SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2r6r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA355_1
(PROTEIN (ADENOSINE
KINASE))		 2r6r CELL DIVISION
PROTEIN FTSZ
(Aquifex
aeolicus) 		6 / 12 GLY 1  14
ILE 1  85
ALA 1 109
GLY 1 106
ALA 1 110
ILE 1 113
 None
None
None
GDP  1 339 (-3.5A)
None
None
 1.44A 1bx4A-2r6r1:
6.2		 1bx4A-2r6r1:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_B_803B311_1
(ANTIGEN CD11A (P180))		 2r6r CELL DIVISION
PROTEIN FTSZ
(Aquifex
aeolicus) 		4 / 7 VAL 1 324
LEU 1 246
TYR 1 157
LEU 1 144
 None
 0.88A 1cqpA-2r6r1:
4.1
1cqpB-2r6r1:
undetectable		 1cqpA-2r6r1:
21.13
1cqpB-2r6r1:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC2_0
(ACTINOMYCIN D)		 2r6r CELL DIVISION
PROTEIN FTSZ
(Aquifex
aeolicus) 		3 / 3 THR 1 105
PRO 1  71
THR 1 107
 GDP  1 339 (-4.3A)
None
None
 0.93A 1dscC-2r6r1:
undetectable		 1dscC-2r6r1:
4.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG2_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 2r6r CELL DIVISION
PROTEIN FTSZ
(Aquifex
aeolicus) 		5 / 12 GLY 1 225
ASP 1 301
GLY 1 229
ALA 1 233
VAL 1 275
 None
 1.06A 1jg2A-2r6r1:
3.4		 1jg2A-2r6r1:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_B_DEXB2999_1
(GLUCOCORTICOID
RECEPTOR)		 2r6r CELL DIVISION
PROTEIN FTSZ
(Aquifex
aeolicus) 		5 / 12 GLY 1 100
MET 1 140
LEU 1 147
ILE 1 165
PHE 1 132
 GDP  1 339 (-3.3A)
None
None
None
None
 1.46A 1p93B-2r6r1:
undetectable		 1p93B-2r6r1:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_2
(POL POLYPROTEIN)		 2r6r CELL DIVISION
PROTEIN FTSZ
(Aquifex
aeolicus) 		5 / 12 ALA 1 117
ILE 1  13
ILE 1  88
ILE 1  82
ALA 1 110
 None
 0.87A 1sguB-2r6r1:
undetectable		 1sguB-2r6r1:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2r6r CELL DIVISION
PROTEIN FTSZ
(Aquifex
aeolicus) 		4 / 5 LEU 1  79
GLY 1 104
PRO 1 111
VAL 1 112
 None
GDP  1 339 (-3.4A)
None
None
 0.81A 2aojA-2r6r1:
undetectable		 2aojA-2r6r1:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_B_GBNB914_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 2r6r CELL DIVISION
PROTEIN FTSZ
(Aquifex
aeolicus) 		5 / 10 GLY 1  14
GLY 1 106
THR 1 105
ALA 1 109
ALA 1 110
 None
GDP  1 339 (-3.5A)
GDP  1 339 (-4.3A)
None
None
 1.08A 2ej3B-2r6r1:
undetectable		 2ej3B-2r6r1:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_C_GBNC1414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 2r6r CELL DIVISION
PROTEIN FTSZ
(Aquifex
aeolicus) 		5 / 8 GLY 1  14
GLY 1 106
THR 1 105
ALA 1 109
ALA 1 110
 None
GDP  1 339 (-3.5A)
GDP  1 339 (-4.3A)
None
None
 1.11A 2ej3C-2r6r1:
undetectable		 2ej3C-2r6r1:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_C_GBNC1414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 2r6r CELL DIVISION
PROTEIN FTSZ
(Aquifex
aeolicus) 		5 / 8 GLY 1 102
GLY 1 100
THR 1 129
ALA 1 128
ALA 1  99
 GDP  1 339 ( 4.5A)
GDP  1 339 (-3.3A)
None
None
None
 1.35A 2ej3C-2r6r1:
undetectable		 2ej3C-2r6r1:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 2r6r CELL DIVISION
PROTEIN FTSZ
(Aquifex
aeolicus) 		5 / 12 THR 1  92
LEU 1  36
ILE 1  39
VAL 1  15
ALA 1 117
 None
 1.33A 2g72B-2r6r1:
undetectable		 2g72B-2r6r1:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN0_A_TDZA501_1
