SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2r5g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2r5g CHLORIDE
INTRACELLULAR
CHANNEL PROTEIN 2
(Homo
sapiens) 		5 / 12 GLY A 211
LEU A 150
ASP A 183
ALA A 219
ALA A 221
 None
 0.99A 2bm9F-2r5gA:
undetectable		 2bm9F-2r5gA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_B_ERYB1399_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 2r5g CHLORIDE
INTRACELLULAR
CHANNEL PROTEIN 2
(Homo
sapiens) 		5 / 12 ILE A 193
TYR A 239
LEU A 216
ALA A 196
ASP A 183
 None
 1.45A 2iyfB-2r5gA:
undetectable		 2iyfB-2r5gA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_B_T44B128_1
(TRANSTHYRETIN)		 2r5g CHLORIDE
INTRACELLULAR
CHANNEL PROTEIN 2
(Homo
sapiens) 		4 / 6 LEU A 186
ALA A 182
LEU A 187
THR A 180
 None
 1.05A 2roxB-2r5gA:
undetectable		 2roxB-2r5gA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_A_SAMA298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 2r5g CHLORIDE
INTRACELLULAR
CHANNEL PROTEIN 2
(Homo
sapiens) 		5 / 12 ALA A 219
SER A 185
PHE A 110
LEU A 216
VAL A 212
 None
 1.23A 2zifA-2r5gA:
undetectable		 2zifA-2r5gA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2r5g CHLORIDE
INTRACELLULAR
CHANNEL PROTEIN 2
(Homo
sapiens) 		5 / 12 LEU A 139
TYR A 123
ILE A 193
ILE A 124
ASP A 202
 None
 0.99A 3uj6A-2r5gA:
undetectable		 3uj6A-2r5gA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I89_A_1FLA201_1
(TRANSTHYRETIN)		 2r5g CHLORIDE
INTRACELLULAR
CHANNEL PROTEIN 2
(Homo
sapiens) 		4 / 6 LEU A 186
ALA A 182
LEU A 187
THR A 180
 None
 1.04A 4i89A-2r5gA:
undetectable		 4i89A-2r5gA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_1
(THYMIDYLATE SYNTHASE)		 2r5g CHLORIDE
INTRACELLULAR
CHANNEL PROTEIN 2
(Homo
sapiens) 		3 / 3 ASN A 237
ASP A  23
GLY A  24
 None
 0.67A 5fctB-2r5gA:
undetectable		 5fctB-2r5gA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWT_D_BEZD202_0
(PR 10 PROTEIN)		 2r5g CHLORIDE
INTRACELLULAR
CHANNEL PROTEIN 2
(Homo
sapiens) 		3 / 3 PHE A 203
ASP A 202
LYS A 198
 None
 0.83A 6awtD-2r5gA:
undetectable		 6awtD-2r5gA:
23.20