SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2r2p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_0
(ALCOHOL
DEHYDROGENASE)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		3 / 3 MET A 788
LEU A 791
SER A 792
 None
 0.56A 1ee2A-2r2pA:
undetectable		 1ee2A-2r2pA:
21.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_B_STIB202_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		6 / 12 VAL A 689
ALA A 705
GLU A 724
MET A 728
THR A 753
ASP A 818
 None
 1.06A 1iepB-2r2pA:
31.5		 1iepB-2r2pA:
37.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDN_A_LEUA487_0
(L-AMINO ACID OXIDASE)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		4 / 7 ASN A 805
HIS A 798
PHE A 819
ILE A 784
 None
 1.17A 1tdnA-2r2pA:
undetectable		 1tdnA-2r2pA:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWH_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		4 / 6 ILE A 681
VAL A 689
ILE A 736
ASP A 818
 None
 0.70A 1uwhA-2r2pA:
28.7		 1uwhA-2r2pA:
32.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWH_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		4 / 6 VAL A 867
ILE A 928
ILE A 784
ASP A 860
 None
 0.77A 1uwhA-2r2pA:
28.7		 1uwhA-2r2pA:
32.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWH_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		4 / 6 ILE A 681
VAL A 689
ILE A 736
ASP A 818
 None
 0.71A 1uwhB-2r2pA:
28.4		 1uwhB-2r2pA:
32.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWH_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		4 / 6 VAL A 867
ILE A 928
ILE A 784
ASP A 860
 None
 0.77A 1uwhB-2r2pA:
28.4		 1uwhB-2r2pA:
32.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		6 / 12 VAL A 689
ALA A 705
GLU A 724
THR A 753
LEU A 791
HIS A 798
 None
 0.88A 1uwjA-2r2pA:
7.5		 1uwjA-2r2pA:
32.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		7 / 12 ILE A 681
VAL A 689
ALA A 705
GLU A 724
THR A 753
LEU A 791
HIS A 798
 None
 1.05A 1uwjB-2r2pA:
7.5		 1uwjB-2r2pA:
32.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EVA_A_ADNA498_1
(TAK1 KINASE - TAB1
CHIMERA FUSION
PROTEIN)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		7 / 11 GLY A 682
GLY A 684
VAL A 689
ALA A 705
TYR A 755
SER A 760
LEU A 807
 None
 0.98A 2evaA-2r2pA:
27.1		 2evaA-2r2pA:
27.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_2
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		3 / 3 VAL A 872
VAL A 867
ASP A 933
 None
 0.75A 2fumD-2r2pA:
18.7		 2fumD-2r2pA:
24.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_A_1N1A501_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		7 / 12 ALA A 705
GLU A 724
MET A 728
ILE A 751
THR A 753
GLY A 759
LEU A 807
 None
 0.48A 2gqgA-2r2pA:
31.8		 2gqgA-2r2pA:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_B_1N1B502_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		8 / 12 VAL A 689
ALA A 705
GLU A 724
MET A 728
ILE A 751
THR A 753
GLY A 759
LEU A 807
 None
 0.70A 2gqgB-2r2pA:
35.0		 2gqgB-2r2pA:
37.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		4 / 6 SER A 792
ASP A 793
SER A 857
VAL A 861
 None
 0.94A 2hdnI-2r2pA:
undetectable
2hdnJ-2r2pA:
undetectable
2hdnL-2r2pA:
undetectable		 2hdnI-2r2pA:
9.06
2hdnJ-2r2pA:
22.99
2hdnL-2r2pA:
22.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_D_STID600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		7 / 12 VAL A 689
ALA A 705
GLU A 724
MET A 728
ILE A 751
THR A 753
ASP A 818
 None
 1.01A 2hyyD-2r2pA:
31.7		 2hyyD-2r2pA:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_D_STID600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		6 / 12 VAL A 689
ALA A 705
MET A 728
ILE A 751
THR A 753
LEU A 807
 None
 0.85A 2hyyD-2r2pA:
31.7		 2hyyD-2r2pA:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITO_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		6 / 12 ALA A 705
GLU A 724
MET A 728
THR A 753
GLY A 759
LEU A 807
 None
 0.70A 2itoA-2r2pA:
34.0		 2itoA-2r2pA:
33.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITY_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		8 / 12 GLY A 682
VAL A 689
