SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2r62'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_A_D16A414_1
(THYMIDYLATE SYNTHASE)		 2r62 CELL DIVISION
PROTEASE FTSH
HOMOLOG
(Helicobacter
pylori) 		5 / 12 PHE A 232
ILE A 266
ASP A 269
GLY A 235
ALA A 316
 None
 1.10A 1hvyA-2r62A:
undetectable		 1hvyA-2r62A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_A_LYAA317_1
(THYMIDYLATE SYNTHASE)		 2r62 CELL DIVISION
PROTEASE FTSH
HOMOLOG
(Helicobacter
pylori) 		5 / 11 PHE A 232
ILE A 266
ASP A 269
GLY A 235
ALA A 316
 None
 1.03A 1ju6A-2r62A:
undetectable		 1ju6A-2r62A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		 2r62 CELL DIVISION
PROTEASE FTSH
HOMOLOG
(Helicobacter
pylori) 		5 / 11 PHE A 232
ILE A 266
ASP A 269
GLY A 235
ALA A 316
 None
 1.04A 1ju6D-2r62A:
undetectable		 1ju6D-2r62A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		 2r62 CELL DIVISION
PROTEASE FTSH
HOMOLOG
(Helicobacter
pylori) 		5 / 10 GLY A 205
VAL A 313
LEU A 297
LEU A 327
ALA A 315
 None
 1.39A 1pbcA-2r62A:
undetectable		 1pbcA-2r62A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_A_SAMA501_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 2r62 CELL DIVISION
PROTEASE FTSH
HOMOLOG
(Helicobacter
pylori) 		5 / 12 MET A 242
GLY A 236
PHE A 239
ALA A 273
ASP A 272
 None
 1.48A 2avdA-2r62A:
undetectable		 2avdA-2r62A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_A_SAMA1300_0
(UPF0088 PROTEIN
AQ_165)		 2r62 CELL DIVISION
PROTEASE FTSH
HOMOLOG
(Helicobacter
pylori) 		5 / 12 LEU A 314
GLY A 235
LEU A 207
LEU A 208
ALA A 220
 None
 0.85A 2egvA-2r62A:
undetectable		 2egvA-2r62A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_B_SAMB1400_0
(UPF0088 PROTEIN
AQ_165)		 2r62 CELL DIVISION
PROTEASE FTSH
HOMOLOG
(Helicobacter
pylori) 		5 / 12 LEU A 314
GLY A 235
LEU A 207
LEU A 208
ALA A 220
 None
 0.92A 2egvB-2r62A:
undetectable		 2egvB-2r62A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_3
(PROTEASE)		 2r62 CELL DIVISION
PROTEASE FTSH
HOMOLOG
(Helicobacter
pylori) 		5 / 12 LEU A 372
GLY A 375
ASP A 380
GLY A 412
ILE A 413
 None
 0.93A 2nnkB-2r62A:
undetectable		 2nnkB-2r62A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_1
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 2r62 CELL DIVISION
PROTEASE FTSH
HOMOLOG
(Helicobacter
pylori) 		5 / 12 ALA A 316
ALA A 315
ILE A 274
PHE A 267
LEU A 254
 None
 1.08A 2nyrA-2r62A:
undetectable		 2nyrA-2r62A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 2r62 CELL DIVISION
PROTEASE FTSH
HOMOLOG
(Helicobacter
pylori) 		4 / 8 PHE A 344
GLY A 375
LEU A 381
PRO A 342
 None
 1.10A 3bgdB-2r62A:
2.1		 3bgdB-2r62A:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_0
(METHYLTRANSFERASE
MPPJ)		 2r62 CELL DIVISION
PROTEASE FTSH
HOMOLOG
(Helicobacter
pylori) 		5 / 12 ILE A 266
GLY A 235
ILE A 271
ALA A 315
ALA A 273
 None
 1.11A 4kicB-2r62A:
undetectable		 4kicB-2r62A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_A_C2FA402_0
(THYMIDYLATE SYNTHASE)		 2r62 CELL DIVISION
PROTEASE FTSH
HOMOLOG
(Helicobacter
pylori) 		5 / 11 PHE A 232
ILE A 266
ASP A 269
GLY A 235
ALA A 316
 None
 1.08A 5fctA-2r62A:
undetectable		 5fctA-2r62A:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_E_D16E402_1
(THYMIDYLATE SYNTHASE)		 2r62 CELL DIVISION
PROTEASE FTSH
HOMOLOG
(Helicobacter
pylori) 		4 / 6 PHE A 232
ILE A 266
ASP A 269
GLY A 235
 None
 0.85A 5x5qE-2r62A:
undetectable		 5x5qE-2r62A:
20.70