SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2r4s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 2r4s ANTIBODY FOR BETA2
ADRENOCEPTOR, HEAVY
CHAIN
(Mus
musculus) 		5 / 12 VAL H 111
LEU H  83
LEU H 109
THR H  87
GLU H  46
 None
 1.36A 1kw0A-2r4sH:
undetectable		 1kw0A-2r4sH:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMT_A_H4BA1426_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 2r4s ANTIBODY FOR BETA2
ADRENOCEPTOR, HEAVY
CHAIN
(Mus
musculus) 		5 / 11 VAL H 111
LEU H  83
LEU H 109
THR H  87
GLU H  46
 None
 1.36A 1mmtA-2r4sH:
undetectable		 1mmtA-2r4sH:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_1
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 2r4s ANTIBODY FOR BETA2
ADRENOCEPTOR, HEAVY
CHAIN
ANTIBODY FOR BETA2
ADRENOCEPTOR, LIGHT
CHAIN
(Mus
musculus;
Mus
musculus) 		3 / 3 THR L  97
GLU H  46
ASP H  90
 None
 0.86A 1nt2A-2r4sL:
undetectable		 1nt2A-2r4sL:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_A_CLMA1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2r4s ANTIBODY FOR BETA2
ADRENOCEPTOR, HEAVY
CHAIN
(Mus
musculus) 		4 / 7 GLY H  54
PRO H  53
ILE H  51
GLY H  56
 None
 0.69A 1usqA-2r4sH:
undetectable		 1usqA-2r4sH:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_B_CLMB1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2r4s ANTIBODY FOR BETA2
ADRENOCEPTOR, HEAVY
CHAIN
(Mus
musculus) 		4 / 6 GLY H  54
PRO H  53
ILE H  51
GLY H  56
 None
 0.69A 1usqB-2r4sH:
undetectable		 1usqB-2r4sH:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2r4s ANTIBODY FOR BETA2
ADRENOCEPTOR, HEAVY
CHAIN
(Mus
musculus) 		4 / 6 GLY H  54
PRO H  53
ILE H  51
GLY H  56
 None
 0.68A 1usqC-2r4sH:
undetectable		 1usqC-2r4sH:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2r4s ANTIBODY FOR BETA2
ADRENOCEPTOR, HEAVY
CHAIN
(Mus
musculus) 		4 / 6 GLY H  54
PRO H  53
ILE H  51
GLY H  56
 None
 0.69A 1usqD-2r4sH:
undetectable		 1usqD-2r4sH:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2r4s ANTIBODY FOR BETA2
ADRENOCEPTOR, HEAVY
CHAIN
(Mus
musculus) 		4 / 6 GLY H  54
PRO H  53
ILE H  51
GLY H  56
 None
 0.68A 1usqE-2r4sH:
undetectable		 1usqE-2r4sH:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_F_CLMF1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2r4s ANTIBODY FOR BETA2
ADRENOCEPTOR, HEAVY
CHAIN
(Mus
musculus) 		4 / 7 GLY H  54
PRO H  53
ILE H  51
GLY H  56
 None
 0.69A 1usqF-2r4sH:
undetectable		 1usqF-2r4sH:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_A_CLMA1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2r4s ANTIBODY FOR BETA2
ADRENOCEPTOR, HEAVY
CHAIN
(Mus
musculus) 		4 / 6 GLY H  54
PRO H  53
ILE H  51
GLY H  56
 None
 0.73A 2jkjA-2r4sH:
undetectable		 2jkjA-2r4sH:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_B_CLMB1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2r4s ANTIBODY FOR BETA2
ADRENOCEPTOR, HEAVY
CHAIN
(Mus
musculus) 		4 / 6 GLY H  54
PRO H  53
ILE H  51
GLY H  56
 None
 0.73A 2jkjB-2r4sH:
1.4		 2jkjB-2r4sH:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_C_CLMC1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2r4s ANTIBODY FOR BETA2
ADRENOCEPTOR, HEAVY
CHAIN
(Mus
