SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2r6f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_A_DVAA8_0
(ACTINOMYCIN D)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		3 / 3 THR A 856
THR A 857
PRO A 855
 None
 0.79A 1a7yA-2r6fA:
undetectable		 1a7yA-2r6fA:
2.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4002_1
(SERUM ALBUMIN)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		4 / 4 ARG A 480
ALA A 482
ALA A 490
GLU A 489
 ADP  A1001 (-3.6A)
None
None
ADP  A1001 ( 4.8A)
 0.97A 1e7bB-2r6fA:
1.8		 1e7bB-2r6fA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_H_TRPH81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		5 / 9 HIS A 518
HIS A 886
ALA A 634
THR A 928
ILE A 891
 None
 1.31A 1gtnG-2r6fA:
2.3
1gtnH-2r6fA:
undetectable		 1gtnG-2r6fA:
6.07
1gtnH-2r6fA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		5 / 10 HIS A 518
HIS A 886
ALA A 634
THR A 928
ILE A 891
 None
 1.37A 1gtnN-2r6fA:
2.1
1gtnO-2r6fA:
2.3		 1gtnN-2r6fA:
6.07
1gtnO-2r6fA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		5 / 10 HIS A 518
HIS A 886
HIS A 927
THR A 928
ILE A 891
 None
 1.18A 1gtnN-2r6fA:
2.1
1gtnO-2r6fA:
2.3		 1gtnN-2r6fA:
6.07
1gtnO-2r6fA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_E_DVAE2_0
(ACTINOMYCIN D)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		3 / 3 THR A 857
PRO A 855
THR A 856
 None
 0.84A 1i3wE-2r6fA:
undetectable		 1i3wE-2r6fA:
2.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_E_DVAE8_0
(ACTINOMYCIN D)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		3 / 3 THR A 856
THR A 857
PRO A 855
 None
 0.87A 1i3wE-2r6fA:
undetectable		 1i3wE-2r6fA:
2.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_F_DVAF8_0
(ACTINOMYCIN D)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		3 / 3 THR A 856
THR A 857
PRO A 855
 None
 0.80A 1i3wF-2r6fA:
undetectable		 1i3wF-2r6fA:
2.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_G_DVAG2_0
(ACTINOMYCIN D)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		3 / 3 THR A 857
PRO A 855
THR A 856
 None
 0.87A 1i3wG-2r6fA:
undetectable		 1i3wG-2r6fA:
2.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_G_DVAG8_0
(ACTINOMYCIN D)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		3 / 3 THR A 856
THR A 857
PRO A 855
 None
 0.86A 1i3wG-2r6fA:
undetectable		 1i3wG-2r6fA:
2.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_H_DVAH8_0
(ACTINOMYCIN D)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		3 / 3 THR A 856
THR A 857
PRO A 855
 None
 0.87A 1i3wH-2r6fA:
undetectable		 1i3wH-2r6fA:
2.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQW_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		5 / 12 ILE A  17
VAL A 509
LEU A  40
LEU A  79
ILE A  76
 None
 1.17A 1kqwA-2r6fA:
undetectable		 1kqwA-2r6fA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MNV_D_DVAD2_0
(ACTINOMYCIN D)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		3 / 3 THR A 857
PRO A 855
THR A 856
 None
 0.82A 1mnvD-2r6fA:
undetectable		 1mnvD-2r6fA:
2.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MNV_D_DVAD8_0
(ACTINOMYCIN D)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		3 / 3 THR A 856
THR A 857
PRO A 855
 None
 0.76A 1mnvD-2r6fA:
undetectable		 1mnvD-2r6fA:
2.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		4 / 5 LEU A 772
CYH A 736
ALA A 738
CYH A 739
 None
ZN  A1006 (-2.3A)
ZN  A1006 ( 4.2A)
ZN  A1006 (-2.3A)
