SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2r4f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HWI_A_115A2_1
(HMG-COA REDUCTASE)		 2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens) 		9 / 9 ARG A 590
MET A 657
SER A 661
VAL A 683
SER A 684
ASN A 686
ASP A 690
LYS A 691
LYS A 692
 RIE  A 876 (-2.9A)
RIE  A 876 (-4.1A)
RIE  A 876 (-2.9A)
RIE  A 876 ( 4.4A)
RIE  A 876 (-2.5A)
RIE  A 876 ( 4.8A)
RIE  A 876 (-3.6A)
RIE  A 876 (-2.8A)
RIE  A 876 (-3.1A)
 0.37A 1hwiA-2r4fA:
53.3		 1hwiA-2r4fA:
95.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		 2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens) 		8 / 8 GLU A 559
CYH A 561
LYS A 735
HIS A 752
ASN A 755
LEU A 853
ALA A 856
LEU A 857
 None
 0.22A 1hwiB-2r4fA:
53.5		 1hwiB-2r4fA:
95.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		 2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens) 		8 / 9 GLU A 559
CYH A 561
LYS A 735
HIS A 752
ASN A 755
LEU A 853
ALA A 856
LEU A 857
 None
 0.20A 1hwiA-2r4fA:
53.3		 1hwiA-2r4fA:
95.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		 2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens) 		8 / 8 ARG A 590
SER A 661
VAL A 683
SER A 684
ASN A 686
ASP A 690
LYS A 691
LYS A 692
 RIE  A 876 (-2.9A)
RIE  A 876 (-2.9A)
RIE  A 876 ( 4.4A)
RIE  A 876 (-2.5A)
RIE  A 876 ( 4.8A)
RIE  A 876 (-3.6A)
RIE  A 876 (-2.8A)
RIE  A 876 (-3.1A)
 0.36A 1hwiB-2r4fA:
53.5		 1hwiB-2r4fA:
95.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		 2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens) 		7 / 7 ARG A 590
VAL A 683
SER A 684
ASN A 686
ASP A 690
LYS A 691
LYS A 692
 RIE  A 876 (-2.9A)
RIE  A 876 ( 4.4A)
RIE  A 876 (-2.5A)
RIE  A 876 ( 4.8A)
RIE  A 876 (-3.6A)
RIE  A 876 (-2.8A)
RIE  A 876 (-3.1A)
 0.29A 1hwiC-2r4fA:
40.5		 1hwiC-2r4fA:
95.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		 2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens) 		8 / 8 GLU A 559
CYH A 561
LYS A 735
HIS A 752
ASN A 755
LEU A 853
ALA A 856
LEU A 857
 None
 0.21A 1hwiD-2r4fA:
40.7		 1hwiD-2r4fA:
95.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		 2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens) 		8 / 8 GLU A 559
CYH A 561
LYS A 735
HIS A 752
ASN A 755
LEU A 853
ALA A 856
LEU A 857
 None
 0.20A 1hwiC-2r4fA:
40.5		 1hwiC-2r4fA:
95.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		 2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens) 		7 / 7 ARG A 590
VAL A 683
SER A 684
ASN A 686
ASP A 690
LYS A 691
LYS A 692
 RIE  A 876 (-2.9A)
RIE  A 876 ( 4.4A)
RIE  A 876 (-2.5A)
RIE  A 876 ( 4.8A)
RIE  A 876 (-3.6A)
RIE  A 876 (-2.8A)
RIE  A 876 (-3.1A)
 0.30A 1hwiD-2r4fA:
40.7		 1hwiD-2r4fA:
95.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HWK_A_117A2_1
(HMG-COA REDUCTASE)		 2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens) 		8 / 8 ARG A 590
SER A 661
VAL A 683
SER A 684
ASN A 686
ASP A 690
LYS A 691
LYS A 692
 RIE  A 876 (-2.9A)
RIE  A 876 (-2.9A)
RIE  A 876 ( 4.4A)
RIE  A 876 (-2.5A)
RIE  A 876 ( 4.8A)
RIE  A 876 (-3.6A)
RIE  A 876 (-2.8A)
RIE  A 876 (-3.1A)
 0.20A 1hwkA-2r4fA:
53.9		 1hwkA-2r4fA:
95.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HWK_A_117A2_2