musculus) 		4 / 6 GLY H  54
PRO H  53
ILE H  51
GLY H  56
 None
 0.73A 2jkjC-2r4sH:
undetectable		 2jkjC-2r4sH:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_E_CLME1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2r4s ANTIBODY FOR BETA2
ADRENOCEPTOR, HEAVY
CHAIN
(Mus
musculus) 		4 / 7 GLY H  54
PRO H  53
ILE H  51
GLY H  56
 None
 0.73A 2jkjE-2r4sH:
undetectable		 2jkjE-2r4sH:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_A_CLMA1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2r4s ANTIBODY FOR BETA2
ADRENOCEPTOR, HEAVY
CHAIN
(Mus
musculus) 		4 / 7 GLY H  54
PRO H  53
ILE H  51
GLY H  56
 None
 0.72A 2jklA-2r4sH:
undetectable		 2jklA-2r4sH:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_B_CLMB1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2r4s ANTIBODY FOR BETA2
ADRENOCEPTOR, HEAVY
CHAIN
(Mus
musculus) 		4 / 6 GLY H  54
PRO H  53
ILE H  51
GLY H  56
 None
 0.74A 2jklB-2r4sH:
undetectable		 2jklB-2r4sH:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2r4s ANTIBODY FOR BETA2
ADRENOCEPTOR, HEAVY
CHAIN
(Mus
musculus) 		4 / 7 GLY H  54
PRO H  53
ILE H  51
GLY H  56
 None
 0.73A 2jklC-2r4sH:
1.5		 2jklC-2r4sH:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_D_CLMD1145_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2r4s ANTIBODY FOR BETA2
ADRENOCEPTOR, HEAVY
CHAIN
(Mus
musculus) 		4 / 7 GLY H  54
PRO H  53
ILE H  51
GLY H  56
 None
 0.72A 2jklD-2r4sH:
undetectable		 2jklD-2r4sH:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2r4s ANTIBODY FOR BETA2
ADRENOCEPTOR, HEAVY
CHAIN
(Mus
musculus) 		4 / 7 GLY H  54
PRO H  53
ILE H  51
GLY H  56
 None
 0.73A 2jklE-2r4sH:
1.4		 2jklE-2r4sH:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2r4s ANTIBODY FOR BETA2
ADRENOCEPTOR, HEAVY
CHAIN
(Mus
musculus) 		4 / 7 GLY H  54
PRO H  53
ILE H  51
GLY H  56
 None
 0.73A 2jklF-2r4sH:
undetectable		 2jklF-2r4sH:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2r4s ANTIBODY FOR BETA2
ADRENOCEPTOR, LIGHT
CHAIN
(Mus
musculus) 		4 / 8 LEU L  78
SER L  77
LEU L  73
TYR L  86
 None
 0.85A 3ln1A-2r4sL:
undetectable		 3ln1A-2r4sL:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUG_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2r4s ANTIBODY FOR BETA2
ADRENOCEPTOR, HEAVY
CHAIN
(Mus
musculus) 		5 / 12 ALA H  24
PHE H  29
THR H  78
ALA H  79
ASP H  73
 None
 1.09A 3sugA-2r4sH:
undetectable		 3sugA-2r4sH:
26.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA CHAIN)		 2r4s ANTIBODY FOR BETA2
ADRENOCEPTOR, HEAVY
CHAIN
(Mus
musculus) 		3 / 3 SER H 203
ALA H 198
VAL H 197
 None
 0.52A 5xiwC-2r4sH:
undetectable		 5xiwC-2r4sH:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AN0_A_HISA520_0
(HISTIDINOL
DEHYDROGENASE)		 2r4s ANTIBODY FOR BETA2
ADRENOCEPTOR, LIGHT
CHAIN
(Mus
musculus) 		4 / 6 GLU L 185
LYS L 183
ARG L 188
GLU L 187
 None
 1.17A 6an0A-2r4sL:
undetectable		 6an0A-2r4sL:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA606_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 2r4s ANTIBODY FOR BETA2
ADRENOCEPTOR, HEAVY
CHAIN
(Mus
musculus) 		4 / 5 GLU H 148
PHE H 146
HIS H 199
THR H 110
 None
 1.11A 6b58A-2r4sH:
undetectable		 6b58A-2r4sH:
16.94