SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2r2w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)		 2r2w PLASMINOGEN
ACTIVATOR, UROKINASE
(Homo
sapiens) 		8 / 8 HIS U  57
ASP U 189
SER U 190
GLN U 192
SER U 195
VAL U 213
GLY U 216
GLY U 226
 4PG  U 300 (-3.9A)
4PG  U 300 (-2.8A)
4PG  U 300 (-2.7A)
4PG  U 300 (-3.7A)
4PG  U 300 (-3.5A)
None
4PG  U 300 (-3.3A)
4PG  U 300 (-3.2A)
 0.53A 1aq7A-2r2wU:
34.4		 1aq7A-2r2wU:
39.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		 2r2w PLASMINOGEN
ACTIVATOR, UROKINASE
(Homo
sapiens) 		5 / 9 ASP U 189
VAL U 213
TRP U 215
GLY U 216
GLY U 226
 4PG  U 300 (-2.8A)
None
None
4PG  U 300 (-3.3A)
4PG  U 300 (-3.2A)
 0.40A 1bcuH-2r2wU:
35.7		 1bcuH-2r2wU:
32.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)		 2r2w PLASMINOGEN
ACTIVATOR, UROKINASE
(Homo
sapiens) 		6 / 12 HIS U  57
ASP U 189
VAL U 213
TRP U 215
GLY U 216
GLY U 226
 4PG  U 300 (-3.9A)
4PG  U 300 (-2.8A)
None
None
4PG  U 300 (-3.3A)
4PG  U 300 (-3.2A)
 0.42A 1etrH-2r2wU:
35.1		 1etrH-2r2wU:
31.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)		 2r2w PLASMINOGEN
ACTIVATOR, UROKINASE
(Homo
sapiens) 		6 / 12 HIS U  57
SER U 195
VAL U 213
TRP U 215
GLY U 216
GLY U 226
 4PG  U 300 (-3.9A)
4PG  U 300 (-3.5A)
None
None
4PG  U 300 (-3.3A)
4PG  U 300 (-3.2A)
 0.51A 1etrH-2r2wU:
35.1		 1etrH-2r2wU:
31.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2r2w PLASMINOGEN
ACTIVATOR, UROKINASE
(Homo
sapiens) 		5 / 8 ASP U 189
SER U 190
VAL U 213
GLY U 216
GLY U 226
 4PG  U 300 (-2.8A)
4PG  U 300 (-2.7A)
None
4PG  U 300 (-3.3A)
4PG  U 300 (-3.2A)
 0.22A 1f5lA-2r2wU:
47.0		 1f5lA-2r2wU:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_A_RBFA501_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2r2w PLASMINOGEN
ACTIVATOR, UROKINASE
(Homo
sapiens) 		5 / 12 GLY U  44
SER U  45
LEU U 209
ILE U  47
ILE U 108
 None
 1.20A 1kyvA-2r2wU:
undetectable
1kyvE-2r2wU:
undetectable		 1kyvA-2r2wU:
21.18
1kyvE-2r2wU:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_C_RBFC503_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2r2w PLASMINOGEN
ACTIVATOR, UROKINASE
(Homo
sapiens) 		5 / 12 ILE U 108
GLY U  44
SER U  45
LEU U 209
ILE U  47
 None
 1.19A 1kyvB-2r2wU:
undetectable
1kyvC-2r2wU:
undetectable		 1kyvB-2r2wU:
21.18
1kyvC-2r2wU:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_D_RBFD504_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2r2w PLASMINOGEN
ACTIVATOR, UROKINASE
(Homo
sapiens) 		5 / 12 ILE U 108
GLY U  44
SER U  45
LEU U 209
ILE U  47
 None
 1.20A 1kyvC-2r2wU:
undetectable
1kyvD-2r2wU:
undetectable		 1kyvC-2r2wU:
21.18
