SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2r79'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 2r79 PERIPLASMIC BINDING
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 113
GLY A  34
ALA A  33
SER A  32
GLY A  52
 None
 1.03A 1fe2A-2r79A:
undetectable		 1fe2A-2r79A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_A_VIBA502_1
(THIAMIN
PYROPHOSPHOKINASE)		 2r79 PERIPLASMIC BINDING
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 8 LEU A  50
SER A  36
GLN A  72
THR A 263
 None
None
None
HEM  A 500 ( 4.9A)
 1.08A 1ig3A-2r79A:
1.4
1ig3B-2r79A:
undetectable		 1ig3A-2r79A:
23.68
1ig3B-2r79A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 2r79 PERIPLASMIC BINDING
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 6 ARG A 272
ASP A  54
TYR A  71
GLU A  39
 None
None
HEM  A 500 (-3.6A)
None
 1.25A 1rjdA-2r79A:
undetectable		 1rjdA-2r79A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 2r79 PERIPLASMIC BINDING
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 6 ARG A 272
ASP A  54
TYR A  71
GLU A  39
 None
None
HEM  A 500 (-3.6A)
None
 1.28A 1rjdB-2r79A:
undetectable		 1rjdB-2r79A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 2r79 PERIPLASMIC BINDING
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 6 ARG A 272
ASP A  54
TYR A  71
GLU A  39
 None
None
HEM  A 500 (-3.6A)
None
 1.26A 1rjdC-2r79A:
undetectable		 1rjdC-2r79A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_0
(HEMK PROTEIN)		 2r79 PERIPLASMIC BINDING
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 GLY A  35
THR A  55
VAL A  53
SER A  32
PRO A  60
 None
None
None
None
GOL  A 880 (-4.3A)
 1.19A 1sg9A-2r79A:
undetectable		 1sg9A-2r79A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_A_CHDA1_0
(LIVER
CARBOXYLESTERASE 1)		 2r79 PERIPLASMIC BINDING
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 5 TRP A 191
GLY A 184
LEU A 265
PRO A 117
 SO4  A 910 (-4.1A)
None
HEM  A 500 ( 4.6A)
None
 1.41A 2dqyA-2r79A:
0.4		 2dqyA-2r79A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA3_0
(FERROCHELATASE)		 2r79 PERIPLASMIC BINDING
PROTEIN
(Pseudomonas
aeruginosa) 		3 / 3 PRO A 209
LEU A 181
ARG A 228
 None
None
HEM  A 500 (-2.8A)
 0.63A 3aqiA-2r79A:
undetectable		 3aqiA-2r79A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB5_0
(FERROCHELATASE)		 2r79 PERIPLASMIC BINDING
PROTEIN
(Pseudomonas
aeruginosa) 		3 / 3 PRO A 209
LEU A 181
ARG A 228
 None
None
HEM  A 500 (-2.8A)
 0.70A 3aqiB-2r79A:
undetectable		 3aqiB-2r79A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECLB600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2r79 PERIPLASMIC BINDING
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 8 THR A  56
TYR A  71
GLY A 267
ILE A 173
 None
HEM  A 500 (-3.6A)
None
HEM  A 500 ( 4.1A)
 0.71A 3jusB-2r79A:
undetectable		 3jusB-2r79A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2r79 PERIPLASMIC BINDING
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 198
PHE A 284
LEU A 258
VAL A 182
VAL A 224
 None
 1.01A 3rukA-2r79A:
undetectable		 3rukA-2r79A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		 2r79 PERIPLASMIC BINDING
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 5 SER A  57
SER A  68
VAL A  53
GLY A  34
 None
 0.92A 3rxhA-2r79A:
undetectable		 3rxhA-2r79A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2r79 PERIPLASMIC BINDING
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 8 LEU A  50
PRO A 271
VAL A 266
GLY A 267
 None
None
HEM  A 500 ( 4.8A)
None
 0.82A 4klrB-2r79A:
2.2		 4klrB-2r79A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA303_1
(CHITOSANASE)		 2r79 PERIPLASMIC BINDING
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 6 GLU A  93
TYR A  71
THR A  56
TYR A 207
 None
HEM  A 500 (-3.6A)
None
HEM  A 500 (-3.5A)
 1.23A 4qwpA-2r79A:
undetectable		 4qwpA-2r79A:
26.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB302_1
(CHITOSANASE)		 2r79 PERIPLASMIC BINDING
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 5 GLU A  93
TYR A  71
THR A  56
TYR A 207
 None
HEM  A 500 (-3.6A)
None
HEM  A 500 (-3.5A)
 1.22A 4qwpB-2r79A:
0.0		 4qwpB-2r79A:
26.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X61_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 2r79 PERIPLASMIC BINDING
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 150
GLY A 276
PRO A 298
ARG A 195
LEU A 273
 None
None
None
SO4  A 910 (-3.8A)
None
 1.25A 4x61A-2r79A:
undetectable		 4x61A-2r79A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_E_GFNE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 2r79 PERIPLASMIC BINDING
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 7 ALA A 196
ARG A 185
GLY A 184
GLU A 205
 None
 1.02A 5btdA-2r79A:
undetectable
5btdB-2r79A:
2.0
5btdC-2r79A:
undetectable		 5btdA-2r79A:
22.66
5btdB-2r79A:
23.03
5btdC-2r79A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2r79 PERIPLASMIC BINDING
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 7 ALA A 196
ARG A 185
GLY A 184
GLU A 205
 None
 1.00A 5btdA-2r79A:
undetectable
5btdC-2r79A:
undetectable
5btdD-2r79A:
2.8		 5btdA-2r79A:
22.66
5btdC-2r79A:
22.66
5btdD-2r79A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 2r79 PERIPLASMIC BINDING
PROTEIN
(Pseudomonas
aeruginosa) 		6 / 12 SER A  32
LEU A  50
VAL A 135
VAL A  42
LEU A  44
ALA A 142
 None
 1.31A 5kpcA-2r79A:
undetectable		 5kpcA-2r79A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_C_SAMC301_0
(NS5)		 2r79 PERIPLASMIC BINDING
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 GLY A  35
GLY A  90
GLY A 267
VAL A  99
ASP A  54
 None
 0.94A 5njvC-2r79A:
undetectable		 5njvC-2r79A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_D_SAMD501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2r79 PERIPLASMIC BINDING
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 10 ILE A 173
GLY A 174
GLY A 177
VAL A 259
LEU A 260
 HEM  A 500 ( 4.1A)
None
None
None
None
 0.86A 5o96C-2r79A:
2.6
5o96D-2r79A:
undetectable		 5o96C-2r79A:
23.73
5o96D-2r79A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)		 2r79 PERIPLASMIC BINDING
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 9 ALA A 202
VAL A 172
ALA A 183
VAL A 223
GLY A 189
 None
 1.23A 6bklA-2r79A:
undetectable
6bklB-2r79A:
undetectable
6bklC-2r79A:
undetectable
6bklD-2r79A:
undetectable		 6bklA-2r79A:
7.30
6bklB-2r79A:
7.30
6bklC-2r79A:
7.30
6bklD-2r79A:
7.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 2r79 PERIPLASMIC BINDING
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 10 LEU A 129
LEU A 122
ILE A  89
SER A 114
GLY A  90
 None
 0.98A 6dm0B-2r79A:
3.5
6dm0C-2r79A:
3.3		 6dm0B-2r79A:
10.18
6dm0C-2r79A:
10.18