ALA A 705
GLU A 724
MET A 728
THR A 753
GLY A 759
LEU A 807
 None
 0.77A 2ityA-2r2pA:
34.2		 2ityA-2r2pA:
33.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITZ_A_IREA2021_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		7 / 12 VAL A 689
ALA A 705
GLU A 724
MET A 728
THR A 753
GLY A 759
LEU A 807
 None
 0.74A 2itzA-2r2pA:
33.7		 2itzA-2r2pA:
33.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IVU_A_ZD6A3015_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		3 / 3 ALA A 705
GLY A 759
SER A 817
 None
 0.27A 2ivuA-2r2pA:
35.3		 2ivuA-2r2pA:
32.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OIQ_A_STIA1001_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		9 / 12 VAL A 689
ALA A 705
GLU A 724
MET A 728
ILE A 751
THR A 753
TYR A 755
LEU A 807
ASP A 818
 None
 0.85A 2oiqA-2r2pA:
32.8		 2oiqA-2r2pA:
43.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OIQ_A_STIA1001_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		8 / 12 VAL A 689
ALA A 705
MET A 728
ILE A 751
THR A 753
TYR A 755
GLY A 759
LEU A 807
 None
 0.65A 2oiqA-2r2pA:
32.8		 2oiqA-2r2pA:
43.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2PL0_A_STIA200_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		8 / 12 VAL A 689
ALA A 705
GLU A 724
MET A 728
ILE A 751
THR A 753
TYR A 755
ASP A 818
 None
 0.89A 2pl0A-2r2pA:
31.1		 2pl0A-2r2pA:
42.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2PL0_A_STIA200_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		7 / 12 VAL A 689
ALA A 705
MET A 728
ILE A 751
THR A 753
TYR A 755
LEU A 807
 None
 0.94A 2pl0A-2r2pA:
31.1		 2pl0A-2r2pA:
42.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q8H_A_TF4A438_1
([PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		4 / 6 LEU A 791
ILE A 727
ARG A 799
ARG A 823
 None
None
SO4  A   1 ( 3.1A)
SO4  A   1 ( 3.9A)
 0.94A 2q8hA-2r2pA:
undetectable		 2q8hA-2r2pA:
20.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WGJ_A_VGHA2346_1
(HEPATOCYTE GROWTH
FACTOR RECEPTOR)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		6 / 12 GLY A 682
VAL A 689
ALA A 705
TYR A 755
MET A 756
GLY A 759
 None
 0.76A 2wgjA-2r2pA:
31.3		 2wgjA-2r2pA:
34.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WGJ_A_VGHA2346_1
(HEPATOCYTE GROWTH
FACTOR RECEPTOR)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		6 / 12 VAL A 689
ALA A 705
TYR A 755
MET A 756
GLY A 759
ASP A 818
 None
 0.53A 2wgjA-2r2pA:
31.3		 2wgjA-2r2pA:
34.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XP2_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		6 / 9 VAL A 689
ALA A 705
MET A 756
GLY A 759
LEU A 807
ASP A 818
 None
 0.37A 2xp2A-2r2pA:
34.4		 2xp2A-2r2pA:
33.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y6O_A_1N1A1892_1
(EPHRIN TYPE-A
RECEPTOR 4)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		10 / 12 ILE A 681
ALA A 705
GLU A 724
MET A 728
ILE A 751
THR A 753
TYR A 755
GLY A 759
LEU A 807
SER A 817
 None
 0.62A 2y6oA-2r2pA:
37.6		 2y6oA-2r2pA:
86.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y6O_A_1N1A1892_1
(EPHRIN TYPE-A
RECEPTOR 4)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		10 / 12 ILE A 681
ALA A 705
LYS A 707
GLU A 724
MET A 728
ILE A 751
TYR A 755
GLY A 759
LEU A 807
SER A 817
 None
 0.77A 2y6oA-2r2pA:
37.6		 2y6oA-2r2pA:
86.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_A_B49A1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		7 / 12 ILE A 681
VAL A 689
ALA A 705
ILE A 737
MET A 756
GLY A 759
LEU A 807
 None
 0.81A 2y7jA-2r2pA:
23.0		 2y7jA-2r2pA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_B_B49B1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		7 / 10 ILE A 681
VAL A 689
ALA A 705
ILE A 737
MET A 756
GLY A 759
LEU A 807
 None
 0.78A 2y7jB-2r2pA:
27.3		 2y7jB-2r2pA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_C_B49C1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		7 / 10 ILE A 681
VAL A 689
ALA A 705
ILE A 737
MET A 756
GLY A 759
LEU A 807
 None
 0.81A 2y7jC-2r2pA:
