SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2r3a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		5 / 11 GLY A 190
ARG A 182
GLY A 183
THR A 192
LEU A 194
 None
None
None
SAM  A 304 (-3.6A)
None
 1.12A 1jg3A-2r3aA:
undetectable		 1jg3A-2r3aA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_B_ADNB550_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		5 / 11 GLY A 190
ARG A 182
GLY A 183
THR A 192
LEU A 194
 None
None
None
SAM  A 304 (-3.6A)
None
 1.08A 1jg3B-2r3aA:
undetectable		 1jg3B-2r3aA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		4 / 7 ALA A 208
TYR A 193
TYR A  59
PHE A 217
 None
SAM  A 304 (-4.2A)
None
None
 1.20A 2ajvH-2r3aA:
undetectable
2ajvL-2r3aA:
undetectable		 2ajvH-2r3aA:
19.40
2ajvL-2r3aA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_B_CHDB2_0
(LIVER
CARBOXYLESTERASE 1)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		3 / 3 TRP A 152
LYS A 189
PRO A  55
 None
SAM  A 304 (-3.9A)
None
 1.08A 2dqyB-2r3aA:
undetectable		 2dqyB-2r3aA:
22.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2R3A_A_SAMA304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		5 / 12 ARG A 150
GLY A 149
HIS A 220
CYH A 289
LEU A 298
 None
None
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
SAM  A 304 (-4.7A)
 1.25A 2r3aA-2r3aA:
47.2		 2r3aA-2r3aA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2R3A_A_SAMA304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		12 / 12 ARG A 150
GLY A 151
TRP A 152
LYS A 189
THR A 192
TYR A 193
HIS A 220
TYR A 261
CYH A 287
LYS A 288
CYH A 289
LEU A 298
 None
SAM  A 304 (-3.5A)
None
SAM  A 304 (-3.9A)
SAM  A 304 (-3.6A)
SAM  A 304 (-4.2A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
None
ZN  A 300 ( 2.3A)
SAM  A 304 (-4.7A)
 0.04A 2r3aA-2r3aA:
47.2		 2r3aA-2r3aA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		4 / 6 ARG A 181
GLY A 183
GLU A 177
GLU A 180
 None
 1.17A 3k9fA-2r3aA:
undetectable
3k9fB-2r3aA:
undetectable
3k9fD-2r3aA:
undetectable		 3k9fA-2r3aA:
19.60
3k9fB-2r3aA:
19.60
3k9fD-2r3aA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEG_A_T27A561_1
(P66 REVERSE
TRANSCRIPTASE)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		5 / 12 LEU A 197
ASN A 230
VAL A 231
VAL A 228
TYR A 169
 None
 1.43A 3megA-2r3aA:
undetectable		 3megA-2r3aA:
21.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OOI_A_SAMA237_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		5 / 12 ARG A 150
GLY A 149
HIS A 220
CYH A 289
LEU A 298
 None
None
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
SAM  A 304 (-4.7A)
 1.03A 3ooiA-2r3aA:
19.6		 3ooiA-2r3aA:
30.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OOI_A_SAMA237_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		10 / 12 ARG A 150
GLY A 151
TRP A 152
TYR A 193
ASN A 219
HIS A 220
TYR A 261
CYH A 287
CYH A 289
LEU A 298
 None
SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.2A)
SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
ZN  A 300 ( 2.3A)
SAM  A 304 (-4.7A)
 0.69A 3ooiA-2r3aA:
19.6		 3ooiA-2r3aA:
30.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OOI_A_SAMA237_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		6 / 12 GLY A 151
TRP A 152
ASN A 219
HIS A 220
TYR A 261
CYH A 287
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 1.22A 3ooiA-2r3aA:
19.6		 3ooiA-2r3aA:
30.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OOI_A_SAMA237_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		8 / 12 TYR A 193
ASN A 219
HIS A 220
TYR A 261
CYH A 287
LYS A 288
CYH A 289
LEU A 298
 SAM  A 304 (-4.2A)
SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
None
ZN  A 300 ( 2.3A)
SAM  A 304 (-4.7A)
 1.01A 3ooiA-2r3aA:
19.6		 3ooiA-2r3aA:
30.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OPE_A_SAMA7_0
(PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		5 / 12 GLY A 151
TRP A 152
HIS A 220
TYR A 261
CYH A 289
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 1.40A 3opeA-2r3aA:
18.8		 3opeA-2r3aA:
28.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OPE_A_SAMA7_0
(PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		7 / 12 GLY A 151
TRP A 152
TYR A 193
ASN A 219
HIS A 220
TYR A 261
CYH A 287
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.2A)
SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 0.58A 3opeA-2r3aA:
18.8		 3opeA-2r3aA:
28.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OPE_A_SAMA7_0
(PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		6 / 12 TYR A 193
ASN A 219
HIS A 220
TYR A 261
CYH A 287
LYS A 288
 SAM  A 304 (-4.2A)
SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
None
 1.00A 3opeA-2r3aA:
18.8		 3opeA-2r3aA:
28.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OPE_B_SAMB8_0
(PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		5 / 9 GLY A 151
TRP A 152
TYR A 193
ASN A 219
TYR A 261
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.2A)
SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
 0.72A 3opeB-2r3aA:
18.3		 3opeB-2r3aA:
28.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_A_SAMA6734_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		5 / 12 GLY A 151
TYR A 193
ASN A 219
HIS A 220
TYR A 261
 SAM  A 304 (-3.5A)
SAM  A 304 (-4.2A)
SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
 0.95A 3qxyA-2r3aA:
5.9		 3qxyA-2r3aA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_B_SAMB480_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		5 / 12 GLY A 151
TYR A 193
ASN A 219
HIS A 220
TYR A 261
 SAM  A 304 (-3.5A)
SAM  A 304 (-4.2A)
SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
 0.91A 3rc0B-2r3aA:
6.3		 3rc0B-2r3aA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQ4_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H2)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		5 / 12 ASN A 219
HIS A 220
TYR A 261
CYH A 287
CYH A 289
 SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
ZN  A 300 ( 2.3A)
 0.43A 3rq4A-2r3aA:
6.1		 3rq4A-2r3aA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		5 / 12 ASN A 219
HIS A 220
TYR A 261
CYH A 287
CYH A 289
 SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
ZN  A 300 ( 2.3A)
 0.47A 3s8pA-2r3aA:
8.4		 3s8pA-2r3aA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		4 / 8 ASP A 187
ILE A 191
GLY A 190
ARG A 295
 None
 0.92A 4acbB-2r3aA:
undetectable
4acbC-2r3aA:
undetectable		 4acbB-2r3aA:
21.49
4acbC-2r3aA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		5 / 12 ASN A 219
HIS A 220
TYR A 261
CYH A 287
CYH A 289
 SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
