SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2r6h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K6C_B_MK1B902_1
(POL POLYPROTEIN)		 2r6h NADH:UBIQUINONE
OXIDOREDUCTASE, NA
TRANSLOCATING, F
SUBUNIT
(Porphyromonas
gingivalis) 		5 / 10 VAL A 392
ILE A 284
GLY A 285
GLY A 286
PRO A 387
 None
 1.06A 1k6cA-2r6hA:
undetectable		 1k6cA-2r6hA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC8_0
(ACTINOMYCIN D)		 2r6h NADH:UBIQUINONE
OXIDOREDUCTASE, NA
TRANSLOCATING, F
SUBUNIT
(Porphyromonas
gingivalis) 		3 / 3 PRO A 247
THR A 231
PRO A 233
 FAD  A   1 ( 4.7A)
None
FAD  A   1 ( 4.8A)
 0.58A 2d55C-2r6hA:
undetectable		 2d55C-2r6hA:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2r6h NADH:UBIQUINONE
OXIDOREDUCTASE, NA
TRANSLOCATING, F
SUBUNIT
(Porphyromonas
gingivalis) 		4 / 7 ARG A 186
ILE A 146
PHE A 187
GLU A 148
 SO4  A   2 ( 2.6A)
None
None
None
 1.50A 3e7gA-2r6hA:
undetectable
3e7gB-2r6hA:
undetectable		 3e7gA-2r6hA:
18.81
3e7gB-2r6hA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_B_H4BB1902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2r6h NADH:UBIQUINONE
OXIDOREDUCTASE, NA
TRANSLOCATING, F
SUBUNIT
(Porphyromonas
gingivalis) 		4 / 7 PHE A 187
GLU A 148
ARG A 186
ILE A 146
 None
None
SO4  A   2 ( 2.6A)
None
 1.49A 3e7gA-2r6hA:
undetectable
3e7gB-2r6hA:
undetectable		 3e7gA-2r6hA:
18.81
3e7gB-2r6hA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_D_H4BD3011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 2r6h NADH:UBIQUINONE
OXIDOREDUCTASE, NA
TRANSLOCATING, F
SUBUNIT
(Porphyromonas
gingivalis) 		4 / 6 PHE A 187
GLU A 148
ARG A 186
ILE A 146
 None
None
SO4  A   2 ( 2.6A)
None
 1.34A 4nosC-2r6hA:
undetectable
4nosD-2r6hA:
undetectable		 4nosC-2r6hA:
17.31
4nosD-2r6hA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2r6h NADH:UBIQUINONE
OXIDOREDUCTASE, NA
TRANSLOCATING, F
SUBUNIT
(Porphyromonas
gingivalis) 		5 / 11 ALA A 291
ALA A 214
GLY A 286
GLY A 287
ALA A 288
 FAD  A   1 ( 3.9A)
None
None
None
FAD  A   1 ( 3.7A)
 0.86A 4qvlK-2r6hA:
undetectable
4qvlL-2r6hA:
undetectable		 4qvlK-2r6hA:
20.34
4qvlL-2r6hA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2r6h NADH:UBIQUINONE
OXIDOREDUCTASE, NA
TRANSLOCATING, F
SUBUNIT
(Porphyromonas
gingivalis) 		5 / 11 ALA A 291
ALA A 214
GLY A 286
GLY A 287
ALA A 288
 FAD  A   1 ( 3.9A)
None
None
None
FAD  A   1 ( 3.7A)
 0.86A 4qvlY-2r6hA:
undetectable
4qvlZ-2r6hA:
undetectable		 4qvlY-2r6hA:
20.34
4qvlZ-2r6hA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2r6h NADH:UBIQUINONE
OXIDOREDUCTASE, NA
TRANSLOCATING, F
SUBUNIT
(Porphyromonas
gingivalis) 		5 / 9 ALA A 291
ALA A 214
GLY A 286
GLY A 287
ALA A 288
 FAD  A   1 ( 3.9A)
None
None
None
FAD  A   1 ( 3.7A)
 0.87A 4qvmK-2r6hA:
undetectable
4qvmL-2r6hA:
undetectable		 4qvmK-2r6hA:
20.34
4qvmL-2r6hA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2r6h NADH:UBIQUINONE
OXIDOREDUCTASE, NA
TRANSLOCATING, F
SUBUNIT
(Porphyromonas
gingivalis) 		5 / 10 ALA A 291
