SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2r7m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3004_1
(SERUM ALBUMIN)		 2r7m 5-FORMAMINOIMIDAZOLE
-4-CARBOXAMIDE-1-(BE
TA)-D-RIBOFURANOSYL
5'-MONOPHOSPHATE
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 6 PHE A 294
GLU A 221
LEU A 222
VAL A 271
 None
 1.01A 1hk1A-2r7mA:
undetectable		 1hk1A-2r7mA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3004_1
(SERUM ALBUMIN)		 2r7m 5-FORMAMINOIMIDAZOLE
-4-CARBOXAMIDE-1-(BE
TA)-D-RIBOFURANOSYL
5'-MONOPHOSPHATE
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 7 PHE A 294
GLU A 221
LEU A 222
VAL A 271
 None
 0.91A 1hk2A-2r7mA:
undetectable		 1hk2A-2r7mA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3004_1
(SERUM ALBUMIN)		 2r7m 5-FORMAMINOIMIDAZOLE
-4-CARBOXAMIDE-1-(BE
TA)-D-RIBOFURANOSYL
5'-MONOPHOSPHATE
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 7 PHE A 294
GLU A 221
LEU A 222
VAL A 271
 None
 0.96A 1hk3A-2r7mA:
undetectable		 1hk3A-2r7mA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 2r7m 5-FORMAMINOIMIDAZOLE
-4-CARBOXAMIDE-1-(BE
TA)-D-RIBOFURANOSYL
5'-MONOPHOSPHATE
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 6 ARG A 120
ASP A  72
ASN A  75
GLU A 105
 None
 1.29A 1rjdA-2r7mA:
2.4		 1rjdA-2r7mA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 2r7m 5-FORMAMINOIMIDAZOLE
-4-CARBOXAMIDE-1-(BE
TA)-D-RIBOFURANOSYL
5'-MONOPHOSPHATE
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 6 ARG A 120
ASP A  72
ASN A  75
GLU A 105
 None
 1.33A 1rjdB-2r7mA:
2.5		 1rjdB-2r7mA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 2r7m 5-FORMAMINOIMIDAZOLE
-4-CARBOXAMIDE-1-(BE
TA)-D-RIBOFURANOSYL
5'-MONOPHOSPHATE
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 6 ARG A 120
ASP A  72
ASN A  75
GLU A 105
 None
 1.30A 1rjdC-2r7mA:
2.4		 1rjdC-2r7mA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_B_PODB700_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2r7m 5-FORMAMINOIMIDAZOLE
-4-CARBOXAMIDE-1-(BE
TA)-D-RIBOFURANOSYL
5'-MONOPHOSPHATE
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A 137
ALA A 135
LYS A 281
LEU A 278
MET A 290
 None
 1.16A 1sa1A-2r7mA:
2.8
1sa1B-2r7mA:
undetectable		 1sa1A-2r7mA:
20.80
1sa1B-2r7mA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB504_1
(YKOF)		 2r7m 5-FORMAMINOIMIDAZOLE
-4-CARBOXAMIDE-1-(BE
TA)-D-RIBOFURANOSYL
5'-MONOPHOSPHATE
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 6 HIS A  27
LEU A 119
ILE A  96
SER A 123
 CL  A 601 ( 4.2A)
None
None
None
 1.18A 1sbrA-2r7mA:
undetectable
1sbrB-2r7mA:
undetectable		 1sbrA-2r7mA:
20.88
1sbrB-2r7mA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_2
(RETINOIC ACID
RECEPTOR, BETA)		 2r7m 5-FORMAMINOIMIDAZOLE
-4-CARBOXAMIDE-1-(BE
TA)-D-RIBOFURANOSYL
5'-MONOPHOSPHATE
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		3 / 3 LEU A  24
PHE A  95
ARG A  83
 None
 0.85A 1xdkB-2r7mA:
undetectable		 1xdkB-2r7mA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_B_LOCB700_2
(TUBULIN BETA-2B
CHAIN)		 2r7m 5-FORMAMINOIMIDAZOLE
-4-CARBOXAMIDE-1-(BE
