLN A  49
LEU A  94
LEU A  99
 None
 1.20A 3bgdA-2r2dA:
undetectable		 3bgdA-2r2dA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHN_A_ACTA108_0
(PROTEIN P-30)		 2r2d ZN-DEPENDENT
HYDROLASES
(Agrobacterium
fabrum) 		3 / 3 THR A 271
SER A 270
ARG A  93
 None
 0.82A 3phnA-2r2dA:
undetectable		 3phnA-2r2dA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		 2r2d ZN-DEPENDENT
HYDROLASES
(Agrobacterium
fabrum) 		4 / 5 HIS A 131
HIS A 113
GLU A 134
HIS A 111
 None
ZN  A 278 ( 3.2A)
None
ZN  A 278 ( 3.2A)
 1.27A 4a7bB-2r2dA:
undetectable		 4a7bB-2r2dA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 2r2d ZN-DEPENDENT
HYDROLASES
(Agrobacterium
fabrum) 		4 / 6 HIS A 113
SER A 110
ASP A 238
ASP A 213
 ZN  A 278 ( 3.2A)
None
None
ZN  A 277 (-2.0A)
 1.32A 4blvA-2r2dA:
undetectable		 4blvA-2r2dA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_A_PXLA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 2r2d ZN-DEPENDENT
HYDROLASES
(Agrobacterium
fabrum) 		4 / 7 GLY A 118
ASP A 115
GLY A  60
HIS A 259
 None
PO4  A 279 (-2.9A)
None
ZN  A 277 (-3.2A)
 0.79A 4c5nA-2r2dA:
undetectable		 4c5nA-2r2dA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 2r2d ZN-DEPENDENT
HYDROLASES
(Agrobacterium
fabrum) 		5 / 10 GLY A 118
ASP A 115
GLY A  60
HIS A 111
HIS A 259
 None
PO4  A 279 (-2.9A)
None
ZN  A 278 ( 3.2A)
ZN  A 277 (-3.2A)
 1.13A 4c5nB-2r2dA:
undetectable		 4c5nB-2r2dA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_C_PXLC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 2r2d ZN-DEPENDENT
HYDROLASES
(Agrobacterium
fabrum) 		4 / 8 GLY A 118
ASP A 115
GLY A  60
HIS A 259
 None
PO4  A 279 (-2.9A)
None
ZN  A 277 (-3.2A)
 0.84A 4c5nC-2r2dA:
undetectable		 4c5nC-2r2dA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_A_ADNA401_1
(APH(2'')-ID)		 2r2d ZN-DEPENDENT
HYDROLASES
(Agrobacterium
fabrum) 		5 / 11 GLY A 229
ALA A 228
ILE A  20
ILE A  13
HIS A 113
 None
None
None
GOL  A 280 ( 4.0A)
ZN  A 278 ( 3.2A)
 1.03A 4dt8A-2r2dA:
undetectable		 4dt8A-2r2dA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_D_FOLD301_1
(FOLATE RECEPTOR
ALPHA)		 2r2d ZN-DEPENDENT
HYDROLASES
(Agrobacterium
fabrum) 		3 / 3 HIS A 116
TRP A  72
SER A 212
 ZN  A 277 ( 3.2A)
None
None
 1.15A 4lrhD-2r2dA:
undetectable		 4lrhD-2r2dA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_B_ADNB501_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 2r2d ZN-DEPENDENT
HYDROLASES
(Agrobacterium
fabrum) 		5 / 12 LEU A 231
HIS A 191
HIS A 113
GLY A 258
HIS A 259
 None
ZN  A 278 ( 3.2A)
ZN  A 278 ( 3.2A)
None
ZN  A 277 (-3.2A)
 1.47A 4lvcB-2r2dA:
undetectable		 4lvcB-2r2dA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UW0_A_SAMA1506_0
