SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2r7a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2r7a BACTERIAL HEME
BINDING PROTEIN
(Shigella
dysenteriae) 		5 / 11 SER A  54
ILE A  26
VAL A  28
ALA A  29
ILE A  65
 None
 1.26A 1uduA-2r7aA:
undetectable		 1uduA-2r7aA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		 2r7a BACTERIAL HEME
BINDING PROTEIN
(Shigella
dysenteriae) 		5 / 12 GLN A 272
ILE A 186
LEU A 189
ARG A 146
ALA A 264
 None
 1.00A 2oc8A-2r7aA:
undetectable		 2oc8A-2r7aA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_D_DVAD8_0
(GRAMICIDIN A)		 2r7a BACTERIAL HEME
BINDING PROTEIN
(Shigella
dysenteriae) 		3 / 3 TRP A  68
VAL A  49
TRP A  87
 None
None
HEM  A 600 (-3.9A)
 1.29A 2xdcC-2r7aA:
undetectable
2xdcD-2r7aA:
undetectable		 2xdcC-2r7aA:
4.00
2xdcD-2r7aA:
4.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_F_DVAF8_0
(VAL-GRAMICIDIN A)		 2r7a BACTERIAL HEME
BINDING PROTEIN
(Shigella
dysenteriae) 		3 / 3 TRP A  68
VAL A  49
TRP A  87
 None
None
HEM  A 600 (-3.9A)
 1.31A 2y5mE-2r7aA:
undetectable
2y5mF-2r7aA:
undetectable		 2y5mE-2r7aA:
4.00
2y5mF-2r7aA:
4.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_D_DVAD8_0
(VAL-GRAMICIDIN A)		 2r7a BACTERIAL HEME
BINDING PROTEIN
(Shigella
dysenteriae) 		3 / 3 TRP A  68
VAL A  49
TRP A  87
 None
None
HEM  A 600 (-3.9A)
 1.29A 2y6nC-2r7aA:
undetectable
2y6nD-2r7aA:
undetectable		 2y6nC-2r7aA:
4.00
2y6nD-2r7aA:
4.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_F_DVAF8_0
(VAL-GRAMICIDIN A)		 2r7a BACTERIAL HEME
BINDING PROTEIN
(Shigella
dysenteriae) 		3 / 3 TRP A  68
VAL A  49
TRP A  87
 None
None
HEM  A 600 (-3.9A)
 1.29A 2y6nE-2r7aA:
undetectable
2y6nF-2r7aA:
undetectable		 2y6nE-2r7aA:
4.00
2y6nF-2r7aA:
4.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 2r7a BACTERIAL HEME
BINDING PROTEIN
(Shigella
dysenteriae) 		5 / 12 LEU A 270
LEU A 274
ALA A 183
ALA A 192
HIS A 198
 None
None
HEM  A 600 (-3.9A)
None
None
 1.30A 3b0wA-2r7aA:
undetectable		 3b0wA-2r7aA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_1
(HIV-1 PROTEASE)		 2r7a BACTERIAL HEME
BINDING PROTEIN
(Shigella
dysenteriae) 		6 / 10 LEU A 109
GLY A  30
ALA A  29
ILE A  76
VAL A  46
VAL A 107
 None
HEM  A 600 (-3.6A)
None
None
None
None
 1.23A 3oxwC-2r7aA:
undetectable		 3oxwC-2r7aA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2r7a BACTERIAL HEME
BINDING PROTEIN
(Shigella
dysenteriae) 		5 / 12 ILE A 186
LEU A 189
GLY A 260
VAL A 267
VAL A 266
 None
 0.84A 3rukB-2r7aA:
undetectable		 3rukB-2r7aA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_1
(HIV-1 PROTEASE)		 2r7a BACTERIAL HEME
BINDING PROTEIN
(Shigella
dysenteriae) 		4 / 7 LEU A 167
ALA A 183
VAL A 218
THR A 220
 None
HEM  A 600 (-3.9A)
None
None
 0.87A 4eyrA-2r7aA:
undetectable		 4eyrA-2r7aA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2r7a BACTERIAL HEME
BINDING PROTEIN
(Shigella
dysenteriae) 		5 / 12 LEU A 116
ILE A 186
GLY A 260
VAL A 267
VAL A 266
 None
 1.11A 4nkvA-2r7aA:
undetectable		 4nkvA-2r7aA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2r7a BACTERIAL HEME
BINDING PROTEIN
(Shigella
dysenteriae) 		6 / 12 LEU A 116
ILE A 186
LEU A 189
GLY A 260
VAL A 267
VAL A 266
 None
 1.05A 4nkvB-2r7aA:
undetectable		 4nkvB-2r7aA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2r7a BACTERIAL HEME
BINDING PROTEIN
(Shigella
dysenteriae) 		5 / 12 LEU A 116
ILE A 186
GLY A 260
VAL A 267
VAL A 266
 None
 1.08A 4nkvC-2r7aA:
