SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2r5v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K4T_D_TTCD990_1
(DNA TOPOISOMERASE I)		 2r5v PCZA361.1
(Amycolatopsis
orientalis) 		4 / 5 GLU A 297
ARG A 324
ASP A 160
THR A 214
 None
None
None
HHH  A4114 (-3.1A)
 1.43A 1k4tA-2r5vA:
undetectable		 1k4tA-2r5vA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RR8_A_TTCA100_1
(DNA TOPOISOMERASE I)		 2r5v PCZA361.1
(Amycolatopsis
orientalis) 		4 / 5 GLU A 297
ARG A 324
ASP A 160
THR A 214
 None
None
None
HHH  A4114 (-3.1A)
 1.41A 1rr8C-2r5vA:
undetectable		 1rr8C-2r5vA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RRJ_B_TTCB990_1
(DNA TOPOISOMERASE I)		 2r5v PCZA361.1
(Amycolatopsis
orientalis) 		4 / 5 GLU A 297
ARG A 324
ASP A 160
THR A 214
 None
None
None
HHH  A4114 (-3.1A)
 1.42A 1rrjA-2r5vA:
undetectable		 1rrjA-2r5vA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXD_B_RWFB2001_1
(SERUM ALBUMIN)		 2r5v PCZA361.1
(Amycolatopsis
orientalis) 		5 / 10 PHE A  29
TRP A  23
LEU A 156
ILE A 322
ALA A 243
 None
None
None
None
CO  A4113 ( 4.4A)
 1.32A 2bxdB-2r5vA:
0.0		 2bxdB-2r5vA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMJ_A_ACRA1001_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 2r5v PCZA361.1
(Amycolatopsis
orientalis) 		5 / 12 ASN A 292
ILE A 227
ILE A 216
PHE A 318
HIS A 241
 None
None
None
None
CO  A4113 ( 3.4A)
 1.41A 2qmjA-2r5vA:
undetectable		 2qmjA-2r5vA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO5_A_CHDA131_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 2r5v PCZA361.1
(Amycolatopsis
orientalis) 		5 / 12 ILE A 317
ILE A 335
ILE A 216
VAL A 203
HIS A 161
 None
HHH  A4114 (-4.3A)
None
None
CO  A4113 ( 3.3A)
 1.04A 2qo5A-2r5vA:
undetectable		 2qo5A-2r5vA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2r5v PCZA361.1
(Amycolatopsis
orientalis) 		5 / 12 ILE A 192
HIS A 241
LEU A 231
ILE A 216
MET A 199
 None
CO  A4113 ( 3.4A)
None
None
None
 1.05A 2xkwB-2r5vA:
undetectable		 2xkwB-2r5vA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_B_VDYB6178_1
(VITAMIN D
HYDROXYLASE)		 2r5v PCZA361.1
(Amycolatopsis
orientalis) 		5 / 12 MET A  11
LEU A  54
ILE A 242
THR A 308
VAL A 261
 None
 1.39A 3a51B-2r5vA:
undetectable		 3a51B-2r5vA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 2r5v PCZA361.1
(Amycolatopsis
orientalis) 		5 / 12 LEU A  52
ALA A 243
VAL A  75
PHE A 119
LEU A 166
 None
CO  A4113 ( 4.4A)
None
None
None
 1.34A 3b0wB-2r5vA:
undetectable		 3b0wB-2r5vA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_A_SALA257_1
(TRANSCRIPTIONAL
REGULATOR)		 2r5v PCZA361.1
(Amycolatopsis
orientalis) 		4 / 8 SER A  35
THR A 125
ILE A 127
THR A 113
 None
 0.97A 3bpxA-2r5vA:
undetectable
3bpxB-2r5vA:
undetectable		 3bpxA-2r5vA:
18.11
3bpxB-2r5vA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2r5v PCZA361.1
(Amycolatopsis
orientalis) 		4 / 7 TYR A 178
ILE A 164
GLY A 118
VAL A   9
 None
 0.89A 3elzA-2r5vA:
undetectable		 3elzA-2r5vA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_C_VIAC901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 2r5v PCZA361.1
(Amycolatopsis
orientalis) 		4 / 7 HIS A 241
LEU A 171
PHE A 119
VAL A 122
 CO  A4113 ( 3.4A)
None
None
None
 1.08A 3jwqC-2r5vA:
undetectable		 3jwqC-2r5vA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F5Z_A_BEZA302_0
(HALOALKANE
DEHALOGENASE)		 2r5v PCZA361.1
(Amycolatopsis
orientalis) 		4 / 8 ASP A 160
VAL A 203
LEU A 303
HIS A 161
 None
None
None
CO  A4113 ( 3.3A)
 0.97A 4f5zA-2r5vA:
undetectable		 4f5zA-2r5vA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2r5v PCZA361.1
(Amycolatopsis
orientalis) 		4 / 5 THR A 113
THR A 125
THR A  55
HIS A  40
 None
 1.30A 4pgfB-2r5vA:
undetectable		 4pgfB-2r5vA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN)		 2r5v PCZA361.1
(Amycolatopsis
orientalis) 		5 / 12 ALA A 134
SER A 133
GLY A 131
ALA A  79
TYR A   8
 None
 1.15A 4r29A-2r5vA:
undetectable		 4r29A-2r5vA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN)		 2r5v PCZA361.1
(Amycolatopsis
orientalis) 		5 / 12 ALA A 134
SER A 133
GLY A 131
ALA A  79
TYR A   8
 None
 1.18A 4r29B-2r5vA:
undetectable		 4r29B-2r5vA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN)		 2r5v PCZA361.1
(Amycolatopsis
orientalis) 		5 / 12 ALA A 134
SER A 133
GLY A 131
ALA A  79
TYR A   8
 None
 1.24A 4r29C-2r5vA:
undetectable		 4r29C-2r5vA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		 2r5v PCZA361.1
(Amycolatopsis
orientalis) 		4 / 6 SER A 284
LEU A 285
ASP A 286
LEU A 280
 None
 0.82A 4wozA-2r5vA:
undetectable
4wozB-2r5vA:
undetectable		 4wozA-2r5vA:
22.19
4wozB-2r5vA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)		 2r5v PCZA361.1
(Amycolatopsis
orientalis) 		5 / 11 ASP A  77
ALA A  79
VAL A 239
GLY A 118
PHE A 119
 None
 1.25A 4xp4A-2r5vA:
undetectable		 4xp4A-2r5vA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 2r5v PCZA361.1
(Amycolatopsis
orientalis) 		4 / 8 LEU A 303
ILE A 216
THR A 214
GLN A 240
 None
None
HHH  A4114 (-3.1A)
None
 0.97A 5ljbA-2r5vA:
undetectable		 5ljbA-2r5vA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MFX_A_ACTA701_0
(GENOME POLYPROTEIN)		 2r5v PCZA361.1
(Amycolatopsis
orientalis) 		4 / 5 THR A 125
HIS A 124
ALA A  79
ASP A  77
 None
 1.44A 5mfxA-2r5vA:
undetectable		 5mfxA-2r5vA:
22.48