SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2r51'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_C_CCSC47_0
(GLUTATHIONE
S-TRANSFERASE)		 2r51 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 26B
(Mus
musculus) 		4 / 6 THR A 256
LEU A 292
LYS A 211
TYR A 270
 None
 1.34A 1gtiC-2r51A:
undetectable		 1gtiC-2r51A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_B_ID2B2_0
(THYMIDINE KINASE)		 2r51 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 26B
(Mus
musculus) 		5 / 12 HIS A  83
GLU A 144
ARG A 131
ARG A 127
GLU A  75
 None
 1.45A 1ki7B-2r51A:
undetectable		 1ki7B-2r51A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2r51 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 26B
(Mus
musculus) 		5 / 12 ILE A  14
LEU A  93
SER A 135
ILE A 134
LEU A  52
 None
 1.32A 1rh3A-2r51A:
undetectable		 1rh3A-2r51A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_2
(POL POLYPROTEIN)		 2r51 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 26B
(Mus
musculus) 		3 / 3 ASP A 146
VAL A 149
PRO A 115
 None
 0.70A 2avvA-2r51A:
undetectable		 2avvA-2r51A:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PIV_A_T3A933_1
(ANDROGEN RECEPTOR)		 2r51 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 26B
(Mus
musculus) 		5 / 9 ILE A 262
GLY A 121
GLU A 224
ASN A 123
TYR A  77
 None
 1.38A 2pivA-2r51A:
undetectable		 2pivA-2r51A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2r51 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 26B
(Mus
musculus) 		5 / 12 VAL A 148
ALA A  25
LEU A 292
LEU A 185
ILE A 209
 None
 0.99A 3gcsA-2r51A:
undetectable		 3gcsA-2r51A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G10_A_ACTA301_0
(GLUTATHIONE
S-TRANSFERASE
HOMOLOG)		 2r51 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 26B
(Mus
musculus) 		4 / 6 ILE A 207
TYR A 183
TYR A 178
PHE A 176
 None
 1.22A 4g10A-2r51A:
undetectable		 4g10A-2r51A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2r51 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 26B
(Mus
musculus) 		4 / 8 ILE A  71
GLU A  85
GLN A  73
ILE A  74
 None
 0.85A 4mj8A-2r51A:
undetectable		 4mj8A-2r51A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2r51 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 26B
(Mus
musculus) 		3 / 3 LEU A 130
ILE A 147
ARG A  22
 None
 0.65A 4mk4B-2r51A:
undetectable		 4mk4B-2r51A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA609_0
(ACETYLCHOLINESTERASE)		 2r51 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 26B
(Mus
musculus) 		4 / 6 TYR A 128
ASP A 146
HIS A  27
TYR A 116
 None
 1.50A 5ov9A-2r51A:
undetectable		 5ov9A-2r51A:
20.77