ZN  A 300 ( 2.3A)
 0.48A 4bupA-2r3aA:
8.3		 4bupA-2r3aA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_A_ASDA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		4 / 7 TYR A 139
ILE A 107
LEU A 257
LEU A 226
 None
 0.84A 4xo7A-2r3aA:
undetectable		 4xo7A-2r3aA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNM_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		6 / 12 GLY A 151
TRP A 152
ASN A 219
HIS A 220
TYR A 261
CYH A 287
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 0.51A 4ynmA-2r3aA:
19.4		 4ynmA-2r3aA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNM_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		5 / 12 GLY A 151
TRP A 152
HIS A 220
TYR A 261
CYH A 289
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 1.34A 4ynmA-2r3aA:
19.4		 4ynmA-2r3aA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNM_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		5 / 12 GLY A 151
TRP A 152
HIS A 220
TYR A 261
CYH A 289
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 1.35A 4ynmB-2r3aA:
18.9		 4ynmB-2r3aA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNM_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		7 / 12 GLY A 151
TRP A 152
TYR A 193
ASN A 219
HIS A 220
TYR A 261
CYH A 287
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.2A)
SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 0.53A 4ynmB-2r3aA:
18.9		 4ynmB-2r3aA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNM_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		5 / 12 GLY A 151
TYR A 193
ASN A 219
TYR A 261
LYS A 288
 SAM  A 304 (-3.5A)
SAM  A 304 (-4.2A)
SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
None
 1.17A 4ynmB-2r3aA:
18.9		 4ynmB-2r3aA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNM_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		5 / 12 GLY A 153
TYR A 193
HIS A 220
TYR A 261
CYH A 287
 None
SAM  A 304 (-4.2A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 1.41A 4ynmB-2r3aA:
18.9		 4ynmB-2r3aA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNP_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		7 / 12 GLY A 151
TRP A 152
TYR A 193
HIS A 220
TYR A 261
CYH A 287
CYH A 289
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.2A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
ZN  A 300 ( 2.3A)
 0.54A 4ynpA-2r3aA:
19.0		 4ynpA-2r3aA:
28.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNP_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		6 / 12 GLY A 151
TRP A 152
TYR A 193
HIS A 220
TYR A 261
CYH A 289
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.2A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 1.49A 4ynpA-2r3aA:
19.0		 4ynpA-2r3aA:
28.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNP_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		6 / 12 GLY A 153
TYR A 193
HIS A 220
TYR A 261
CYH A 287
CYH A 289
 None
SAM  A 304 (-4.2A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
ZN  A 300 ( 2.3A)
 1.42A 4ynpA-2r3aA:
19.0		 4ynpA-2r3aA:
28.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNP_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		5 / 12 GLY A 153
TYR A 193
HIS A 220
TYR A 261
CYH A 289
 None
SAM  A 304 (-4.2A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 1.19A 4ynpA-2r3aA:
19.0		 4ynpA-2r3aA:
28.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNP_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		6 / 12 TYR A 193
HIS A 220
TYR A 261
CYH A 287
LYS A 288
CYH A 289
 SAM  A 304 (-4.2A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
None
ZN  A 300 ( 2.3A)
 0.86A 4ynpA-2r3aA:
19.0		 4ynpA-2r3aA:
28.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNP_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		5 / 10 GLY A 151
TRP A 152
HIS A 220
TYR A 261
CYH A 289
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 1.28A 4ynpB-2r3aA:
18.8		 4ynpB-2r3aA:
28.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNP_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		7 / 10 GLY A 151
TRP A 152
TYR A 193
ASN A 219
HIS A 220
TYR A 261
CYH A 287
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.2A)
SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 0.69A 4ynpB-2r3aA:
18.8		 4ynpB-2r3aA:
28.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_A_SAMA3004_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		5 / 12 GLY A 151
TRP A 152
HIS A 220
TYR A 261
CYH A 289
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 1.31A 4ypaA-2r3aA:
19.2		 4ypaA-2r3aA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_A_SAMA3004_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		8 / 12 GLY A 151
TRP A 152
TYR A 193
ASN A 219
HIS A 220
TYR A 261
CYH A 287
LYS A 288
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.2A)
SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
None
 0.69A 4ypaA-2r3aA:
19.2		 4ypaA-2r3aA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_A_SAMA3004_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		5 / 12 GLY A 153
TYR A 193
HIS A 220
TYR A 261
CYH A 287
 None
SAM  A 304 (-4.2A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 1.46A 4ypaA-2r3aA:
19.2		 4ypaA-2r3aA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		7 / 12 GLY A 151
TRP A 152
ASN A 219
HIS A 220
TYR A 261
CYH A 287
LYS A 288
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
None
 0.68A 4ypaB-2r3aA:
19.4		 4ypaB-2r3aA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		5 / 12 GLY A 151
TRP A 152
HIS A 220
TYR A 261
CYH A 289
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 1.26A 4ypaB-2r3aA:
19.4		 4ypaB-2r3aA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_C_SAMC2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		7 / 12 GLY A 151
TRP A 152
ASN A 219
HIS A 220
TYR A 261
CYH A 287
LYS A 288
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
None
 0.69A 4ypaC-2r3aA:
19.2		 4ypaC-2r3aA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_C_SAMC2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		5 / 12 GLY A 151
TRP A 152
HIS A 220
TYR A 261
CYH A 289
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 1.29A 4ypaC-2r3aA:
19.2		 4ypaC-2r3aA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_D_SAMD2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		5 / 12 GLY A 151
TRP A 152
HIS A 220
TYR A 261
CYH A 289
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 1.27A 4ypaD-2r3aA:
19.0		 4ypaD-2r3aA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_D_SAMD2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		8 / 12 GLY A 151
