SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2r4g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2r4g TELOMERASE REVERSE
TRANSCRIPTASE
(Tetrahymena
thermophila) 		4 / 8 ASN A 317
GLN A 282
PHE A 318
ASN A 322
 None
 1.33A 1p6kA-2r4gA:
1.2		 1p6kA-2r4gA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2r4g TELOMERASE REVERSE
TRANSCRIPTASE
(Tetrahymena
thermophila) 		4 / 8 ASN A 317
GLN A 282
PHE A 318
ASN A 322
 None
 1.28A 1p6kB-2r4gA:
undetectable		 1p6kB-2r4gA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2r4g TELOMERASE REVERSE
TRANSCRIPTASE
(Tetrahymena
thermophila) 		4 / 8 ASN A 317
GLN A 282
PHE A 318
ASN A 322
 None
 1.24A 1rs7B-2r4gA:
undetectable		 1rs7B-2r4gA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_P_CHDP4271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 2r4g TELOMERASE REVERSE
TRANSCRIPTASE
(Tetrahymena
thermophila) 		4 / 7 GLN A 382
PHE A 379
LEU A 405
PHE A 401
 None
 1.03A 1v55P-2r4gA:
undetectable
1v55W-2r4gA:
undetectable		 1v55P-2r4gA:
19.66
1v55W-2r4gA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2r4g TELOMERASE REVERSE
TRANSCRIPTASE
(Tetrahymena
thermophila) 		4 / 8 ASN A 317
GLN A 282
PHE A 318
ASN A 322
 None
 1.33A 1zzqA-2r4gA:
undetectable		 1zzqA-2r4gA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2r4g TELOMERASE REVERSE
TRANSCRIPTASE
(Tetrahymena
thermophila) 		4 / 8 ASN A 317
GLN A 282
PHE A 318
ASN A 322
 None
 1.27A 1zzqB-2r4gA:
undetectable		 1zzqB-2r4gA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2r4g TELOMERASE REVERSE
TRANSCRIPTASE
(Tetrahymena
thermophila) 		4 / 8 ASN A 317
GLN A 282
PHE A 318
ASN A 322
 None
 1.27A 1zzuB-2r4gA:
1.8		 1zzuB-2r4gA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_C_CHDC310_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2r4g TELOMERASE REVERSE
TRANSCRIPTASE
(Tetrahymena
thermophila) 		4 / 7 GLN A 382
PHE A 379
LEU A 405
PHE A 401
 None
 1.00A 2dysC-2r4gA:
undetectable
2dysJ-2r4gA:
undetectable		 2dysC-2r4gA:
19.66
2dysJ-2r4gA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2r4g TELOMERASE REVERSE
TRANSCRIPTASE
(Tetrahymena
thermophila) 		4 / 7 GLN A 382
PHE A 379
LEU A 405
PHE A 401
 None
 0.98A 2eijC-2r4gA:
1.8
2eijJ-2r4gA:
undetectable		 2eijC-2r4gA:
19.66
2eijJ-2r4gA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2r4g TELOMERASE REVERSE
TRANSCRIPTASE
(Tetrahymena
thermophila) 		4 / 7 GLN A 382
PHE A 379
LEU A 405
PHE A 401
 None
 1.03A 2eijP-2r4gA:
undetectable
2eijW-2r4gA:
undetectable		 2eijP-2r4gA:
19.66
2eijW-2r4gA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2r4g TELOMERASE REVERSE
TRANSCRIPTASE
(Tetrahymena
thermophila) 		4 / 7 GLN A 382
PHE A 379
LEU A 405
PHE A 401
 None
 0.90A 2zxwC-2r4gA:
1.9
2zxwJ-2r4gA:
undetectable		 2zxwC-2r4gA:
19.66
2zxwJ-2r4gA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2r4g TELOMERASE REVERSE
TRANSCRIPTASE
(Tetrahymena
thermophila) 		4 / 6 GLN A 382
PHE A 379
LEU A 405
PHE A 401
 None
 0.91A 2zxwP-2r4gA:
undetectable
2zxwW-2r4gA:
undetectable		 2zxwP-2r4gA:
19.66
2zxwW-2r4gA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2r4g TELOMERASE REVERSE
TRANSCRIPTASE
(Tetrahymena
thermophila) 		4 / 5 GLN A 382
PHE A 379
LEU A 405
PHE A 401
 None
 0.89A 3ablC-2r4gA:
undetectable
3ablJ-2r4gA:
undetectable		 3ablC-2r4gA:
19.66
3ablJ-2r4gA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2r4g TELOMERASE REVERSE
TRANSCRIPTASE