1kyvD-2r2wU:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_E_RBFE505_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2r2w PLASMINOGEN
ACTIVATOR, UROKINASE
(Homo
sapiens) 		5 / 12 ILE U 108
GLY U  44
SER U  45
LEU U 209
ILE U  47
 None
 1.17A 1kyvD-2r2wU:
undetectable
1kyvE-2r2wU:
undetectable		 1kyvD-2r2wU:
21.18
1kyvE-2r2wU:
21.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TNL_A_TPAA900_1
(TRYPSIN)		 2r2w PLASMINOGEN
ACTIVATOR, UROKINASE
(Homo
sapiens) 		6 / 6 ASP U 189
SER U 190
SER U 195
VAL U 213
GLY U 216
GLY U 226
 4PG  U 300 (-2.8A)
4PG  U 300 (-2.7A)
4PG  U 300 (-3.5A)
None
4PG  U 300 (-3.3A)
4PG  U 300 (-3.2A)
 0.64A 1tnlA-2r2wU:
15.6		 1tnlA-2r2wU:
38.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_1
(PROTEASE)		 2r2w PLASMINOGEN
ACTIVATOR, UROKINASE
(Homo
sapiens) 		6 / 12 GLY U  44
ALA U  31
ILE U  24
ILE U 121
PRO U 114
ALA U 112
 None
 1.17A 2nmzA-2r2wU:
undetectable		 2nmzA-2r2wU:
17.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)		 2r2w PLASMINOGEN
ACTIVATOR, UROKINASE
(Homo
sapiens) 		5 / 6 ASP U 189
SER U 190
VAL U 213
GLY U 216
GLY U 226
 4PG  U 300 (-2.8A)
4PG  U 300 (-2.7A)
None
4PG  U 300 (-3.3A)
4PG  U 300 (-3.2A)
 0.42A 2otvA-2r2wU:
15.5		 2otvA-2r2wU:
39.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 2r2w PLASMINOGEN
ACTIVATOR, UROKINASE
(Homo
sapiens) 		6 / 12 ASP U 189
VAL U 213
TRP U 215
GLY U 216
GLY U 226
TYR U 228
 4PG  U 300 (-2.8A)
None
None
4PG  U 300 (-3.3A)
4PG  U 300 (-3.2A)
None
 0.35A 2p16A-2r2wU:
33.5		 2p16A-2r2wU:
32.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB927_0
(FERROCHELATASE)		 2r2w PLASMINOGEN
ACTIVATOR, UROKINASE
(Homo
sapiens) 		3 / 3 LEU U 235
PRO U 236
ARG U 230
 None
 0.62A 2qd4B-2r2wU:
undetectable		 2qd4B-2r2wU:
19.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)		 2r2w PLASMINOGEN
ACTIVATOR, UROKINASE
(Homo
sapiens) 		5 / 8 ASP U 189
SER U 190
VAL U 213
GLY U 216
GLY U 226
 4PG  U 300 (-2.8A)
4PG  U 300 (-2.7A)
None
4PG  U 300 (-3.3A)
4PG  U 300 (-3.2A)
 0.31A 2vinA-2r2wU:
46.7		 2vinA-2r2wU:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)		 2r2w PLASMINOGEN
ACTIVATOR, UROKINASE
(Homo
sapiens) 		4 / 8 SER U 190
SER U 195
VAL U 213
GLY U 216
 4PG  U 300 (-2.7A)
4PG  U 300 (-3.5A)
None
4PG  U 300 (-3.3A)
 0.77A 2vinA-2r2wU:
46.7		 2vinA-2r2wU:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		 2r2w PLASMINOGEN
ACTIVATOR, UROKINASE
(Homo
sapiens) 		7 / 12 ASP U 189
VAL U 213
TRP U 215
GLY U 216
GLY U 219
GLY U 226
TYR U 228
 4PG  U 300 (-2.8A)
None
None
4PG  U 300 (-3.3A)
None
4PG  U 300 (-3.2A)
None
 0.39A 2w26A-2r2wU:
33.5		 2w26A-2r2wU:
32.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)		 2r2w PLASMINOGEN
ACTIVATOR, UROKINASE
(Homo