(WBDD)		 2r2d ZN-DEPENDENT
HYDROLASES
(Agrobacterium
fabrum) 		5 / 12 ALA A  85
ARG A  14
ILE A  13
LEU A  10
ILE A  41
 None
None
GOL  A 280 ( 4.0A)
None
None
 0.97A 4uw0A-2r2dA:
undetectable		 4uw0A-2r2dA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYA_A_X8ZA307_1
(METALLO-BETA-LACTAMA
SE)		 2r2d ZN-DEPENDENT
HYDROLASES
(Agrobacterium
fabrum) 		6 / 11 HIS A 111
HIS A 113
ASP A 115
HIS A 116
HIS A 191
HIS A 259
 ZN  A 278 ( 3.2A)
ZN  A 278 ( 3.2A)
PO4  A 279 (-2.9A)
ZN  A 277 ( 3.2A)
ZN  A 278 ( 3.2A)
ZN  A 277 (-3.2A)
 0.68A 5ayaA-2r2dA:
14.4		 5ayaA-2r2dA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYA_A_X8ZA307_1
(METALLO-BETA-LACTAMA
SE)		 2r2d ZN-DEPENDENT
HYDROLASES
(Agrobacterium
fabrum) 		6 / 11 HIS A 111
HIS A 113
ASP A 115
HIS A 116
SER A 212
HIS A 259
 ZN  A 278 ( 3.2A)
ZN  A 278 ( 3.2A)
PO4  A 279 (-2.9A)
ZN  A 277 ( 3.2A)
None
ZN  A 277 (-3.2A)
 1.31A 5ayaA-2r2dA:
14.4		 5ayaA-2r2dA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_A_ADNA501_1
(ADENOSYLHOMOCYSTEINA
SE)		 2r2d ZN-DEPENDENT
HYDROLASES
(Agrobacterium
fabrum) 		5 / 12 LEU A 231
HIS A 191
HIS A 113
GLY A 258
HIS A 259
 None
ZN  A 278 ( 3.2A)
ZN  A 278 ( 3.2A)
None
ZN  A 277 (-3.2A)
 1.46A 5hm8A-2r2dA:
undetectable		 5hm8A-2r2dA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_B_ADNB501_1
(ADENOSYLHOMOCYSTEINA
SE)		 2r2d ZN-DEPENDENT
HYDROLASES
(Agrobacterium
fabrum) 		5 / 12 LEU A 231
HIS A 191
HIS A 113
GLY A 258
HIS A 259
 None
ZN  A 278 ( 3.2A)
ZN  A 278 ( 3.2A)
None
ZN  A 277 (-3.2A)
 1.46A 5hm8B-2r2dA:
undetectable		 5hm8B-2r2dA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_C_ADNC501_1
(ADENOSYLHOMOCYSTEINA
SE)		 2r2d ZN-DEPENDENT
HYDROLASES
(Agrobacterium
fabrum) 		5 / 12 LEU A 231
HIS A 191
HIS A 113
GLY A 258
HIS A 259
 None
ZN  A 278 ( 3.2A)
ZN  A 278 ( 3.2A)
None
ZN  A 277 (-3.2A)
 1.47A 5hm8C-2r2dA:
undetectable		 5hm8C-2r2dA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_D_ADND501_1
(ADENOSYLHOMOCYSTEINA
SE)		 2r2d ZN-DEPENDENT
HYDROLASES
(Agrobacterium
fabrum) 		5 / 12 LEU A 231
HIS A 191
HIS A 113
GLY A 258
HIS A 259
 None
ZN  A 278 ( 3.2A)
ZN  A 278 ( 3.2A)
None
ZN  A 277 (-3.2A)
 1.47A 5hm8D-2r2dA:
undetectable		 5hm8D-2r2dA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_E_ADNE501_1
(ADENOSYLHOMOCYSTEINA
SE)		 2r2d ZN-DEPENDENT
HYDROLASES
(Agrobacterium
fabrum) 		5 / 12 LEU A 231
HIS A 191
HIS A 113
GLY A 258
HIS A 259
 None
ZN  A 278 ( 3.2A)
ZN  A 278 ( 3.2A)
None
ZN  A 277 (-3.2A)
 1.46A 5hm8E-2r2dA:
undetectable		 5hm8E-2r2dA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_F_ADNF501_1
(ADENOSYLHOMOCYSTEINA