23.0		 2y7jC-2r2pA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_D_B49D1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		7 / 10 ILE A 681
VAL A 689
ALA A 705
ILE A 737
MET A 756
GLY A 759
LEU A 807
 None
 0.74A 2y7jD-2r2pA:
27.0		 2y7jD-2r2pA:
21.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YFX_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		5 / 8 ALA A 705
MET A 756
GLY A 759
LEU A 807
ASP A 818
 None
 0.30A 2yfxA-2r2pA:
25.7		 2yfxA-2r2pA:
33.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZVA_A_1N1A513_1
(TYROSINE-PROTEIN
KINASE LYN)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		8 / 12 ALA A 705
GLU A 724
MET A 728
ILE A 751
THR A 753
MET A 756
GLY A 759
LEU A 807
 None
 0.44A 2zvaA-2r2pA:
34.9		 2zvaA-2r2pA:
41.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZVA_A_1N1A513_1
(TYROSINE-PROTEIN
KINASE LYN)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		8 / 12 ALA A 705
LYS A 707
GLU A 724
MET A 728
ILE A 751
MET A 756
GLY A 759
LEU A 807
 None
 0.67A 2zvaA-2r2pA:
34.9		 2zvaA-2r2pA:
41.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0F_A_B49A9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		6 / 11 VAL A 689
ALA A 705
THR A 753
TYR A 755
GLY A 759
LEU A 807
 None
 0.75A 3g0fA-2r2pA:
24.0		 3g0fA-2r2pA:
32.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0F_B_B49B9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		6 / 10 VAL A 689
ALA A 705
THR A 753
TYR A 755
GLY A 759
LEU A 807
 None
 0.70A 3g0fB-2r2pA:
31.2		 3g0fB-2r2pA:
32.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G5D_A_1N1A1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		9 / 12 VAL A 689
ALA A 705
GLU A 724
MET A 728
ILE A 751
THR A 753
TYR A 755
GLY A 759
LEU A 807
 None
 0.74A 3g5dA-2r2pA:
33.7		 3g5dA-2r2pA:
42.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G5D_B_1N1B1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		8 / 12 VAL A 689
ALA A 705
GLU A 724
MET A 728
THR A 753
TYR A 755
GLY A 759
LEU A 807
 None
 0.68A 3g5dB-2r2pA:
34.1		 3g5dB-2r2pA:
42.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		7 / 12 VAL A 689
ALA A 705
GLU A 724
ILE A 737
THR A 753
HIS A 798
ASP A 818
 None
 1.28A 3gp0A-2r2pA:
21.8		 3gp0A-2r2pA:
28.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_2
(CARBONIC ANHYDRASE 2)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		3 / 3 GLU A 669
HIS A 664
THR A 744
 None
 0.85A 3hkuA-2r2pA:
undetectable		 3hkuA-2r2pA:
20.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K54_A_1N1A1_1
(TYROSINE-PROTEIN
KINASE BTK)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		9 / 12 ALA A 705
GLU A 724
MET A 728
ILE A 751
THR A 753
TYR A 755
GLY A 759
LEU A 807
SER A 817
 None
 0.61A 3k54A-2r2pA:
31.9		 3k54A-2r2pA:
35.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K54_A_1N1A1_1
(TYROSINE-PROTEIN
KINASE BTK)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		9 / 12 ALA A 705
LYS A 707
GLU A 724
MET A 728
ILE A 751
TYR A 755
GLY A 759
LEU A 807
SER A 817
 None
 0.75A 3k54A-2r2pA:
31.9		 3k54A-2r2pA:
35.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MIY_A_B49A1_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		7 / 11 ILE A 681
ALA A 705
LYS A 707
MET A 756
GLY A 759
LEU A 807
SER A 817
 None
 0.63A 3miyA-2r2pA:
29.6		 3miyA-2r2pA:
36.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		7 / 9 ILE A 681
ALA A 705
LYS A 707
MET A 756
GLY A 759
LEU A 807
SER A 817
 None
 0.68A 3miyB-2r2pA:
27.3		 3miyB-2r2pA:
36.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		6 / 12 VAL A 689
ALA A 705
GLU A 724
MET A 728
THR A 753
ASP A 818
 None
 0.94A 3ms9A-2r2pA:
31.0		 3ms9A-2r2pA:
37.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		6 / 12 VAL A 689
ALA A 705
GLU A 724
MET A 728
THR A 753
ASP A 818
 None
 0.98A 3mssA-2r2pA:
31.3		 3mssA-2r2pA:
37.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_C_STIC1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		6 / 12 VAL A 689
ALA A 705
GLU A 724
MET A 728
THR A 753
ASP A 818
 None
 1.00A 3mssC-2r2pA:
31.2		 3mssC-2r2pA:
37.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OEZ_A_STIA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		6 / 12 VAL A 689
ALA A 705
GLU A 724
MET A 728
THR A 753
TYR A 755
 None
 0.59A 3oezA-2r2pA:
32.5		 3oezA-2r2pA:
43.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OEZ_A_STIA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		6 / 12 VAL A 689
ALA A 705
THR A 753
TYR A 755
GLY A 759
LEU A 807
 None
 0.42A 3oezA-2r2pA:
32.5		 3oezA-2r2pA:
43.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OEZ_B_STIB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		7 / 12 VAL A 689
ALA A 705
GLU A 724
MET A 728
ILE A 751
THR A 753
TYR A 755
 None
 0.83A 3oezB-2r2pA:
32.5		 3oezB-2r2pA:
43.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OEZ_B_STIB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		7 / 12 VAL A 689
ALA A 705
MET A 728
ILE A 751
THR A 753
TYR A 755
LEU A 807
 None
 0.67A 3oezB-2r2pA:
32.5		 3oezB-2r2pA:
43.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_1
(P38A)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		6 / 12 GLY A 682
VAL A 689
ALA A 705
ILE A 737
THR A 753
LEU A 807
 None
 1.06A 3ohtA-2r2pA:
17.3		 3ohtA-2r2pA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_1
(P38A)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		6 / 12 GLY A 682
VAL A 689
ALA A 705
ILE A 737
THR A 753
GLY A 759
 None
 1.15A 3ohtB-2r2pA:
17.5		 3ohtB-2r2pA:
22.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OXZ_A_0LIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		6 / 12 ALA A 705
GLU A 724
MET A 728
THR A 753
GLY A 759
HIS A 798
 None
 0.88A 3oxzA-2r2pA:
26.4		 3oxzA-2r2pA:
37.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OXZ_A_0LIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		5 / 9 ILE A 751
MET A 756
ARG A 799
LEU A 807
VAL A 816
 None
None
SO4  A   1 ( 3.1A)
None
None
 0.78A 3oxzA-2r2pA:
26.4		 3oxzA-2r2pA:
37.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_A_1N1A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		8 / 12 VAL A 689
ALA A 705
GLU A 724
MET A 728
THR A 753
TYR A 755
GLY A 759
LEU A 807
 None
 0.62A 3qlgA-2r2pA:
26.9		 3qlgA-2r2pA:
43.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_B_1N1B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		8 / 12 VAL A 689
ALA A 705
GLU A 724
MET A 728
THR A 753
TYR A 755
GLY A 759
LEU A 807
 None
 0.62A 3qlgB-2r2pA:
27.9		 3qlgB-2r2pA:
43.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_1
(CYCLIN-DEPENDENT
KINASE 8)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		7 / 12 VAL A 689
ALA A 705
GLU A 724
ILE A 737
TYR A 755
LEU A 791
HIS A 798
 None
 1.14A 3rgfA-2r2pA:
17.2		 3rgfA-2r2pA:
21.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_A_1N1A1_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		8 / 12 VAL A 689
ALA A 705
MET A 728
ILE A 751
THR A 753
TYR A 755
GLY A 759
LEU A 807
 None
 0.53A 3sxrA-2r2pA:
33.6		 3sxrA-2r2pA:
35.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_B_1N1B2_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		7 / 12 VAL A 689
ALA A 705
MET A 728
THR A 753
TYR A 755
GLY A 759
LEU A 807
 None
 0.54A 3sxrB-2r2pA:
33.3		 3sxrB-2r2pA:
35.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_B_1N1B2_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		7 / 12 VAL A 689
MET A 728
THR A 753
TYR A 755
GLY A 759
LEU A 807
SER A 817
 None
 0.77A 3sxrB-2r2pA:
33.3		 3sxrB-2r2pA:
35.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UE4_A_DB8A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		6 / 12 ALA A 705
ILE A 751
THR A 753
MET A 756
GLY A 759
LEU A 807
 None
 0.34A 3ue4A-2r2pA:
35.5		 3ue4A-2r2pA:
37.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UE4_B_DB8B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		7 / 12 VAL A 689
ALA A 705
MET A 728
ILE A 751
THR A 753
GLY A 759
LEU A 807
 None
 0.62A 3ue4B-2r2pA:
35.6		 3ue4B-2r2pA:
37.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_D_ACHD301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		4 / 8 TYR A 879
