SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2r3b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ESW_A_ACRA652_1
(AMYLOMALTASE)		 2r3b YJEF-RELATED PROTEIN
(Enterococcus
faecalis) 		4 / 6 GLY A 213
ASP A 216
GLY A  38
TYR A  37
 EDO  A 294 (-3.3A)
EDO  A 294 (-3.4A)
None
None
 0.95A 1eswA-2r3bA:
undetectable		 1eswA-2r3bA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_0
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 2r3b YJEF-RELATED PROTEIN
(Enterococcus
faecalis) 		5 / 12 GLY A 224
ALA A 227
THR A  56
ALA A 239
ILE A 222
 None
 1.10A 1nt2A-2r3bA:
4.4		 1nt2A-2r3bA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		 2r3b YJEF-RELATED PROTEIN
(Enterococcus
faecalis) 		4 / 7 THR A 268
TYR A 269
TYR A 273
LEU A 242
 EDO  A 295 ( 4.5A)
EDO  A 295 (-3.8A)
None
None
 1.00A 1qzrA-2r3bA:
undetectable		 1qzrA-2r3bA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		 2r3b YJEF-RELATED PROTEIN
(Enterococcus
faecalis) 		4 / 7 THR A 268
TYR A 269
TYR A 273
LEU A 242
 EDO  A 295 ( 4.5A)
EDO  A 295 (-3.8A)
None
None
 1.02A 1qzrB-2r3bA:
undetectable		 1qzrB-2r3bA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_A_FOLA1161_0
(DIHYDROFOLATE
REDUCTASE)		 2r3b YJEF-RELATED PROTEIN
(Enterococcus
faecalis) 		6 / 12 ALA A 237
PHE A 225
ILE A 246
LEU A 266
PRO A 267
ILE A 221
 None
 1.50A 2d0kA-2r3bA:
undetectable		 2d0kA-2r3bA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_B_PXLB1005_1
(PYRIDOXINE KINASE)		 2r3b YJEF-RELATED PROTEIN
(Enterococcus
faecalis) 		4 / 7 SER A 244
LEU A 218
THR A 214
GLY A 208
 None
None
EDO  A 294 (-4.8A)
None
 0.90A 2ddwB-2r3bA:
5.5		 2ddwB-2r3bA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FL5_F_RBFF204_1
(IMMUNOGLOBULIN IGG1
LAMBDA LIGHT CHAIN
IMMUNOGLOBULIN IGG1
HEAVY CHAIN)		 2r3b YJEF-RELATED PROTEIN
(Enterococcus
faecalis) 		4 / 8 ASN A 202
ARG A   2
VAL A 240
TYR A 241
 None
 1.04A 2fl5E-2r3bA:
undetectable
2fl5F-2r3bA:
undetectable		 2fl5E-2r3bA:
20.38
2fl5F-2r3bA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 2r3b YJEF-RELATED PROTEIN
(Enterococcus
faecalis) 		5 / 11 LEU A 112
LEU A 116
ILE A 132
THR A 151
PRO A 152
 None
 1.36A 2ft9A-2r3bA:
undetectable		 2ft9A-2r3bA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		 2r3b YJEF-RELATED PROTEIN
(Enterococcus
faecalis) 		5 / 12 SER A  51
LEU A  97
LEU A  30
ALA A 227
GLU A  74
 None
 1.22A 2v0mC-2r3bA:
undetectable		 2v0mC-2r3bA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2r3b YJEF-RELATED PROTEIN
(Enterococcus
faecalis) 		6 / 12 GLY A  32
ILE A 126
LEU A 125
LEU A 116
VAL A 115
ILE A 111
 None
 1.44A 3adxB-2r3bA:
undetectable		 3adxB-2r3bA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC505_2
(PHOSPHOLIPASE A2)		 2r3b YJEF-RELATED PROTEIN
(Enterococcus
faecalis) 		4 / 5 VAL A  28
VAL A  95
GLN A 122
PHE A  25
 None
 1.08A 3bjwH-2r3bA:
undetectable		 3bjwH-2r3bA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_2
(PHOSPHOLIPASE A2)		 2r3b YJEF-RELATED PROTEIN
(Enterococcus
faecalis) 		4 / 6 VAL A  28
VAL A  95
GLN A 122
PHE A  25
 None
 1.14A 3bjwF-2r3bA:
undetectable		 3bjwF-2r3bA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC59_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2r3b YJEF-RELATED PROTEIN