SE)		 2r2d ZN-DEPENDENT
HYDROLASES
(Agrobacterium
fabrum) 		5 / 12 LEU A 231
HIS A 191
HIS A 113
GLY A 258
HIS A 259
 None
ZN  A 278 ( 3.2A)
ZN  A 278 ( 3.2A)
None
ZN  A 277 (-3.2A)
 1.47A 5hm8F-2r2dA:
undetectable		 5hm8F-2r2dA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_G_ADNG501_1
(ADENOSYLHOMOCYSTEINA
SE)		 2r2d ZN-DEPENDENT
HYDROLASES
(Agrobacterium
fabrum) 		5 / 12 LEU A 231
HIS A 191
HIS A 113
GLY A 258
HIS A 259
 None
ZN  A 278 ( 3.2A)
ZN  A 278 ( 3.2A)
None
ZN  A 277 (-3.2A)
 1.46A 5hm8G-2r2dA:
undetectable		 5hm8G-2r2dA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_H_ADNH501_1
(ADENOSYLHOMOCYSTEINA
SE)		 2r2d ZN-DEPENDENT
HYDROLASES
(Agrobacterium
fabrum) 		5 / 12 LEU A 231
HIS A 191
HIS A 113
GLY A 258
HIS A 259
 None
ZN  A 278 ( 3.2A)
ZN  A 278 ( 3.2A)
None
ZN  A 277 (-3.2A)
 1.46A 5hm8H-2r2dA:
undetectable		 5hm8H-2r2dA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_B_AG2B501_1
(ARGININE/AGMATINE
ANTIPORTER)		 2r2d ZN-DEPENDENT
HYDROLASES
(Agrobacterium
fabrum) 		4 / 6 ILE A 156
GLY A  70
ASN A  69
ILE A 152
 None
 0.95A 5j4nB-2r2dA:
undetectable		 5j4nB-2r2dA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 2r2d ZN-DEPENDENT
HYDROLASES
(Agrobacterium
fabrum) 		6 / 12 ASP A 213
ALA A  45
SER A  44
THR A 106
GLY A 197
LEU A 198
 ZN  A 277 (-2.0A)
None
None
None
None
None
 1.36A 5m5cB-2r2dA:
undetectable		 5m5cB-2r2dA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 2r2d ZN-DEPENDENT
HYDROLASES
(Agrobacterium
fabrum) 		5 / 10 ALA A  45
SER A  44
THR A 106
GLY A 197
LEU A 198
 None
 1.18A 5m5cE-2r2dA:
undetectable		 5m5cE-2r2dA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZW_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 2r2d ZN-DEPENDENT
HYDROLASES
(Agrobacterium
fabrum) 		5 / 10 HIS A 111
HIS A 113
HIS A 116
HIS A 191
ASP A 213
 ZN  A 278 ( 3.2A)
ZN  A 278 ( 3.2A)
ZN  A 277 ( 3.2A)
ZN  A 278 ( 3.2A)
ZN  A 277 (-2.0A)
 0.45A 5nzwA-2r2dA:
5.0		 5nzwA-2r2dA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0G_B_DAHB98_0
(MELC
TYROSINASE)		 2r2d ZN-DEPENDENT
HYDROLASES
(Agrobacterium
fabrum) 		5 / 11 HIS A 191
HIS A 259
HIS A 116
SER A 110
HIS A 113
 ZN  A 278 ( 3.2A)
ZN  A 277 (-3.2A)
ZN  A 277 ( 3.2A)
None
ZN  A 278 ( 3.2A)
 1.44A 5z0gA-2r2dA:
undetectable
5z0gB-2r2dA:
undetectable		 5z0gA-2r2dA:
15.33
5z0gB-2r2dA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA814_0
(UNCHARACTERIZED
PROTEIN)		 2r2d ZN-DEPENDENT
HYDROLASES
(Agrobacterium
fabrum) 		4 / 5 TYR A 275
GLN A 205
THR A 254
LEU A 256
 GOL  A 281 (-4.4A)
GOL  A 281 ( 4.3A)
GOL  A 281 ( 4.6A)
None
 1.14A 6d8pA-2r2dA:
undetectable		 6d8pA-2r2dA:
18.50