 0.99A 1mz9D-2r6fA:
undetectable		 1mz9D-2r6fA:
5.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OVF_B_DVAB2_0
(ACTINOMYCIN D)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		3 / 3 THR A 857
PRO A 855
THR A 856
 None
 0.86A 1ovfB-2r6fA:
undetectable		 1ovfB-2r6fA:
2.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_A_DVAA8_0
(ACTINOMYCIN X2)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		3 / 3 THR A 856
THR A 857
PRO A 855
 None
 0.78A 1qfiA-2r6fA:
undetectable		 1qfiA-2r6fA:
2.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_F_DVAF2_0
(7-AMINO-ACTINOMYCIN
D)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		3 / 3 THR A 857
PRO A 855
THR A 856
 None
 0.85A 1unjF-2r6fA:
undetectable		 1unjF-2r6fA:
2.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_F_DVAF8_0
(7-AMINO-ACTINOMYCIN
D)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		3 / 3 THR A 856
THR A 857
PRO A 855
 None
 0.78A 1unjF-2r6fA:
undetectable		 1unjF-2r6fA:
2.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_R_DVAR8_0
(7-AMINO-ACTINOMYCIN
D)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		3 / 3 THR A 856
THR A 857
PRO A 855
 None
 0.83A 1unjR-2r6fA:
undetectable		 1unjR-2r6fA:
2.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_N_TRPN81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		5 / 10 HIS A 518
HIS A 886
HIS A 927
THR A 928
ILE A 891
 None
 1.23A 1utdN-2r6fA:
2.2
1utdO-2r6fA:
2.2		 1utdN-2r6fA:
6.07
1utdO-2r6fA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_R_TRPR81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		5 / 10 HIS A 518
HIS A 886
HIS A 927
THR A 928
ILE A 891
 None
 1.21A 1utdR-2r6fA:
2.3
1utdS-2r6fA:
2.1		 1utdR-2r6fA:
6.07
1utdS-2r6fA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		4 / 7 ILE A 689
LEU A 826
THR A 808
LEU A 809
 None
 0.87A 1v55A-2r6fA:
undetectable
1v55J-2r6fA:
undetectable		 1v55A-2r6fA:
19.77
1v55J-2r6fA:
5.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC2_0
(N8-ACTINOMYCIN D)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		3 / 3 THR A 699
PRO A 697
THR A 701
 None
 0.82A 209dC-2r6fA:
undetectable		 209dC-2r6fA:
2.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		4 / 8 LEU A 852
VAL A 870
LEU A 868
VAL A 890
 None
 0.98A 2bdmA-2r6fA:
1.7		 2bdmA-2r6fA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I2Z_A_SALA1100_1
(SERUM ALBUMIN)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		4 / 5 LEU A 678
LEU A 651
ILE A 672
ALA A 656
 None
 0.73A 2i2zA-2r6fA:
1.9		 2i2zA-2r6fA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		4 / 5 LEU A 752
VAL A 541
LEU A 539
ARG A 492
 None
 0.91A 2oiqA-2r6fA:
undetectable		 2oiqA-2r6fA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PIW_A_T3A932_1
(ANDROGEN RECEPTOR)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		4 / 6 LEU A 507
VAL A 509
ILE A 540
ILE A   4
 None
 0.88A 2piwA-2r6fA:
undetectable		 2piwA-2r6fA:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		3 / 3 ASP A 606
THR A 916
PRO A 917
 None
 0.69A 2pynB-2r6fA:
undetectable		 2pynB-2r6fA:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		3 / 3 ASP A 606
THR A 916
PRO A 917
 None
 0.68A 2qakB-2r6fA:
undetectable		 2qakB-2r6fA:
7.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKK_E_MFXE1100_1
(TOPOISOMERASE IV
DNA)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		3 / 3 ARG A 930
GLU A 546
