SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2r4i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1YAJ_K_BEZK4387_0 (CES1 PROTEIN)	2r4i	UNCHARACTERIZED PROTEIN (Cytophaga hutchinsonii)	3 / 3	TRP A 111 LEU A 29 LYS A 13	IPA A 125 (-3.5A) None None	1.39A	1yajK-2r4iA: undetectable	1yajK-2r4iA: 14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2VN1_A_FK5A501_1 (70 KDA PEPTIDYLPROLYL ISOMERASE)	2r4i	UNCHARACTERIZED PROTEIN (Cytophaga hutchinsonii)	5 / 11	TYR A 53 PHE A 36 VAL A 63 TYR A 100 CYH A 118	IPA A 127 (-4.6A) IPA A 127 ( 4.1A) None None IPA A 126 ( 3.7A)	1.34A	2vn1A-2r4iA: undetectable	2vn1A-2r4iA: 21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NDI_A_SAMA601_0 (METHYLTRANSFERASE)	2r4i	UNCHARACTERIZED PROTEIN (Cytophaga hutchinsonii)	5 / 12	TYR A 68 GLU A 84 ILE A 85 PHE A 98 ILE A 18	CIT A 123 (-4.9A) None None IPA A 126 ( 4.1A) None	1.15A	3ndiA-2r4iA: undetectable	3ndiA-2r4iA: 19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OU6_C_SAMC300_0 (SAM-DEPENDENT METHYLTRANSFERASE)	2r4i	UNCHARACTERIZED PROTEIN (Cytophaga hutchinsonii)	5 / 12	TYR A 53 GLU A 88 ALA A 59 GLY A 56 SER A 55	IPA A 127 (-4.6A) None None None None	1.23A	3ou6C-2r4iA: undetectable	3ou6C-2r4iA: 20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OU6_D_SAMD300_0 (SAM-DEPENDENT METHYLTRANSFERASE)	2r4i	UNCHARACTERIZED PROTEIN (Cytophaga hutchinsonii)	5 / 12	TYR A 53 GLU A 88 ALA A 59 GLY A 56 SER A 55	IPA A 127 (-4.6A) None None None None	1.22A	3ou6D-2r4iA: undetectable	3ou6D-2r4iA: 20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ZZC_E_ACTE406_0 (PROTON-GATED ION CHANNEL)	2r4i	UNCHARACTERIZED PROTEIN (Cytophaga hutchinsonii)	4 / 5	ILE A 83 ARG A 102 TYR A 68 GLU A 11	None None CIT A 123 (-4.9A) None	1.15A	4zzcE-2r4iA: undetectable	4zzcE-2r4iA: 19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BP4_A_SAMA505_1 (HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-9 SPECIFIC)	2r4i	UNCHARACTERIZED PROTEIN (Cytophaga hutchinsonii)	3 / 3	ILE A 69 ASN A 82 CYH A 118	None None IPA A 126 ( 3.7A)	0.93A	6bp4A-2r4iA: undetectable	6bp4A-2r4iA: 17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FGC_A_ACTA811_0 (GEPHYRIN)	2r4i	UNCHARACTERIZED PROTEIN (Cytophaga hutchinsonii)	3 / 3	LEU A 30 LEU A 14 ARG A 102	None	0.47A	6fgcA-2r4iA: undetectable	6fgcA-2r4iA: 15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FGD_A_ACTA810_0 (GEPHYRIN)	2r4i	UNCHARACTERIZED PROTEIN (Cytophaga hutchinsonii)	3 / 3	LEU A 30 LEU A 14 ARG A 102	None	0.47A	6fgdA-2r4iA: undetectable	6fgdA-2r4iA: 15.11

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1YAJ_K_BEZK4387_0","CES1 PROTEIN","2r4i","UNCHARACTERIZED PROTEIN","Cytophaga hutchinsonii",3,"TRP A 111;LEU A  29;LYS A  13","IPA A 125 (-3.5A);None;None","1.39A","1yajK-2r4iA:undetectable","1yajK-2r4iA:14.59"],["2VN1_A_FK5A501_1","70 KDA PEPTIDYLPROLYL ISOMERASE","2r4i","UNCHARACTERIZED PROTEIN","Cytophaga hutchinsonii",5,"TYR A  53;PHE A  36;VAL A  63;TYR A 100;CYH A 118","IPA A 127 (-4.6A);IPA A 127 ( 4.1A);None;None;IPA A 126 ( 3.7A)","1.34A","2vn1A-2r4iA:undetectable","2vn1A-2r4iA:21.58"],["3NDI_A_SAMA601_0","METHYLTRANSFERASE","2r4i","UNCHARACTERIZED PROTEIN","Cytophaga hutchinsonii",5,"TYR A  68;GLU A  84;ILE A  85;PHE A  98;ILE A  18","CIT A 123 (-4.9A);None;None;IPA A 126 ( 4.1A);None","1.15A","3ndiA-2r4iA:undetectable","3ndiA-2r4iA:19.35"],["3OU6_C_SAMC300_0","SAM-DEPENDENT METHYLTRANSFERASE","2r4i","UNCHARACTERIZED PROTEIN","Cytophaga hutchinsonii",5,"TYR A  53;GLU A  88;ALA A  59;GLY A  56;SER A  55","IPA A 127 (-4.6A);None;None;None;None","1.23A","3ou6C-2r4iA:undetectable","3ou6C-2r4iA:20.60"],["3OU6_D_SAMD300_0","SAM-DEPENDENT METHYLTRANSFERASE","2r4i","UNCHARACTERIZED PROTEIN","Cytophaga hutchinsonii",5,"TYR A  53;GLU A  88;ALA A  59;GLY A  56;SER A  55","IPA A 127 (-4.6A);None;None;None;None","1.22A","3ou6D-2r4iA:undetectable","3ou6D-2r4iA:20.60"],["4ZZC_E_ACTE406_0","PROTON-GATED ION CHANNEL","2r4i","UNCHARACTERIZED PROTEIN","Cytophaga hutchinsonii",4,"ILE A  83;ARG A 102;TYR A  68;GLU A  11","None;None;CIT A 123 (-4.9A);None","1.15A","4zzcE-2r4iA:undetectable","4zzcE-2r4iA:19.50"],["6BP4_A_SAMA505_1","HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-9 SPECIFIC","2r4i","UNCHARACTERIZED PROTEIN","Cytophaga hutchinsonii",3,"ILE A  69;ASN A  82;CYH A 118","None;None;IPA A 126 ( 3.7A)","0.93A","6bp4A-2r4iA:undetectable","6bp4A-2r4iA:17.38"],["6FGC_A_ACTA811_0","GEPHYRIN","2r4i","UNCHARACTERIZED PROTEIN","Cytophaga hutchinsonii",3,"LEU A  30;LEU A  14;ARG A 102","None","0.47A","6fgcA-2r4iA:undetectable","6fgcA-2r4iA:15.11"],["6FGD_A_ACTA810_0","GEPHYRIN","2r4i","UNCHARACTERIZED PROTEIN","Cytophaga hutchinsonii",3,"LEU A  30;LEU A  14;ARG A 102","None","0.47A","6fgdA-2r4iA:undetectable","6fgdA-2r4iA:15.11"]]