SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2r3s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_D_DVAD8_0
(GRAMICIDIN A)		 2r3s UNCHARACTERIZED
PROTEIN
(Nostoc
punctiforme) 		3 / 3 TRP A 196
VAL A 137
TRP A 136
 EDO  A 336 ( 3.7A)
None
EDO  A 341 ( 3.8A)
 1.36A 1gmkC-2r3sA:
undetectable
1gmkD-2r3sA:
undetectable		 1gmkC-2r3sA:
4.74
1gmkD-2r3sA:
4.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_1
(HEMK PROTEIN)		 2r3s UNCHARACTERIZED
PROTEIN
(Nostoc
punctiforme) 		3 / 3 ASP A 233
PHE A 192
ASN A 188
 None
 0.67A 1sg9B-2r3sA:
13.4		 1sg9B-2r3sA:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_A_DVAA6_0
(MINI-GRAMICIDIN A)		 2r3s UNCHARACTERIZED
PROTEIN
(Nostoc
punctiforme) 		3 / 3 ALA A 197
VAL A 199
TRP A 136
 None
None
EDO  A 341 ( 3.8A)
 1.01A 1tkqA-2r3sA:
undetectable		 1tkqA-2r3sA:
4.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT0_A_ACTA4901_0
(PYRANOSE OXIDASE)		 2r3s UNCHARACTERIZED
PROTEIN
(Nostoc
punctiforme) 		4 / 6 GLN A 327
PHE A 271
HIS A 242
ASN A 239
 None
None
None
CL  A 335 ( 4.3A)
 1.16A 1tt0A-2r3sA:
3.6		 1tt0A-2r3sA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT0_B_ACTB3901_0
(PYRANOSE OXIDASE)		 2r3s UNCHARACTERIZED
PROTEIN
(Nostoc
punctiforme) 		4 / 6 GLN A 327
PHE A 271
HIS A 242
ASN A 239
 None
None
None
CL  A 335 ( 4.3A)
 1.17A 1tt0B-2r3sA:
undetectable		 1tt0B-2r3sA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT0_C_ACTC6901_0
(PYRANOSE OXIDASE)		 2r3s UNCHARACTERIZED
PROTEIN
(Nostoc
punctiforme) 		4 / 6 GLN A 327
PHE A 271
HIS A 242
ASN A 239
 None
None
None
CL  A 335 ( 4.3A)
 1.19A 1tt0C-2r3sA:
2.7		 1tt0C-2r3sA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT0_D_ACTD5901_0
(PYRANOSE OXIDASE)		 2r3s UNCHARACTERIZED
PROTEIN
(Nostoc
punctiforme) 		4 / 6 GLN A 327
PHE A 271
HIS A 242
ASN A 239
 None
None
None
CL  A 335 ( 4.3A)
 1.15A 1tt0D-2r3sA:
2.9		 1tt0D-2r3sA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC2_0
(ACTINOMYCIN D)		 2r3s UNCHARACTERIZED
PROTEIN
(Nostoc
punctiforme) 		3 / 3 THR A 279
PRO A 273
PRO A 281
 None
 0.84A 2d55C-2r3sA:
undetectable		 2d55C-2r3sA:
3.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_A_GBNA2414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 2r3s UNCHARACTERIZED
PROTEIN
(Nostoc
punctiforme) 		4 / 8 GLY A 108
THR A 113
ALA A 114
ALA A 115
 None
 0.57A 2ej3A-2r3sA:
undetectable		 2ej3A-2r3sA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4L_A_TPVA403_1
(PROTEASE)		 2r3s UNCHARACTERIZED
PROTEIN
(Nostoc
punctiforme) 		5 / 12 LEU A 260
ILE A 191
GLY A 193
VAL A 194
VAL A 266
 None
None
None
EDO  A 336 (-4.6A)
None
 1.21A 2o4lA-2r3sA:
undetectable		 2o4lA-2r3sA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		 2r3s UNCHARACTERIZED
PROTEIN
(Nostoc
punctiforme) 		4 / 7 PHE A 286
PHE A 244
THR A 294
ILE A 256
 None
 0.81A 2v0mB-2r3sA:
undetectable		 2v0mB-2r3sA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		 2r3s UNCHARACTERIZED
PROTEIN
(Nostoc
punctiforme) 		3 / 3 SER A 287
THR A 293
PHE A 139
 None
None
EDO  A 337 ( 4.2A)
 0.77A 2x91A-2r3sA:
undetectable		 2x91A-2r3sA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBU_D_ADND504_1
(UNCHARACTERIZED
CONSERVED PROTEIN)		 2r3s UNCHARACTERIZED
PROTEIN
(Nostoc
punctiforme) 		3 / 3 PHE A 269
ASN A 239
PHE A 271
 None
CL  A 335 ( 4.3A)
None
 0.92A 2zbuD-2r3sA:
undetectable		 2zbuD-2r3sA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 2r3s UNCHARACTERIZED
PROTEIN
(Nostoc
punctiforme) 		5 / 12 ALA A 259
GLN A 251
LEU A 241
VAL A 266
THR A 258
 None
 1.14A 3ix9A-2r3sA:
undetectable		 3ix9A-2r3sA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 2r3s UNCHARACTERIZED
PROTEIN
(Nostoc
punctiforme) 		5 / 12 ALA A 259
GLN A 251
LEU A 241
VAL A 266
THR A 258
 None
 1.16A 3ix9B-2r3sA:
2.1		 3ix9B-2r3sA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSK_B_ACTB901_0