sapiens) 		7 / 11 HIS U  57
ASP U 189
SER U 190
GLN U 192
TRP U 215
GLY U 216
GLY U 226
 4PG  U 300 (-3.9A)
4PG  U 300 (-2.8A)
4PG  U 300 (-2.7A)
4PG  U 300 (-3.7A)
None
4PG  U 300 (-3.3A)
4PG  U 300 (-3.2A)
 0.48A 3gy3A-2r2wU:
14.9		 3gy3A-2r2wU:
39.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)		 2r2w PLASMINOGEN
ACTIVATOR, UROKINASE
(Homo
sapiens) 		7 / 11 HIS U  57
SER U 190
GLN U 192
SER U 195
TRP U 215
GLY U 216
GLY U 226
 4PG  U 300 (-3.9A)
4PG  U 300 (-2.7A)
4PG  U 300 (-3.7A)
4PG  U 300 (-3.5A)
None
4PG  U 300 (-3.3A)
4PG  U 300 (-3.2A)
 0.65A 3gy3A-2r2wU:
14.9		 3gy3A-2r2wU:
39.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 2r2w PLASMINOGEN
ACTIVATOR, UROKINASE
(Homo
sapiens) 		5 / 12 LEU U 106
GLY U  43
GLY U  44
SER U 190
ASP U 102
 None
None
None
4PG  U 300 (-2.7A)
None
 1.02A 3i5uB-2r2wU:
undetectable		 3i5uB-2r2wU:
22.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 2r2w PLASMINOGEN
ACTIVATOR, UROKINASE
(Homo
sapiens) 		6 / 6 SER U 190
SER U 195
VAL U 213
TRP U 215
GLY U 216
GLY U 226
 4PG  U 300 (-2.7A)
4PG  U 300 (-3.5A)
None
None
4PG  U 300 (-3.3A)
4PG  U 300 (-3.2A)
 0.56A 3rxfA-2r2wU:
14.1		 3rxfA-2r2wU:
39.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		 2r2w PLASMINOGEN
ACTIVATOR, UROKINASE
(Homo
sapiens) 		5 / 5 ASP U 189
SER U 190
SER U 195
VAL U 213
GLY U 226
 4PG  U 300 (-2.8A)
4PG  U 300 (-2.7A)
4PG  U 300 (-3.5A)
None
4PG  U 300 (-3.2A)
 0.59A 3rxhA-2r2wU:
15.4		 3rxhA-2r2wU:
39.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD392_1
(TETX2 PROTEIN)		 2r2w PLASMINOGEN
ACTIVATOR, UROKINASE
(Homo
sapiens) 		4 / 5 HIS U  99
SER U 214
SER U 195
VAL U 213
 4PG  U 300 (-4.1A)
None
4PG  U 300 (-3.5A)
None
 1.42A 4a99D-2r2wU:
undetectable		 4a99D-2r2wU:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 2r2w PLASMINOGEN
ACTIVATOR, UROKINASE
(Homo
sapiens) 		5 / 6 PHE U  59
ALA U 104
GLY U  44
LEU U 106
VAL U  52
 None
 1.28A 4dubB-2r2wU:
undetectable		 4dubB-2r2wU:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_2
(DIPEPTIDYL PEPTIDASE
4)		 2r2w PLASMINOGEN
ACTIVATOR, UROKINASE
(Homo
sapiens) 		3 / 3 PHE U 141
TYR U  67
TYR U  34
 None
 1.05A 4ffwA-2r2wU:
undetectable		 4ffwA-2r2wU:
16.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FU8_A_ACTA302_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2r2w PLASMINOGEN
ACTIVATOR, UROKINASE
(Homo
sapiens) 		4 / 5 HIS U  57
GLN U 192
GLY U 193
SER U 195
 4PG  U 300 (-3.9A)
4PG  U 300 (-3.7A)
4PG  U 300 (-4.1A)
4PG  U 300 (-3.5A)
 1.04A 4fu8A-2r2wU:
45.9		 4fu8A-2r2wU:
99.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FU8_A_ACTA302_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2r2w PLASMINOGEN