TRP A 152
TYR A 193
ASN A 219
HIS A 220
TYR A 261
CYH A 287
LYS A 288
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.2A)
SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
None
 0.94A 4ypaD-2r3aA:
19.0		 4ypaD-2r3aA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPE_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		5 / 12 GLY A 151
TRP A 152
HIS A 220
TYR A 261
CYH A 289
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 1.35A 4ypeA-2r3aA:
19.7		 4ypeA-2r3aA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPE_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		7 / 12 GLY A 151
TRP A 152
TYR A 193
ASN A 219
HIS A 220
TYR A 261
CYH A 287
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.2A)
SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 0.52A 4ypeA-2r3aA:
19.7		 4ypeA-2r3aA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPE_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		5 / 12 GLY A 153
TYR A 193
HIS A 220
TYR A 261
CYH A 287
 None
SAM  A 304 (-4.2A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 1.36A 4ypeA-2r3aA:
19.7		 4ypeA-2r3aA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPE_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		6 / 12 TYR A 193
ASN A 219
HIS A 220
TYR A 261
CYH A 287
LYS A 288
 SAM  A 304 (-4.2A)
SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
None
 0.91A 4ypeA-2r3aA:
19.7		 4ypeA-2r3aA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPE_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		7 / 11 GLY A 151
TRP A 152
ASN A 219
HIS A 220
TYR A 261
CYH A 287
LYS A 288
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
None
 0.82A 4ypeB-2r3aA:
19.7		 4ypeB-2r3aA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPE_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		5 / 11 GLY A 151
TRP A 152
HIS A 220
TYR A 261
CYH A 289
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 1.38A 4ypeB-2r3aA:
19.7		 4ypeB-2r3aA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPE_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		7 / 11 GLY A 151
TRP A 152
TYR A 193
ASN A 219
HIS A 220
TYR A 261
CYH A 287
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.2A)
SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 0.44A 4ypeB-2r3aA:
19.7		 4ypeB-2r3aA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPU_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		5 / 12 GLY A 151
TRP A 152
HIS A 220
TYR A 261
CYH A 289
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 1.38A 4ypuA-2r3aA:
19.1		 4ypuA-2r3aA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPU_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		8 / 12 GLY A 151
TRP A 152
TYR A 193
ASN A 219
HIS A 220
TYR A 261
CYH A 287
LYS A 288
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.2A)
SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
None
 0.92A 4ypuA-2r3aA:
19.1		 4ypuA-2r3aA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPU_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		5 / 12 GLY A 153
TYR A 193
HIS A 220
TYR A 261
CYH A 287
 None
SAM  A 304 (-4.2A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 1.42A 4ypuA-2r3aA:
19.1		 4ypuA-2r3aA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPU_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		5 / 11 GLY A 151
TRP A 152
ASN A 219
HIS A 220
LYS A 288
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
None
 0.87A 4ypuB-2r3aA:
18.5		 4ypuB-2r3aA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPU_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		5 / 11 GLY A 151
TRP A 152
ASN A 219
HIS A 220
TYR A 261
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
 0.19A 4ypuB-2r3aA:
18.5		 4ypuB-2r3aA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPU_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		5 / 11 GLY A 151
TYR A 193
ASN A 219
HIS A 220
TYR A 261
 SAM  A 304 (-3.5A)
SAM  A 304 (-4.2A)
SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
 0.62A 4ypuB-2r3aA:
18.5		 4ypuB-2r3aA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2D_F_LFXF102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		3 / 4 ARG A 181
GLY A 183
GLU A 180
 None
 0.63A 4z2dB-2r3aA:
undetectable
4z2dC-2r3aA:
undetectable		 4z2dB-2r3aA:
19.76
4z2dC-2r3aA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		5 / 12 PHE A 217
HIS A 220
TYR A 261
CYH A 287
CYH A 289
 None
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
ZN  A 300 ( 2.3A)
 1.31A 5cprB-2r3aA:
7.4		 5cprB-2r3aA:
23.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JHN_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		5 / 12 GLY A 151
TRP A 152
HIS A 220
TYR A 261
CYH A 289
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 1.37A 5jhnA-2r3aA:
28.0		 5jhnA-2r3aA:
35.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JHN_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		7 / 12 GLY A 151
TRP A 152
TYR A 193
ASN A 219
HIS A 220
TYR A 261
CYH A 287
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.2A)
SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 0.43A 5jhnA-2r3aA:
28.0		 5jhnA-2r3aA:
35.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JHN_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		5 / 12 GLY A 151
TRP A 152
HIS A 220
TYR A 261
CYH A 289
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 1.40A 5jhnB-2r3aA:
28.2		 5jhnB-2r3aA:
35.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JHN_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		7 / 12 GLY A 151
TRP A 152
TYR A 193
ASN A 219
HIS A 220
TYR A 261
CYH A 287
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.2A)
SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 0.42A 5jhnB-2r3aA:
28.2		 5jhnB-2r3aA:
35.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JIN_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		5 / 12 GLY A 151
TRP A 152
HIS A 220
TYR A 261
CYH A 289
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 1.39A 5jinA-2r3aA:
18.4		 5jinA-2r3aA:
35.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JIN_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		6 / 12 GLY A 151
TRP A 152
TYR A 193
HIS A 220
TYR A 261
CYH A 287
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.2A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 0.37A 5jinA-2r3aA:
18.4		 5jinA-2r3aA:
35.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JIN_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		6 / 12 TRP A 152
