SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2r7e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AX9_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 2r7e COAGULATION FACTOR
VIII
(Homo
sapiens) 		4 / 8 GLY B1948
GLU B1844
PHE B1883
HIS B1848
 None
 0.95A 1ax9A-2r7eB:
undetectable		 1ax9A-2r7eB:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_A_BEZA349_0
(D-AMINO ACID OXIDASE)		 2r7e COAGULATION FACTOR
VIII
(Homo
sapiens) 		4 / 5 TYR B2115
TYR B2105
ILE B2145
GLY B2117
 None
 1.00A 1kifA-2r7eB:
undetectable		 1kifA-2r7eB:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_B_BEZB349_0
(D-AMINO ACID OXIDASE)		 2r7e COAGULATION FACTOR
VIII
(Homo
sapiens) 		4 / 5 TYR B2115
TYR B2105
ILE B2145
GLY B2117
 None
 0.99A 1kifB-2r7eB:
undetectable		 1kifB-2r7eB:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_C_BEZC349_0
(D-AMINO ACID OXIDASE)		 2r7e COAGULATION FACTOR
VIII
(Homo
sapiens) 		4 / 5 TYR B2115
TYR B2105
ILE B2145
GLY B2117
 None
 1.00A 1kifC-2r7eB:
undetectable		 1kifC-2r7eB:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_D_BEZD349_0
(D-AMINO ACID OXIDASE)		 2r7e COAGULATION FACTOR
VIII
(Homo
sapiens) 		4 / 5 TYR B2115
TYR B2105
ILE B2145
GLY B2117
 None
 0.99A 1kifD-2r7eB:
undetectable		 1kifD-2r7eB:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_E_BEZE349_0
(D-AMINO ACID OXIDASE)		 2r7e COAGULATION FACTOR
VIII
(Homo
sapiens) 		4 / 5 TYR B2115
TYR B2105
ILE B2145
GLY B2117
 None
 0.99A 1kifE-2r7eB:
undetectable		 1kifE-2r7eB:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_F_BEZF349_0
(D-AMINO ACID OXIDASE)		 2r7e COAGULATION FACTOR
VIII
(Homo
sapiens) 		4 / 5 TYR B2115
TYR B2105
ILE B2145
GLY B2117
 None
 0.99A 1kifF-2r7eB:
undetectable		 1kifF-2r7eB:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_G_BEZG349_0
(D-AMINO ACID OXIDASE)		 2r7e COAGULATION FACTOR
VIII
(Homo
sapiens) 		4 / 5 TYR B2115
TYR B2105
ILE B2145
GLY B2117
 None
 0.99A 1kifG-2r7eB:
undetectable		 1kifG-2r7eB:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_H_BEZH349_0
(D-AMINO ACID OXIDASE)		 2r7e COAGULATION FACTOR
VIII
(Homo
sapiens) 		4 / 5 TYR B2115
TYR B2105
ILE B2145
GLY B2117
 None
 0.99A 1kifH-2r7eB:
undetectable		 1kifH-2r7eB:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_0
(N,N-DIMETHYLGLYCINE
OXIDASE)		 2r7e COAGULATION FACTOR
VIII
(Homo
sapiens) 		5 / 12 LEU B1932
TYR B1762
GLY B1931
ASN B1922
TYR B1943
 None
 1.44A 1pj7A-2r7eB:
undetectable		 1pj7A-2r7eB:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE9_A_BEZA352_0
(D-AMINO ACID OXIDASE)		 2r7e COAGULATION FACTOR
VIII
(Homo
sapiens) 		4 / 5 TYR B2115
TYR B2105
ILE B2145
GLY B2117
 None
 1.08A 1ve9A-2r7eB:
undetectable		 1ve9A-2r7eB:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WYG_A_SALA4005_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2r7e COAGULATION FACTOR
VIII
(Homo
sapiens) 		5 / 10 ARG B1776
PHE B1775
THR B1812
ALA B1702
ALA B1701
 None
 1.27A 1wygA-2r7eB:
undetectable		 1wygA-2r7eB:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_G_BEZG2352_0