TRP A 869
TYR A 895
TRP A 880
 None
 1.42A 3wipD-2r2pA:
undetectable
3wipE-2r2pA:
undetectable		 3wipD-2r2pA:
21.31
3wipE-2r2pA:
21.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		6 / 12 ALA A 705
MET A 756
GLY A 759
THR A 763
LEU A 807
ASP A 818
 None
 0.41A 3zbfA-2r2pA:
29.4		 3zbfA-2r2pA:
38.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_A_0LIA1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		6 / 9 ILE A 727
MET A 728
ILE A 736
ILE A 737
TYR A 755
MET A 756
 None
 0.65A 3zosA-2r2pA:
30.6		 3zosA-2r2pA:
35.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_B_0LIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		5 / 9 ILE A 727
MET A 728
ILE A 736
TYR A 755
MET A 756
 None
 0.68A 3zosB-2r2pA:
30.7		 3zosB-2r2pA:
35.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ANQ_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		6 / 9 VAL A 689
ALA A 705
MET A 756
GLY A 759
LEU A 807
ASP A 818
 None
 0.32A 4anqA-2r2pA:
34.1		 4anqA-2r2pA:
32.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ANS_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		6 / 9 VAL A 689
ALA A 705
MET A 756
GLY A 759
LEU A 807
ASP A 818
 None
 0.32A 4ansA-2r2pA:
34.1		 4ansA-2r2pA:
32.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_A_STIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		9 / 12 VAL A 689
ALA A 705
GLU A 724
ILE A 727
MET A 728
ILE A 737
THR A 753
TYR A 755
ASP A 818
 None
 0.94A 4bkjA-2r2pA:
30.7		 4bkjA-2r2pA:
35.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_A_STIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		8 / 12 VAL A 689
ALA A 705
ILE A 727
MET A 728
ILE A 737
THR A 753
TYR A 755
LEU A 807
 None
 1.01A 4bkjA-2r2pA:
30.7		 4bkjA-2r2pA:
35.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_B_STIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		8 / 12 VAL A 689
ALA A 705
GLU A 724
ILE A 727
MET A 728
ILE A 737
THR A 753
ASP A 818
 None
 0.98A 4bkjB-2r2pA:
30.5		 4bkjB-2r2pA:
35.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_B_STIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		7 / 12 VAL A 689
ALA A 705
ILE A 727
MET A 728
ILE A 737
THR A 753
LEU A 807
 None
 1.01A 4bkjB-2r2pA:
30.5		 4bkjB-2r2pA:
35.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		4 / 5 VAL A 689
ILE A 736
TYR A 755
MET A 756
 None
 0.65A 4c8bA-2r2pA:
27.3		 4c8bA-2r2pA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		3 / 3 TYR A 755
MET A 756
ILE A 736
 None
 0.59A 4c8bB-2r2pA:
26.9		 4c8bB-2r2pA:
28.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CKI_A_ADNA2022_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		6 / 11 GLY A 682
GLY A 684
VAL A 689
ALA A 705
TYR A 755
GLY A 759
 None
 0.81A 4ckiA-2r2pA:
35.7		 4ckiA-2r2pA:
33.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CKI_A_ADNA2022_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		6 / 11 GLY A 682
VAL A 689
ALA A 705
TYR A 755
GLY A 759
LEU A 807
 None
 0.76A 4ckiA-2r2pA:
35.7		 4ckiA-2r2pA:
33.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CKI_A_ADNA2022_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		6 / 11 VAL A 689
ALA A 705
TYR A 755
GLY A 759
SER A 760
LEU A 807
 None
 0.81A 4ckiA-2r2pA:
35.7		 4ckiA-2r2pA:
33.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CSV_A_STIA1265_1
(SRC-ABL TYROSINE
KINASE ANCESTOR)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		8 / 12 VAL A 689
ALA A 705
GLU A 724
ILE A 727
MET A 728
THR A 753
TYR A 755
ASP A 818
 None
 0.84A 4csvA-2r2pA:
32.8		 4csvA-2r2pA:
43.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CSV_A_STIA1265_1
(SRC-ABL TYROSINE
KINASE ANCESTOR)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		6 / 12 VAL A 689
ALA A 705
ILE A 727
THR A 753
TYR A 755
LEU A 807
 None
 0.59A 4csvA-2r2pA:
32.8		 4csvA-2r2pA:
43.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HJO_A_AQ4A1001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		6 / 12 VAL A 689
ALA A 705
THR A 753
MET A 756
GLY A 759
LEU A 807
 None
 0.45A 4hjoA-2r2pA:
30.4		 4hjoA-2r2pA:
33.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		5 / 12 SER A 863
LEU A 801
PHE A 925
ASP A 793
GLY A 795
 None
 1.47A 4j7xA-2r2pA:
undetectable		 4j7xA-2r2pA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		5 / 12 SER A 863
LEU A 801
PHE A 925
ASP A 793
GLY A 795
 None
 1.45A 4j7xF-2r2pA:
undetectable		 4j7xF-2r2pA:
20.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		9 / 12 VAL A 689
ALA A 705
GLU A 724
MET A 728
ILE A 751
THR A 753
TYR A 755
GLY A 759
ASP A 818
 None
 0.57A 4mxoA-2r2pA:
35.0		 4mxoA-2r2pA:
43.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		9 / 12 VAL A 689
ALA A 705
GLU A 724
ILE A 751
THR A 753
TYR A 755
GLY A 759
LEU A 807
ASP A 818
 None
 0.56A 4mxoB-2r2pA:
34.9		 4mxoB-2r2pA:
43.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		8 / 12 ALA A 705
GLU A 724
MET A 728
ILE A 751
THR A 753
TYR A 755
GLY A 759
LEU A 807
 None
 0.57A 4mxxA-2r2pA:
34.7		 4mxxA-2r2pA:
43.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		7 / 12 VAL A 689
ALA A 705
LYS A 707
TYR A 755
MET A 756
GLY A 759
LEU A 807
 None
 0.77A 4mxxB-2r2pA:
32.3		 4mxxB-2r2pA:
43.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		7 / 12 VAL A 689
ALA A 705
THR A 753
TYR A 755
MET A 756
GLY A 759
LEU A 807
 None
 0.36A 4mxxB-2r2pA:
32.3		 4mxxB-2r2pA:
43.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXY_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		7 / 12 VAL A 689
ALA A 705
GLU A 724
TYR A 755
GLY A 759
LEU A 807
ASP A 818
 None
 0.60A 4mxyB-2r2pA:
30.2		 4mxyB-2r2pA:
42.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXZ_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		7 / 12 VAL A 689
ALA A 705
GLU A 724
TYR A 755
GLY A 759
LEU A 807
ASP A 818
 None
 0.60A 4mxzB-2r2pA:
30.2		 4mxzB-2r2pA:
42.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMN_A_DB8A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		7 / 12 ILE A 681
ALA A 705
GLU A 724
ILE A 751
TYR A 755
LEU A 807
ASP A 818
 None
 0.69A 4qmnA-2r2pA:
29.4		 4qmnA-2r2pA:
27.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMS_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		6 / 11 ILE A 681
ALA A 705
ILE A 751
TYR A 755
LEU A 807
ASP A 818
 None
 0.78A 4qmsA-2r2pA:
29.1		 4qmsA-2r2pA:
27.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMZ_A_B49A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		6 / 12 ILE A 681
GLY A 682
VAL A 689
ALA A 705
TYR A 755
LEU A 807
 None
 0.67A 4qmzA-2r2pA:
29.4		 4qmzA-2r2pA:
27.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QRC_A_0LIA802_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		5 / 12 ALA A 705
GLU A 724
MET A 728
LEU A 791
ARG A 799
 None
None
None
None
SO4  A   1 ( 3.1A)
 1.08A 4qrcA-2r2pA:
32.2		 4qrcA-2r2pA:
32.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R7I_A_STIA1001_1
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		7 / 12 VAL A 689
ALA A 705
LYS A 707
GLU A 724
MET A 728
THR A 753
ASP A 818
 None
 0.93A 4r7iA-2r2pA:
32.0		 4r7iA-2r2pA:
31.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R7I_A_STIA1001_1
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		7 / 12 VAL A 689
ALA A 705
LYS A 707
GLU A 724
THR A 753
LEU A 807
ASP A 818
 None
 1.07A 4r7iA-2r2pA:
32.0		 4r7iA-2r2pA:
31.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RZV_A_032A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		5 / 12 ALA A 705
LYS A 707
ILE A 751
THR A 753
SER A 760
 None
 0.72A 4rzvA-2r2pA:
7.6		 4rzvA-2r2pA:
31.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TYJ_A_0LIA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		6 / 12 ALA A 705
GLU A 724
MET A 728
HIS A 798
LEU A 807
ASP A 818
 None
 1.23A 4tyjA-2r2pA:
28.2		 4tyjA-2r2pA:
31.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U5J_A_RXTA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		8 / 11 VAL A 689
ALA A 705
TYR A 755
MET A 756
GLY A 759
ASN A 805
LEU A 807
ASP A 818
 None
 0.53A 4u5jA-2r2pA:
35.1		 4u5jA-2r2pA:
43.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U5J_B_RXTB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		7 / 9 VAL A 689
ALA A 705
TYR A 755
MET A 756
GLY A 759
LEU A 807
ASP A 818
 None
 0.44A 4u5jB-2r2pA:
34.3		 4u5jB-2r2pA:
43.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UW0_A_SAMA1506_0
(WBDD)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		5 / 12 GLY A 741
ALA A 725
ILE A 670
VAL A 752
ILE A 675
 None
 1.05A 4uw0A-2r2pA:
6.3		 4uw0A-2r2pA:
20.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		6 / 11 ALA A 705
THR A 753
MET A 756
GLY A 759
ASN A 805
LEU A 807
 None
 0.33A 4wa9A-2r2pA:
31.2		 4wa9A-2r2pA:
37.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		7 / 12 VAL A 689
ALA A 705
THR A 753
MET A 756
GLY A 759
ASN A 805
LEU A 807
 None
 0.58A 4wa9B-2r2pA:
34.8		 4wa9B-2r2pA:
37.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_A_1N1A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		7 / 12 VAL A 689
ALA A 705
MET A 728
ILE A 751
THR A 753
GLY A 759
LEU A 807
 None
 0.75A 4xeyA-2r2pA:
31.7		 4xeyA-2r2pA:
30.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLI_A_1N1A601_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		8 / 12 ALA A 705
GLU A 724
MET A 728
THR A 753
TYR A 755
MET A 756
GLY A 759
LEU A 807
 None
 0.55A 4xliA-2r2pA:
35.6		 4xliA-2r2pA:
38.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLI_B_1N1B600_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		8 / 12 ALA A 705
GLU A 724
MET A 728
ILE A 751
THR A 753
TYR A 755
GLY A 759
LEU A 807
 None
 0.50A 4xliB-2r2pA:
31.6		 4xliB-2r2pA:
38.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAA_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		6 / 9 VAL A 689
ALA A 705
MET A 756
GLY A 759
LEU A 807
ASP A 818
 None
 0.33A 5aaaA-2r2pA:
34.6		 5aaaA-2r2pA:
33.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		7 / 10 VAL A 689
ALA A 705
LYS A 707
MET A 756
GLY A 759
LEU A 807
ASP A 818
 None
 1.06A 5aacA-2r2pA:
34.1		 5aacA-2r2pA:
33.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5BVW_A_1N1A1009_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		9 / 12 VAL A 689
ALA A 705
GLU A 724
MET A 728
ILE A 737
THR A 753
TYR A 755
GLY A 759
LEU A 807
 None
 0.98A 5bvwA-2r2pA:
26.4		 5bvwA-2r2pA:
35.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		5 / 12 VAL A 689
ALA A 705
LYS A 707
THR A 753
PHE A 819
 None
 0.86A 5cswB-2r2pA:
27.2		 5cswB-2r2pA:
32.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_B_1N1B501_1
(PROTEIN-TYROSINE
KINASE 6)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		6 / 12 VAL A 689
ALA A 705
ILE A 751
THR A 753
GLY A 759
LEU A 807
 None
 0.63A 5h2uB-2r2pA:
29.5		 5h2uB-2r2pA:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		5 / 12 ALA A 705
ILE A 751
THR A 753
GLY A 759
LEU A 807
 None
 0.61A 5h2uC-2r2pA:
29.4		 5h2uC-2r2pA:
37.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		6 / 12 VAL A 689
ALA A 705
ILE A 737
ILE A 751
THR A 753
TYR A 755
 None
 0.59A 5hesA-2r2pA:
10.8		 5hesA-2r2pA:
27.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		6 / 12 VAL A 689
ALA A 705
ILE A 737
THR A 753
TYR A 755
PHE A 819
 None
 0.79A 5hesA-2r2pA:
10.8		 5hesA-2r2pA:
27.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		5 / 12 GLY A 684
VAL A 689
ALA A 705
ILE A 751
THR A 753
 None
 0.70A 5hieA-2r2pA:
26.2		 5hieA-2r2pA:
32.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		5 / 12 GLY A 684
VAL A 689
ALA A 705
ILE A 751
THR A 753
 None
 0.71A 5hieB-2r2pA:
26.3		 5hieB-2r2pA:
32.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_D_P06D801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		5 / 12 GLY A 684
VAL A 689
ALA A 705
ILE A 751
THR A 753
 None
 0.71A 5hieD-2r2pA:
26.3		 5hieD-2r2pA:
32.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I9X_A_DB8A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		10 / 12 ILE A 681
ALA A 705
GLU A 724
ILE A 737
ILE A 751
THR A 753
TYR A 755
GLY A 759
LEU A 807
SER A 817
 None
 0.57A 5i9xA-2r2pA:
36.6		 5i9xA-2r2pA:
68.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I9Y_A_1N1A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		9 / 12 ILE A 681
ALA A 705
GLU A 724
MET A 728
THR A 753
TYR A 755
GLY A 759
LEU A 807
SER A 817
 None
 0.55A 5i9yA-2r2pA:
36.7		 5i9yA-2r2pA:
68.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I9Y_A_1N1A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		9 / 12 ILE A 681
ALA A 705
LYS A 707
GLU A 724
MET A 728
TYR A 755
GLY A 759
LEU A 807
SER A 817
 None
 0.68A 5i9yA-2r2pA:
36.7		 5i9yA-2r2pA:
68.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I9Y_A_1N1A1001_2
(EPHRIN TYPE-A
RECEPTOR 2)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		3 / 3 ILE A 737
ILE A 751
MET A 756
 None
 0.20A 5i9yA-2r2pA:
36.7		 5i9yA-2r2pA:
68.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		8 / 12 ILE A 681
GLY A 682
VAL A 689
ALA A 705
LYS A 707
GLU A 724
TYR A 755
GLY A 759
 None
 0.86A 5mafA-2r2pA:
21.1		 5mafA-2r2pA:
21.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5P9I_A_1E8A701_1
(TYROSINE-PROTEIN
KINASE BTK)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		6 / 12 GLY A 684
VAL A 689
ALA A 705
ILE A 751
THR A 753
SER A 817
 None
 0.87A 5p9iA-2r2pA:
31.0		 5p9iA-2r2pA:
36.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5P9I_A_1E8A701_1
(TYROSINE-PROTEIN
KINASE BTK)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		8 / 12 VAL A 689
ALA A 705
LYS A 707
ILE A 751
THR A 753
GLY A 759
LEU A 807
SER A 817
 None
 0.97A 5p9iA-2r2pA:
31.0		 5p9iA-2r2pA:
36.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5P9I_A_1E8A701_1
(TYROSINE-PROTEIN
KINASE BTK)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		8 / 12 VAL A 689
ALA A 705
LYS A 707
THR A 753
GLY A 759
LEU A 807
SER A 817
PHE A 819
 None
 1.23A 5p9iA-2r2pA:
31.0		 5p9iA-2r2pA:
36.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PBE_A_TYLA2001_1
(BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		4 / 6 PRO A 878
VAL A 887
VAL A 891
ILE A 866
 None
 0.92A 5pbeA-2r2pA:
undetectable		 5pbeA-2r2pA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		7 / 12 ILE A 681
GLY A 682
ALA A 705
GLU A 724
TYR A 755
GLY A 759
ASP A 818
 None
 0.84A 5vc3A-2r2pA:
25.3		 5vc3A-2r2pA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSD_A_1N1A901_0
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		10 / 12 VAL A 689
ALA A 705
GLU A 724
MET A 728
ILE A 737
THR A 753
TYR A 755
MET A 756
GLY A 759
LEU A 807
 None
 0.97A 6bsdA-2r2pA:
31.0		 6bsdA-2r2pA:
15.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FNM_A_1N1A1001_1
(-)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		10 / 12 ILE A 681
VAL A 689
ALA A 705
GLU A 724
ILE A 751
THR A 753
MET A 756
GLY A 759
LEU A 807
SER A 817
 None
 0.56A 6fnmA-2r2pA:
38.3		 6fnmA-2r2pA:
73.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FNM_A_1N1A1001_1
(-)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		10 / 12 ILE A 681
VAL A 689
ALA A 705
GLU A 724
MET A 728
ILE A 751
THR A 753
MET A 756
GLY A 759
LEU A 807
 None
 0.54A 6fnmA-2r2pA:
38.3		 6fnmA-2r2pA:
73.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FNM_A_1N1A1001_1
(-)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		10 / 12 ILE A 681
VAL A 689
ALA A 705
LYS A 707
GLU A 724
ILE A 751
MET A 756
GLY A 759
LEU A 807
SER A 817
 None
 0.70A 6fnmA-2r2pA:
38.3		 6fnmA-2r2pA:
73.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_0
(TYROSINE-PROTEIN
KINASE ABL1)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		7 / 12 VAL A 689
ALA A 705
GLU A 724
MET A 728
ILE A 751
THR A 753
ASP A 818
 None
 0.99A 6hd4B-2r2pA:
25.7		 6hd4B-2r2pA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_0
(TYROSINE-PROTEIN
KINASE ABL1)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		7 / 12 VAL A 689
ALA A 705
GLU A 724
MET A 728
ILE A 751
THR A 753
ASP A 818
 None
 0.98A 6hd6A-2r2pA:
31.4		 6hd6A-2r2pA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens) 		4 / 7 ILE A 751
MET A 756
GLY A 759
ARG A 799
 None
None
None
SO4  A   1 ( 3.1A)
 0.91A 6hd6B-2r2pA:
31.2		 6hd6B-2r2pA:
16.48