(HMG-COA REDUCTASE)		 2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens) 		11 / 11 GLU A 559
CYH A 561
SER A 565
ARG A 568
LYS A 735
HIS A 752
ASN A 755
SER A 852
LEU A 853
ALA A 856
LEU A 857
 None
 0.17A 1hwkB-2r4fA:
53.9		 1hwkB-2r4fA:
95.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HWK_A_117A2_2
(HMG-COA REDUCTASE)		 2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens) 		6 / 11 SER A 565
ARG A 568
LYS A 735
HIS A 752
SER A 852
ALA A 855
 None
 1.46A 1hwkB-2r4fA:
53.9		 1hwkB-2r4fA:
95.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HWK_B_117B1_1
(HMG-COA REDUCTASE)		 2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens) 		11 / 11 GLU A 559
CYH A 561
SER A 565
ARG A 568
LYS A 735
HIS A 752
ASN A 755
SER A 852
LEU A 853
ALA A 856
LEU A 857
 None
 0.20A 1hwkA-2r4fA:
53.9		 1hwkA-2r4fA:
95.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HWK_B_117B1_1
(HMG-COA REDUCTASE)		 2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens) 		6 / 11 SER A 565
ARG A 568
LYS A 735
HIS A 752
SER A 852
ALA A 855
 None
 1.45A 1hwkA-2r4fA:
53.9		 1hwkA-2r4fA:
95.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HWK_B_117B1_2
(HMG-COA REDUCTASE)		 2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens) 		9 / 9 ARG A 590
MET A 657
SER A 661
VAL A 683
SER A 684
ASN A 686
ASP A 690
LYS A 691
LYS A 692
 RIE  A 876 (-2.9A)
RIE  A 876 (-4.1A)
RIE  A 876 (-2.9A)
RIE  A 876 ( 4.4A)
RIE  A 876 (-2.5A)
RIE  A 876 ( 4.8A)
RIE  A 876 (-3.6A)
RIE  A 876 (-2.8A)
RIE  A 876 (-3.1A)
 0.38A 1hwkB-2r4fA:
53.9		 1hwkB-2r4fA:
95.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HWK_C_117C4_1
(HMG-COA REDUCTASE)		 2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens) 		8 / 8 ARG A 590
SER A 661
VAL A 683
SER A 684
ASN A 686
ASP A 690
LYS A 691
LYS A 692
 RIE  A 876 (-2.9A)
RIE  A 876 (-2.9A)
RIE  A 876 ( 4.4A)
RIE  A 876 (-2.5A)
RIE  A 876 ( 4.8A)
RIE  A 876 (-3.6A)
RIE  A 876 (-2.8A)
RIE  A 876 (-3.1A)
 0.18A 1hwkC-2r4fA:
41.0		 1hwkC-2r4fA:
95.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HWK_C_117C4_2
(HMG-COA REDUCTASE)		 2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens) 		11 / 11 GLU A 559
CYH A 561
SER A 565
ARG A 568
LYS A 735
HIS A 752
ASN A 755
SER A 852
LEU A 853
ALA A 856
LEU A 857
 None
 0.18A 1hwkD-2r4fA:
41.1		 1hwkD-2r4fA:
95.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HWK_C_117C4_2
(HMG-COA REDUCTASE)		 2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens) 		6 / 11 SER A 565
ARG A 568
LYS A 735
HIS A 752
SER A 852
ALA A 855
 None
 1.45A 1hwkD-2r4fA:
41.1		 1hwkD-2r4fA:
95.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HWK_D_117D3_1
(HMG-COA REDUCTASE)		 2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens) 		11 / 11 GLU A 559
CYH A 561
SER A 565
ARG A 568
LYS A 735
HIS A 752
ASN A 755
SER A 852
LEU A 853
ALA A 856
LEU A 857
 None
 0.17A 1hwkC-2r4fA:
41.0		 1hwkC-2r4fA:
95.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HWK_D_117D3_1
(HMG-COA REDUCTASE)		 2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens) 		6 / 11 SER A 565
ARG A 568
LYS A 735
HIS A 752
SER A 852
ALA A 855
 None
 1.46A 1hwkC-2r4fA:
41.0		 1hwkC-2r4fA:
95.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HWK_D_117D3_2
(HMG-COA REDUCTASE)		 2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens) 		8 / 8 ARG A 590
SER A 661
VAL A 683
SER A 684
ASN A 686
ASP A 690
LYS A 691
LYS A 692
 RIE  A 876 (-2.9A)
RIE  A 876 (-2.9A)
RIE  A 876 ( 4.4A)
RIE  A 876 (-2.5A)
RIE  A 876 ( 4.8A)
RIE  A 876 (-3.6A)
RIE  A 876 (-2.8A)
RIE  A 876 (-3.1A)
 0.18A 1hwkD-2r4fA:
41.1		 1hwkD-2r4fA:
95.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z35_A_2FAA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens) 		5 / 10 MET A 588
ARG A 646
THR A 689
GLY A 685
THR A 664
 None
 1.46A 1z35A-2r4fA:
undetectable		 1z35A-2r4fA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMA_A_SAMA375_0
(PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE)		 2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens) 		5 / 11 GLY A 591
SER A 684
ASN A 697
THR A 589
GLN A 770
 None
RIE  A 876 (-2.5A)
None
None
None
 1.34A 2hmaA-2r4fA:
undetectable		 2hmaA-2r4fA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_A_RBFA200_1
(DODECIN)		 2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens) 		4 / 8 ARG A 702
ARG A 650
GLN A 632
ARG A 836
 None
 1.30A 2vxaA-2r4fA:
0.6
2vxaC-2r4fA:
0.6
2vxaE-2r4fA:
0.7		 2vxaA-2r4fA:
9.56
2vxaC-2r4fA:
9.56
2vxaE-2r4fA:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_B_RBFB200_1
(DODECIN)		 2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens) 		4 / 8 ARG A 650
GLN A 632
ARG A 702
ARG A 836
 None
 1.33A 2vxaA-2r4fA:
0.6
2vxaB-2r4fA:
0.6
2vxaK-2r4fA:
0.6		 2vxaA-2r4fA:
9.56
2vxaB-2r4fA:
9.56
2vxaK-2r4fA:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_C_RBFC200_1
(DODECIN)		 2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens) 		4 / 8 ARG A 650
GLN A 632
ARG A 702
ARG A 836
 None
 1.29A 2vxaB-2r4fA:
0.6
2vxaC-2r4fA:
0.6
2vxaG-2r4fA:
0.6		 2vxaB-2r4fA:
9.56
2vxaC-2r4fA:
9.56
2vxaG-2r4fA:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_D_RBFD200_1
(DODECIN)		 2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens) 		4 / 8 ARG A 702
ARG A 650
GLN A 632
ARG A 836
 None
 1.31A 2vxaD-2r4fA:
0.6
2vxaF-2r4fA:
0.6
2vxaI-2r4fA:
0.6		 2vxaD-2r4fA:
9.56
2vxaF-2r4fA:
9.56
2vxaI-2r4fA:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_E_RBFE200_1
(DODECIN)		 2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens) 		4 / 8 ARG A 650
GLN A 632
ARG A 702
ARG A 836
 None
 1.30A 2vxaD-2r4fA:
0.6
2vxaE-2r4fA:
0.7
2vxaL-2r4fA:
0.5		 2vxaD-2r4fA:
9.56
2vxaE-2r4fA:
9.56
2vxaL-2r4fA:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_H_RBFH200_1
(DODECIN)		 2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens) 		4 / 8 ARG A 836
ARG A 650
GLN A 632
ARG A 702
 None
 1.32A 2vxaB-2r4fA:
0.6
2vxaG-2r4fA:
0.6
2vxaH-2r4fA:
0.6		 2vxaB-2r4fA:
9.56
2vxaG-2r4fA:
9.56
2vxaH-2r4fA:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_I_RBFI200_1
(DODECIN)		 2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens) 		4 / 8 ARG A 650
GLN A 632
ARG A 702
ARG A 836
 None
 1.32A 2vxaH-2r4fA:
0.6
2vxaI-2r4fA:
0.6
2vxaJ-2r4fA:
0.6		 2vxaH-2r4fA:
9.56
2vxaI-2r4fA:
9.56
2vxaJ-2r4fA:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_J_RBFJ200_1
