SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2r4j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_A_RBFA301_1
(PROTEIN (FLAVODOXIN))		 2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		4 / 7 THR A 206
ASN A 204
THR A 173
GLY A 217
 FAD  A 600 (-4.0A)
None
None
None
 1.03A 1bu5A-2r4jA:
4.6		 1bu5A-2r4jA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_A_RBFA301_1
(PROTEIN (FLAVODOXIN))		 2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		4 / 7 THR A 206
THR A 173
GLY A 217
ASP A 216
 FAD  A 600 (-4.0A)
None
None
None
 0.78A 1bu5A-2r4jA:
4.6		 1bu5A-2r4jA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_B_RBFB302_1
(PROTEIN (FLAVODOXIN))		 2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		4 / 8 THR A 206
THR A 173
GLY A 217
ASP A 216
 FAD  A 600 (-4.0A)
None
None
None
 0.78A 1bu5B-2r4jA:
undetectable		 1bu5B-2r4jA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_X_BRLX504_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 ILE A 267
PHE A 257
GLY A 269
HIS A  50
TYR A  55
 None
None
None
FAD  A 600 ( 4.6A)
13P  A1968 (-4.6A)
 1.34A 1fm6X-2r4jA:
undetectable		 1fm6X-2r4jA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_B_CCSB47_0
(GLUTATHIONE
S-TRANSFERASE)		 2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		4 / 7 LEU A  37
THR A 168
LEU A  32
GLY A  10
 None
None
None
FAD  A 600 ( 3.7A)
 0.89A 1gtiB-2r4jA:
undetectable		 1gtiB-2r4jA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1502_0
(FERROCHELATASE)		 2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		4 / 8 ARG A 470
LEU A 454
GLY A 474
MET A 475
 None
 1.05A 1hrkA-2r4jA:
2.6		 1hrkA-2r4jA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIN_A_KTNA801_1
(CYTOCHROME P450
107A1)		 2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 11 ALA A 449
LEU A 413
ALA A 414
ALA A 418
LEU A 428
 None
 1.03A 1jinA-2r4jA:
undetectable		 1jinA-2r4jA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHU_A_ESTA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A  17
SER A 384
LEU A 386
ILE A  13
LEU A 151
 None
 1.08A 1lhuA-2r4jA:
undetectable		 1lhuA-2r4jA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUV_A_VK3A4558_1
(PROTEIN YGIN)		 2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		4 / 7 TYR A  55
HIS A  50
LEU A  48
ILE A 247
 13P  A1968 (-4.6A)
FAD  A 600 ( 4.6A)
FAD  A 600 (-4.1A)
None
 0.97A 1tuvA-2r4jA:
2.2		 1tuvA-2r4jA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 422
ARG A 395
ASP A 394
ALA A 418
ALA A 399
 None
 1.06A 2br4C-2r4jA:
2.7		 2br4C-2r4jA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_0
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 THR A  41
ILE A  18
GLY A  15
GLY A  12
ALA A 205
 EDO  A1958 ( 3.2A)
None
None
FAD  A 600 (-3.0A)
None
 0.88A 2fk8A-2r4jA:
3.1		 2fk8A-2r4jA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_B_SALB503_1
(SALICYLATE
SYNTHETASE, IRP9)		 2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 11 GLU A  60
THR A 357
THR A 331
ARG A  62
GLY A 352
 None
 1.41A 2fn1B-2r4jA:
undetectable		 2fn1B-2r4jA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXE_A_DR7A102_1
(POL PROTEIN)		 2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 ASP A  36
GLY A  11
GLY A  12
ILE A  13
PRO A 318
 None
FAD  A 600 ( 4.6A)
FAD  A 600 (-3.0A)
None
None
 0.84A 2fxeA-2r4jA:
undetectable		 2fxeA-2r4jA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q2H_B_ACTB501_0
(SECRETION CHAPERONE,
PHAGE-DISPLAY
