SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2r3v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C8L_A_CFFA940_1
(PROTEIN (GLYCOGEN
PHOSPHORYLASE))		 2r3v MEVALONATE KINASE
(Homo
sapiens) 		4 / 6 ASN A 205
PHE A 190
ALA A 189
GLY A 192
 None
 1.13A 1c8lA-2r3vA:
1.6		 1c8lA-2r3vA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1503_0
(FERROCHELATASE)		 2r3v MEVALONATE KINASE
(Homo
sapiens) 		3 / 3 LEU A 137
PRO A 138
LEU A 143
 None
 0.48A 1hrkA-2r3vA:
undetectable		 1hrkA-2r3vA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_B_HISB450_0
(HISTIDYL-TRNA
SYNTHETASE)		 2r3v MEVALONATE KINASE
(Homo
sapiens) 		5 / 12 GLU A  19
THR A 332
GLN A 302
GLY A 336
GLY A 338
 None
 1.30A 1httB-2r3vA:
undetectable		 1httB-2r3vA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_D_HISD450_0
(HISTIDYL-TRNA
SYNTHETASE)		 2r3v MEVALONATE KINASE
(Homo
sapiens) 		5 / 12 GLU A  19
THR A 332
GLN A 302
GLY A 336
GLY A 338
 None
 1.30A 1httD-2r3vA:
undetectable		 1httD-2r3vA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA6_A_STRA401_1
(MINERALOCORTICOID
RECEPTOR)		 2r3v MEVALONATE KINASE
(Homo
sapiens) 		5 / 12 LEU A 343
LEU A 294
LEU A  16
CYH A 319
THR A 322
 None
 1.40A 2aa6A-2r3vA:
undetectable		 2aa6A-2r3vA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA502_0
(CHORISMATE SYNTHASE)		 2r3v MEVALONATE KINASE
(Homo
sapiens) 		3 / 3 GLY A 171
ASP A 172
SER A 381
 None
 0.73A 2qhfA-2r3vA:
undetectable		 2qhfA-2r3vA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_B_SAMB301_0
(UPF0217 PROTEIN
AF_1056)		 2r3v MEVALONATE KINASE
(Homo
sapiens) 		5 / 11 LEU A  33
ILE A 372
GLY A 373
GLY A 212
LEU A 143
 None
 0.98A 2qmmA-2r3vA:
undetectable
2qmmB-2r3vA:
undetectable		 2qmmA-2r3vA:
20.57
2qmmB-2r3vA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BCR_A_AZZA940_1
(GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM)		 2r3v MEVALONATE KINASE
(Homo
sapiens) 		4 / 5 ASN A 205
PHE A 190
ALA A 189
GLY A 192
 None
 1.18A 3bcrA-2r3vA:
undetectable		 3bcrA-2r3vA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_D_MTXD2000_2
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 2r3v MEVALONATE KINASE
(Homo
sapiens) 		3 / 3 LEU A   7
ARG A 388
ASN A  34
 None
 0.68A 3qxvD-2r3vA:
undetectable		 3qxvD-2r3vA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2r3v MEVALONATE KINASE
(Homo
sapiens) 		5 / 12 HIS A 197
LEU A 137
GLY A 140
ALA A 147
ALA A 148
 None
 1.02A 3sufA-2r3vA:
undetectable		 3sufA-2r3vA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2r3v MEVALONATE KINASE
(Homo
sapiens) 		3 / 3 LEU A 137
PRO A 138
LEU A 143
 None
 0.48A 3w1wB-2r3vA:
undetectable		 3w1wB-2r3vA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CCQ_A_ACTA1317_0
(THIOREDOXIN
REDUCTASE)		 2r3v MEVALONATE KINASE
(Homo
sapiens) 		3 / 3 LEU A 327
GLU A 295
SER A 329
 None
 0.68A 4ccqA-2r3vA:
undetectable		 4ccqA-2r3vA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		 2r3v MEVALONATE KINASE
(Homo
sapiens) 		4 / 7 ASN A 236
LEU A 234
GLY A 140
SER A 145
 None
 0.77A 4cp3A-2r3vA:
undetectable
4cp3B-2r3vA:
undetectable		 4cp3A-2r3vA:
15.26
4cp3B-2r3vA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 2r3v MEVALONATE KINASE
(Homo
sapiens) 		4 / 7 THR A 332
LEU A 343
VAL A  31
VAL A  14
 None
 0.98A 4cp4A-2r3vA:
undetectable		 4cp4A-2r3vA:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		 2r3v MEVALONATE KINASE
(Homo
sapiens) 		3 / 3 HIS A  17
VAL A 310
LEU A 331
 None
 0.76A 4m2vA-2r3vA:
undetectable		 4m2vA-2r3vA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_B_1LDB501_0
(CYTOSINE DEAMINASE)		 2r3v MEVALONATE KINASE
(Homo
sapiens) 		5 / 12 LEU A 305
ILE A 271
HIS A  17
GLU A  19
LEU A 331
 None
 1.39A 4r88B-2r3vA:
undetectable		 4r88B-2r3vA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_C_1LDC501_0
(CYTOSINE DEAMINASE)		 2r3v MEVALONATE KINASE
(Homo
sapiens) 		5 / 12 LEU A 305
ILE A 271
HIS A  17
GLU A  19
LEU A 331
 None
 1.38A 4r88C-2r3vA:
undetectable		 4r88C-2r3vA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_D_1LDD501_0
(CYTOSINE DEAMINASE)		 2r3v MEVALONATE KINASE
(Homo
sapiens) 		5 / 12 LEU A 305
ILE A 271
HIS A  17
GLU A  19
LEU A 331
 None
 1.40A 4r88D-2r3vA:
undetectable		 4r88D-2r3vA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_E_1LDE501_0
(CYTOSINE DEAMINASE)		 2r3v MEVALONATE KINASE
(Homo
sapiens) 		5 / 12 LEU A 305
ILE A 271
HIS A  17
GLU A  19
LEU A 331
 None
 1.39A 4r88E-2r3vA:
undetectable		 4r88E-2r3vA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_F_1LDF502_0
(CYTOSINE DEAMINASE)		 2r3v MEVALONATE KINASE
(Homo
sapiens) 		5 / 12 LEU A 305
ILE A 271
HIS A  17
GLU A  19
LEU A 331
 None
 1.39A 4r88F-2r3vA:
undetectable		 4r88F-2r3vA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 2r3v MEVALONATE KINASE
(Homo
sapiens) 		5 / 12 PRO A 138
LEU A 137
GLY A 338
LEU A 318
LEU A 234
 None
 1.08A 5emlA-2r3vA:
undetectable		 5emlA-2r3vA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSE_C_HQEC1583_1
(UREASE SUBUNIT ALPHA)		 2r3v MEVALONATE KINASE
(Homo
sapiens) 		4 / 5 ILE A 119
GLN A 123
CYH A 161
GLU A 162
 None
 1.40A 5fseC-2r3vA:
undetectable		 5fseC-2r3vA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HSW_A_ACTA501_0
(ORF 37)		 2r3v MEVALONATE KINASE
(Homo
sapiens) 		4 / 5 ARG A  36
SER A   9
SER A 378
SER A 208
 None
 1.34A 5hswA-2r3vA:
undetectable		 5hswA-2r3vA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_A_SAMA304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 2r3v MEVALONATE KINASE
(Homo
sapiens) 		5 / 12 LEU A 305
GLY A 336
GLY A 311
ILE A  15
LEU A 246
 None
 1.00A 5l0zA-2r3vA:
undetectable		 5l0zA-2r3vA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIG_A_EDTA501_0
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 2r3v MEVALONATE KINASE
(Homo
sapiens) 		4 / 6 ASN A 186
THR A 209
ASN A 205
ILE A 221
 None
 1.32A 5uigA-2r3vA:
undetectable		 5uigA-2r3vA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_C_HFGC1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 2r3v MEVALONATE KINASE
(Homo
sapiens) 		5 / 12 LEU A 153
VAL A 133
GLU A 193
HIS A 197
GLY A 142
 None
 1.28A 5xipC-2r3vA:
undetectable		 5xipC-2r3vA:
21.86