(DODECIN)		 2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens) 		4 / 8 ARG A 836
ARG A 702
ARG A 650
GLN A 632
 None
 1.30A 2vxaD-2r4fA:
0.6
2vxaJ-2r4fA:
0.6
2vxaL-2r4fA:
0.5		 2vxaD-2r4fA:
9.56
2vxaJ-2r4fA:
9.56
2vxaL-2r4fA:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_K_RBFK200_1
(DODECIN)		 2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens) 		4 / 8 ARG A 836
ARG A 650
GLN A 632
ARG A 702
 None
 1.29A 2vxaH-2r4fA:
0.6
2vxaJ-2r4fA:
0.6
2vxaK-2r4fA:
0.6		 2vxaH-2r4fA:
9.56
2vxaJ-2r4fA:
9.56
2vxaK-2r4fA:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_L_RBFL200_1
(DODECIN)		 2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens) 		4 / 8 ARG A 836
ARG A 650
GLN A 632
ARG A 702
 None
 1.30A 2vxaA-2r4fA:
0.6
2vxaK-2r4fA:
0.6
2vxaL-2r4fA:
0.5		 2vxaA-2r4fA:
9.56
2vxaK-2r4fA:
9.56
2vxaL-2r4fA:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens) 		5 / 12 SER A 565
HIS A 752
LEU A 851
VAL A 717
MET A 728
 None
 1.49A 3dzyD-2r4fA:
0.0		 3dzyD-2r4fA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_0
(NEURAMINIDASE)		 2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens) 		5 / 12 GLU A 482
ARG A 495
ARG A 490
ALA A 459
GLU A 486
 None
 0.82A 3k37A-2r4fA:
undetectable		 3k37A-2r4fA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_A_BCZA1001_0
(NEURAMINIDASE)		 2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens) 		5 / 12 GLU A 482
ARG A 495
ARG A 490
ALA A 459
GLU A 486
 None
 0.95A 3k39A-2r4fA:
undetectable		 3k39A-2r4fA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_C_BCZC1001_0
(NEURAMINIDASE)		 2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens) 		5 / 12 GLU A 482
ARG A 495
ARG A 490
ALA A 459
GLU A 486
 None
 0.96A 3k39C-2r4fA:
undetectable		 3k39C-2r4fA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_D_BCZD1001_0
(NEURAMINIDASE)		 2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens) 		5 / 12 GLU A 482
ARG A 495
ARG A 490
ALA A 459
GLU A 486
 None
 0.95A 3k39D-2r4fA:
undetectable		 3k39D-2r4fA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_E_BCZE1001_0
(NEURAMINIDASE)		 2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens) 		5 / 12 GLU A 482
ARG A 495
ARG A 490
ALA A 459
GLU A 486
 None
 0.95A 3k39E-2r4fA:
undetectable		 3k39E-2r4fA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_F_BCZF1001_0
(NEURAMINIDASE)		 2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens) 		5 / 12 GLU A 482
ARG A 495
ARG A 490
ALA A 459
GLU A 486
 None
 0.94A 3k39F-2r4fA:
undetectable		 3k39F-2r4fA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_G_BCZG1001_0
(NEURAMINIDASE)		 2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens) 		5 / 12 GLU A 482
ARG A 495
ARG A 490
ALA A 459
GLU A 486
 None
 0.95A 3k39G-2r4fA:
undetectable		 3k39G-2r4fA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_H_BCZH1001_0
(NEURAMINIDASE)		 2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens) 		5 / 12 GLU A 482
ARG A 495
ARG A 490
ALA A 459
GLU A 486
 None
 0.95A 3k39H-2r4fA:
undetectable		 3k39H-2r4fA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_I_BCZI1001_0