TYR A 193
ASN A 219
HIS A 220
TYR A 261
CYH A 287
 None
SAM  A 304 (-4.2A)
SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 0.41A 5jinB-2r3aA:
28.2		 5jinB-2r3aA:
35.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JIY_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		5 / 12 GLY A 151
TRP A 152
HIS A 220
TYR A 261
CYH A 289
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 1.37A 5jiyA-2r3aA:
28.1		 5jiyA-2r3aA:
35.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JIY_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		7 / 12 GLY A 151
TRP A 152
TYR A 193
ASN A 219
HIS A 220
TYR A 261
CYH A 287
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.2A)
SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 0.38A 5jiyA-2r3aA:
28.1		 5jiyA-2r3aA:
35.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JIY_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		5 / 12 GLY A 151
TRP A 152
HIS A 220
TYR A 261
CYH A 289
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 1.42A 5jiyB-2r3aA:
28.2		 5jiyB-2r3aA:
35.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JIY_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		7 / 12 GLY A 151
TRP A 152
TYR A 193
ASN A 219
HIS A 220
TYR A 261
CYH A 287
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.2A)
SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 0.41A 5jiyB-2r3aA:
28.2		 5jiyB-2r3aA:
35.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JJ0_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		5 / 12 GLY A 151
TRP A 152
HIS A 220
TYR A 261
CYH A 289
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 1.39A 5jj0A-2r3aA:
28.1		 5jj0A-2r3aA:
35.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JJ0_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		6 / 12 GLY A 151
TRP A 152
TYR A 193
HIS A 220
TYR A 261
CYH A 287
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.2A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 0.39A 5jj0A-2r3aA:
28.1		 5jj0A-2r3aA:
35.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JJ0_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		6 / 12 GLY A 151
TRP A 152
ASN A 219
HIS A 220
TYR A 261
CYH A 287
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 0.33A 5jj0B-2r3aA:
28.1		 5jj0B-2r3aA:
35.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JJ0_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		5 / 12 GLY A 151
TRP A 152
HIS A 220
TYR A 261
CYH A 289
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 1.44A 5jj0B-2r3aA:
28.1		 5jj0B-2r3aA:
35.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		6 / 12 ARG A 150
GLY A 149
HIS A 220
THR A 285
CYH A 289
LEU A 298
 None
None
SAM  A 304 (-4.9A)
None
ZN  A 300 ( 2.3A)
SAM  A 304 (-4.7A)
 1.08A 5lsuA-2r3aA:
20.4		 5lsuA-2r3aA:
28.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		9 / 12 ARG A 150
GLY A 151
TRP A 152
TYR A 193
HIS A 220
THR A 285
CYH A 287
CYH A 289
LEU A 298
 None
SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.2A)
SAM  A 304 (-4.9A)
None
ZN  A 300 ( 2.3A)
ZN  A 300 ( 2.3A)
SAM  A 304 (-4.7A)
 0.53A 5lsuA-2r3aA:
20.4		 5lsuA-2r3aA:
28.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		6 / 12 HIS A 220
ASN A 299
THR A 285
CYH A 287
CYH A 289
LEU A 298
 SAM  A 304 (-4.9A)
None
None
ZN  A 300 ( 2.3A)
ZN  A 300 ( 2.3A)
SAM  A 304 (-4.7A)
 1.34A 5lsuA-2r3aA:
20.4		 5lsuA-2r3aA:
28.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_B_SAMB1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		6 / 12 ARG A 150
GLY A 149
HIS A 220
THR A 285
CYH A 289
LEU A 298
 None
None
SAM  A 304 (-4.9A)
None
ZN  A 300 ( 2.3A)
SAM  A 304 (-4.7A)
 1.27A 5lsuB-2r3aA:
20.3		 5lsuB-2r3aA:
28.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_B_SAMB1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		8 / 12 ARG A 150
GLY A 151
TRP A 152
TYR A 193
HIS A 220
THR A 285
CYH A 289
LEU A 298
 None
SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.2A)
SAM  A 304 (-4.9A)
None
ZN  A 300 ( 2.3A)
SAM  A 304 (-4.7A)
 0.61A 5lsuB-2r3aA:
20.3		 5lsuB-2r3aA:
28.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_B_SAMB1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		5 / 12 HIS A 220
ASN A 299
THR A 285
CYH A 289
LEU A 298
 SAM  A 304 (-4.9A)
None
None
ZN  A 300 ( 2.3A)
SAM  A 304 (-4.7A)
 1.41A 5lsuB-2r3aA:
20.3		 5lsuB-2r3aA:
28.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_B_SAMB1304_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		3 / 3 ASN A 219
TYR A 261
CYH A 287
 SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 0.16A 5lsuB-2r3aA:
20.3		 5lsuB-2r3aA:
28.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5T0K_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		5 / 12 GLY A 151
TRP A 152
HIS A 220
TYR A 261
CYH A 289
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 1.38A 5t0kA-2r3aA:
28.2		 5t0kA-2r3aA:
34.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5T0K_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		7 / 12 GLY A 151
TRP A 152
TYR A 193
ASN A 219
HIS A 220
TYR A 261
CYH A 287
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.2A)
SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 0.44A 5t0kA-2r3aA:
28.2		 5t0kA-2r3aA:
34.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5T0K_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		5 / 12 GLY A 153
TYR A 193
HIS A 220
TYR A 261
CYH A 287
 None
SAM  A 304 (-4.2A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 1.36A 5t0kA-2r3aA:
28.2		 5t0kA-2r3aA:
34.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5T0K_B_SAMB1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		6 / 12 GLY A 151
TRP A 152
ASN A 219
HIS A 220
TYR A 261
CYH A 287
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 0.29A 5t0kB-2r3aA:
28.1		 5t0kB-2r3aA:
34.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5T0K_B_SAMB1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		5 / 12 GLY A 151
TRP A 152
HIS A 220
TYR A 261
CYH A 289
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 1.37A 5t0kB-2r3aA:
28.1		 5t0kB-2r3aA:
34.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5T0M_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		6 / 12 TRP A 152
TYR A 193
ASN A 219
HIS A 220
TYR A 261
CYH A 287
 None
SAM  A 304 (-4.2A)
SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 0.41A 5t0mA-2r3aA:
28.4		 5t0mA-2r3aA:
34.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5T0M_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		5 / 12 GLY A 151
TRP A 152
HIS A 220
TYR A 261
