SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2r50'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 2r50 NON-SYMBIOTIC
HEMOGLOBIN
(Zea
mays) 		4 / 7 PHE A  54
PHE A  40
PHE A  44
VAL A 113
 HEM  A 166 (-4.1A)
None
None
HEM  A 166 ( 4.4A)
 0.97A 1lh6A-2r50A:
19.4		 1lh6A-2r50A:
44.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KUH_A_HLTA150_1
(CALMODULIN)		 2r50 NON-SYMBIOTIC
HEMOGLOBIN
(Zea
mays) 		4 / 6 LEU A 133
MET A  28
MET A 137
MET A 142
 None
 1.29A 2kuhA-2r50A:
undetectable		 2kuhA-2r50A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2r50 NON-SYMBIOTIC
HEMOGLOBIN
(Zea
mays) 		4 / 7 GLU A 127
HIS A 117
VAL A 154
PHE A  39
 None
None
HEM  A 166 ( 4.5A)
None
 1.04A 4a97H-2r50A:
undetectable		 4a97H-2r50A:
17.82