(NEURAMINIDASE)		 2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens) 		5 / 12 GLU A 482
ARG A 495
ARG A 490
ALA A 459
GLU A 486
 None
 0.95A 3k39I-2r4fA:
undetectable		 3k39I-2r4fA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_J_BCZJ1001_0
(NEURAMINIDASE)		 2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens) 		5 / 12 GLU A 482
ARG A 495
ARG A 490
ALA A 459
GLU A 486
 None
 0.97A 3k39J-2r4fA:
undetectable		 3k39J-2r4fA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_K_BCZK1001_0
(NEURAMINIDASE)		 2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens) 		5 / 12 GLU A 482
ARG A 495
ARG A 490
ALA A 459
GLU A 486
 None
 0.94A 3k39K-2r4fA:
undetectable		 3k39K-2r4fA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_L_BCZL1001_0
(NEURAMINIDASE)		 2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens) 		5 / 12 GLU A 482
ARG A 495
ARG A 490
ALA A 459
GLU A 486
 None
 0.96A 3k39L-2r4fA:
undetectable		 3k39L-2r4fA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_M_BCZM1001_0
(NEURAMINIDASE)		 2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens) 		5 / 12 GLU A 482
ARG A 495
ARG A 490
ALA A 459
GLU A 486
 None
 0.96A 3k39M-2r4fA:
undetectable		 3k39M-2r4fA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_N_BCZN1001_0
(NEURAMINIDASE)		 2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens) 		5 / 12 GLU A 482
ARG A 495
ARG A 490
ALA A 459
GLU A 486
 None
 0.95A 3k39N-2r4fA:
undetectable		 3k39N-2r4fA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_O_BCZO1001_0
(NEURAMINIDASE)		 2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens) 		5 / 12 GLU A 482
ARG A 495
ARG A 490
ALA A 459
GLU A 486
 None
 0.98A 3k39O-2r4fA:
undetectable		 3k39O-2r4fA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_P_BCZP1001_0
(NEURAMINIDASE)		 2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens) 		5 / 12 GLU A 482
ARG A 495
ARG A 490
ALA A 459
GLU A 486
 None
 0.97A 3k39P-2r4fA:
undetectable		 3k39P-2r4fA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_2
(CYTOCHROME P450 3A4)		 2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens) 		4 / 7 PHE A 615
ILE A 680
THR A 636
THR A 625
 None
 1.29A 3nxuA-2r4fA:
undetectable		 3nxuA-2r4fA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_J_ACHJ301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens) 		4 / 8 LEU A 851
MET A 847
THR A 779
TYR A 792
 None
 1.23A 3wipF-2r4fA:
undetectable
3wipJ-2r4fA:
undetectable		 3wipF-2r4fA:
18.71
3wipJ-2r4fA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_C_T1CC392_1
(TETX2 PROTEIN)		 2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens) 		5 / 11 ASN A 686
MET A 588
GLY A 591
SER A 684
GLY A 773
 RIE  A 876 ( 4.8A)
None
None
RIE  A 876 (-2.5A)
None
 1.47A 4a6nC-2r4fA:
undetectable		 4a6nC-2r4fA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AT0_A_ACTA1490_0
(3-KETOSTEROID-DELTA4
-5ALPHA-DEHYDROGENAS
E)		 2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens) 		3 / 3 GLU A 782
TYR A 792
SER A 794
 None
 0.95A 4at0A-2r4fA:
undetectable		 4at0A-2r4fA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPN_B_ZMRB700_1
(NEURAMINIDASE)		 2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens) 		5 / 12 GLU A 482
