SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2r6z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 2r6z UPF0341 PROTEIN IN
RSP 3' REGION
(Neisseria
gonorrhoeae) 		5 / 12 THR A  91
GLY A  93
GLY A  95
GLN A 113
ASP A 168
 None
 0.97A 1wg8B-2r6zA:
12.7		 1wg8B-2r6zA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2r6z UPF0341 PROTEIN IN
RSP 3' REGION
(Neisseria
gonorrhoeae) 		4 / 6 VAL A  87
MET A 152
ILE A  75
ILE A 164
 None
 0.91A 3gcsA-2r6zA:
undetectable		 3gcsA-2r6zA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_2
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 2r6z UPF0341 PROTEIN IN
RSP 3' REGION
(Neisseria
gonorrhoeae) 		3 / 3 ARG A 211
THR A  91
THR A 237
 None
 0.79A 3k2hB-2r6zA:
1.9		 3k2hB-2r6zA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 2r6z UPF0341 PROTEIN IN
RSP 3' REGION
(Neisseria
gonorrhoeae) 		5 / 12 ILE A 125
GLY A 124
ASP A 123
ARG A 126
ALA A  92
 None
 1.16A 5h5fA-2r6zA:
1.8		 5h5fA-2r6zA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_F_MTXF402_1
(THYMIDYLATE SYNTHASE)		 2r6z UPF0341 PROTEIN IN
RSP 3' REGION
(Neisseria
gonorrhoeae) 		5 / 12 ILE A  55
GLY A 124
THR A  11
ALA A 118
VAL A 117
 None
 1.15A 5x66F-2r6zA:
undetectable		 5x66F-2r6zA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_B_SAMB601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 2r6z UPF0341 PROTEIN IN
RSP 3' REGION
(Neisseria
gonorrhoeae) 		4 / 7 GLY A  93
GLY A  95
GLU A 112
ASN A 147
 None
 0.60A 5ybbB-2r6zA:
6.2		 5ybbB-2r6zA:
19.45