SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2r5f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_1
(ESTROGEN RECEPTOR)		 2r5f TRANSCRIPTIONAL
REGULATOR, PUTATIVE
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 12 ALA A 100
LEU A 104
LEU A 281
ILE A 213
LEU A 164
 None
 0.97A 1errB-2r5fA:
undetectable		 1errB-2r5fA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_A_ID2A1_0
(THYMIDINE KINASE)		 2r5f TRANSCRIPTIONAL
REGULATOR, PUTATIVE
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 12 GLU A 141
GLN A 162
ALA A 165
ARG A 202
GLU A 198
 None
 1.11A 1ki7A-2r5fA:
undetectable		 1ki7A-2r5fA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B17_A_DIFA701_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 2r5f TRANSCRIPTIONAL
REGULATOR, PUTATIVE
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 10 LEU A 302
ALA A 209
ILE A 210
GLY A 212
ASP A 245
 None
None
None
SO4  A   1 ( 3.8A)
None
 1.37A 2b17A-2r5fA:
undetectable		 2b17A-2r5fA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		 2r5f TRANSCRIPTIONAL
REGULATOR, PUTATIVE
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 8 ARG A 249
LEU A 271
LEU A 302
VAL A 280
 None
 1.01A 2bdmA-2r5fA:
undetectable		 2bdmA-2r5fA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_A_THRA401_0
(ASPARTOKINASE)		 2r5f TRANSCRIPTIONAL
REGULATOR, PUTATIVE
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 8 GLY A 295
ALA A 292
THR A 311
ILE A 213
 None
 0.74A 2dtjA-2r5fA:
undetectable
2dtjB-2r5fA:
undetectable		 2dtjA-2r5fA:
17.47
2dtjB-2r5fA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_C_IBPC1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 2r5f TRANSCRIPTIONAL
REGULATOR, PUTATIVE
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 10 THR A 311
ILE A  96
GLY A 212
GLY A 282
THR A 307
 None
None
SO4  A   1 ( 3.8A)
None
None
 1.27A 2wd9C-2r5fA:
3.4		 2wd9C-2r5fA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA271_0
(PROTEIN SSM1)		 2r5f TRANSCRIPTIONAL
REGULATOR, PUTATIVE
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 5 GLY A 286
LYS A 289
GLU A 215
GLY A 285
 None
SO4  A   1 (-2.9A)
None
None
 1.06A 3onnA-2r5fA:
3.0		 3onnA-2r5fA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2r5f TRANSCRIPTIONAL
REGULATOR, PUTATIVE
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 12 ALA A 296
GLY A 255
GLY A 300
LEU A 302
ALA A 292
 None
 1.10A 3ou6A-2r5fA:
undetectable		 3ou6A-2r5fA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2r5f TRANSCRIPTIONAL
REGULATOR, PUTATIVE
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 12 ALA A 296
GLY A 255
GLY A 300
LEU A 302
ALA A 292
 None
 1.07A 3ou6B-2r5fA:
undetectable		 3ou6B-2r5fA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2r5f TRANSCRIPTIONAL
REGULATOR, PUTATIVE
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 12 ALA A 296
GLY A 255
GLY A 300
LEU A 302
ALA A 292
 None
 1.10A 3ou7B-2r5fA:
2.9		 3ou7B-2r5fA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2r5f TRANSCRIPTIONAL
REGULATOR, PUTATIVE
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 12 VAL A 211
LEU A 315
LEU A 302
GLY A 285
ALA A 284
 None
 1.09A 3rr3C-2r5fA:
undetectable		 3rr3C-2r5fA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2r5f TRANSCRIPTIONAL
REGULATOR, PUTATIVE
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 12 VAL A 211
LEU A 315
LEU A 302
GLY A 285
ALA A 284
 None
 1.09A 3rr3D-2r5fA:
undetectable		 3rr3D-2r5fA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAW_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 2r5f TRANSCRIPTIONAL
REGULATOR, PUTATIVE
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 11 THR A  84
VAL A  81
GLU A  82
SER A  91
ILE A  96
 None
 1.08A 3uawA-2r5fA:
undetectable		 3uawA-2r5fA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAY_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 2r5f TRANSCRIPTIONAL
REGULATOR, PUTATIVE
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 10 THR A 207
GLY A 115
VAL A 142
GLU A 141
ILE A 116
 None
 1.30A 3uayA-2r5fA:
undetectable		 3uayA-2r5fA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_2
(TUBULIN BETA-2B
CHAIN)		 2r5f TRANSCRIPTIONAL
REGULATOR, PUTATIVE
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 12 LEU A 283
ALA A 100
LEU A 104
ILE A 116
ILE A 114
 None
 1.00A 4o2bB-2r5fA:
undetectable		 4o2bB-2r5fA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_2
(TUBULIN BETA-2B
CHAIN)		 2r5f TRANSCRIPTIONAL
REGULATOR, PUTATIVE
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 12 LEU A 283
ALA A 100
LEU A 104
ILE A 116
ILE A 114
 None
 0.97A 4o2bD-2r5fA:
undetectable		 4o2bD-2r5fA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_B_SAMB801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 2r5f TRANSCRIPTIONAL
REGULATOR, PUTATIVE
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 11 ILE A 277
ASP A 112
ALA A 209
LEU A 274
VAL A 211
 None
 1.24A 5hw4B-2r5fA:
undetectable		 5hw4B-2r5fA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIO_B_LOCB502_1
(TUBULIN BETA CHAIN)		 2r5f TRANSCRIPTIONAL
REGULATOR, PUTATIVE
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 12 LEU A 283
ALA A 100
LEU A 104
ILE A 116
ILE A 114
 None
 0.98A 5mioB-2r5fA:
undetectable		 5mioB-2r5fA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		 2r5f TRANSCRIPTIONAL
REGULATOR, PUTATIVE
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 12 LEU A 175
GLY A 147
GLY A 148
VAL A 266
LEU A 145
 None
 1.19A 5uc1A-2r5fA:
undetectable		 5uc1A-2r5fA:
13.26