SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2r7y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_1
(HIV-1 PROTEASE)		 2r7y RIBONUCLEASE H
(Bacillus
halodurans) 		5 / 9 LEU A 161
GLY A 108
GLY A  79
ILE A  80
ILE A 158
 None
 0.98A 1hpvA-2r7yA:
undetectable		 1hpvA-2r7yA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDW_B_017B401_2
(PROTEASE)		 2r7y RIBONUCLEASE H
(Bacillus
halodurans) 		5 / 9 LEU A 161
GLY A 108
GLY A  79
ILE A  80
ILE A 158
 None
 0.95A 2idwB-2r7yA:
undetectable		 2idwB-2r7yA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_A_SAMA500_0
(HYPOTHETICAL PROTEIN)		 2r7y RIBONUCLEASE H
(Bacillus
halodurans) 		4 / 7 VAL A  70
ALA A 112
PRO A 128
THR A 176
 None
 0.96A 2q6oA-2r7yA:
undetectable		 2q6oA-2r7yA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A7E_A_SAMA216_1
(CATECHOL
O-METHYLTRANSFERASE)		 2r7y RIBONUCLEASE H
(Bacillus
halodurans) 		4 / 6 GLY A 103
SER A 147
ILE A 100
ILE A  80
 None
 0.96A 3a7eA-2r7yA:
undetectable		 3a7eA-2r7yA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_B_NCAB302_0
(ADP-RIBOSYL CYCLASE
1)		 2r7y RIBONUCLEASE H
(Bacillus
halodurans) 		4 / 7 ASP A 163
TRP A 159
SER A 147
THR A 104
 None
 1.39A 3dzgB-2r7yA:
undetectable		 3dzgB-2r7yA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UPR_A_1KXA277_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 2r7y RIBONUCLEASE H
(Bacillus
halodurans) 		5 / 10 TYR A 119
ILE A 129
ASP A  87
SER A  69
TYR A 130
 None
 1.18A 3uprA-2r7yA:
undetectable		 3uprA-2r7yA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UPR_C_1KXC277_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 2r7y RIBONUCLEASE H
(Bacillus
halodurans) 		5 / 10 TYR A 119
ILE A 129
ASP A  87
SER A  69
TYR A 130
 None
 1.21A 3uprC-2r7yA:
undetectable		 3uprC-2r7yA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_2
(ADENOSINE KINASE,
PUTATIVE)		 2r7y RIBONUCLEASE H
(Bacillus
halodurans) 		4 / 5 LEU A 117
ALA A 165
PHE A 110
ASN A 170
 None
 1.24A 3uq6A-2r7yA:
undetectable		 3uq6A-2r7yA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_A_ADNA401_2
(PUTATIVE ADENOSINE
KINASE)		 2r7y RIBONUCLEASE H
(Bacillus
halodurans) 		4 / 4 LEU A 117
ALA A 165
PHE A 110
ASN A 170
 None
 1.32A 3vaqA-2r7yA:
undetectable		 3vaqA-2r7yA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_A_ADNA401_2
(PUTATIVE ADENOSINE
KINASE)		 2r7y RIBONUCLEASE H
(Bacillus
halodurans) 		4 / 4 LEU A 117
ALA A 165
PHE A 110
ASN A 170
 None
 1.28A 3vasA-2r7yA:
undetectable		 3vasA-2r7yA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRJ_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN
10-MER PEPTIDE)		 2r7y RIBONUCLEASE H
(Bacillus
halodurans) 		5 / 12 TYR A 119
ILE A 129
ASP A  87
SER A  69
TYR A 130
 None
 1.23A 3vrjA-2r7yA:
undetectable
3vrjC-2r7yA:
undetectable		 3vrjA-2r7yA:
20.07
3vrjC-2r7yA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 2r7y RIBONUCLEASE H
(Bacillus
halodurans) 		3 / 3 ASP A 163
ASN A 170
SER A 147
 None
 0.87A 4obwA-2r7yA:
undetectable		 4obwA-2r7yA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U98_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 2r7y RIBONUCLEASE H
(Bacillus
halodurans) 		5 / 10 TYR A 119
ILE A 129
ASP A  87
SER A  69
TYR A 130
 None
 1.17A 5u98A-2r7yA:
undetectable		 5u98A-2r7yA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U98_D_1KXD301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 2r7y RIBONUCLEASE H
(Bacillus
halodurans) 		5 / 10 TYR A 119
ILE A 129
ASP A  87
SER A  69
TYR A 130
 None
 1.17A 5u98D-2r7yA:
undetectable		 5u98D-2r7yA:
20.00