SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2r5m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_1
(FATTY ACID-BINDING
PROTEIN)		 2r5m POLYCOMB PROTEIN SCM
(Drosophila
melanogaster) 		3 / 3 TYR A 357
ARG A 364
GLN A 196
 None
 0.90A 1tw4A-2r5mA:
undetectable		 1tw4A-2r5mA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_2
(FIV PROTEASE)		 2r5m POLYCOMB PROTEIN SCM
(Drosophila
melanogaster) 		6 / 9 ALA A 225
ASP A 240
ILE A 224
GLY A 208
ILE A 207
LEU A 237
 None
 1.48A 3ogpB-2r5mA:
undetectable		 3ogpB-2r5mA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNJ_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 2r5m POLYCOMB PROTEIN SCM
(Drosophila
melanogaster) 		4 / 8 THR A 347
CYH A 359
TYR A 357
LEU A 320
 None
 1.47A 6cnjD-2r5mA:
undetectable
6cnjE-2r5mA:
undetectable		 6cnjD-2r5mA:
14.64
6cnjE-2r5mA:
13.11