(Enterococcus
faecalis) 		3 / 3 GLY A  26
GLY A  52
GLY A  54
 None
 0.40A 3bogC-2r3bA:
undetectable		 3bogC-2r3bA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_A_SALA257_1
(TRANSCRIPTIONAL
REGULATOR)		 2r3b YJEF-RELATED PROTEIN
(Enterococcus
faecalis) 		4 / 8 ALA A  75
CYH A  72
ILE A  42
THR A  45
 None
 0.97A 3bpxA-2r3bA:
undetectable
3bpxB-2r3bA:
undetectable		 3bpxA-2r3bA:
20.71
3bpxB-2r3bA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID6_C_SAMC301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2r3b YJEF-RELATED PROTEIN
(Enterococcus
faecalis) 		5 / 12 GLY A 224
ALA A 227
THR A  56
ALA A 239
ILE A 222
 None
 1.16A 3id6C-2r3bA:
4.5		 3id6C-2r3bA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_C_DX2C270_1
(PTERIDINE REDUCTASE
1)		 2r3b YJEF-RELATED PROTEIN
(Enterococcus
faecalis) 		4 / 8 SER A 244
VAL A 256
LEU A 258
PRO A 259
 None
 1.11A 3jq7C-2r3bA:
7.2		 3jq7C-2r3bA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2r3b YJEF-RELATED PROTEIN
(Enterococcus
faecalis) 		5 / 12 ILE A  59
VAL A  58
GLY A  33
LEU A  30
PRO A  67
 None
 0.97A 3mb5A-2r3bA:
4.6		 3mb5A-2r3bA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RET_A_SALA201_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 2r3b YJEF-RELATED PROTEIN
(Enterococcus
faecalis) 		5 / 10 VAL A 115
ALA A  93
VAL A  95
GLN A 118
ILE A  31
 None
 1.39A 3retA-2r3bA:
undetectable
3retB-2r3bA:
undetectable		 3retA-2r3bA:
17.04
3retB-2r3bA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RET_A_SALA201_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 2r3b YJEF-RELATED PROTEIN
(Enterococcus
faecalis) 		5 / 10 VAL A 115
ALA A  93
VAL A  95
GLN A 118
ILE A  98
 None
 1.40A 3retA-2r3bA:
undetectable
3retB-2r3bA:
undetectable		 3retA-2r3bA:
17.04
3retB-2r3bA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2r3b YJEF-RELATED PROTEIN
(Enterococcus
faecalis) 		5 / 11 ILE A 262
ASP A 216
GLY A 220
ALA A 219
VAL A 185
 None
EDO  A 294 (-3.4A)
None
None
None
 1.19A 3rukD-2r3bA:
undetectable		 3rukD-2r3bA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTP_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 2r3b YJEF-RELATED PROTEIN
(Enterococcus
faecalis) 		5 / 12 GLY A 101
ALA A  40
SER A  44
ASP A 128
GLN A 137
 None
 0.99A 4rtpA-2r3bA:
3.4		 4rtpA-2r3bA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3A_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 2r3b YJEF-RELATED PROTEIN
(Enterococcus
faecalis) 		5 / 12 PHE A  80
GLY A  99
GLY A 101
ILE A 126
LEU A  97
 None
 1.12A 6b3aA-2r3bA:
2.7		 6b3aA-2r3bA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3B_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 2r3b YJEF-RELATED PROTEIN
(Enterococcus
faecalis) 		5 / 12 PHE A  80
GLY A  99
GLY A 101
ILE A 126
LEU A  97
 None
 1.12A 6b3bA-2r3bA:
3.1		 6b3bA-2r3bA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_A_CXQA507_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 2r3b YJEF-RELATED PROTEIN
(Enterococcus
faecalis) 		4 / 5 ARG A 175
ALA A 178
GLN A 176
ILE A 184
 None
 1.19A 6f6sA-2r3bA:
undetectable
6f6sB-2r3bA:
undetectable		 6f6sA-2r3bA:
15.77
6f6sB-2r3bA:
14.81