SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2r5u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ6_A_CAMA502_0
(CYTOCHROME P450-CAM)		 2r5u REPLICATIVE DNA
HELICASE
(Mycobacterium
tuberculosis) 		4 / 5 PHE A  57
TYR A  66
LEU A  49
ASP A  56
 None
 1.33A 1dz6A-2r5uA:
undetectable		 1dz6A-2r5uA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1868_0
(FPRA)		 2r5u REPLICATIVE DNA
HELICASE
(Mycobacterium
tuberculosis) 		3 / 3 ALA A  61
HIS A  62
VAL A  65
 None
 0.28A 1lqtB-2r5uA:
undetectable		 1lqtB-2r5uA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1425_0
(FPRA)		 2r5u REPLICATIVE DNA
HELICASE
(Mycobacterium
tuberculosis) 		3 / 3 ALA A  61
HIS A  62
VAL A  65
 None
 0.28A 1lquB-2r5uA:
undetectable		 1lquB-2r5uA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 2r5u REPLICATIVE DNA
HELICASE
(Mycobacterium
tuberculosis) 		4 / 7 PHE A  57
TYR A  66
GLY A 117
ASP A  56
 None
 0.90A 2a1mA-2r5uA:
undetectable		 2a1mA-2r5uA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_D_SAMD201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 2r5u REPLICATIVE DNA
HELICASE
(Mycobacterium
tuberculosis) 		5 / 11 ILE A 107
ILE A  97
GLY A  99
LEU A  35
VAL A  65
 None
 0.87A 5twjD-2r5uA:
undetectable		 5twjD-2r5uA:
25.62