ALA A 214
GLY A 286
GLY A 287
ALA A 288
 FAD  A   1 ( 3.9A)
None
None
None
FAD  A   1 ( 3.7A)
 0.87A 4qvmY-2r6hA:
undetectable
4qvmZ-2r6hA:
undetectable		 4qvmY-2r6hA:
20.34
4qvmZ-2r6hA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2r6h NADH:UBIQUINONE
OXIDOREDUCTASE, NA
TRANSLOCATING, F
SUBUNIT
(Porphyromonas
gingivalis) 		5 / 10 ALA A 291
ALA A 214
GLY A 286
GLY A 287
ALA A 288
 FAD  A   1 ( 3.9A)
None
None
None
FAD  A   1 ( 3.7A)
 0.85A 4qvpK-2r6hA:
undetectable
4qvpL-2r6hA:
undetectable		 4qvpK-2r6hA:
20.34
4qvpL-2r6hA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2r6h NADH:UBIQUINONE
OXIDOREDUCTASE, NA
TRANSLOCATING, F
SUBUNIT
(Porphyromonas
gingivalis) 		5 / 10 ALA A 291
ALA A 214
GLY A 286
GLY A 287
ALA A 288
 FAD  A   1 ( 3.9A)
None
None
None
FAD  A   1 ( 3.7A)
 0.85A 4qvpY-2r6hA:
undetectable
4qvpZ-2r6hA:
undetectable		 4qvpY-2r6hA:
20.34
4qvpZ-2r6hA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2r6h NADH:UBIQUINONE
OXIDOREDUCTASE, NA
TRANSLOCATING, F
SUBUNIT
(Porphyromonas
gingivalis) 		5 / 11 ALA A 291
ALA A 214
GLY A 286
GLY A 287
ALA A 288
 FAD  A   1 ( 3.9A)
None
None
None
FAD  A   1 ( 3.7A)
 0.85A 4qw1K-2r6hA:
undetectable
4qw1L-2r6hA:
undetectable		 4qw1K-2r6hA:
20.34
4qw1L-2r6hA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2r6h NADH:UBIQUINONE
OXIDOREDUCTASE, NA
TRANSLOCATING, F
SUBUNIT
(Porphyromonas
gingivalis) 		5 / 10 ALA A 291
ALA A 214
GLY A 286
GLY A 287
ALA A 288
 FAD  A   1 ( 3.9A)
None
None
None
FAD  A   1 ( 3.7A)
 0.85A 4qw1Y-2r6hA:
undetectable
4qw1Z-2r6hA:
undetectable		 4qw1Y-2r6hA:
20.34
4qw1Z-2r6hA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2r6h NADH:UBIQUINONE
OXIDOREDUCTASE, NA
TRANSLOCATING, F
SUBUNIT
(Porphyromonas
gingivalis) 		5 / 10 ALA A 291
ALA A 214
GLY A 286
GLY A 287
ALA A 288
 FAD  A   1 ( 3.9A)
None
None
None
FAD  A   1 ( 3.7A)
 0.87A 4qw3K-2r6hA:
undetectable
4qw3L-2r6hA:
undetectable		 4qw3K-2r6hA:
20.34
4qw3L-2r6hA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2r6h NADH:UBIQUINONE
OXIDOREDUCTASE, NA
TRANSLOCATING, F
SUBUNIT
(Porphyromonas
gingivalis) 		5 / 10 ALA A 291
ALA A 214
GLY A 286
GLY A 287
ALA A 288
 FAD  A   1 ( 3.9A)
None
None
None
FAD  A   1 ( 3.7A)
 0.87A 4qw3Y-2r6hA:
undetectable
4qw3Z-2r6hA:
undetectable		 4qw3Y-2r6hA:
20.34
4qw3Z-2r6hA:
20.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U9U_A_ACTA1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 2r6h NADH:UBIQUINONE
OXIDOREDUCTASE, NA
TRANSLOCATING, F
SUBUNIT
(Porphyromonas
gingivalis) 		4 / 5 GLY A 287
ALA A 288
GLY A 384
PRO A 385
 None
FAD  A   1 ( 3.7A)
None
None
 0.40A 4u9uA-2r6hA:
41.7		 4u9uA-2r6hA:
56.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U9U_B_ACTB1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 2r6h NADH:UBIQUINONE
OXIDOREDUCTASE, NA
TRANSLOCATING, F
SUBUNIT
(Porphyromonas
gingivalis) 		4 / 5 GLY A 287
ALA A 288
GLY A 384
PRO A 385
 None
FAD  A   1 ( 3.7A)
None
None