SER A 926
 None
 0.94A 2xkkA-2r6fA:
undetectable
2xkkC-2r6fA:
undetectable		 2xkkA-2r6fA:
24.34
2xkkC-2r6fA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRL_A_DXTA1211_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		5 / 12 PHE A 632
HIS A 872
THR A 916
LEU A 932
ILE A 891
 None
 1.41A 2xrlA-2r6fA:
undetectable		 2xrlA-2r6fA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		3 / 3 ARG A 411
ASP A 106
ASN A 268
 None
 0.54A 2zzmA-2r6fA:
undetectable		 2zzmA-2r6fA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		4 / 8 ILE A 689
LEU A 826
THR A 808
LEU A 809
 None
 0.87A 3abmN-2r6fA:
undetectable
3abmW-2r6fA:
undetectable		 3abmN-2r6fA:
19.77
3abmW-2r6fA:
5.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		4 / 7 ILE A 689
LEU A 826
THR A 808
LEU A 809
 None
 0.91A 3ag3A-2r6fA:
undetectable
3ag3J-2r6fA:
undetectable		 3ag3A-2r6fA:
19.77
3ag3J-2r6fA:
5.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCM_X_SAMX5452_0
(UNCHARACTERIZED
PROTEIN TM_1570)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		5 / 11 GLY A 901
GLY A 909
ILE A 884
SER A 639
VAL A 638
 None
 0.93A 3dcmX-2r6fA:
undetectable		 3dcmX-2r6fA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB301_0
(DISULFIDE
INTERCHANGE PROTEIN)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		4 / 6 LYS A 658
ALA A 656
PRO A 666
HIS A 669
 None
 1.34A 3gv1A-2r6fA:
undetectable
3gv1B-2r6fA:
undetectable		 3gv1A-2r6fA:
9.03
3gv1B-2r6fA:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IAZ_A_AINA1202_1
(LACTOTRANSFERRIN)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		3 / 3 GLU A 830
GLY A 858
THR A 857
 None
 0.57A 3iazA-2r6fA:
undetectable		 3iazA-2r6fA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		4 / 6 LEU A 809
VAL A 883
VAL A 870
ILE A 684
 None
 1.20A 3k5vB-2r6fA:
undetectable		 3k5vB-2r6fA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_A_AC2A301_1
(DEOXYCYTIDINE KINASE)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		5 / 9 ILE A 864
GLU A 546
ARG A 938
ASP A 939
LEU A 868
 None
 1.36A 3mjrA-2r6fA:
undetectable		 3mjrA-2r6fA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_2
(PROTEASE)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		3 / 3 ARG A 533
LEU A 539
THR A 548
 None
 0.85A 3oxcA-2r6fA:
undetectable		 3oxcA-2r6fA:
7.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_2
(HIV-1 PROTEASE)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		5 / 10 LEU A 849
ASP A 853
VAL A 650
VAL A 681
ILE A 851
 None
 1.03A 3oxwD-2r6fA:
undetectable		 3oxwD-2r6fA:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_B_ACRB701_1
(ALPHA-GLUCOSIDASE)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		5 / 12 ILE A 898
ILE A 864
ILE A 596
PHE A 632
HIS A 872
 None
 1.12A 3phaB-2r6fA:
undetectable		 3phaB-2r6fA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_1
(HIV-1 PROTEASE)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		5 / 8 ASN A 696
GLY A 820
GLY A 743
ILE A 744
THR A 692
 None
None
ZN  A1006 ( 4.4A)
None
None
 1.49A 3so9A-2r6fA:
undetectable		 3so9A-2r6fA:
7.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUG_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		5 / 12 VAL A 757
ARG A  10
GLY A  49
ALA A  47
ASP A  72
 None
 0.99A 3sugA-2r6fA:
undetectable		 3sugA-2r6fA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_2
(CARBONIC ANHYDRASE)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		3 / 3 GLN A 368