ACTIVATOR, UROKINASE
(Homo
sapiens) 		4 / 5 HIS U  57
TYR U 151
GLY U 193
SER U 195
 4PG  U 300 (-3.9A)
None
4PG  U 300 (-4.1A)
4PG  U 300 (-3.5A)
 0.77A 4fu8A-2r2wU:
45.9		 4fu8A-2r2wU:
99.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FU8_A_ACTA304_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2r2w PLASMINOGEN
ACTIVATOR, UROKINASE
(Homo
sapiens) 		3 / 3 ARG U  35
HIS U  37
TYR U  60
 None
 0.56A 4fu8A-2r2wU:
45.9		 4fu8A-2r2wU:
99.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FU9_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2r2w PLASMINOGEN
ACTIVATOR, UROKINASE
(Homo
sapiens) 		3 / 3 GLN U 169
THR U 177
THR U 178
 None
SO4  U 401 (-3.1A)
None
 0.40A 4fu9A-2r2wU:
45.9		 4fu9A-2r2wU:
99.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FU9_A_ACTA312_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2r2w PLASMINOGEN
ACTIVATOR, UROKINASE
(Homo
sapiens) 		3 / 3 ARG U  35
HIS U  37
TYR U  60
 None
 0.43A 4fu9A-2r2wU:
45.9		 4fu9A-2r2wU:
99.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FUF_A_ACTA310_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2r2w PLASMINOGEN
ACTIVATOR, UROKINASE
(Homo
sapiens) 		3 / 3 GLN U 169
THR U 177
THR U 178
 None
SO4  U 401 (-3.1A)
None
 0.44A 4fufA-2r2wU:
45.9		 4fufA-2r2wU:
99.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HFP_D_15UD402_1
(PROTHROMBIN)		 2r2w PLASMINOGEN
ACTIVATOR, UROKINASE
(Homo
sapiens) 		5 / 12 HIS U  57
ASP U 189
VAL U 213
TRP U 215
GLY U 226
 4PG  U 300 (-3.9A)
4PG  U 300 (-2.8A)
None
None
4PG  U 300 (-3.2A)
 0.42A 4hfpD-2r2wU:
35.0		 4hfpD-2r2wU:
31.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDJ_A_SAMA301_0
(MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE)		 2r2w PLASMINOGEN
ACTIVATOR, UROKINASE
(Homo
sapiens) 		5 / 12 VAL U 231
GLY U  44
ILE U 103
LEU U 105
LEU U  46
 None
 1.03A 4qdjA-2r2wU:
undetectable		 4qdjA-2r2wU:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		 2r2w PLASMINOGEN
ACTIVATOR, UROKINASE
(Homo
sapiens) 		5 / 12 HIS U  57
VAL U 213
TRP U 215
GLY U 216
GLY U 226
 4PG  U 300 (-3.9A)
None
None
4PG  U 300 (-3.3A)
4PG  U 300 (-3.2A)
 0.32A 4rn6B-2r2wU:
30.3		 4rn6B-2r2wU:
29.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP3_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 2r2w PLASMINOGEN
ACTIVATOR, UROKINASE
(Homo
sapiens) 		4 / 6 ALA U 112
GLN U 113
LEU U  68
MET U  81
 None
 1.27A 4xp3A-2r2wU:
undetectable		 4xp3A-2r2wU:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 2r2w PLASMINOGEN
ACTIVATOR, UROKINASE
(Homo
sapiens) 		5 / 12 GLY U 211
SER U  45
THR U 229
VAL U 200
ALA U 183
 None
 0.93A 5kpcA-2r2wU:
undetectable		 5kpcA-2r2wU:
21.39