 0.39A 4u9uB-2r6hA:
41.7		 4u9uB-2r6hA:
56.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2r6h NADH:UBIQUINONE
OXIDOREDUCTASE, NA
TRANSLOCATING, F
SUBUNIT
(Porphyromonas
gingivalis) 		5 / 11 ALA A 291
ALA A 214
GLY A 286
GLY A 287
ALA A 288
 FAD  A   1 ( 3.9A)
None
None
None
FAD  A   1 ( 3.7A)
 0.86A 5bxnK-2r6hA:
undetectable
5bxnL-2r6hA:
undetectable		 5bxnK-2r6hA:
20.34
5bxnL-2r6hA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2r6h NADH:UBIQUINONE
OXIDOREDUCTASE, NA
TRANSLOCATING, F
SUBUNIT
(Porphyromonas
gingivalis) 		5 / 11 ALA A 291
ALA A 214
GLY A 286
GLY A 287
ALA A 288
 FAD  A   1 ( 3.9A)
None
None
None
FAD  A   1 ( 3.7A)
 0.87A 5bxnY-2r6hA:
undetectable
5bxnZ-2r6hA:
undetectable		 5bxnY-2r6hA:
20.34
5bxnZ-2r6hA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2r6h NADH:UBIQUINONE
OXIDOREDUCTASE, NA
TRANSLOCATING, F
SUBUNIT
(Porphyromonas
gingivalis) 		5 / 9 ALA A 291
ALA A 214
GLY A 286
GLY A 287
ALA A 288
 FAD  A   1 ( 3.9A)
None
None
None
FAD  A   1 ( 3.7A)
 0.85A 5d0xK-2r6hA:
undetectable
5d0xL-2r6hA:
undetectable		 5d0xK-2r6hA:
20.68
5d0xL-2r6hA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2r6h NADH:UBIQUINONE
OXIDOREDUCTASE, NA
TRANSLOCATING, F
SUBUNIT
(Porphyromonas
gingivalis) 		5 / 9 ALA A 291
ALA A 214
GLY A 286
GLY A 287
ALA A 288
 FAD  A   1 ( 3.9A)
None
None
None
FAD  A   1 ( 3.7A)
 0.86A 5d0xY-2r6hA:
undetectable
5d0xZ-2r6hA:
undetectable		 5d0xY-2r6hA:
20.68
5d0xZ-2r6hA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW9_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 2r6h NADH:UBIQUINONE
OXIDOREDUCTASE, NA
TRANSLOCATING, F
SUBUNIT
(Porphyromonas
gingivalis) 		4 / 8 GLY A 289
ALA A 291
CYH A 383
GLY A 384
 None
FAD  A   1 ( 3.9A)
None
None
 0.59A 5vw9A-2r6hA:
24.3		 5vw9A-2r6hA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW9_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 2r6h NADH:UBIQUINONE
OXIDOREDUCTASE, NA
TRANSLOCATING, F
SUBUNIT
(Porphyromonas
gingivalis) 		4 / 8 SER A 212
GLY A 289
ALA A 291
CYH A 383
 FAD  A   1 ( 3.3A)
None
FAD  A   1 ( 3.9A)
None
 0.74A 5vw9A-2r6hA:
24.3		 5vw9A-2r6hA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_K_BO2K301_0
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2r6h NADH:UBIQUINONE
OXIDOREDUCTASE, NA
TRANSLOCATING, F
SUBUNIT
(Porphyromonas
gingivalis) 		5 / 11 ALA A 291
ALA A 214
GLY A 286
GLY A 287
ALA A 288
 FAD  A   1 ( 3.9A)
None
None
None
FAD  A   1 ( 3.7A)
 0.80A 6hwdK-2r6hA:
undetectable
6hwdL-2r6hA:
undetectable		 6hwdK-2r6hA:
14.07
6hwdL-2r6hA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_Y_BO2Y301_0
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2r6h NADH:UBIQUINONE
OXIDOREDUCTASE, NA
TRANSLOCATING, F
SUBUNIT
(Porphyromonas
gingivalis) 		5 / 11 ALA A 291
ALA A 214
GLY A 286
GLY A 287
ALA A 288
 FAD  A   1 ( 3.9A)
None
None
None
FAD  A   1 ( 3.7A)
 0.81A 6hwdY-2r6hA:
undetectable
6hwdZ-2r6hA:
undetectable		 6hwdY-2r6hA:
14.07
6hwdZ-2r6hA:
14.18