PHE A 356
TYR A 358
 None
 0.96A 3ucjB-2r6fA:
undetectable		 3ucjB-2r6fA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V7P_A_BEZA430_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		4 / 7 ILE A 426
GLY A 427
PHE A 441
PHE A 440
 None
 0.68A 3v7pA-2r6fA:
undetectable		 3v7pA-2r6fA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		4 / 8 TYR A 315
VAL A 375
ILE A 376
ASN A 378
 None
 1.07A 4a97C-2r6fA:
undetectable		 4a97C-2r6fA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		4 / 8 TYR A 315
VAL A 375
ILE A 376
ASN A 378
 None
 1.10A 4a97G-2r6fA:
undetectable		 4a97G-2r6fA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_2
(GUANINE DEAMINASE)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		4 / 5 HIS A 660
LEU A 852
LEU A 882
ASP A 853
 None
 1.19A 4aqlA-2r6fA:
2.4		 4aqlA-2r6fA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		5 / 12 VAL A 101
ASP A 106
THR A 477
ILE A 461
ILE A 426
 None
 1.26A 4eb6B-2r6fA:
undetectable
4eb6C-2r6fA:
undetectable		 4eb6B-2r6fA:
19.49
4eb6C-2r6fA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_B_ASWB1301_1
(DNA TOPOISOMERASE
2-BETA)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		4 / 7 ILE A 292
PRO A 293
ALA A 303
GLN A 394
 None
 0.92A 4g0uB-2r6fA:
2.2		 4g0uB-2r6fA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G10_A_ACTA301_0
(GLUTATHIONE
S-TRANSFERASE
HOMOLOG)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		4 / 6 ILE A 370
TYR A 358
TYR A 314
PHE A 356
 None
 0.72A 4g10A-2r6fA:
undetectable		 4g10A-2r6fA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HIV_D_DVAD2_0
(ACTINOMYCIN D)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		3 / 3 THR A 857
PRO A 855
THR A 856
 None
 0.88A 4hivD-2r6fA:
undetectable		 4hivD-2r6fA:
2.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQ1_B_NPSB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		4 / 8 VAL A 375
VAL A 291
ILE A 292
LEU A 299
 None
 0.74A 4jq1B-2r6fA:
undetectable		 4jq1B-2r6fA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_B_STRB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		4 / 6 VAL A 375
VAL A 291
ILE A 292
LEU A 299
 None
 0.85A 4l1wB-2r6fA:
undetectable		 4l1wB-2r6fA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2R_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		4 / 4 HIS A 886
GLU A 512
HIS A 544
LEU A 867
 None
 1.43A 4m2rA-2r6fA:
undetectable		 4m2rA-2r6fA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCU_A_SAMA603_0
(CYSTATHIONINE
BETA-SYNTHASE)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		4 / 7 ASP A 853
GLN A 832
THR A 857
ILE A 515
 None
 1.05A 4pcuA-2r6fA:
undetectable		 4pcuA-2r6fA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		4 / 8 THR A 701
ILE A 707
LEU A 814
PHE A 704
 None
 1.00A 4r38B-2r6fA:
undetectable		 4r38B-2r6fA:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		4 / 6 SER A 644
GLY A 488
GLU A 489
ASP A 511
 ADP  A1001 (-2.4A)
None
ADP  A1001 ( 4.8A)
None
 0.99A 4uckB-2r6fA:
undetectable		 4uckB-2r6fA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0S_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 610
LEU A 651
ILE A 672
VAL A 681
LEU A 678
 None
 0.93A 4y0sA-2r6fA:
undetectable		 4y0sA-2r6fA:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0S_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		5 / 12 VAL A 635
LEU A 849
