SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2r41'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DHJ_B_MTXB361_1 (DIHYDROFOLATE REDUCTASE)	2r41	UNCHARACTERIZED PROTEIN (Enterococcus faecalis)	5 / 12	ILE A 87 ALA A 89 ILE A 73 LEU A 75 PRO A 76	None	0.96A	1dhjB-2r41A: undetectable	1dhjB-2r41A: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JOL_B_FFOB361_0 (DIHYDROFOLATE REDUCTASE)	2r41	UNCHARACTERIZED PROTEIN (Enterococcus faecalis)	5 / 12	ILE A 87 ALA A 89 ILE A 73 LEU A 75 PRO A 76	None	0.89A	1jolB-2r41A: undetectable	1jolB-2r41A: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RE7_B_FOLB361_0 (DIHYDROFOLATE REDUCTASE)	2r41	UNCHARACTERIZED PROTEIN (Enterococcus faecalis)	5 / 12	ILE A 87 ALA A 89 ILE A 73 LEU A 75 PRO A 76	None	0.76A	1re7B-2r41A: undetectable	1re7B-2r41A: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RX8_A_FOLA161_0 (DIHYDROFOLATE REDUCTASE)	2r41	UNCHARACTERIZED PROTEIN (Enterococcus faecalis)	5 / 12	ILE A 87 ALA A 89 ILE A 73 LEU A 75 PRO A 76	None	0.84A	1rx8A-2r41A: undetectable	1rx8A-2r41A: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XFH_A_CL6A1414_1 (ERYTHROMYCIN B/D C-12 HYDROXYLASE)	2r41	UNCHARACTERIZED PROTEIN (Enterococcus faecalis)	5 / 8	HIS A 61 LEU A 43 ILE A 41 LEU A 37 LEU A 47	None	0.99A	2xfhA-2r41A: undetectable	2xfhA-2r41A: 15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4P3Q_A_FOLA201_0 (DIHYDROFOLATE REDUCTASE)	2r41	UNCHARACTERIZED PROTEIN (Enterococcus faecalis)	5 / 12	ILE A 87 ALA A 89 ILE A 73 LEU A 75 PRO A 76	None	0.94A	4p3qA-2r41A: undetectable	4p3qA-2r41A: 20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EAJ_B_FOLB201_0 (DIHYDROFOLATE REDUCTASE)	2r41	UNCHARACTERIZED PROTEIN (Enterococcus faecalis)	5 / 12	ILE A 87 ALA A 89 ILE A 73 LEU A 75 PRO A 76	None	1.05A	5eajB-2r41A: undetectable	5eajB-2r41A: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5LJB_A_RTLA201_1 (RETINOL-BINDING PROTEIN 1)	2r41	UNCHARACTERIZED PROTEIN (Enterococcus faecalis)	4 / 8	LEU A 75 LEU A 31 ILE A 41 GLN A 64	None	1.04A	5ljbA-2r41A: undetectable	5ljbA-2r41A: 18.40

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1DHJ_B_MTXB361_1","DIHYDROFOLATE REDUCTASE","2r41","UNCHARACTERIZED PROTEIN","Enterococcus faecalis",5,"ILE A  87;ALA A  89;ILE A  73;LEU A  75;PRO A  76","None","0.96A","1dhjB-2r41A:undetectable","1dhjB-2r41A:20.00"],["1JOL_B_FFOB361_0","DIHYDROFOLATE REDUCTASE","2r41","UNCHARACTERIZED PROTEIN","Enterococcus faecalis",5,"ILE A  87;ALA A  89;ILE A  73;LEU A  75;PRO A  76","None","0.89A","1jolB-2r41A:undetectable","1jolB-2r41A:20.00"],["1RE7_B_FOLB361_0","DIHYDROFOLATE REDUCTASE","2r41","UNCHARACTERIZED PROTEIN","Enterococcus faecalis",5,"ILE A  87;ALA A  89;ILE A  73;LEU A  75;PRO A  76","None","0.76A","1re7B-2r41A:undetectable","1re7B-2r41A:20.00"],["1RX8_A_FOLA161_0","DIHYDROFOLATE REDUCTASE","2r41","UNCHARACTERIZED PROTEIN","Enterococcus faecalis",5,"ILE A  87;ALA A  89;ILE A  73;LEU A  75;PRO A  76","None","0.84A","1rx8A-2r41A:undetectable","1rx8A-2r41A:20.00"],["2XFH_A_CL6A1414_1","ERYTHROMYCIN B\/D C-12 HYDROXYLASE","2r41","UNCHARACTERIZED PROTEIN","Enterococcus faecalis",5,"HIS A  61;LEU A  43;ILE A  41;LEU A  37;LEU A  47","None","0.99A","2xfhA-2r41A:undetectable","2xfhA-2r41A:15.52"],["4P3Q_A_FOLA201_0","DIHYDROFOLATE REDUCTASE","2r41","UNCHARACTERIZED PROTEIN","Enterococcus faecalis",5,"ILE A  87;ALA A  89;ILE A  73;LEU A  75;PRO A  76","None","0.94A","4p3qA-2r41A:undetectable","4p3qA-2r41A:20.86"],["5EAJ_B_FOLB201_0","DIHYDROFOLATE REDUCTASE","2r41","UNCHARACTERIZED PROTEIN","Enterococcus faecalis",5,"ILE A  87;ALA A  89;ILE A  73;LEU A  75;PRO A  76","None","1.05A","5eajB-2r41A:undetectable","5eajB-2r41A:20.00"],["5LJB_A_RTLA201_1","RETINOL-BINDING PROTEIN 1","2r41","UNCHARACTERIZED PROTEIN","Enterococcus faecalis",4,"LEU A  75;LEU A  31;ILE A  41;GLN A  64","None","1.04A","5ljbA-2r41A:undetectable","5ljbA-2r41A:18.40"]]