(Tetrahymena
thermophila) 		4 / 5 GLN A 391
PHE A 398
LEU A 459
PHE A 307
 BR  A   5 ( 4.6A)
None
None
None
 1.31A 3ablC-2r4gA:
undetectable
3ablJ-2r4gA:
undetectable		 3ablC-2r4gA:
19.66
3ablJ-2r4gA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2r4g TELOMERASE REVERSE
TRANSCRIPTASE
(Tetrahymena
thermophila) 		4 / 6 GLN A 382
PHE A 379
LEU A 405
PHE A 401
 None
 1.04A 3ablP-2r4gA:
undetectable
3ablW-2r4gA:
undetectable		 3ablP-2r4gA:
19.66
3ablW-2r4gA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2r4g TELOMERASE REVERSE
TRANSCRIPTASE
(Tetrahymena
thermophila) 		4 / 6 GLN A 382
PHE A 379
LEU A 405
PHE A 401
 None
 0.85A 3ag1C-2r4gA:
undetectable
3ag1J-2r4gA:
undetectable		 3ag1C-2r4gA:
19.66
3ag1J-2r4gA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE)		 2r4g TELOMERASE REVERSE
TRANSCRIPTASE
(Tetrahymena
thermophila) 		4 / 8 ASN A 317
GLN A 282
PHE A 318
ASN A 322
 None
 1.31A 3n62A-2r4gA:
undetectable		 3n62A-2r4gA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 2r4g TELOMERASE REVERSE
TRANSCRIPTASE
(Tetrahymena
thermophila) 		4 / 8 ASN A 317
GLN A 282
PHE A 318
ASN A 322
 None
 1.28A 3n62B-2r4gA:
undetectable		 3n62B-2r4gA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 2r4g TELOMERASE REVERSE
TRANSCRIPTASE
(Tetrahymena
thermophila) 		4 / 8 ASN A 317
GLN A 282
PHE A 318
ASN A 322
 None
 1.28A 3n66B-2r4gA:
undetectable		 3n66B-2r4gA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_0
(METHYLTRANSFERASE
WBDD)		 2r4g TELOMERASE REVERSE
TRANSCRIPTASE
(Tetrahymena
thermophila) 		6 / 12 GLY A 457
ASN A 297
ILE A 460
LEU A 420
VAL A 419
ILE A 464
 None
 1.43A 4aztA-2r4gA:
undetectable		 4aztA-2r4gA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB806_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2r4g TELOMERASE REVERSE
TRANSCRIPTASE
(Tetrahymena
thermophila) 		4 / 7 ASN A 317
GLN A 282
PHE A 318
ASN A 322
 None
 1.29A 4kcnB-2r4gA:
undetectable		 4kcnB-2r4gA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2r4g TELOMERASE REVERSE
TRANSCRIPTASE
(Tetrahymena
thermophila) 		4 / 6 GLN A 382
PHE A 379
LEU A 405
PHE A 401
 None
 1.13A 5b1bC-2r4gA:
undetectable
5b1bJ-2r4gA:
undetectable		 5b1bC-2r4gA:
19.66
5b1bJ-2r4gA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB308_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2r4g TELOMERASE REVERSE
TRANSCRIPTASE
(Tetrahymena
thermophila) 		3 / 3 LEU A 265
ILE A 478
TYR A 373
 None
 0.67A 5uunB-2r4gA:
undetectable		 5uunB-2r4gA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_MTLA805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2r4g TELOMERASE REVERSE
TRANSCRIPTASE
(Tetrahymena
thermophila) 		4 / 8 ASN A 317
GLN A 282
PHE A 318
ASN A 322
 None
 1.30A 5vunA-2r4gA:
undetectable		 5vunA-2r4gA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2r4g TELOMERASE REVERSE
TRANSCRIPTASE
(Tetrahymena
thermophila) 		4 / 8 ASN A 317
GLN A 282
PHE A 318
ASN A 322
 None
 1.28A 5vunB-2r4gA:
undetectable		 5vunB-2r4gA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2r4g TELOMERASE REVERSE
TRANSCRIPTASE
(Tetrahymena
thermophila) 		4 / 8 ASN A 317
GLN A 282
PHE A 318
ASN A 322
 None
 1.28A 5vuoB-2r4gA:
undetectable		 5vuoB-2r4gA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2r4g TELOMERASE REVERSE
TRANSCRIPTASE
(Tetrahymena
thermophila) 		4 / 8 ASN A 317
GLN A 282
PHE A 318
ASN A 322
 None
 1.28A 6auuB-2r4gA:
undetectable		 6auuB-2r4gA:
19.77