LEU A 655
VAL A 612
LEU A 629
 None
 0.86A 4y0sA-2r6fA:
undetectable		 4y0sA-2r6fA:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_B_ADNB902_1
(MYOSIN HEAVY CHAIN
KINASE A)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		5 / 10 PHE A 632
VAL A 890
LEU A 859
LEU A 868
LEU A 867
 None
 1.26A 4zmeB-2r6fA:
undetectable		 4zmeB-2r6fA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		5 / 10 HIS A 518
HIS A 886
HIS A 927
THR A 928
ILE A 897
 None
 1.47A 5eeuG-2r6fA:
2.1
5eeuH-2r6fA:
2.2		 5eeuG-2r6fA:
6.07
5eeuH-2r6fA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		5 / 10 HIS A 518
HIS A 886
HIS A 927
THR A 928
ILE A 891
 None
 1.17A 5eeuR-2r6fA:
2.1
5eeuS-2r6fA:
2.1		 5eeuR-2r6fA:
6.07
5eeuS-2r6fA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		5 / 10 HIS A 518
HIS A 886
HIS A 927
THR A 928
ILE A 891
 None
 1.17A 5eeuT-2r6fA:
2.2
5eeuU-2r6fA:
2.2		 5eeuT-2r6fA:
6.07
5eeuU-2r6fA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		5 / 10 HIS A 518
HIS A 886
HIS A 927
THR A 928
ILE A 897
 None
 1.47A 5eevG-2r6fA:
2.2
5eevH-2r6fA:
2.1		 5eevG-2r6fA:
6.07
5eevH-2r6fA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		5 / 10 HIS A 518
HIS A 886
HIS A 927
THR A 928
ILE A 891
 None
 1.17A 5eevR-2r6fA:
2.1
5eevS-2r6fA:
2.2		 5eevR-2r6fA:
6.07
5eevS-2r6fA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		5 / 10 HIS A 518
HIS A 886
HIS A 927
THR A 928
ILE A 891
 None
 1.17A 5eevT-2r6fA:
2.1
5eevU-2r6fA:
2.2		 5eevT-2r6fA:
6.07
5eevU-2r6fA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		5 / 10 HIS A 518
HIS A 886
HIS A 927
THR A 928
ILE A 891
 None
 1.18A 5eewR-2r6fA:
2.1
5eewS-2r6fA:
2.2		 5eewR-2r6fA:
6.07
5eewS-2r6fA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		5 / 10 HIS A 518
HIS A 886
HIS A 927
THR A 928
ILE A 891
 None
 1.17A 5eewT-2r6fA:
2.2
5eewU-2r6fA:
2.2		 5eewT-2r6fA:
6.07
5eewU-2r6fA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		5 / 11 HIS A 518
HIS A 886
ALA A 634
THR A 928
ILE A 891
 None
 1.29A 5eexI-2r6fA:
2.2
5eexJ-2r6fA:
2.0		 5eexI-2r6fA:
6.07
5eexJ-2r6fA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		5 / 11 HIS A 518
HIS A 886
HIS A 927
THR A 928
ILE A 891
 None
 1.21A 5eexI-2r6fA:
2.2
5eexJ-2r6fA:
2.0		 5eexI-2r6fA:
6.07
5eexJ-2r6fA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		5 / 10 HIS A 518
HIS A 886
ALA A 634
THR A 928
ILE A 891
 None
 1.30A 5eexA-2r6fA:
2.2
5eexK-2r6fA:
2.1		 5eexA-2r6fA:
6.07
5eexK-2r6fA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		5 / 10 HIS A 518
HIS A 886
HIS A 927
THR A 928
ILE A 891
 None
 1.20A 5eexA-2r6fA:
2.2
5eexK-2r6fA:
2.1		 5eexA-2r6fA:
6.07
5eexK-2r6fA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		5 / 10 HIS A 518
HIS A 886
HIS A 927
THR A 928
ILE A 891
 None
 1.17A 5eexR-2r6fA:
2.1
5eexS-2r6fA:
2.1		 5eexR-2r6fA:
6.07
5eexS-2r6fA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		5 / 10 HIS A 518
HIS A 886
HIS A 927
THR A 928
ILE A 891
 None
 1.17A 5eexT-2r6fA:
2.1
5eexU-2r6fA:
2.2		 5eexT-2r6fA:
6.07
5eexU-2r6fA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		5 / 11 HIS A 518
HIS A 886
ALA A 634
THR A 928
ILE A 891
 None
 1.29A 5eeyI-2r6fA:
2.2
5eeyJ-2r6fA:
2.0		 5eeyI-2r6fA:
6.07
5eeyJ-2r6fA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		5 / 11 HIS A 518
HIS A 886
HIS A 927
THR A 928
ILE A 891
 None
 1.21A 5eeyI-2r6fA:
2.2
5eeyJ-2r6fA:
2.0		 5eeyI-2r6fA:
6.07