DERIVED PEPTIDE)		 2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		3 / 3 ARG A 359
SER A 384
TYR A 358
 None
 0.94A 2q2hA-2r4jA:
undetectable
2q2hB-2r4jA:
undetectable		 2q2hA-2r4jA:
13.41
2q2hB-2r4jA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_L_ASDL1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		4 / 7 ALA A 449
LEU A 429
ALA A 432
PHE A 408
 None
 0.86A 2vcvL-2r4jA:
undetectable		 2vcvL-2r4jA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_D_DVAD8_0
(GRAMICIDIN A)		 2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		3 / 3 TRP A 145
VAL A 258
TRP A 261
 None
 0.73A 2xdcC-2r4jA:
undetectable
2xdcD-2r4jA:
undetectable		 2xdcC-2r4jA:
2.63
2xdcD-2r4jA:
2.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_F_DVAF8_0
(GRAMICIDIN A)		 2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		3 / 3 TRP A 145
VAL A 258
TRP A 261
 None
 0.79A 2xdcE-2r4jA:
undetectable
2xdcF-2r4jA:
undetectable		 2xdcE-2r4jA:
2.63
2xdcF-2r4jA:
2.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_F_DVAF8_0
(VAL-GRAMICIDIN A)		 2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		3 / 3 TRP A 145
VAL A 258
TRP A 261
 None
 0.73A 2y5mE-2r4jA:
undetectable
2y5mF-2r4jA:
undetectable		 2y5mE-2r4jA:
2.63
2y5mF-2r4jA:
2.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_D_DVAD8_0
(VAL-GRAMICIDIN A)		 2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		3 / 3 TRP A 145
VAL A 258
TRP A 261
 None
 0.73A 2y6nC-2r4jA:
undetectable
2y6nD-2r4jA:
undetectable		 2y6nC-2r4jA:
2.63
2y6nD-2r4jA:
2.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_F_DVAF8_0
(VAL-GRAMICIDIN A)		 2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		3 / 3 TRP A 145
VAL A 258
TRP A 261
 None
 0.73A 2y6nE-2r4jA:
undetectable
2y6nF-2r4jA:
undetectable		 2y6nE-2r4jA:
2.63
2y6nF-2r4jA:
2.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		6 / 12 GLY A  10
GLY A  11
ILE A  18
ALA A  34
ALA A 172
VAL A 203
 FAD  A 600 ( 3.7A)
FAD  A 600 ( 4.6A)
None
FAD  A 600 ( 3.3A)
FAD  A 600 (-3.7A)
None
 1.42A 2yqzA-2r4jA:
3.8		 2yqzA-2r4jA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		6 / 12 GLY A  10
GLY A  11
ILE A  18
LEU A  32
ALA A  34
ALA A 172
 FAD  A 600 ( 3.7A)
FAD  A 600 ( 4.6A)
None
None
FAD  A 600 ( 3.3A)
FAD  A 600 (-3.7A)
 1.14A 2yqzA-2r4jA:
3.8		 2yqzA-2r4jA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		6 / 12 GLY A  10
GLY A  11
ILE A  18
ALA A  34
ALA A 172
VAL A 203
 FAD  A 600 ( 3.7A)
FAD  A 600 ( 4.6A)
None
FAD  A 600 ( 3.3A)
FAD  A 600 (-3.7A)
None
 1.42A 2yqzB-2r4jA:
3.9		 2yqzB-2r4jA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		6 / 12 GLY A  10
GLY A  11
ILE A  18
LEU A  32
ALA A  34
ALA A 172
 FAD  A 600 ( 3.7A)
FAD  A 600 ( 4.6A)
None
None
FAD  A 600 ( 3.3A)
FAD  A 600 (-3.7A)
 1.14A 2yqzB-2r4jA:
3.9		 2yqzB-2r4jA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDY_A_RBFA187_1
(LUMAZINE PROTEIN)		 2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 VAL A 210
SER A 349
ILE A  18
ALA A 365
ILE A 338
 None
 1.00A 3ddyA-2r4jA:
undetectable		 3ddyA-2r4jA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		4 / 5 ILE A 101
PHE A 257
PHE A  87
TYR A 141
 BOG  A 800 ( 4.0A)
None
None
None
 1.35A 3em0A-2r4jA:
undetectable		 3em0A-2r4jA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 7 ILE A 101
PHE A 257
PHE A  87
TYR A 141
GLY A 122
 BOG  A 800 ( 4.0A)
None
None
None
None
 1.24A 3em0B-2r4jA:
undetectable		 3em0B-2r4jA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 LEU A 336
GLY A 353
GLY A 352
PRO A 318
SER A  45
