SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2r48'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_1
(ESTROGEN RECEPTOR)		 2r48 PHOSPHOTRANSFERASE
SYSTEM (PTS)
MANNOSE-SPECIFIC
ENZYME IIBCA
COMPONENT
(Bacillus
subtilis) 		5 / 12 ALA A  96
LEU A  97
LEU A  77
ILE A   6
LEU A  23
 None
 1.22A 1errA-2r48A:
undetectable		 1errA-2r48A:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5R_A_RBFA859_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2r48 PHOSPHOTRANSFERASE
SYSTEM (PTS)
MANNOSE-SPECIFIC
ENZYME IIBCA
COMPONENT
(Bacillus
subtilis) 		5 / 11 LEU A  48
GLU A  37
ALA A  19
ARG A  71
PHE A  72
 None
 1.06A 1l5rA-2r48A:
undetectable		 1l5rA-2r48A:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2r48 PHOSPHOTRANSFERASE
SYSTEM (PTS)
MANNOSE-SPECIFIC
ENZYME IIBCA
COMPONENT
(Bacillus
subtilis) 		5 / 10 VAL A  67
VAL A  82
GLY A  81
ALA A  62
SER A  79
 None
 1.10A 1pxxA-2r48A:
undetectable		 1pxxA-2r48A:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_B_DIFB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2r48 PHOSPHOTRANSFERASE
SYSTEM (PTS)
MANNOSE-SPECIFIC
ENZYME IIBCA
COMPONENT
(Bacillus
subtilis) 		5 / 9 VAL A  67
VAL A  82
GLY A  81
ALA A  62
SER A  79
 None
 1.11A 1pxxB-2r48A:
undetectable		 1pxxB-2r48A:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_D_DIFD3701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2r48 PHOSPHOTRANSFERASE
SYSTEM (PTS)
MANNOSE-SPECIFIC
ENZYME IIBCA
COMPONENT
(Bacillus
subtilis) 		5 / 10 VAL A  67
VAL A  82
GLY A  81
ALA A  62
SER A  79
 None
 1.09A 1pxxD-2r48A:
undetectable		 1pxxD-2r48A:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_1
(POL POLYPROTEIN)		 2r48 PHOSPHOTRANSFERASE
SYSTEM (PTS)
MANNOSE-SPECIFIC
ENZYME IIBCA
COMPONENT
(Bacillus
subtilis) 		5 / 8 ALA A  26
ILE A  34
ILE A  60
GLY A  85
ILE A  86
 None
 1.25A 1sh9A-2r48A:
undetectable		 1sh9A-2r48A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2r48 PHOSPHOTRANSFERASE
SYSTEM (PTS)
MANNOSE-SPECIFIC
ENZYME IIBCA
COMPONENT
(Bacillus
subtilis) 		5 / 12 VAL A  67
VAL A  82
GLY A  81
ALA A  62
SER A  79
 None
 1.11A 3rr3C-2r48A:
undetectable		 3rr3C-2r48A:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2r48 PHOSPHOTRANSFERASE
SYSTEM (PTS)
MANNOSE-SPECIFIC
ENZYME IIBCA
COMPONENT
(Bacillus
subtilis) 		5 / 12 VAL A  67
VAL A  82
GLY A  81
ALA A  62
SER A  79
 None
 1.11A 3rr3D-2r48A:
undetectable		 3rr3D-2r48A:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_B_IMNB701_1
(CYCLOOXYGENASE-2)		 2r48 PHOSPHOTRANSFERASE
SYSTEM (PTS)
MANNOSE-SPECIFIC
ENZYME IIBCA
COMPONENT
(Bacillus
subtilis) 		5 / 12 VAL A  67
VAL A  82
GLY A  81
ALA A  62
SER A  79
 None
 1.17A 4coxB-2r48A:
undetectable		 4coxB-2r48A:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		 2r48 PHOSPHOTRANSFERASE
SYSTEM (PTS)
MANNOSE-SPECIFIC
ENZYME IIBCA
COMPONENT
(Bacillus
subtilis) 		3 / 3 GLY A  43
GLU A  37
THR A  38
 None
 0.47A 4kouA-2r48A:
undetectable		 4kouA-2r48A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2r48 PHOSPHOTRANSFERASE
SYSTEM (PTS)
MANNOSE-SPECIFIC
ENZYME IIBCA
COMPONENT
(Bacillus
subtilis) 		5 / 12 VAL A  67
VAL A  82
GLY A  81
ALA A  62
SER A  79
 None
 1.15A 4rrwB-2r48A:
undetectable		 4rrwB-2r48A:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_A_LURA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2r48 PHOSPHOTRANSFERASE
SYSTEM (PTS)
MANNOSE-SPECIFIC
ENZYME IIBCA
COMPONENT
(Bacillus
subtilis) 		5 / 12 VAL A  67
VAL A  82
GLY A  81
ALA A  62
SER A  79
 None
 1.06A 4rrxA-2r48A:
undetectable		 4rrxA-2r48A:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_B_LURB706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2r48 PHOSPHOTRANSFERASE
SYSTEM (PTS)
MANNOSE-SPECIFIC
ENZYME IIBCA
COMPONENT
(Bacillus
subtilis) 		5 / 12 VAL A  67
VAL A  82
GLY A  81
ALA A  62
SER A  79
 None
 1.06A 4rrxB-2r48A:
undetectable		 4rrxB-2r48A:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2r48 PHOSPHOTRANSFERASE
SYSTEM (PTS)
MANNOSE-SPECIFIC
ENZYME IIBCA
COMPONENT
(Bacillus
subtilis) 		5 / 12 VAL A  67
VAL A  82
GLY A  81
ALA A  62
SER A  79
 None
 1.15A 4rrzB-2r48A:
undetectable		 4rrzB-2r48A:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_2
(TUBULIN BETA CHAIN)		 2r48 PHOSPHOTRANSFERASE
SYSTEM (PTS)
MANNOSE-SPECIFIC
ENZYME IIBCA
COMPONENT
(Bacillus
subtilis) 		5 / 12 LEU A  97
ALA A   1
ILE A  60
LYS A  76
ALA A  96
 None
 1.19A 5eypB-2r48A:
2.4		 5eypB-2r48A:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 2r48 PHOSPHOTRANSFERASE
SYSTEM (PTS)
MANNOSE-SPECIFIC
ENZYME IIBCA
COMPONENT
(Bacillus
subtilis) 		3 / 3 ALA A  19
ASN A  22
LEU A  23
 None
 0.49A 5i1nC-2r48A:
undetectable		 5i1nC-2r48A:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2r48 PHOSPHOTRANSFERASE
SYSTEM (PTS)
MANNOSE-SPECIFIC
ENZYME IIBCA
COMPONENT
(Bacillus
subtilis) 		5 / 12 VAL A  67
VAL A  82
GLY A  81
ALA A  62
SER A  79
 None
 1.11A 5ikqA-2r48A:
undetectable		 5ikqA-2r48A:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2r48 PHOSPHOTRANSFERASE
SYSTEM (PTS)
MANNOSE-SPECIFIC
ENZYME IIBCA
COMPONENT
(Bacillus
subtilis) 		5 / 12 VAL A  67
VAL A  82
GLY A  81
ALA A  62
SER A  79
 None
 0.97A 5jw1A-2r48A:
undetectable		 5jw1A-2r48A:
13.46