TA)-D-RIBOFURANOSYL
5'-MONOPHOSPHATE
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 11 LEU A 137
ALA A 135
LYS A 281
LEU A 278
MET A 290
 None
 1.11A 3e22B-2r7mA:
undetectable		 3e22B-2r7mA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2r7m 5-FORMAMINOIMIDAZOLE
-4-CARBOXAMIDE-1-(BE
TA)-D-RIBOFURANOSYL
5'-MONOPHOSPHATE
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 8 ASP A 148
ILE A 149
VAL A 153
VAL A 155
 None
 0.75A 3fi0B-2r7mA:
undetectable		 3fi0B-2r7mA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM201_1
(PROTEIN S100-A4)		 2r7m 5-FORMAMINOIMIDAZOLE
-4-CARBOXAMIDE-1-(BE
TA)-D-RIBOFURANOSYL
5'-MONOPHOSPHATE
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 7 GLY A 325
CYH A 295
PHE A 294
GLY A 340
 None
 0.95A 3ko0M-2r7mA:
undetectable
3ko0P-2r7mA:
undetectable		 3ko0M-2r7mA:
15.26
3ko0P-2r7mA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP201_1
(PROTEIN S100-A4)		 2r7m 5-FORMAMINOIMIDAZOLE
-4-CARBOXAMIDE-1-(BE
TA)-D-RIBOFURANOSYL
5'-MONOPHOSPHATE
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 7 GLY A 340
GLY A 325
CYH A 295
PHE A 294
 None
 0.85A 3ko0M-2r7mA:
undetectable
3ko0P-2r7mA:
undetectable		 3ko0M-2r7mA:
15.26
3ko0P-2r7mA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_3
(PROTEASE)		 2r7m 5-FORMAMINOIMIDAZOLE
-4-CARBOXAMIDE-1-(BE
TA)-D-RIBOFURANOSYL
5'-MONOPHOSPHATE
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A   7
ILE A 291
PRO A  91
VAL A  90
ILE A  88
 None
 0.85A 3ndtB-2r7mA:
undetectable		 3ndtB-2r7mA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUJ_B_478B401_1
(PROTEASE)		 2r7m 5-FORMAMINOIMIDAZOLE
-4-CARBOXAMIDE-1-(BE
TA)-D-RIBOFURANOSYL
5'-MONOPHOSPHATE
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 10 ILE A   7
ILE A 291
PRO A  91
VAL A  90
ILE A  88
 None
 1.02A 3nujA-2r7mA:
undetectable		 3nujA-2r7mA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUO_B_478B478_1
(PROTEASE)		 2r7m 5-FORMAMINOIMIDAZOLE
-4-CARBOXAMIDE-1-(BE
TA)-D-RIBOFURANOSYL
5'-MONOPHOSPHATE
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 9 ILE A   7
ILE A 291
PRO A  91
VAL A  90
ILE A  88
 None
 1.01A 3nuoA-2r7mA:
undetectable		 3nuoA-2r7mA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEO_B_LLTB261_1
(DEOXYCYTIDINE KINASE)		 2r7m 5-FORMAMINOIMIDAZOLE
-4-CARBOXAMIDE-1-(BE
TA)-D-RIBOFURANOSYL
5'-MONOPHOSPHATE
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 7 VAL A 271
LEU A 222
TYR A 328
PHE A 207
 None
 1.06A 3qeoB-2r7mA:
undetectable		 3qeoB-2r7mA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1475_0
(MJ0495-LIKE PROTEIN)		 2r7m 5-FORMAMINOIMIDAZOLE
-4-CARBOXAMIDE-1-(BE
TA)-D-RIBOFURANOSYL
5'-MONOPHOSPHATE
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 8 ILE A  78
ASP A  72
ILE A  73
PHE A  70
GLY A  25
 None
 1.38A 4ac9C-2r7mA:
undetectable		 4ac9C-2r7mA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2r7m 5-FORMAMINOIMIDAZOLE
-4-CARBOXAMIDE-1-(BE
TA)-D-RIBOFURANOSYL
5'-MONOPHOSPHATE
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 8 ILE A  78
ASP A  72
ILE A  73
PHE A  70