5eeyJ-2r6fA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		5 / 10 HIS A 518
HIS A 886
HIS A 927
THR A 928
ILE A 891
 None
 1.17A 5eeyR-2r6fA:
2.1
5eeyS-2r6fA:
2.2		 5eeyR-2r6fA:
6.07
5eeyS-2r6fA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		5 / 10 HIS A 518
HIS A 886
HIS A 927
THR A 928
ILE A 891
 None
 1.17A 5eeyT-2r6fA:
2.2
5eeyU-2r6fA:
2.2		 5eeyT-2r6fA:
6.07
5eeyU-2r6fA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		5 / 11 HIS A 518
HIS A 886
ALA A 634
THR A 928
ILE A 891
 None
 1.29A 5eezI-2r6fA:
2.2
5eezJ-2r6fA:
2.0		 5eezI-2r6fA:
6.07
5eezJ-2r6fA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		5 / 11 HIS A 518
HIS A 886
HIS A 927
THR A 928
ILE A 891
 None
 1.21A 5eezI-2r6fA:
2.2
5eezJ-2r6fA:
2.0		 5eezI-2r6fA:
6.07
5eezJ-2r6fA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		5 / 10 HIS A 518
HIS A 886
HIS A 927
THR A 928
ILE A 891
 None
 1.17A 5eezR-2r6fA:
2.2
5eezS-2r6fA:
2.1		 5eezR-2r6fA:
6.07
5eezS-2r6fA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		5 / 10 HIS A 518
HIS A 886
HIS A 927
THR A 928
ILE A 891
 None
 1.17A 5eezT-2r6fA:
2.2
5eezU-2r6fA:
2.2		 5eezT-2r6fA:
6.07
5eezU-2r6fA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		5 / 11 HIS A 518
HIS A 886
ALA A 634
THR A 928
ILE A 891
 None
 1.28A 5ef0I-2r6fA:
2.2
5ef0J-2r6fA:
2.0		 5ef0I-2r6fA:
6.07
5ef0J-2r6fA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		5 / 11 HIS A 518
HIS A 886
HIS A 927
THR A 928
ILE A 891
 None
 1.21A 5ef0I-2r6fA:
2.2
5ef0J-2r6fA:
2.0		 5ef0I-2r6fA:
6.07
5ef0J-2r6fA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		5 / 10 HIS A 518
HIS A 886
ALA A 634
THR A 928
ILE A 891
 None
 1.29A 5ef0A-2r6fA:
2.2
5ef0K-2r6fA:
2.2		 5ef0A-2r6fA:
6.07
5ef0K-2r6fA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		5 / 10 HIS A 518
HIS A 886
HIS A 927
THR A 928
ILE A 891
 None
 1.20A 5ef0A-2r6fA:
2.2
5ef0K-2r6fA:
2.2		 5ef0A-2r6fA:
6.07
5ef0K-2r6fA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		5 / 10 HIS A 518
HIS A 886
HIS A 927
THR A 928
ILE A 891
 None
 1.17A 5ef0R-2r6fA:
2.2
5ef0S-2r6fA:
2.1		 5ef0R-2r6fA:
6.07
5ef0S-2r6fA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		5 / 10 HIS A 518
HIS A 886
HIS A 927
THR A 928
ILE A 891
 None
 1.17A 5ef0T-2r6fA:
2.2
5ef0U-2r6fA:
2.2		 5ef0T-2r6fA:
6.07
5ef0U-2r6fA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		5 / 11 HIS A 518
HIS A 886
ALA A 634
THR A 928
ILE A 891
 None
 1.29A 5ef1I-2r6fA:
2.2
5ef1J-2r6fA:
2.1		 5ef1I-2r6fA:
6.07
5ef1J-2r6fA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		5 / 11 HIS A 518
HIS A 886
HIS A 927
THR A 928
ILE A 891
 None
 1.21A 5ef1I-2r6fA:
2.2
5ef1J-2r6fA:
2.1		 5ef1I-2r6fA:
6.07
5ef1J-2r6fA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		5 / 10 HIS A 518
HIS A 886
HIS A 927
THR A 928
ILE A 891
 None
 1.18A 5ef1R-2r6fA:
2.1
5ef1S-2r6fA:
2.1		 5ef1R-2r6fA:
6.07
5ef1S-2r6fA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		5 / 10 HIS A 518
HIS A 886
HIS A 927
THR A 928
ILE A 891
 None
 1.17A 5ef1T-2r6fA:
2.1
5ef1U-2r6fA:
2.2		 5ef1T-2r6fA:
6.07
5ef1U-2r6fA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		5 / 11 HIS A 518
HIS A 886
ALA A 634
THR A 928
ILE A 891
 None
 1.29A 5ef2I-2r6fA:
2.2
5ef2J-2r6fA:
undetectable		 5ef2I-2r6fA:
6.07
5ef2J-2r6fA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		5 / 11 HIS A 518
HIS A 886
HIS A 927
THR A 928
ILE A 891
 None
 1.21A 5ef2I-2r6fA:
2.2
5ef2J-2r6fA:
undetectable		 5ef2I-2r6fA:
6.07
5ef2J-2r6fA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		5 / 10 HIS A 518
HIS A 886
HIS A 927
THR A 928
ILE A 891
 None
 1.17A 5ef2R-2r6fA:
2.2
5ef2S-2r6fA:
2.1		 5ef2R-2r6fA:
6.07
5ef2S-2r6fA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		5 / 10 HIS A 518
HIS A 886
HIS A 927
THR A 928
ILE A 891
 None
 1.17A 5ef2T-2r6fA:
2.1
5ef2U-2r6fA:
2.2		 5ef2T-2r6fA:
6.07
5ef2U-2r6fA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		5 / 11 HIS A 518
HIS A 886
ALA A 634
THR A 928
ILE A 891
 None
 1.29A 5ef3I-2r6fA:
2.2
5ef3J-2r6fA:
2.0		 5ef3I-2r6fA:
6.07
5ef3J-2r6fA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		5 / 11 HIS A 518
HIS A 886
HIS A 927
THR A 928
ILE A 891
 None
 1.21A 5ef3I-2r6fA:
2.2
5ef3J-2r6fA:
2.0		 5ef3I-2r6fA:
6.07
5ef3J-2r6fA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		5 / 10 HIS A 518
HIS A 886
ALA A 634
THR A 928
ILE A 891
 None
 1.30A 5ef3A-2r6fA:
2.2
5ef3K-2r6fA:
2.2		 5ef3A-2r6fA:
6.07
5ef3K-2r6fA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		5 / 10 HIS A 518
HIS A 886
HIS A 927
THR A 928
ILE A 891
 None
 1.20A 5ef3A-2r6fA:
2.2
5ef3K-2r6fA:
2.2		 5ef3A-2r6fA:
6.07
5ef3K-2r6fA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		5 / 10 HIS A 518
HIS A 886
HIS A 927
THR A 928
ILE A 891
 None
 1.18A 5ef3R-2r6fA:
2.2
5ef3S-2r6fA:
2.1		 5ef3R-2r6fA:
6.07
5ef3S-2r6fA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		5 / 10 HIS A 518
HIS A 886
HIS A 927
THR A 928
ILE A 891
 None
 1.17A 5ef3T-2r6fA:
2.2
5ef3U-2r6fA:
2.2		 5ef3T-2r6fA:
6.07
5ef3U-2r6fA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESE_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		4 / 8 TYR A 315
LEU A 318
ILE A 304
PHE A 372
 None
 0.90A 5eseA-2r6fA:
undetectable		 5eseA-2r6fA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		5 / 12 ALA A 482
ILE A 115
PHE A 441
GLY A 422
THR A 477
 None
 1.19A 5jlcA-2r6fA:
undetectable		 5jlcA-2r6fA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUE_A_VIVA302_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		5 / 12 ILE A 328
VAL A 332
LEU A 299
ILE A 304
PHE A 372
 None
 0.89A 5mueA-2r6fA:
undetectable		 5mueA-2r6fA:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_D_PFLD410_1
(PROTON-GATED ION
CHANNEL)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		5 / 9 PRO A  22
TYR A 554
ILE A 556
VAL A  19
ILE A 540
 None
 1.30A 5mzrD-2r6fA:
undetectable		 5mzrD-2r6fA:
5.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		5 / 12 VAL A 650
THR A 645
LEU A 675
LEU A 678
VAL A 681
 None
ADP  A1001 (-3.7A)
None
None
None
 1.36A 6a93B-2r6fA:
undetectable		 6a93B-2r6fA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AF6_A_GLYA507_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		3 / 3 TYR A  60
HIS A 750
MET A 749
 None
 1.18A 6af6A-2r6fA:
undetectable		 6af6A-2r6fA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_B_ACTB804_0
(UNCHARACTERIZED
PROTEIN)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		4 / 4 HIS A 872
VAL A 890
LEU A 868
ALA A 894
 None
 1.41A 6d8pB-2r6fA:
undetectable		 6d8pB-2r6fA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2r6f EXCINUCLEASE ABC
SUBUNIT A
(Geobacillus
stearothermophil
us) 		4 / 5 ILE A 689
LEU A 826
THR A 808
LEU A 809
 None
 0.90A 6nmpN-2r6fA:
undetectable
6nmpW-2r6fA:
undetectable		 6nmpN-2r6fA:
19.77
6nmpW-2r6fA:
5.05