SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2r5j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_0
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 2r5j MAJOR CAPSID PROTEIN
L1
(Alphapapillomavi
rus
9) 		4 / 4 THR A 154
LEU A 156
LEU A 246
GLN A 315
 None
 1.06A 1fbmA-2r5jA:
undetectable		 1fbmA-2r5jA:
6.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_A_NCAA506_0
(NAD-DEPENDENT
DEACETYLASE 2)		 2r5j MAJOR CAPSID PROTEIN
L1
(Alphapapillomavi
rus
9) 		4 / 6 ALA A 345
SER A 347
ASN A 357
ASP A 350
 None
 0.95A 1yc2A-2r5jA:
undetectable		 1yc2A-2r5jA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC5_A_NCAA2001_0
(NAD-DEPENDENT
DEACETYLASE)		 2r5j MAJOR CAPSID PROTEIN
L1
(Alphapapillomavi
rus
9) 		4 / 7 ALA A 345
SER A 347
ASN A 357
ASP A 350
 None
 0.90A 1yc5A-2r5jA:
undetectable		 1yc5A-2r5jA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_A_8MOA501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 2r5j MAJOR CAPSID PROTEIN
L1
(Alphapapillomavi
rus
9) 		5 / 11 PHE A 372
PHE A 374
ILE A 159
GLY A 160
LEU A  77
 None
 1.00A 1z11A-2r5jA:
undetectable		 1z11A-2r5jA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B9E_A_SAMA1201_0
(NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2)		 2r5j MAJOR CAPSID PROTEIN
L1
(Alphapapillomavi
rus
9) 		5 / 12 CYH A 229
PRO A 232
GLY A 166
LEU A  68
ASP A 223
 None
 1.46A 2b9eA-2r5jA:
undetectable		 2b9eA-2r5jA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_0
(NON-STRUCTURAL
PROTEIN 5)		 2r5j MAJOR CAPSID PROTEIN
L1
(Alphapapillomavi
rus
9) 		5 / 12 GLY A 116
GLY A 114
THR A 338
ASP A 150
ILE A 117
 None
 0.99A 2wa2B-2r5jA:
undetectable		 2wa2B-2r5jA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB0_A_DIFA701_1
(LACTOTRANSFERRIN)		 2r5j MAJOR CAPSID PROTEIN
L1
(Alphapapillomavi
rus
9) 		4 / 4 PRO A 308
TYR A 309
GLY A 104
THR A 103
 None
 1.29A 3ib0A-2r5jA:
undetectable		 3ib0A-2r5jA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_G_TFPG201_1
(PROTEIN S100-A4)		 2r5j MAJOR CAPSID PROTEIN
L1
(Alphapapillomavi
rus
9) 		5 / 9 GLY A 160
PHE A 328
GLY A 243
ILE A 165
PHE A 446
 None
 1.07A 3ko0F-2r5jA:
undetectable
3ko0G-2r5jA:
undetectable		 3ko0F-2r5jA:
13.43
3ko0G-2r5jA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_Q_TFPQ201_1
(PROTEIN S100-A4)		 2r5j MAJOR CAPSID PROTEIN
L1
(Alphapapillomavi
rus
9) 		4 / 8 GLY A 160
PHE A 328
ILE A 165
PHE A 446
 None
 0.96A 3ko0O-2r5jA:
undetectable
3ko0Q-2r5jA:
undetectable		 3ko0O-2r5jA:
13.43
3ko0Q-2r5jA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHG_C_SAMC4001_0
(RNA-DIRECTED RNA
POLYMERASE NS5)		 2r5j MAJOR CAPSID PROTEIN
L1
(Alphapapillomavi
rus
9) 		5 / 12 GLY A 116
GLY A 114
THR A 338
ASP A 150
ILE A 117
 None
 0.93A 5ehgC-2r5jA:
undetectable		 5ehgC-2r5jA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKM_A_SAMA311_0
(NS5 METHYL
TRANSFERASE)		 2r5j MAJOR CAPSID PROTEIN
L1
(Alphapapillomavi
rus
9) 		5 / 12 GLY A 116
GLY A 114
THR A 338
ASP A 150
ILE A 117
 None
 0.93A 5ikmA-2r5jA:
undetectable		 5ikmA-2r5jA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS5_A_ASCA202_0
(CYTOCHROME C')		 2r5j MAJOR CAPSID PROTEIN
L1
(Alphapapillomavi
rus
9) 		3 / 3 CYH A 229
LYS A 230
HIS A 168
 None
 1.13A 5js5A-2r5jA:
undetectable		 5js5A-2r5jA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_2
(CYTOCHROME P450 2C9)		 2r5j MAJOR CAPSID PROTEIN
L1
(Alphapapillomavi
rus
9) 		3 / 3 LEU A 195
VAL A 201
ASP A 202
 None
 0.60A 5x23A-2r5jA:
undetectable		 5x23A-2r5jA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_1
(CYTOCHROME P450 1A1)		 2r5j MAJOR CAPSID PROTEIN
L1
(Alphapapillomavi
rus
9) 		3 / 3 SER A 226
SER A 227
ALA A  51
 None
 0.71A 6dwnC-2r5jA:
undetectable		 6dwnC-2r5jA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_B_ACTB403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 2r5j MAJOR CAPSID PROTEIN
L1
(Alphapapillomavi
rus
9) 		3 / 3 PHE A 305
ARG A 336
GLN A 155
 None
 1.18A 6g1pB-2r5jA:
undetectable		 6g1pB-2r5jA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_B_ACTB403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 2r5j MAJOR CAPSID PROTEIN
L1
(Alphapapillomavi
rus
9) 		3 / 3 PHE A 462
ARG A 466
GLN A 461
 None
 1.04A 6g1pB-2r5jA:
undetectable		 6g1pB-2r5jA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2r5j MAJOR CAPSID PROTEIN
L1
(Alphapapillomavi
rus
9) 		4 / 7 ASP A 197
THR A 445
TYR A 444
LEU A 195
 None
 1.19A 6nmfA-2r5jA:
undetectable
6nmfC-2r5jA:
undetectable
6nmfP-2r5jA:
undetectable		 6nmfA-2r5jA:
23.56
6nmfC-2r5jA:
20.14
6nmfP-2r5jA:
20.14