(PYRANOSE 2-OXIDASE)		 2r3s UNCHARACTERIZED
PROTEIN
(Nostoc
punctiforme) 		4 / 6 GLN A 327
PHE A 271
HIS A 242
ASN A 239
 None
None
None
CL  A 335 ( 4.3A)
 1.18A 3lskB-2r3sA:
undetectable		 3lskB-2r3sA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSK_D_ACTD901_0
(PYRANOSE 2-OXIDASE)		 2r3s UNCHARACTERIZED
PROTEIN
(Nostoc
punctiforme) 		4 / 6 GLN A 327
PHE A 271
HIS A 242
ASN A 239
 None
None
None
CL  A 335 ( 4.3A)
 1.21A 3lskD-2r3sA:
undetectable		 3lskD-2r3sA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 2r3s UNCHARACTERIZED
PROTEIN
(Nostoc
punctiforme) 		5 / 12 HIS A 243
GLY A 297
GLY A 120
LEU A 241
ASP A 298
 EDO  A 341 (-3.7A)
None
None
None
None
 1.08A 4blvA-2r3sA:
10.4		 4blvA-2r3sA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2r3s UNCHARACTERIZED
PROTEIN
(Nostoc
punctiforme) 		5 / 11 ALA A 259
PHE A 244
LEU A 241
VAL A 266
THR A 258
 None
 1.42A 4eilA-2r3sA:
2.3		 4eilA-2r3sA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2r3s UNCHARACTERIZED
PROTEIN
(Nostoc
punctiforme) 		5 / 11 ALA A 259
PHE A 244
LEU A 241
VAL A 266
THR A 258
 None
 1.43A 4eilC-2r3sA:
undetectable		 4eilC-2r3sA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2r3s UNCHARACTERIZED
PROTEIN
(Nostoc
punctiforme) 		5 / 11 ALA A 259
PHE A 244
LEU A 241
VAL A 266
THR A 258
 None
 1.41A 4eilE-2r3sA:
undetectable		 4eilE-2r3sA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2r3s UNCHARACTERIZED
PROTEIN
(Nostoc
punctiforme) 		5 / 10 ALA A 259
PHE A 244
LEU A 241
VAL A 266
THR A 258
 None
 1.48A 4kyaC-2r3sA:
undetectable		 4kyaC-2r3sA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_2
(ADENOSINE KINASE)		 2r3s UNCHARACTERIZED
PROTEIN
(Nostoc
punctiforme) 		4 / 5 ASN A 206
LEU A 177
SER A 174
ASN A 239
 None
None
EDO  A 337 (-3.6A)
CL  A 335 ( 4.3A)
 1.26A 4n09C-2r3sA:
4.0		 4n09C-2r3sA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA602_1
(SERUM ALBUMIN)		 2r3s UNCHARACTERIZED
PROTEIN
(Nostoc
punctiforme) 		4 / 8 LYS A  23
ALA A  24
LEU A  28
LEU A  58
 None
 0.72A 4po0A-2r3sA:
undetectable		 4po0A-2r3sA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 2r3s UNCHARACTERIZED
PROTEIN
(Nostoc
punctiforme) 		3 / 3 ASN A 274
PHE A 302
TYR A 305
 None
 0.86A 4u15A-2r3sA:
undetectable		 4u15A-2r3sA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2r3s UNCHARACTERIZED
PROTEIN
(Nostoc
punctiforme) 		4 / 8 PHE A 240
ALA A 173
LEU A 236
LEU A 237
 EDO  A 336 ( 4.9A)
None
None
None
 1.04A 5dzkd-2r3sA:
undetectable
5dzkr-2r3sA:
undetectable		 5dzkd-2r3sA:
21.36
5dzkr-2r3sA:
0.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A210_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 2r3s UNCHARACTERIZED
PROTEIN
(Nostoc
punctiforme) 		5 / 12 LEU A 252
GLN A 251
PHE A 224
LEU A 129
TYR A 305
 None
 1.41A 5i8fA-2r3sA:
undetectable		 5i8fA-2r3sA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGT_A_ERYA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 2r3s UNCHARACTERIZED
PROTEIN
(Nostoc
punctiforme) 		4 / 5 MET A 308
ASP A 270
TYR A 305
PHE A 286
 None
 1.42A 5igtA-2r3sA:
0.0		 5igtA-2r3sA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 2r3s UNCHARACTERIZED
PROTEIN
(Nostoc
punctiforme) 		4 / 7 VAL A 266
ALA A 332
LEU A 237
LEU A 241
 None
 0.58A 5jq7A-2r3sA:
undetectable		 5jq7A-2r3sA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_H_CVIH301_1
(REGULATORY PROTEIN
TETR)		 2r3s UNCHARACTERIZED
PROTEIN
(Nostoc
punctiforme) 		4 / 8 GLN A 184
GLY A 179
ILE A 154
GLN A 327
 None
 0.89A 5vlmH-2r3sA:
undetectable		 5vlmH-2r3sA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECE_C_DVAC3010_0
(VLM2
DODECADEPSIPEPTIDE)		 2r3s UNCHARACTERIZED
PROTEIN
(Nostoc
punctiforme) 		3 / 3 ALA A 285
PHE A 271
GLN A 326
 None
None
EDO  A 340 (-4.3A)
 0.66A 6eceA-2r3sA:
3.3		 6eceA-2r3sA:
20.16