SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2r2i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGF_A_ADNA501_1
(ADENOSINE DEAMINASE)		 2r2i GUANYLYL
CYCLASE-ACTIVATING
PROTEIN 1
(Gallus
gallus) 		5 / 12 HIS A 176
ASP A 166
GLU A  10
SER A  13
ASP A 173
 None
 1.35A 2pgfA-2r2iA:
undetectable		 2pgfA-2r2iA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2r2i GUANYLYL
CYCLASE-ACTIVATING
PROTEIN 1
(Gallus
gallus) 		3 / 3 ILE A 118
PHE A  62
HIS A 176
 None
MYR  A   1 ( 4.7A)
None
 0.51A 3h0aA-2r2iA:
undetectable		 3h0aA-2r2iA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_C_TFPC202_1
(PROTEIN S100-A4)		 2r2i GUANYLYL
CYCLASE-ACTIVATING
PROTEIN 1
(Gallus
gallus) 		5 / 11 LEU A 149
SER A 150
PHE A 154
ILE A 141
GLU A 153
 None
None
None
None
CA  A 502 (-2.3A)
 1.38A 3ko0A-2r2iA:
6.8
3ko0B-2r2iA:
6.6
3ko0C-2r2iA:
6.7
3ko0D-2r2iA:
6.7		 3ko0A-2r2iA:
16.32
3ko0B-2r2iA:
16.32
3ko0C-2r2iA:
16.32
3ko0D-2r2iA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD202_1
(PROTEIN S100-A4)		 2r2i GUANYLYL
CYCLASE-ACTIVATING
PROTEIN 1
(Gallus
gallus) 		5 / 11 GLU A 153
LEU A 149
SER A 150
PHE A 154
ILE A 141
 CA  A 502 (-2.3A)
None
None
None
None
 1.49A 3ko0C-2r2iA:
6.7
3ko0D-2r2iA:
6.7
3ko0E-2r2iA:
6.8
3ko0F-2r2iA:
6.7		 3ko0C-2r2iA:
16.32
3ko0D-2r2iA:
16.32
3ko0E-2r2iA:
16.32
3ko0F-2r2iA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE202_1
(PROTEIN S100-A4)		 2r2i GUANYLYL
CYCLASE-ACTIVATING
PROTEIN 1
(Gallus
gallus) 		5 / 11 LEU A 149
SER A 150
PHE A 154
ILE A 141
GLU A 153
 None
None
None
None
CA  A 502 (-2.3A)
 1.49A 3ko0C-2r2iA:
6.7
3ko0D-2r2iA:
6.7
3ko0E-2r2iA:
6.8
3ko0F-2r2iA:
6.7		 3ko0C-2r2iA:
16.32
3ko0D-2r2iA:
16.32
3ko0E-2r2iA:
16.32
3ko0F-2r2iA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_F_TFPF202_1
(PROTEIN S100-A4)		 2r2i GUANYLYL
CYCLASE-ACTIVATING
PROTEIN 1
(Gallus
gallus) 		5 / 11 GLU A 153
LEU A 149
SER A 150
PHE A 154
ILE A 141
 CA  A 502 (-2.3A)
None
None
None
None
 1.35A 3ko0E-2r2iA:
6.8
3ko0F-2r2iA:
6.7
3ko0G-2r2iA:
6.4
3ko0H-2r2iA:
6.5		 3ko0E-2r2iA:
16.32
3ko0F-2r2iA:
16.32
3ko0G-2r2iA:
16.32
3ko0H-2r2iA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT202_1
(PROTEIN S100-A4)		 2r2i GUANYLYL
CYCLASE-ACTIVATING
PROTEIN 1
(Gallus
gallus) 		5 / 11 GLU A 153
LEU A 149
SER A 150
PHE A 154
ILE A 141
 CA  A 502 (-2.3A)
None
None
None
None
 1.43A 3ko0Q-2r2iA:
5.8
3ko0R-2r2iA:
6.6
3ko0S-2r2iA:
6.7
3ko0T-2r2iA:
6.6		 3ko0Q-2r2iA:
16.32
3ko0R-2r2iA:
16.32
3ko0S-2r2iA:
16.32
3ko0T-2r2iA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA506_0
(RNA POLYMERASE
3D-POL)		 2r2i GUANYLYL
CYCLASE-ACTIVATING
PROTEIN 1
(Gallus
gallus) 		3 / 3 VAL A 100
GLY A 102
LYS A  96
 None
 0.70A 4k50A-2r2iA:
