SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2r4q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5R_A_RBFA859_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2r4q PHOSPHOTRANSFERASE
SYSTEM (PTS)
FRUCTOSE-SPECIFIC
ENZYME IIABC
COMPONENT
(Bacillus
subtilis) 		5 / 11 LEU A 217
GLU A 206
ALA A 188
ARG A 240
PHE A 241
 None
 0.96A 1l5rA-2r4qA:
undetectable		 1l5rA-2r4qA:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5R_A_RBFA859_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2r4q PHOSPHOTRANSFERASE
SYSTEM (PTS)
FRUCTOSE-SPECIFIC
ENZYME IIABC
COMPONENT
(Bacillus
subtilis) 		5 / 11 LEU A 217
GLU A 206
ALA A 189
ARG A 240
PHE A 241
 None
 1.11A 1l5rA-2r4qA:
undetectable		 1l5rA-2r4qA:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1300_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 2r4q PHOSPHOTRANSFERASE
SYSTEM (PTS)
FRUCTOSE-SPECIFIC
ENZYME IIABC
COMPONENT
(Bacillus
subtilis) 		5 / 11 GLY A 254
ALA A 231
LEU A 247
VAL A 205
VAL A 175
 None
 1.09A 1ukbA-2r4qA:
undetectable		 1ukbA-2r4qA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		 2r4q PHOSPHOTRANSFERASE
SYSTEM (PTS)
FRUCTOSE-SPECIFIC
ENZYME IIABC
COMPONENT
(Bacillus
subtilis) 		3 / 3 GLY A 212
GLU A 206
THR A 207
 None
 0.48A 4kouA-2r4qA:
undetectable		 4kouA-2r4qA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2r4q PHOSPHOTRANSFERASE
SYSTEM (PTS)
FRUCTOSE-SPECIFIC
ENZYME IIABC
COMPONENT
(Bacillus
subtilis) 		4 / 5 LEU A 192
LYS A 193
ALA A 196
LEU A 199
 None
 0.77A 5vkqA-2r4qA:
undetectable
5vkqD-2r4qA:
undetectable		 5vkqA-2r4qA:
5.21
5vkqD-2r4qA:
5.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2r4q PHOSPHOTRANSFERASE
SYSTEM (PTS)
FRUCTOSE-SPECIFIC
ENZYME IIABC
COMPONENT
(Bacillus
subtilis) 		4 / 5 LEU A 192
LYS A 193
ALA A 196
LEU A 199
 None
 0.76A 5vkqA-2r4qA:
undetectable
5vkqB-2r4qA:
undetectable		 5vkqA-2r4qA:
5.21
5vkqB-2r4qA:
5.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2r4q PHOSPHOTRANSFERASE
SYSTEM (PTS)
FRUCTOSE-SPECIFIC
ENZYME IIABC
COMPONENT
(Bacillus
subtilis) 		4 / 5 LEU A 192
LYS A 193
ALA A 196
LEU A 199
 None
 0.76A 5vkqB-2r4qA:
undetectable
5vkqC-2r4qA:
undetectable		 5vkqB-2r4qA:
5.21
5vkqC-2r4qA:
5.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2r4q PHOSPHOTRANSFERASE
SYSTEM (PTS)
FRUCTOSE-SPECIFIC
ENZYME IIABC
COMPONENT
(Bacillus
subtilis) 		4 / 5 LEU A 192
LYS A 193
ALA A 196
LEU A 199
 None
 0.76A 5vkqC-2r4qA:
undetectable
5vkqD-2r4qA:
undetectable		 5vkqC-2r4qA:
5.21
5vkqD-2r4qA:
5.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_B_LOCB504_2
(TUBULIN BETA CHAIN)		 2r4q PHOSPHOTRANSFERASE
SYSTEM (PTS)
FRUCTOSE-SPECIFIC
ENZYME IIABC
COMPONENT
(Bacillus
subtilis) 		5 / 12 LEU A 199
THR A 176
ALA A 174
ILE A 172
ILE A 229
 None
 0.98A 5xiwB-2r4qA:
2.3		 5xiwB-2r4qA:
19.09