SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2r77'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_2
(ASPARTYLPROTEASE)		 2r77 PHOSPHATIDYLETHANOLA
MINE-BINDING
PROTEIN, PUTATIVE
(Plasmodium
falciparum) 		5 / 9 LEU A 131
VAL A  91
ILE A 191
VAL A 110
ILE A 107
 None
 0.94A 1ohrB-2r77A:
undetectable		 1ohrB-2r77A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_E_ASDE1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2r77 PHOSPHATIDYLETHANOLA
MINE-BINDING
PROTEIN, PUTATIVE
(Plasmodium
falciparum) 		5 / 9 LEU A  46
PRO A  20
LEU A  42
LEU A  25
PHE A  35
 None
 1.24A 2vcvE-2r77A:
undetectable		 2vcvE-2r77A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP3_B_AICB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2r77 PHOSPHATIDYLETHANOLA
MINE-BINDING
PROTEIN, PUTATIVE
(Plasmodium
falciparum) 		3 / 3 ALA A  52
ARG A  72
LYS A 121
 None
 1.05A 3kp3B-2r77A:
undetectable		 3kp3B-2r77A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQE_B_017B101_1
(ASPARTYL PROTEASE)		 2r77 PHOSPHATIDYLETHANOLA
MINE-BINDING
PROTEIN, PUTATIVE
(Plasmodium
falciparum) 		5 / 11 LEU A 131
VAL A  91
ILE A 191
VAL A 110
ILE A 107
 None
 0.98A 4dqeA-2r77A:
undetectable		 4dqeA-2r77A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 2r77 PHOSPHATIDYLETHANOLA
MINE-BINDING
PROTEIN, PUTATIVE
(Plasmodium
falciparum) 		5 / 12 VAL A  44
PHE A  35
VAL A 185
SER A 152
VAL A 197
 None
 1.34A 6ap6A-2r77A:
undetectable		 6ap6A-2r77A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 2r77 PHOSPHATIDYLETHANOLA
MINE-BINDING
PROTEIN, PUTATIVE
(Plasmodium
falciparum) 		5 / 12 VAL A  44
PHE A  35
VAL A 185
SER A 152
VAL A 197
 None
 1.35A 6ap6B-2r77A:
undetectable		 6ap6B-2r77A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2r77 PHOSPHATIDYLETHANOLA
MINE-BINDING
PROTEIN, PUTATIVE
(Plasmodium
falciparum) 		5 / 10 PHE A  76
GLY A 198
ILE A 151
ILE A  74
ILE A  48
 None
 1.12A 6ebpD-2r77A:
undetectable		 6ebpD-2r77A:
20.10