undetectable		 4k50A-2r2iA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE504_0
(RNA POLYMERASE
3D-POL)		 2r2i GUANYLYL
CYCLASE-ACTIVATING
PROTEIN 1
(Gallus
gallus) 		3 / 3 VAL A 100
GLY A 102
LYS A  96
 None
 0.76A 4k50E-2r2iA:
undetectable		 4k50E-2r2iA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI504_0
(RNA POLYMERASE
3D-POL)		 2r2i GUANYLYL
CYCLASE-ACTIVATING
PROTEIN 1
(Gallus
gallus) 		3 / 3 VAL A 100
GLY A 102
LYS A  96
 None
 0.67A 4k50I-2r2iA:
undetectable		 4k50I-2r2iA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V02_R_657R201_0
(CALMODULIN-1
SMALL CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
PROTEIN 2)		 2r2i GUANYLYL
CYCLASE-ACTIVATING
PROTEIN 1
(Gallus
gallus) 		5 / 10 ALA A  78
LEU A  81
VAL A  82
LEU A  97
ILE A 118
 MYR  A   1 (-3.5A)
None
MYR  A   1 ( 4.6A)
None
None
 1.07A 5v02B-2r2iA:
undetectable
5v02R-2r2iA:
7.1		 5v02B-2r2iA:
21.11
5v02R-2r2iA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA603_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 2r2i GUANYLYL
CYCLASE-ACTIVATING
PROTEIN 1
(Gallus
gallus) 		3 / 3 TYR A  54
ASN A 122
LEU A 180
 None
 0.81A 6b58A-2r2iA:
undetectable		 6b58A-2r2iA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_A_ECLA1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 2r2i GUANYLYL
CYCLASE-ACTIVATING
PROTEIN 1
(Gallus
gallus) 		4 / 7 PHE A  62
ILE A  70
LEU A  33
ILE A 177
 MYR  A   1 ( 4.7A)
MYR  A   1 ( 4.7A)
BME  A 301 (-4.1A)
MYR  A   1 ( 4.6A)
 0.84A 6b5vA-2r2iA:
undetectable
6b5vC-2r2iA:
undetectable		 6b5vA-2r2iA:
19.27
6b5vC-2r2iA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_B_ECLB1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 2r2i GUANYLYL
CYCLASE-ACTIVATING
PROTEIN 1
(Gallus
gallus) 		4 / 7 PHE A  62
ILE A  70
LEU A  33
ILE A 177
 MYR  A   1 ( 4.7A)
MYR  A   1 ( 4.7A)
BME  A 301 (-4.1A)
MYR  A   1 ( 4.6A)
 0.84A 6b5vA-2r2iA:
undetectable
6b5vB-2r2iA:
undetectable		 6b5vA-2r2iA:
19.27
6b5vB-2r2iA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_C_ECLC1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 2r2i GUANYLYL
CYCLASE-ACTIVATING
PROTEIN 1
(Gallus
gallus) 		4 / 7 PHE A  62
ILE A  70
LEU A  33
ILE A 177
 MYR  A   1 ( 4.7A)
MYR  A   1 ( 4.7A)
BME  A 301 (-4.1A)
MYR  A   1 ( 4.6A)
 0.84A 6b5vC-2r2iA:
undetectable
6b5vD-2r2iA:
undetectable		 6b5vC-2r2iA:
19.27
6b5vD-2r2iA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_D_ECLD1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 2r2i GUANYLYL
CYCLASE-ACTIVATING
PROTEIN 1
(Gallus
gallus) 		4 / 7 PHE A  62
ILE A  70
LEU A  33
ILE A 177
 MYR  A   1 ( 4.7A)
MYR  A   1 ( 4.7A)
BME  A 301 (-4.1A)
MYR  A   1 ( 4.6A)
 0.84A 6b5vB-2r2iA:
undetectable
6b5vD-2r2iA:
undetectable		 6b5vB-2r2iA:
19.27
6b5vD-2r2iA:
19.27