(CYTOCHROME P450 2C8)		 2r6r CELL DIVISION
PROTEIN FTSZ
(Aquifex
aeolicus) 		5 / 12 ILE 1 193
THR 1 194
VAL 1 210
VAL 1 125
ILE 1 160
 None
 1.16A 2vn0A-2r6r1:
undetectable		 2vn0A-2r6r1:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_C_X2NC1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 2r6r CELL DIVISION
PROTEIN FTSZ
(Aquifex
aeolicus) 		5 / 12 PHE 1 326
VAL 1 324
ALA 1 156
ALA 1 126
LEU 1 101
 None
 1.14A 2x2nC-2r6r1:
undetectable		 2x2nC-2r6r1:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 2r6r CELL DIVISION
PROTEIN FTSZ
(Aquifex
aeolicus) 		5 / 12 PRO 1  71
GLY 1 104
GLY 1 103
LEU 1  79
ILE 1  85
 None
GDP  1 339 (-3.4A)
GDP  1 339 (-3.6A)
None
None
 0.97A 3douA-2r6r1:
3.7		 3douA-2r6r1:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LBD_A_9CRA424_1
(RETINOIC ACID
RECEPTOR GAMMA)		 2r6r CELL DIVISION
PROTEIN FTSZ
(Aquifex
aeolicus) 		5 / 12 ALA 1 178
ILE 1 165
SER 1 169
GLY 1  18
ILE 1 175
 None
None
None
GDP  1 339 (-3.4A)
None
 1.31A 3lbdA-2r6r1:
undetectable		 3lbdA-2r6r1:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_1
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT)		 2r6r CELL DIVISION
PROTEIN FTSZ
(Aquifex
aeolicus) 		5 / 10 VAL 1  23
LEU 1  46
GLY 1  19
VAL 1  15
GLY 1  17
 None
None
None
None
GDP  1 339 (-3.6A)
 1.26A 3ls4H-2r6r1:
undetectable		 3ls4H-2r6r1:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_A_CGEA501_1
(CYTOCHROME P450 2B4)		 2r6r CELL DIVISION
PROTEIN FTSZ
(Aquifex
aeolicus) 		5 / 10 VAL 1 283
ILE 1 289
ILE 1 261
VAL 1 305
VAL 1 259
 None
 0.98A 3me6A-2r6r1:
undetectable		 3me6A-2r6r1:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_I_SAMI228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2r6r CELL DIVISION
PROTEIN FTSZ
(Aquifex
aeolicus) 		5 / 12 GLY 1  14
ALA 1  99
ILE 1  13
PHE 1  96
VAL 1  23
 None
 1.01A 3nvkI-2r6r1:
3.2		 3nvkI-2r6r1:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA271_0
(PROTEIN SSM1)		 2r6r CELL DIVISION
PROTEIN FTSZ
(Aquifex
aeolicus) 		4 / 5 GLY 1 102
GLU 1 135
GLY 1 100
PRO 1 131
 GDP  1 339 ( 4.5A)
GDP  1 339 (-2.7A)
GDP  1 339 (-3.3A)
GDP  1 339 ( 4.4A)
 0.99A 3onnA-2r6r1:
6.0		 3onnA-2r6r1:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_A_478A200_1
(HIV-1 PROTEASE)		 2r6r CELL DIVISION
PROTEIN FTSZ
(Aquifex
aeolicus) 		4 / 6 GLU 1 321
PRO 1 137
ARG 1 133
GLY 1 320
 None
 1.37A 3oxvA-2r6r1:
undetectable		 3oxvA-2r6r1:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2r6r CELL DIVISION
PROTEIN FTSZ
(Aquifex
aeolicus) 		5 / 12 GLY 1 106
ALA 1 109
LEU 1  46
THR 1  41
ILE 1  57
 GDP  1 339 (-3.5A)
None
None
None
None
 1.18A 4hytA-2r6r1:
5.9		 4hytA-2r6r1:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_C_OBNC2004_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2r6r CELL DIVISION
PROTEIN FTSZ
(Aquifex
aeolicus) 		5 / 12 GLY 1 106
ALA 1 109
LEU 1  46
THR 1  41
ILE 1  57
 GDP  1 339 (-3.5A)
None
None
None
None
 1.15A 4hytC-2r6r1:
2.0		 4hytC-2r6r1:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_A_SUZA201_1
(TRANSTHYRETIN)		 2r6r CELL DIVISION
PROTEIN FTSZ
(Aquifex
aeolicus) 		4 / 7 LYS 1  54
ALA 1  38
LEU 1  36
SER 1  98
 None
 0.91A 4ikjA-2r6r1:
undetectable
4ikjB-2r6r1:
undetectable		 4ikjA-2r6r1:
18.71
4ikjB-2r6r1:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_A_SUZA201_1
(TRANSTHYRETIN)		 2r6r CELL DIVISION
PROTEIN FTSZ
(Aquifex
aeolicus) 		4 / 8 LYS 1  54
ALA 1  38
LEU 1  36
SER 1  98
 None
 0.86A 4ikkA-2r6r1:
undetectable
4ikkB-2r6r1:
undetectable		 4ikkA-2r6r1:
18.71
4ikkB-2r6r1:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2r6r CELL DIVISION
PROTEIN FTSZ
(Aquifex
aeolicus) 		5 / 10 ALA 1 110
ILE 1  39
ALA 1  77
ALA 1  78
ILE 1  57
 None
 1.01A 4lbgA-2r6r1:
7.9		 4lbgA-2r6r1:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_1
(ADENOSINE KINASE)		 2r6r CELL DIVISION
PROTEIN FTSZ
(Aquifex
aeolicus) 		5 / 12 GLY 1  16
GLY 1  17
ASN 1  40
GLY 1  66
ASP 1  42
 GDP  1 339 (-3.5A)
GDP  1 339 (-3.6A)
GDP  1 339 ( 4.4A)
None
None
 0.96A 4n09B-2r6r1:
8.6		 4n09B-2r6r1:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_1
(ADENOSINE KINASE)		 2r6r CELL DIVISION
PROTEIN FTSZ
(Aquifex
aeolicus) 		5 / 12 GLY 1  16
GLY 1  17
ASN 1  40
GLY 1  66
ASP 1  42
 GDP  1 339 (-3.5A)
GDP  1 339 (-3.6A)
GDP  1 339 ( 4.4A)
None
None
 0.95A 4n09C-2r6r1:
7.9		 4n09C-2r6r1:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2r6r CELL DIVISION
PROTEIN FTSZ
(Aquifex
aeolicus) 		5 / 12 GLU 1  28
ASP 1 183
LEU 1 186
GLY 1  14
ALA 1  99
 None
GDP  1 339 (-3.2A)
None
None
None
 1.23A 4xe5A-2r6r1:
undetectable		 4xe5A-2r6r1:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_A_SALA801_1
(PROTEIN POLYBROMO-1)		 2r6r CELL DIVISION
PROTEIN FTSZ
(Aquifex
aeolicus) 		4 / 7 ILE 1  85
LEU 1  79
ALA 1 109
ILE 1 113
 None
 0.76A 4y03A-2r6r1:
undetectable		 4y03A-2r6r1:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_2
(TUBULIN ALPHA-1B
CHAIN)		 2r6r CELL DIVISION
PROTEIN FTSZ
(Aquifex
aeolicus) 		4 / 7 VAL 1 275
ILE 1 279
VAL 1 305
ILE 1 303
 None
 0.65A 5bmvC-2r6r1:
26.8		 5bmvC-2r6r1:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_2
(TUBULIN ALPHA-1B
CHAIN)		 2r6r CELL DIVISION
PROTEIN FTSZ
(Aquifex
aeolicus) 		4 / 7 VAL 1 305
ILE 1 303
VAL 1 275
ILE 1 279
 None
 0.72A 5bmvC-2r6r1:
26.8		 5bmvC-2r6r1:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 2r6r CELL DIVISION
PROTEIN FTSZ
(Aquifex
aeolicus) 		5 / 12 GLY 1  74
ILE 1  57
THR 1 105
GLY 1  16
GLY 1 146
 None
None
GDP  1 339 (-4.3A)
GDP  1 339 (-3.5A)
None
 1.05A 5d4uA-2r6r1:
3.7		 5d4uA-2r6r1:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 2r6r CELL DIVISION
PROTEIN FTSZ
(Aquifex
aeolicus) 		5 / 12 GLY 1  74
ILE 1  57
THR 1 105
GLY 1  16
GLY 1 146
 None
None
GDP  1 339 (-4.3A)
GDP  1 339 (-3.5A)
None
 1.05A 5d4uB-2r6r1:
3.7		 5d4uB-2r6r1:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 2r6r CELL DIVISION
PROTEIN FTSZ
(Aquifex
aeolicus) 		5 / 12 GLY 1  74
ILE 1  57
THR 1 105
GLY 1  16
GLY 1 146
 None
None
GDP  1 339 (-4.3A)
GDP  1 339 (-3.5A)
None
 1.01A 5d4uD-2r6r1:
undetectable		 5d4uD-2r6r1:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_A_ADNA401_1
(ADENOSINE KINASE)		 2r6r CELL DIVISION
PROTEIN FTSZ
(Aquifex
aeolicus) 		6 / 12 GLY 1  16
ILE 1  13
ALA 1 109
GLY 1 108
ALA 1 110
ILE 1 113
 GDP  1 339 (-3.5A)
None
None
None
None
None
 1.32A 5kb6A-2r6r1:
8.1		 5kb6A-2r6r1:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_B_ADNB401_1
(ADENOSINE KINASE)		 2r6r CELL DIVISION
PROTEIN FTSZ
(Aquifex
aeolicus) 		6 / 12 GLY 1  16
ILE 1  13
ALA 1 109
GLY 1 108
ALA 1 110
ILE 1 113
 GDP  1 339 (-3.5A)
None
None
None
None
None
 1.32A 5kb6B-2r6r1:
7.6		 5kb6B-2r6r1:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_2
(PROTEASE E35D-SQV)		 2r6r CELL DIVISION
PROTEIN FTSZ
(Aquifex
aeolicus) 		5 / 9 LEU 1 245
VAL 1 308
ILE 1 193
GLY 1 192
ILE 1 222
 None
 1.09A 5kqxB-2r6r1:
undetectable		 5kqxB-2r6r1:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M24_A_9CRA501_1
(RETINOIC ACID
RECEPTOR GAMMA)		 2r6r CELL DIVISION
PROTEIN FTSZ
(Aquifex
aeolicus) 		6 / 12 PHE 1 132
ALA 1 178
ILE 1 165
SER 1 169
GLY 1  18
ILE 1 175
 None
None
None
None
GDP  1 339 (-3.4A)
None
 1.33A 5m24A-2r6r1:
undetectable		 5m24A-2r6r1:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 2r6r CELL DIVISION
PROTEIN FTSZ
(Aquifex
aeolicus) 		4 / 6 LEU 1 186
VAL 1 190
THR 1 194
LEU 1 219
 None
 0.96A 5tudD-2r6r1:
undetectable		 5tudD-2r6r1:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2r6r CELL DIVISION
PROTEIN FTSZ
(Aquifex
aeolicus) 		5 / 12 GLY 1 292
VAL 1 125
LEU 1 123
SER 1 195
ILE 1 193
 None
 1.17A 5vooA-2r6r1:
2.4		 5vooA-2r6r1:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2r6r CELL DIVISION
PROTEIN FTSZ
(Aquifex
aeolicus) 		5 / 12 GLY 1 292
VAL 1 125
LEU 1 123
SER 1 195
ILE 1 193
 None
 1.15A 5vooB-2r6r1:
2.7		 5vooB-2r6r1:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2r6r CELL DIVISION
PROTEIN FTSZ
(Aquifex
aeolicus) 		5 / 12 GLY 1 292
VAL 1 125
LEU 1 123
SER 1 195
ILE 1 193
 None
 1.13A 5vooC-2r6r1:
2.6		 5vooC-2r6r1:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW9_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 2r6r CELL DIVISION
PROTEIN FTSZ
(Aquifex
aeolicus) 		4 / 8 THR 1 105
GLY 1 106
ALA 1 109
SER 1  20
 GDP  1 339 (-4.3A)
GDP  1 339 (-3.5A)
None
None
 0.56A 5vw9A-2r6r1:
3.1		 5vw9A-2r6r1:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_1
(NS3 PROTEASE)		 2r6r CELL DIVISION
PROTEIN FTSZ
(Aquifex
aeolicus) 		5 / 9 VAL 1 182
ASP 1 183
LEU 1 101
ALA 1  99
VAL 1  15
 GDP  1 339 (-4.3A)
GDP  1 339 (-3.2A)
None
None
None
 1.23A 6c2mB-2r6r1:
undetectable		 6c2mB-2r6r1:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_1
(NS3 PROTEASE)		 2r6r CELL DIVISION
PROTEIN FTSZ
(Aquifex
aeolicus) 		4 / 9 VAL 1 182
ASP 1 183
LEU 1 101
VAL 1  15
 GDP  1 339 (-4.3A)
GDP  1 339 (-3.2A)
None
None
 0.97A 6c2mD-2r6r1:
undetectable		 6c2mD-2r6r1:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_A_IXXA609_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 2r6r CELL DIVISION
PROTEIN FTSZ
(Aquifex
aeolicus) 		4 / 7 LEU 1 219
VAL 1 319
LEU 1 246
LEU 1 144
 None
 0.46A 6g9bA-2r6r1:
undetectable
6g9bB-2r6r1:
undetectable		 6g9bA-2r6r1:
11.50
6g9bB-2r6r1:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NQA_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 2r6r CELL DIVISION
PROTEIN FTSZ
(Aquifex
aeolicus) 		5 / 10 THR 1 105
GLY 1  64
GLY 1  58
GLU 1  59
ASN 1  40
 GDP  1 339 (-4.3A)
None
None
None
GDP  1 339 ( 4.4A)
 1.28A 6nqaK-2r6r1:
undetectable		 6nqaK-2r6r1:
21.35