(D-AMINO-ACID OXIDASE)		 2r7e COAGULATION FACTOR
VIII
(Homo
sapiens) 		4 / 5 TYR B2115
TYR B2105
ILE B2145
GLY B2117
 None
 0.92A 2du8G-2r7eB:
undetectable		 2du8G-2r7eB:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQD_A_CUA601_0
(BLUE COPPER OXIDASE
CUEO)		 2r7e COAGULATION FACTOR
VIII
(Homo
sapiens) 		4 / 4 HIS B1954
CYH B2000
HIS B2005
MET B2010
 CU  B2404 (-3.2A)
CU  B2404 (-2.2A)
CU  B2404 (-3.5A)
CU  B2404 ( 4.8A)
 0.98A 2fqdA-2r7eB:
17.8		 2fqdA-2r7eB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQE_A_CUA601_0
(BLUE COPPER OXIDASE
CUEO)		 2r7e COAGULATION FACTOR
VIII
(Homo
sapiens) 		4 / 4 HIS B1954
CYH B2000
HIS B2005
MET B2010
 CU  B2404 (-3.2A)
CU  B2404 (-2.2A)
CU  B2404 (-3.5A)
CU  B2404 ( 4.8A)
 0.96A 2fqeA-2r7eB:
17.9		 2fqeA-2r7eB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQF_A_CUA601_0
(BLUE COPPER OXIDASE
CUEO)		 2r7e COAGULATION FACTOR
VIII
(Homo
sapiens) 		4 / 4 HIS B1954
CYH B2000
HIS B2005
MET B2010
 CU  B2404 (-3.2A)
CU  B2404 (-2.2A)
CU  B2404 (-3.5A)
CU  B2404 ( 4.8A)
 0.97A 2fqfA-2r7eB:
17.9		 2fqfA-2r7eB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQG_A_CUA601_0
(BLUE COPPER OXIDASE
CUEO)		 2r7e COAGULATION FACTOR
VIII
(Homo
sapiens) 		4 / 4 HIS B1954
CYH B2000
HIS B2005
MET B2010
 CU  B2404 (-3.2A)
CU  B2404 (-2.2A)
CU  B2404 (-3.5A)
CU  B2404 ( 4.8A)
 0.99A 2fqgA-2r7eB:
17.8		 2fqgA-2r7eB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HKK_A_ALEA300_1
(CARBONIC ANHYDRASE 2)		 2r7e COAGULATION FACTOR
VIII
(Homo
sapiens) 		4 / 6 ASN B2019
HIS B2082
ILE B1940
GLN B1874
 NAG  B2431 ( 4.8A)
None
None
None
 1.20A 2hkkA-2r7eB:
undetectable		 2hkkA-2r7eB:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HKK_A_ALEA300_1
(CARBONIC ANHYDRASE 2)		 2r7e COAGULATION FACTOR
VIII
(Homo
sapiens) 		4 / 6 ASN B2019
HIS B2082
ILE B1940
GLN B1938
 NAG  B2431 ( 4.8A)
None
None
NAG  B2431 (-3.4A)
 1.19A 2hkkA-2r7eB:
undetectable		 2hkkA-2r7eB:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_A_CUA1337_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 2r7e COAGULATION FACTOR
VIII
(Homo
sapiens) 		4 / 4 HIS B1954
CYH B2000
HIS B2005
MET B2010
 CU  B2404 (-3.2A)
CU  B2404 (-2.2A)
CU  B2404 (-3.5A)
CU  B2404 ( 4.8A)
 1.18A 2xxgA-2r7eB:
10.8		 2xxgA-2r7eB:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 2r7e COAGULATION FACTOR
VIII
(Homo
sapiens) 		3 / 3 TYR B1762
GLU B1875
THR B1985
 None
 1.04A 2y7hB-2r7eB:
undetectable		 2y7hB-2r7eB:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_B_ACTB600_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 2r7e COAGULATION FACTOR
VIII
(Homo
sapiens) 		4 / 5 HIS B2005
ALA B2008
GLU B1914
HIS B1919
 CU  B2404 (-3.5A)
None
None
None
 1.18A 3mbgB-2r7eB:
undetectable
3mbgC-2r7eB:
undetectable		 3mbgB-2r7eB:
10.46
3mbgC-2r7eB:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_C_ACTC600_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 2r7e COAGULATION FACTOR
VIII
(Homo
sapiens) 		4 / 5 GLU B1914
HIS B1919
HIS B2005
ALA B2008
 None
None
CU  B2404 (-3.5A)
None
 1.19A 3mbgB-2r7eB:
undetectable
3mbgC-2r7eB:
undetectable		 3mbgB-2r7eB:
10.46
3mbgC-2r7eB:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_2
(HIV-1 PROTEASE)		 2r7e COAGULATION FACTOR
VIII
(Homo
sapiens) 		5 / 10 LEU B1759
VAL B1847
GLY B1981
VAL B1982
ILE B1852
 None
 1.06A 3oxwB-2r7eB:
undetectable		 3oxwB-2r7eB:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_A_CUA601_0
(LACCASE-1)		 2r7e COAGULATION FACTOR
VIII
(Homo
sapiens) 		4 / 5 HIS B1954
CYH B2000
ILE B2002
HIS B2005
 CU  B2404 (-3.2A)
CU  B2404 (-2.2A)
CU  B2404 (-2.6A)
CU  B2404 (-3.5A)
 0.98A 3qpkA-2r7eB:
7.7		 3qpkA-2r7eB:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_B_CUB601_0
(LACCASE-1)		 2r7e COAGULATION FACTOR
VIII
(Homo
sapiens) 		4 / 4 HIS B1954
CYH B2000
ILE B2002
HIS B2005
 CU  B2404 (-3.2A)
CU  B2404 (-2.2A)
CU  B2404 (-2.6A)
CU  B2404 (-3.5A)
 0.99A 3qpkB-2r7eB:
12.4		 3qpkB-2r7eB:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_F_ACTF402_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 2r7e COAGULATION FACTOR
VIII
(Homo
sapiens) 		3 / 3 PHE B1743
ASP B1740
ARG B1776
 None
 0.87A 4eahF-2r7eB:
undetectable		 4eahF-2r7eB:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_G_ACTG401_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 2r7e COAGULATION FACTOR
VIII
(Homo
sapiens) 		3 / 3 PHE B1743
ASP B1740
ARG B1776
 None
 0.87A 4eahG-2r7eB:
undetectable		 4eahG-2r7eB:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EF3_A_CUA1001_0
(BLUE COPPER OXIDASE
CUEO)		 2r7e COAGULATION FACTOR
VIII
(Homo
sapiens) 		4 / 4 HIS B1954
CYH B2000
HIS B2005
MET B2010
 CU  B2404 (-3.2A)
CU  B2404 (-2.2A)
CU  B2404 (-3.5A)
CU  B2404 ( 4.8A)
 1.03A 4ef3A-2r7eB:
17.7		 4ef3A-2r7eB:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_C_LYAC304_2
(FOLATE RECEPTOR BETA)		 2r7e COAGULATION FACTOR
VIII
(Homo
sapiens) 		3 / 3 TYR B2256
GLN B2284
TRP B2313
 None
 0.81A 4kn2C-2r7eB:
undetectable		 4kn2C-2r7eB:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 2r7e COAGULATION FACTOR
VIII
(Homo
sapiens) 		6 / 12 ALA B1836
ALA B1834
LEU B1929
HIS B1755
ALA B1877
GLY B1757
 None
 1.38A 4v04B-2r7eB:
undetectable		 4v04B-2r7eB:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_B_GBMB801_1
(PROLINE--TRNA LIGASE)		 2r7e COAGULATION FACTOR
VIII
(Homo
sapiens) 		5 / 9 ILE B2071
LEU B2151
THR B2086
ARG B2052
ILE B2084
 None
 1.41A 5ifuB-2r7eB:
undetectable		 5ifuB-2r7eB:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2r7e COAGULATION FACTOR
VIII
(Homo
sapiens) 		5 / 12 ILE B1763
GLY B1853
ALA B1834
SER B1791
ILE B1790
 None
 1.21A 5ih0A-2r7eB:
undetectable		 5ih0A-2r7eB:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_A_PFLA412_1
(PROTON-GATED ION
CHANNEL)		 2r7e COAGULATION FACTOR
VIII
(Homo
sapiens) 		5 / 10 TYR B1837
ILE B1771
VAL B1773
TYR B1786
ILE B1790
 None
 1.28A 5mzrA-2r7eB:
undetectable		 5mzrA-2r7eB:
7.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_C_PFLC409_1
(PROTON-GATED ION
CHANNEL)		 2r7e COAGULATION FACTOR
VIII
(Homo
sapiens) 		5 / 10 TYR B1837
ILE B1771
VAL B1773
TYR B1786
ILE B1790
 None
 1.29A 5mzrC-2r7eB:
undetectable		 5mzrC-2r7eB:
7.79