 None
FAD  A 600 (-4.5A)
None
None
FAD  A 600 (-4.2A)
 0.99A 3i5uB-2r4jA:
2.2		 3i5uB-2r4jA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 ILE A 391
GLY A 389
GLY A 388
ALA A 154
ILE A  81
 None
 1.10A 3jayA-2r4jA:
undetectable		 3jayA-2r4jA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_C_DX2C270_1
(PTERIDINE REDUCTASE
1)		 2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		4 / 8 ARG A 317
SER A 326
ASP A 252
VAL A 256
 13P  A1968 ( 3.6A)
None
None
13P  A1968 ( 4.5A)
 1.14A 3jq7C-2r4jA:
5.3		 3jq7C-2r4jA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_2
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		3 / 3 ARG A 306
THR A 298
THR A 271
 None
EDO  A1955 (-3.9A)
None
 0.80A 3k2hB-2r4jA:
undetectable		 3k2hB-2r4jA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_1
(NEURAMINIDASE)		 2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		3 / 3 ASP A 263
ARG A 238
ARG A 395
 None
 0.80A 3k37A-2r4jA:
undetectable		 3k37A-2r4jA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_A_30BA500_1
(GENOME POLYPROTEIN)		 2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 163
ARG A  25
ALA A  22
ALA A  19
ASP A  21
 None
 0.96A 3keeA-2r4jA:
undetectable		 3keeA-2r4jA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_C_30BC500_1
(GENOME POLYPROTEIN)		 2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 163
ARG A  25
ALA A  22
ALA A  19
ASP A  21
 None
 0.97A 3keeC-2r4jA:
undetectable		 3keeC-2r4jA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_1
(GENOME POLYPROTEIN)		 2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 163
ARG A  25
ALA A  22
ALA A  19
ASP A  21
 None
 0.98A 3keeD-2r4jA:
undetectable		 3keeD-2r4jA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_B_XRAB233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 11 PHE A  87
PHE A 257
GLY A  51
GLY A  52
TYR A  55
 None
None
None
None
13P  A1968 (-4.6A)
 1.36A 3owxA-2r4jA:
undetectable
3owxB-2r4jA:
undetectable		 3owxA-2r4jA:
19.64
3owxB-2r4jA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_0
(MNMC2)		 2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A  11
GLY A  17
TYR A 358
ASN A  14
ALA A  34
 FAD  A 600 ( 4.6A)
None
None
FAD  A 600 (-3.7A)
FAD  A 600 ( 3.3A)
 0.95A 3vywC-2r4jA:
undetectable		 3vywC-2r4jA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_B_CLQB303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 11 PHE A  87
PHE A 257
GLY A  51
GLY A  52
TYR A  55
 None
None
None
None
13P  A1968 (-4.6A)
 1.33A 4fglA-2r4jA:
3.8
4fglB-2r4jA:
undetectable		 4fglA-2r4jA:
20.21
4fglB-2r4jA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA407_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		3 / 3 GLU A 251
ARG A  92
HIS A  94
 None
 0.81A 4kf9A-2r4jA:
undetectable		 4kf9A-2r4jA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR4_C_AICC401_1
(OUTER MEMBRANE
PROTEIN F)		 2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		4 / 8 ARG A 317
ARG A 332
ASP A 252
ARG A  54
 13P  A1968 ( 3.6A)
13P  A1968 (-3.9A)
None
13P  A1968 ( 3.6A)
 1.39A 4kr4C-2r4jA:
undetectable		 4kr4C-2r4jA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_A_8PRA603_1
(TRANSPORTER)		 2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 ALA A 418
TYR A 421
TYR A 417
PHE A 446
THR A 471
 None
None
None
None
EDO  A1957 ( 4.4A)
 1.07A 4mm4A-2r4jA:
undetectable		 4mm4A-2r4jA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA206_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		4 / 4 ALA A  16