ARG A 495
ARG A 490
ALA A 459
GLU A 486
 None
 0.96A 4cpnB-2r4fA:
undetectable		 4cpnB-2r4fA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA506_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens) 		4 / 4 PRO A 477
LEU A 481
ILE A 494
ARG A 490
 None
 1.44A 4f4dA-2r4fA:
undetectable		 4f4dA-2r4fA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA305_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens) 		4 / 6 LEU A 851
GLU A 850
ILE A 793
MET A 781
 None
 0.88A 4ww7A-2r4fA:
undetectable		 4ww7A-2r4fA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_A_STRA604_1
(CYTOCHROME P450
21-HYDROXYLASE)		 2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens) 		5 / 12 VAL A 583
ASP A 586
LEU A 838
ILE A 802
GLY A 803
 None
 1.03A 4y8wA-2r4fA:
undetectable		 4y8wA-2r4fA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens) 		5 / 12 GLY A 806
ILE A 696
GLY A 591
THR A 664
MET A 657
 SO4  A   1 ( 4.6A)
None
None
None
RIE  A 876 (-4.1A)
 1.14A 4zdyA-2r4fA:
undetectable		 4zdyA-2r4fA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_E_SAME301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens) 		5 / 12 GLY A 808
GLY A 806
GLY A 803
ALA A 525
LEU A 811
 None
SO4  A   1 ( 4.6A)
None
None
None
 0.86A 5c0oE-2r4fA:
undetectable		 5c0oE-2r4fA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens) 		5 / 12 GLY A 808
GLY A 806
GLY A 803
ALA A 525
LEU A 811
 None
SO4  A   1 ( 4.6A)
None
None
None
 0.83A 5c0oG-2r4fA:
undetectable		 5c0oG-2r4fA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens) 		5 / 12 GLY A 806
ILE A 696
GLY A 591
THR A 664
MET A 657
 SO4  A   1 ( 4.6A)
None
None
None
RIE  A 876 (-4.1A)
 1.11A 5eslA-2r4fA:
undetectable		 5eslA-2r4fA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_C_SAMC801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens) 		5 / 12 ILE A 802
GLY A 803
THR A 804
ALA A 839
VAL A 583
 None
 1.23A 5hw4C-2r4fA:
undetectable		 5hw4C-2r4fA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_C_SAMC801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens) 		5 / 12 ILE A 802
GLY A 803
THR A 804
ALA A 839
VAL A 706
 None
 1.20A 5hw4C-2r4fA:
undetectable		 5hw4C-2r4fA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAH_C_RFPC3001_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens) 		5 / 12 LEU A 821
GLN A 837
ARG A 840
LEU A 544
ARG A 582
 None
 1.42A 5uahC-2r4fA:
0.5		 5uahC-2r4fA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QSA615_1
(SERUM ALBUMIN)		 2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens) 		4 / 8 LEU A 851
HIS A 752
LEU A 544
ILE A 756
 None
 0.95A 5v0vA-2r4fA:
undetectable		 5v0vA-2r4fA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_B_STRB502_1
(CYTOCHROME P450
CYP260A1)		 2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens) 		4 / 6 LEU A 668
ALA A 667
LEU A 643
THR A 636
 None
 0.98A 6f88B-2r4fA:
undetectable		 6f88B-2r4fA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F8C_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens) 		4 / 6 ALA A 579
GLY A 569
THR A 566
ILE A 756
 None
 0.90A 6f8cA-2r4fA:
undetectable		 6f8cA-2r4fA:
11.34