CYH A 289
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 1.36A 5t0mB-2r3aA:
28.2		 5t0mB-2r3aA:
34.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5T0M_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		7 / 12 GLY A 151
TRP A 152
TYR A 193
ASN A 219
HIS A 220
TYR A 261
CYH A 287
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.2A)
SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 0.42A 5t0mB-2r3aA:
28.2		 5t0mB-2r3aA:
34.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TEG_B_SAMB401_0
(HISTONE H4 MUTANT
PEPTIDE WITH
H4K20NORLEUCINE
N-LYSINE
METHYLTRANSFERASE
KMT5A)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		5 / 10 GLY A 151
TYR A 193
ASN A 219
HIS A 220
TYR A 261
 SAM  A 304 (-3.5A)
SAM  A 304 (-4.2A)
SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
 0.35A 5tegB-2r3aA:
12.6
5tegE-2r3aA:
undetectable		 5tegB-2r3aA:
23.78
5tegE-2r3aA:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TQR_B_SAMB8009_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2, POLYCOMB
PROTEIN SUZ12)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		5 / 10 GLY A 151
TYR A 193
ASN A 219
HIS A 220
TYR A 261
 SAM  A 304 (-3.5A)
SAM  A 304 (-4.2A)
SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
 0.66A 5tqrB-2r3aA:
13.2		 5tqrB-2r3aA:
14.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TTF_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		5 / 11 GLY A 151
TRP A 152
HIS A 220
TYR A 261
CYH A 289
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 1.39A 5ttfA-2r3aA:
28.0		 5ttfA-2r3aA:
34.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TTF_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		7 / 11 GLY A 151
TRP A 152
TYR A 193
ASN A 219
HIS A 220
TYR A 261
CYH A 287
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.2A)
SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 0.38A 5ttfA-2r3aA:
28.0		 5ttfA-2r3aA:
34.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TTF_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		5 / 12 GLY A 151
TRP A 152
HIS A 220
TYR A 261
CYH A 289
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 1.41A 5ttfB-2r3aA:
28.1		 5ttfB-2r3aA:
34.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TTF_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		7 / 12 GLY A 151
TRP A 152
TYR A 193
ASN A 219
HIS A 220
TYR A 261
CYH A 287
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.2A)
SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 0.35A 5ttfB-2r3aA:
28.1		 5ttfB-2r3aA:
34.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TTF_C_SAMC1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		6 / 12 GLY A 151
TRP A 152
ASN A 219
HIS A 220
TYR A 261
CYH A 287
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 0.42A 5ttfC-2r3aA:
28.0		 5ttfC-2r3aA:
34.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TTF_D_SAMD1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		5 / 11 GLY A 151
TRP A 152
HIS A 220
TYR A 261
CYH A 289
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 1.45A 5ttfD-2r3aA:
18.4		 5ttfD-2r3aA:
34.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TTF_D_SAMD1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		7 / 11 GLY A 151
TRP A 152
TYR A 193
ASN A 219
HIS A 220
TYR A 261
CYH A 287
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.2A)
SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 0.49A 5ttfD-2r3aA:
18.4		 5ttfD-2r3aA:
34.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TTG_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		5 / 12 GLY A 151
TRP A 152
HIS A 220
TYR A 261
CYH A 289
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 1.42A 5ttgA-2r3aA:
28.0		 5ttgA-2r3aA:
35.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TTG_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		7 / 12 GLY A 151
TRP A 152
TYR A 193
ASN A 219
HIS A 220
TYR A 261
CYH A 287
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.2A)
SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 0.41A 5ttgA-2r3aA:
28.0		 5ttgA-2r3aA:
35.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TTG_B_SAMB1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		5 / 11 GLY A 151
TRP A 152
HIS A 220
TYR A 261
CYH A 289
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 1.43A 5ttgB-2r3aA:
18.4		 5ttgB-2r3aA:
35.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TTG_B_SAMB1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		7 / 11 GLY A 151
TRP A 152
TYR A 193
ASN A 219
HIS A 220
TYR A 261
CYH A 287
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.2A)
SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 0.44A 5ttgB-2r3aA:
18.4		 5ttgB-2r3aA:
35.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TUY_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		5 / 12 GLY A 151
TRP A 152
HIS A 220
TYR A 261
CYH A 289
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 1.42A 5tuyA-2r3aA:
28.1		 5tuyA-2r3aA:
35.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TUY_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		7 / 12 GLY A 151
TRP A 152
TYR A 193
ASN A 219
HIS A 220
TYR A 261
CYH A 287
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.2A)
SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 0.41A 5tuyA-2r3aA:
28.1		 5tuyA-2r3aA:
35.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TUY_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		5 / 12 GLY A 151
TRP A 152
HIS A 220
TYR A 261
CYH A 289
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 1.43A 5tuyB-2r3aA:
18.0		 5tuyB-2r3aA:
35.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TUY_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		7 / 12 GLY A 151
TRP A 152
TYR A 193
ASN A 219
HIS A 220
TYR A 261
CYH A 287
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.2A)
SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 0.40A 5tuyB-2r3aA:
18.0		 5tuyB-2r3aA:
35.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TUZ_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		7 / 12 GLY A 151
TRP A 152
ASN A 219
HIS A 220
TYR A 261
CYH A 287
CYH A 289
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
ZN  A 300 ( 2.3A)
 0.30A 5tuzA-2r3aA:
28.4		 5tuzA-2r3aA:
35.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TUZ_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		5 / 12 GLY A 151
TRP A 152
HIS A 220
TYR A 261
CYH A 289
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 1.40A 5tuzB-2r3aA:
18.6		 5tuzB-2r3aA:
35.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TUZ_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		7 / 12 GLY A 151
TRP A 152
TYR A 193
ASN A 219
HIS A 220
TYR A 261
CYH A 287
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.2A)
SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 0.41A 5tuzB-2r3aA:
18.6		 5tuzB-2r3aA:
35.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UPD_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		6 / 11 ARG A 150
GLY A 149
HIS A 220
CYH A 287
CYH A 289
LEU A 298
 None
None
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
ZN  A 300 ( 2.3A)
SAM  A 304 (-4.7A)
 1.06A 5updA-2r3aA:
19.7		 5updA-2r3aA:
30.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UPD_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		10 / 11 ARG A 150
GLY A 151
TRP A 152
TYR A 193
ASN A 219
HIS A 220
TYR A 261
CYH A 287
CYH A 289
LEU A 298
 None
SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.2A)
SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
ZN  A 300 ( 2.3A)
SAM  A 304 (-4.7A)
 0.53A 5updA-2r3aA:
19.7		 5updA-2r3aA:
30.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V21_A_SAMA1804_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		5 / 12 GLY A 151
TRP A 152
HIS A 220
TYR A 261
CYH A 289
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 1.30A 5v21A-2r3aA:
18.5		 5v21A-2r3aA:
28.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V21_A_SAMA1804_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		8 / 12 GLY A 151
TRP A 152
TYR A 193
ASN A 219
HIS A 220
TYR A 261
CYH A 287
LEU A 298
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.2A)
SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
SAM  A 304 (-4.7A)
 0.59A 5v21A-2r3aA:
18.5		 5v21A-2r3aA:
28.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V21_A_SAMA1804_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		6 / 12 GLY A 153
TYR A 193
HIS A 220
TYR A 261
CYH A 287
LEU A 298
 None
SAM  A 304 (-4.2A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
SAM  A 304 (-4.7A)
 1.42A 5v21A-2r3aA:
18.5		 5v21A-2r3aA:
28.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V37_A_SAMA504_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SMYD3)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		5 / 12 ARG A 150
GLY A 151
ASN A 219
HIS A 220
TYR A 261
 None
SAM  A 304 (-3.5A)
SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
 1.18A 5v37A-2r3aA:
5.8		 5v37A-2r3aA:
21.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V9I_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		5 / 12 GLY A 151
TRP A 152
HIS A 220
TYR A 261
CYH A 289
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 1.39A 5v9iA-2r3aA:
28.1		 5v9iA-2r3aA:
34.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V9I_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		7 / 12 GLY A 151
TRP A 152
TYR A 193
ASN A 219
HIS A 220
TYR A 261
CYH A 287
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.2A)
SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 0.38A 5v9iA-2r3aA:
28.1		 5v9iA-2r3aA:
34.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V9I_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		5 / 11 GLY A 151
TRP A 152
HIS A 220
TYR A 261
CYH A 289
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 1.42A 5v9iB-2r3aA:
28.1		 5v9iB-2r3aA:
34.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V9I_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		7 / 11 GLY A 151
TRP A 152
TYR A 193
ASN A 219
HIS A 220
TYR A 261
CYH A 287
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.2A)
SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 0.37A 5v9iB-2r3aA:
28.1		 5v9iB-2r3aA:
34.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V9I_C_SAMC1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		5 / 11 GLY A 151
TRP A 152
HIS A 220
TYR A 261
CYH A 289
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 1.46A 5v9iC-2r3aA:
28.1		 5v9iC-2r3aA:
34.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V9I_C_SAMC1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		7 / 11 GLY A 151
TRP A 152
TYR A 193
ASN A 219
HIS A 220
TYR A 261
CYH A 287
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.2A)
SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 0.46A 5v9iC-2r3aA:
28.1		 5v9iC-2r3aA:
34.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V9I_D_SAMD1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		6 / 12 GLY A 151
TRP A 152
TYR A 193
HIS A 220
TYR A 261
CYH A 287
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.2A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 0.53A 5v9iD-2r3aA:
28.0		 5v9iD-2r3aA:
34.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V9J_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		5 / 12 GLY A 151
TRP A 152
HIS A 220
TYR A 261
CYH A 289
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 1.39A 5v9jA-2r3aA:
18.8		 5v9jA-2r3aA:
35.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V9J_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		7 / 12 GLY A 151
TRP A 152
TYR A 193
ASN A 219
HIS A 220
TYR A 261
CYH A 287
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.2A)
SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 0.44A 5v9jA-2r3aA:
18.8		 5v9jA-2r3aA:
35.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V9J_B_SAMB1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		5 / 12 GLY A 151
TRP A 152
HIS A 220
TYR A 261
CYH A 289
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 1.43A 5v9jB-2r3aA:
28.3		 5v9jB-2r3aA:
35.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V9J_B_SAMB1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		7 / 12 GLY A 151
TRP A 152
TYR A 193
ASN A 219
HIS A 220
TYR A 261
CYH A 287
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.2A)
SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 0.46A 5v9jB-2r3aA:
28.3		 5v9jB-2r3aA:
35.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSC_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		5 / 12 GLY A 151
TRP A 152
HIS A 220
TYR A 261
CYH A 289
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 1.35A 5vscA-2r3aA:
28.1		 5vscA-2r3aA:
33.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSC_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		7 / 12 GLY A 151
TRP A 152
TYR A 193
ASN A 219
HIS A 220
TYR A 261
CYH A 287
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.2A)
SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 0.39A 5vscA-2r3aA:
28.1		 5vscA-2r3aA:
33.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSC_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		5 / 12 GLY A 151