ALA A  19
ALA A  20
ALA A  23
 None
 0.13A 4oadA-2r4jA:
undetectable		 4oadA-2r4jA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA208_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		4 / 4 ALA A  16
ALA A  19
ALA A  20
ALA A  23
 None
 0.12A 4oaeA-2r4jA:
undetectable		 4oaeA-2r4jA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 ALA A 154
LEU A  37
GLY A  17
GLU A 363
ALA A  20
 None
 1.15A 4pclA-2r4jA:
3.6		 4pclA-2r4jA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN)		 2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 ARG A 401
GLY A 393
ILE A  81
GLY A 422
GLU A 426
 None
None
None
None
EDO  A1962 ( 4.4A)
 1.12A 4r29D-2r4jA:
undetectable		 4r29D-2r4jA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_A_URFA302_1
(URIDINE
PHOSPHORYLASE)		 2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		4 / 7 THR A 173
GLY A 217
GLN A 212
ILE A   9
 None
None
None
FAD  A 600 (-4.6A)
 0.87A 4txnA-2r4jA:
undetectable		 4txnA-2r4jA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_B_URFB302_1
(URIDINE
PHOSPHORYLASE)		 2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		4 / 7 THR A 173
GLY A 217
GLN A 212
ILE A   9
 None
None
None
FAD  A 600 (-4.6A)
 0.87A 4txnB-2r4jA:
undetectable		 4txnB-2r4jA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_C_URFC302_1
(URIDINE
PHOSPHORYLASE)		 2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		4 / 7 THR A 173
GLY A 217
GLN A 212
ILE A   9
 None
None
None
FAD  A 600 (-4.6A)
 0.86A 4txnC-2r4jA:
undetectable		 4txnC-2r4jA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_D_URFD302_1
(URIDINE
PHOSPHORYLASE)		 2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		4 / 7 THR A 173
GLY A 217
GLN A 212
ILE A   9
 None
None
None
FAD  A 600 (-4.6A)
 0.87A 4txnD-2r4jA:
undetectable		 4txnD-2r4jA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKW_A_TESA601_1
(AROMATASE)		 2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 11 ILE A 234
ILE A 284
THR A 271
VAL A 256
VAL A 258
 None
None
None
13P  A1968 ( 4.5A)
None
 1.40A 5jkwA-2r4jA:
undetectable		 5jkwA-2r4jA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 LEU A 451
ASP A 441
GLY A 443
LEU A 467
ALA A 463
 None
 1.39A 5kc4E-2r4jA:
undetectable		 5kc4E-2r4jA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LBT_A_6T0A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 10 PHE A  87
PHE A 257
GLY A  51
GLY A  52
TYR A  55
 None
None
None
None
13P  A1968 (-4.6A)
 1.33A 5lbtA-2r4jA:
undetectable
5lbtB-2r4jA:
undetectable		 5lbtA-2r4jA:
19.57
5lbtB-2r4jA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LBT_A_6T0A304_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 10 GLY A  51
GLY A  52
TYR A  55
PHE A  87
PHE A 257
 None
None
13P  A1968 (-4.6A)
None
None
 1.40A 5lbtA-2r4jA:
undetectable
5lbtB-2r4jA:
undetectable		 5lbtA-2r4jA:
19.57
5lbtB-2r4jA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_D_ADND502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		3 / 3 THR A 206
THR A 170
LEU A  30
 FAD  A 600 (-4.0A)
None
None
 0.57A 5m66D-2r4jA:
3.1		 5m66D-2r4jA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		 2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		4 / 7 HIS A  80
GLY A 422
ARG A 150
LEU A 153
 None
 1.05A 6btxA-2r4jA:
undetectable		 6btxA-2r4jA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA811_0
(GEPHYRIN)		 2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		3 / 3 LEU A  75
LEU A 117
ARG A  71
 None
 0.69A 6fgcA-2r4jA:
5.0		 6fgcA-2r4jA:
20.34