undetectable		 4nkvC-2r7aA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2r7a BACTERIAL HEME
BINDING PROTEIN
(Shigella
dysenteriae) 		5 / 12 LEU A 116
ILE A 186
GLY A 260
VAL A 267
VAL A 266
 None
 1.08A 4nkvD-2r7aA:
undetectable		 4nkvD-2r7aA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2r7a BACTERIAL HEME
BINDING PROTEIN
(Shigella
dysenteriae) 		5 / 12 LEU A 116
ILE A 186
GLY A 260
VAL A 267
VAL A 266
 None
 1.04A 4nkxA-2r7aA:
undetectable		 4nkxA-2r7aA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 2r7a BACTERIAL HEME
BINDING PROTEIN
(Shigella
dysenteriae) 		4 / 7 ALA A 190
ARG A 262
GLY A 260
GLU A  35
 None
 0.96A 5bs8A-2r7aA:
undetectable
5bs8B-2r7aA:
undetectable
5bs8C-2r7aA:
undetectable		 5bs8A-2r7aA:
19.37
5bs8B-2r7aA:
21.19
5bs8C-2r7aA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_E_GFNE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 2r7a BACTERIAL HEME
BINDING PROTEIN
(Shigella
dysenteriae) 		4 / 7 ALA A 190
ARG A 262
GLY A 260
GLU A  35
 None
 0.93A 5btdA-2r7aA:
undetectable
5btdB-2r7aA:
undetectable
5btdC-2r7aA:
undetectable		 5btdA-2r7aA:
19.37
5btdB-2r7aA:
21.19
5btdC-2r7aA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2r7a BACTERIAL HEME
BINDING PROTEIN
(Shigella
dysenteriae) 		4 / 7 ALA A 190
ARG A 262
GLY A 260
GLU A  35
 None
 0.97A 5btdA-2r7aA:
undetectable
5btdC-2r7aA:
undetectable
5btdD-2r7aA:
undetectable		 5btdA-2r7aA:
19.37
5btdC-2r7aA:
19.37
5btdD-2r7aA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 2r7a BACTERIAL HEME
BINDING PROTEIN
(Shigella
dysenteriae) 		4 / 6 ALA A 190
ARG A 262
GLY A 260
GLU A  35
 None
 0.95A 5btgA-2r7aA:
undetectable
5btgB-2r7aA:
2.7
5btgC-2r7aA:
undetectable		 5btgA-2r7aA:
19.37
5btgB-2r7aA:
21.19
5btgC-2r7aA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MXB_A_ML1A222_1
(CLASS 10 PLANT
PATHOGENESIS-RELATED
PROTEIN)		 2r7a BACTERIAL HEME
BINDING PROTEIN
(Shigella
dysenteriae) 		5 / 10 VAL A  28
ILE A  85
LEU A 126
ARG A  45
GLY A  43
 None
 1.06A 5mxbA-2r7aA:
undetectable		 5mxbA-2r7aA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 2r7a BACTERIAL HEME
BINDING PROTEIN
(Shigella
dysenteriae) 		5 / 12 LEU A 147
SER A 269
VAL A 267
ALA A 192
ALA A 190
 None
 1.15A 5tzoB-2r7aA:
undetectable		 5tzoB-2r7aA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_0
(REGULATORY PROTEIN
TETR)		 2r7a BACTERIAL HEME
BINDING PROTEIN
(Shigella
dysenteriae) 		5 / 12 ALA A 192
GLU A 268
LEU A 189
TYR A 201
ASP A 265
 None
None
None
HEM  A 600 (-4.2A)
None
 1.50A 5vlmA-2r7aA:
undetectable		 5vlmA-2r7aA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_0
(REGULATORY PROTEIN
TETR)		 2r7a BACTERIAL HEME
BINDING PROTEIN
(Shigella
dysenteriae) 		5 / 12 ALA A 192
GLU A 268
LEU A 189
TYR A 201
ASP A 265
 None
None
None
HEM  A 600 (-4.2A)
None
 1.45A 5vlmC-2r7aA:
undetectable		 5vlmC-2r7aA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_1
(REGULATORY PROTEIN
TETR)		 2r7a BACTERIAL HEME
BINDING PROTEIN
(Shigella
dysenteriae) 		4 / 8 ILE A 186
TYR A 201
VAL A 251
ASP A 265
 None
HEM  A 600 (-4.2A)
None
None
 1.14A 5vlmF-2r7aA:
undetectable		 5vlmF-2r7aA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_C_SAMC301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 2r7a BACTERIAL HEME
BINDING PROTEIN
(Shigella
dysenteriae) 		5 / 12 THR A  52
THR A  53
ILE A  26
VAL A  84
ILE A  37
 HEM  A 600 (-3.9A)
None
None
None
None
 0.90A 6emuC-2r7aA:
undetectable		 6emuC-2r7aA:
19.53