TRP A 152
HIS A 220
TYR A 261
CYH A 289
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 1.33A 5vscB-2r3aA:
18.2		 5vscB-2r3aA:
33.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSC_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		7 / 12 GLY A 151
TRP A 152
TYR A 193
ASN A 219
HIS A 220
TYR A 261
CYH A 287
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.2A)
SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 0.38A 5vscB-2r3aA:
18.2		 5vscB-2r3aA:
33.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSD_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		6 / 12 GLY A 151
TRP A 152
ASN A 219
HIS A 220
TYR A 261
CYH A 287
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 0.28A 5vsdA-2r3aA:
18.7		 5vsdA-2r3aA:
35.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSD_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		5 / 12 GLY A 151
TRP A 152
HIS A 220
TYR A 261
CYH A 289
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 1.41A 5vsdA-2r3aA:
18.7		 5vsdA-2r3aA:
35.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSD_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		5 / 12 GLY A 151
TRP A 152
HIS A 220
TYR A 261
CYH A 289
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 1.42A 5vsdB-2r3aA:
18.7		 5vsdB-2r3aA:
35.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSD_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		7 / 12 GLY A 151
TRP A 152
TYR A 193
ASN A 219
HIS A 220
TYR A 261
CYH A 287
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.2A)
SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 0.44A 5vsdB-2r3aA:
18.7		 5vsdB-2r3aA:
35.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSE_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		5 / 12 GLY A 151
TRP A 152
HIS A 220
TYR A 261
CYH A 289
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 1.37A 5vseA-2r3aA:
28.3		 5vseA-2r3aA:
33.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSE_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		7 / 12 GLY A 151
TRP A 152
TYR A 193
ASN A 219
HIS A 220
TYR A 261
CYH A 287
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.2A)
SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 0.38A 5vseA-2r3aA:
28.3		 5vseA-2r3aA:
33.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSE_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		5 / 12 GLY A 151
TRP A 152
HIS A 220
TYR A 261
CYH A 289
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 1.34A 5vseB-2r3aA:
28.0		 5vseB-2r3aA:
33.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSE_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		7 / 12 GLY A 151
TRP A 152
TYR A 193
ASN A 219
HIS A 220
TYR A 261
CYH A 287
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.2A)
SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 0.39A 5vseB-2r3aA:
28.0		 5vseB-2r3aA:
33.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSF_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		6 / 12 GLY A 151
TRP A 152
ASN A 219
HIS A 220
TYR A 261
CYH A 287
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 0.30A 5vsfA-2r3aA:
18.8		 5vsfA-2r3aA:
35.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSF_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		5 / 12 GLY A 151
TRP A 152
HIS A 220
TYR A 261
CYH A 289
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 1.43A 5vsfA-2r3aA:
18.8		 5vsfA-2r3aA:
35.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSF_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		5 / 12 GLY A 151
TRP A 152
HIS A 220
TYR A 261
CYH A 289
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 1.41A 5vsfB-2r3aA:
18.8		 5vsfB-2r3aA:
35.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSF_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		7 / 12 GLY A 151
TRP A 152
TYR A 193
ASN A 219
HIS A 220
TYR A 261
CYH A 287
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.2A)
SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 0.39A 5vsfB-2r3aA:
18.8		 5vsfB-2r3aA:
35.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXD_A_SAMA501_0
(SMYD3
METHYLTRANSFERASE)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		5 / 12 ARG A 150
GLY A 151
ASN A 219
HIS A 220
TYR A 261
 None
SAM  A 304 (-3.5A)
SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
 0.81A 5xxdA-2r3aA:
5.3		 5xxdA-2r3aA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5K_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		5 / 12 ARG A 150
GLY A 149
HIS A 220
CYH A 289
LEU A 298
 None
None
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
SAM  A 304 (-4.7A)
 1.50A 6a5kA-2r3aA:
5.7		 6a5kA-2r3aA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5K_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		9 / 12 ARG A 150
GLY A 151
TRP A 152
ASN A 219
HIS A 220
TYR A 261
CYH A 287
CYH A 289
LEU A 298
 None
SAM  A 304 (-3.5A)
None
SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
ZN  A 300 ( 2.3A)
SAM  A 304 (-4.7A)
 0.65A 6a5kA-2r3aA:
5.7		 6a5kA-2r3aA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5K_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		7 / 12 ARG A 150
GLY A 153
HIS A 220
TYR A 261
CYH A 287
CYH A 289
LEU A 298
 None
None
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
ZN  A 300 ( 2.3A)
SAM  A 304 (-4.7A)
 1.44A 6a5kA-2r3aA:
5.7		 6a5kA-2r3aA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5K_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		5 / 12 GLY A 151
TRP A 152
HIS A 220
TYR A 261
CYH A 289
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 1.44A 6a5kA-2r3aA:
5.7		 6a5kA-2r3aA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5M_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		5 / 12 ARG A 150
GLY A 149
HIS A 220
CYH A 289
LEU A 298
 None
None
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
SAM  A 304 (-4.7A)
 1.43A 6a5mA-2r3aA:
26.3		 6a5mA-2r3aA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5M_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		10 / 12 ARG A 150
GLY A 151
TRP A 152
TYR A 193
ASN A 219
HIS A 220
TYR A 261
CYH A 287
CYH A 289
LEU A 298
 None
SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.2A)
SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
ZN  A 300 ( 2.3A)
SAM  A 304 (-4.7A)
 0.72A 6a5mA-2r3aA:
26.3		 6a5mA-2r3aA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5M_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		6 / 12 GLY A 151
TRP A 152
ASN A 219
HIS A 220
TYR A 261
CYH A 287
