SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2r5r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_C_BEZC1218_0
(PEROXIREDOXIN 6.)		 2r5r UPF0343 PROTEIN
NE1163
(Nitrosomonas
europaea) 		4 / 8 PRO A 116
VAL A 117
SER A 118
GLU A 208
 None
 0.99A 2v41C-2r5rA:
undetectable
2v41D-2r5rA:
undetectable		 2v41C-2r5rA:
22.48
2v41D-2r5rA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_F_BEZF1222_0
(PEROXIREDOXIN 6.)		 2r5r UPF0343 PROTEIN
NE1163
(Nitrosomonas
europaea) 		4 / 7 PRO A 116
VAL A 117
SER A 118
GLU A 208
 None
 1.02A 2v41E-2r5rA:
undetectable
2v41F-2r5rA:
undetectable		 2v41E-2r5rA:
22.48
2v41F-2r5rA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_B_H3PB552_1
(GLUTAMATE
DEHYDROGENASE)		 2r5r UPF0343 PROTEIN
NE1163
(Nitrosomonas
europaea) 		3 / 3 TYR A 200
TYR A 126
ILE A 111
 None
 0.78A 3eteA-2r5rA:
undetectable
3eteB-2r5rA:
undetectable		 3eteA-2r5rA:
21.41
3eteB-2r5rA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RFA_A_SAMA406_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE N)		 2r5r UPF0343 PROTEIN
NE1163
(Nitrosomonas
europaea) 		5 / 12 PHE A  61
MET A  92
GLU A  71
SER A  67
VAL A  26
 None
 1.28A 3rfaA-2r5rA:
0.4		 3rfaA-2r5rA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RFA_B_SAMB406_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE N)		 2r5r UPF0343 PROTEIN
NE1163
(Nitrosomonas
europaea) 		5 / 12 PHE A  61
MET A  92
GLU A  71
SER A  67
VAL A  26
 None
 1.29A 3rfaB-2r5rA:
0.1		 3rfaB-2r5rA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2r5r UPF0343 PROTEIN
NE1163
(Nitrosomonas
europaea) 		4 / 6 ILE A 131
VAL A 176
LEU A 233
ILE A 243
 None
 0.94A 4asdA-2r5rA:
undetectable		 4asdA-2r5rA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QT3_A_RAPA202_1
(FK506-BINDING
PROTEIN (FKBP)-TYPE
PEPTIDYL-PROPYL
ISOMERASE)		 2r5r UPF0343 PROTEIN
NE1163
(Nitrosomonas
europaea) 		5 / 10 ASP A 186
PHE A 181
GLU A  83
TYR A 109
ILE A 111
 None
IMD  A 270 (-4.5A)
None
None
None
 1.37A 4qt3A-2r5rA:
undetectable		 4qt3A-2r5rA:
21.63