GLY A  25
 None
 1.36A 4acaC-2r7mA:
undetectable		 4acaC-2r7mA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQF_B_017B101_1
(ASPARTYL PROTEASE)		 2r7m 5-FORMAMINOIMIDAZOLE
-4-CARBOXAMIDE-1-(BE
TA)-D-RIBOFURANOSYL
5'-MONOPHOSPHATE
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A   7
ILE A 291
PRO A  91
VAL A  90
ILE A  88
 None
 0.96A 4dqfA-2r7mA:
undetectable		 4dqfA-2r7mA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK6_B_LURB201_1
(TRANSTHYRETIN)		 2r7m 5-FORMAMINOIMIDAZOLE
-4-CARBOXAMIDE-1-(BE
TA)-D-RIBOFURANOSYL
5'-MONOPHOSPHATE
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 8 LEU A 137
GLU A 273
ALA A 135
LEU A 132
 None
 0.97A 4ik6B-2r7mA:
undetectable		 4ik6B-2r7mA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_1
(ADENOSINE KINASE)		 2r7m 5-FORMAMINOIMIDAZOLE
-4-CARBOXAMIDE-1-(BE
TA)-D-RIBOFURANOSYL
5'-MONOPHOSPHATE
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		6 / 12 ASP A 316
LEU A 222
GLY A 317
GLY A 318
ASN A 258
CYH A 295
 CL  A 601 ( 3.9A)
None
AMP  A 401 ( 3.5A)
AMP  A 401 ( 4.4A)
AMP  A 401 (-3.0A)
None
 1.39A 4n09C-2r7mA:
4.7		 4n09C-2r7mA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 2r7m 5-FORMAMINOIMIDAZOLE
-4-CARBOXAMIDE-1-(BE
TA)-D-RIBOFURANOSYL
5'-MONOPHOSPHATE
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A 356
ILE A 118
LEU A 119
GLY A 292
ILE A 291
 None
 1.20A 4o1eA-2r7mA:
undetectable		 4o1eA-2r7mA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN)		 2r7m 5-FORMAMINOIMIDAZOLE
-4-CARBOXAMIDE-1-(BE
TA)-D-RIBOFURANOSYL
5'-MONOPHOSPHATE
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ARG A 345
SER A 214
GLY A 292
ALA A  36
GLY A 340
 None
 1.26A 4r29C-2r7mA:
undetectable		 4r29C-2r7mA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_A_ADNA1002_1
(MYOSIN HEAVY CHAIN
KINASE A)		 2r7m 5-FORMAMINOIMIDAZOLE
-4-CARBOXAMIDE-1-(BE
TA)-D-RIBOFURANOSYL
5'-MONOPHOSPHATE
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 11 PHE A  41
GLY A 340
LEU A 216
LEU A 351
PHE A 113
 None
 0.96A 4zmeA-2r7mA:
0.0		 4zmeA-2r7mA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_1
(PROTEASE E35D-APV)		 2r7m 5-FORMAMINOIMIDAZOLE
-4-CARBOXAMIDE-1-(BE
TA)-D-RIBOFURANOSYL
5'-MONOPHOSPHATE
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 9 ILE A   7
ILE A 291
PRO A  91
VAL A  90
ILE A  88
 None
 0.87A 5kr0A-2r7mA:
undetectable		 5kr0A-2r7mA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_C_ROCC101_2
(PROTEASE PR5-SQV)		 2r7m 5-FORMAMINOIMIDAZOLE
-4-CARBOXAMIDE-1-(BE
TA)-D-RIBOFURANOSYL
5'-MONOPHOSPHATE
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		5 / 9 ILE A   7
ILE A 291
PRO A  91
VAL A  90
ILE A  88
 None
 0.91A 5kr2D-2r7mA:
undetectable		 5kr2D-2r7mA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_2
(CYTOCHROME P450 3A4)		 2r7m 5-FORMAMINOIMIDAZOLE
-4-CARBOXAMIDE-1-(BE
TA)-D-RIBOFURANOSYL
5'-MONOPHOSPHATE
SYNTHETASE
(Methanocaldococc
us
jannaschii) 		4 / 6 ARG A 314
PHE A 212
ILE A  32
THR A  28
 CL  A 601 (-3.6A)
None
None
None
 1.04A 5vceA-2r7mA:
undetectable		 5vceA-2r7mA:
22.47