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 1.23A 6a5mA-2r3aA:
26.3		 6a5mA-2r3aA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5M_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		5 / 12 GLY A 153
TYR A 193
HIS A 220
TYR A 261
CYH A 289
 None
SAM  A 304 (-4.2A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 1.29A 6a5mA-2r3aA:
26.3		 6a5mA-2r3aA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AGO_A_SAMA2301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		5 / 11 GLY A 151
TRP A 152
ASN A 219
HIS A 220
CYH A 287
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 1.30A 6agoA-2r3aA:
18.5		 6agoA-2r3aA:
29.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AGO_A_SAMA2301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		7 / 11 GLY A 151
TRP A 152
ASN A 219
HIS A 220
TYR A 261
CYH A 287
CYH A 289
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
ZN  A 300 ( 2.3A)
 0.80A 6agoA-2r3aA:
18.5		 6agoA-2r3aA:
29.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AGO_A_SAMA2301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		6 / 11 TYR A 193
ASN A 219
HIS A 220
TYR A 261
CYH A 287
CYH A 289
 SAM  A 304 (-4.2A)
SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
ZN  A 300 ( 2.3A)
 1.06A 6agoA-2r3aA:
18.5		 6agoA-2r3aA:
29.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BP4_A_SAMA505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		7 / 12 GLY A 151
TRP A 152
HIS A 220
TYR A 261
LYS A 288
CYH A 289
LEU A 298
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
None
ZN  A 300 ( 2.3A)
SAM  A 304 (-4.7A)
 0.89A 6bp4A-2r3aA:
29.0		 6bp4A-2r3aA:
38.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BP4_B_SAMB505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		8 / 12 GLY A 151
TRP A 152
TYR A 193
HIS A 220
TYR A 261
CYH A 287
CYH A 289
LEU A 298
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.2A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
ZN  A 300 ( 2.3A)
SAM  A 304 (-4.7A)
 0.63A 6bp4B-2r3aA:
29.3		 6bp4B-2r3aA:
38.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BP4_B_SAMB505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		6 / 12 GLY A 151
TRP A 152
TYR A 193
HIS A 220
TYR A 261
CYH A 289
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.2A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 1.48A 6bp4B-2r3aA:
29.3		 6bp4B-2r3aA:
38.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BP4_B_SAMB505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		6 / 12 GLY A 153
TYR A 193
HIS A 220
TYR A 261
CYH A 287
CYH A 289
 None
SAM  A 304 (-4.2A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
ZN  A 300 ( 2.3A)
 1.49A 6bp4B-2r3aA:
29.3		 6bp4B-2r3aA:
38.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BP4_B_SAMB505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		5 / 12 GLY A 153
TYR A 193
HIS A 220
TYR A 261
CYH A 289
 None
SAM  A 304 (-4.2A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 1.17A 6bp4B-2r3aA:
29.3		 6bp4B-2r3aA:
38.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CEN_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		6 / 11 ARG A 150
GLY A 149
HIS A 220
CYH A 287
CYH A 289
LEU A 298
 None
None
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
ZN  A 300 ( 2.3A)
SAM  A 304 (-4.7A)
 1.17A 6cenA-2r3aA:
20.3		 6cenA-2r3aA:
29.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CEN_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		10 / 11 ARG A 150
GLY A 151
TRP A 152
TYR A 193
ASN A 219
HIS A 220
TYR A 261
CYH A 287
CYH A 289
LEU A 298
 None
SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.2A)
SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
ZN  A 300 ( 2.3A)
SAM  A 304 (-4.7A)
 0.60A 6cenA-2r3aA:
20.3		 6cenA-2r3aA:
29.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CHG_C_SAMC1101_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-4 SPECIFIC)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		5 / 12 TRP A 152
TYR A 193
PHE A 217
ASN A 219
HIS A 220
 None
SAM  A 304 (-4.2A)
None
SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
 0.64A 6chgC-2r3aA:
9.0		 6chgC-2r3aA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CHG_C_SAMC1101_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-4 SPECIFIC)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		5 / 12 TRP A 152
TYR A 193
PHE A 217
HIS A 220
LEU A 298
 None
SAM  A 304 (-4.2A)
None
SAM  A 304 (-4.9A)
SAM  A 304 (-4.7A)
 1.10A 6chgC-2r3aA:
9.0		 6chgC-2r3aA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_2
(TUBULIN BETA CHAIN)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		4 / 5 LEU A 194
THR A 175
PRO A 241
ARG A 242
 None
 1.37A 6ew0B-2r3aA:
undetectable		 6ew0B-2r3aA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_2
(TUBULIN BETA CHAIN)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		4 / 5 LEU A 194
THR A 175
PRO A 241
ARG A 242
 None
 1.37A 6ew0D-2r3aA:
undetectable		 6ew0D-2r3aA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_2
(TUBULIN BETA CHAIN)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		4 / 5 LEU A 194
THR A 175
PRO A 241
ARG A 242
 None
 1.37A 6ew0H-2r3aA:
undetectable		 6ew0H-2r3aA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_2
(TUBULIN BETA CHAIN)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		4 / 5 LEU A 194
THR A 175
PRO A 241
ARG A 242
 None
 1.37A 6ew0I-2r3aA:
undetectable		 6ew0I-2r3aA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6INE_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		6 / 12 ASN A 219
HIS A 220
TYR A 261
CYH A 287
LYS A 288
CYH A 289
 SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
None
ZN  A 300 ( 2.3A)
 0.83A 6ineA-2r3aA:
17.7		 6ineA-2r3aA:
29.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6INE_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		6 / 12 GLY A 151
TRP A 152
ASN A 219
HIS A 220
TYR A 261
CYH A 287
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 1.19A 6ineA-2r3aA:
17.7		 6ineA-2r3aA:
29.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6INE_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		7 / 12 GLY A 151
TRP A 152
ASN A 219
HIS A 220
TYR A 261
CYH A 287
CYH A 289
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
ZN  A 300 ( 2.3A)
 0.24A 6ineA-2r3aA:
17.7		 6ineA-2r3aA:
29.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_B_LLLB301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens) 		4 / 7 ASP A  57
TYR A 211
GLU A 172
ASP A 207
 None
 1.22A 6mn5B-2r3aA:
undetectable		 6mn5B-2r3aA:
14.24