SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2r87'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3004_1
(SERUM ALBUMIN)		 2r87 PURP PROTEIN PF1517
(Pyrococcus
furiosus) 		4 / 6 PHE A 267
GLU A 195
LEU A 196
VAL A 245
 None
 1.05A 1hk1A-2r87A:
undetectable		 1hk1A-2r87A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ME7_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 2r87 PURP PROTEIN PF1517
(Pyrococcus
furiosus) 		4 / 8 SER A  12
ILE A  16
GLY A 313
GLY A 291
 None
 0.78A 1me7A-2r87A:
undetectable		 1me7A-2r87A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EZ7_A_DHIA301_0
(CARBONIC ANHYDRASE 2)		 2r87 PURP PROTEIN PF1517
(Pyrococcus
furiosus) 		4 / 6 HIS A  11
ASN A 293
GLN A  15
PRO A  68
 PO4  A 402 (-3.8A)
None
None
None
 1.44A 2ez7A-2r87A:
undetectable		 2ez7A-2r87A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A27_A_SAMA250_1
(UNCHARACTERIZED
PROTEIN MJ1557)		 2r87 PURP PROTEIN PF1517
(Pyrococcus
furiosus) 		3 / 3 MET A 197
GLU A 319
ASN A 326
 None
 1.10A 3a27A-2r87A:
3.5		 3a27A-2r87A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_1
(PROTEASE)		 2r87 PURP PROTEIN PF1517
(Pyrococcus
furiosus) 		6 / 12 LEU A 108
GLY A 249
ALA A 248
PRO A 116
VAL A 115
ILE A 113
 None
None
None
ADP  A 400 (-4.6A)
None
None
 1.35A 3ndtA-2r87A:
undetectable		 3ndtA-2r87A:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 2r87 PURP PROTEIN PF1517
(Pyrococcus
furiosus) 		5 / 12 PHE A 186
VAL A 332
VAL A 310
ARG A 315
TYR A 306
 None
None
None
None
PO4  A 501 (-4.5A)
 1.44A 3p6gA-2r87A:
undetectable		 3p6gA-2r87A:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA506_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2r87 PURP PROTEIN PF1517
(Pyrococcus
furiosus) 		4 / 4 PRO A 183
LEU A 269
ILE A 113
ARG A 251
 None
 1.40A 4f4dA-2r87A:
2.7		 4f4dA-2r87A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_1
(DIHYDROPTEROATE
SYNTHASE DHPS)		 2r87 PURP PROTEIN PF1517
(Pyrococcus
furiosus) 		3 / 3 LYS A 164
ASN A 169
ASP A 121
 None
 0.90A 4o1eA-2r87A:
undetectable		 4o1eA-2r87A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_ADNB2415_1
(RNA-DIRECTED RNA
POLYMERASE L)		 2r87 PURP PROTEIN PF1517
(Pyrococcus
furiosus) 		4 / 7 GLU A 270
PHE A 282
ARG A 101
TYR A 142
 ADP  A 400 (-3.3A)
ADP  A 400 (-3.4A)
ADP  A 400 ( 4.7A)
ADP  A 400 (-4.5A)
 1.12A 4uciB-2r87A:
undetectable		 4uciB-2r87A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ5_B_ACTB404_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 2r87 PURP PROTEIN PF1517
(Pyrococcus
furiosus) 		3 / 3 TYR A 142
ARG A 101
LYS A 132
 ADP  A 400 (-4.5A)
ADP  A 400 ( 4.7A)
ADP  A 400 (-2.8A)
 1.30A 4wq5B-2r87A:
undetectable		 4wq5B-2r87A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_A_CL6A502_1
(CYTOCHROME P-450)		 2r87 PURP PROTEIN PF1517
(Pyrococcus
furiosus) 		4 / 5 LEU A  38
ALA A  29
THR A   7
ILE A  16
 None
 0.91A 4xe3A-2r87A:
undetectable		 4xe3A-2r87A:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)		 2r87 PURP PROTEIN PF1517
(Pyrococcus
furiosus) 		4 / 6 GLU A 193
GLY A  19
ASP A  22
GLY A 313
 None
 0.99A 5cdpA-2r87A:
undetectable
5cdpB-2r87A:
undetectable		 5cdpA-2r87A:
20.91
5cdpB-2r87A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_B_SALB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2r87 PURP PROTEIN PF1517
(Pyrococcus
furiosus) 		4 / 7 VAL A 229
TYR A 182
GLY A 291
ALA A 290
 None
None
None
PO4  A 402 (-3.6A)
 0.88A 5f1aB-2r87A:
undetectable		 5f1aB-2r87A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MM4_B_TA1B501_1
(TUBULIN BETA CHAIN)		 2r87 PURP PROTEIN PF1517
(Pyrococcus
furiosus) 		5 / 10 GLU A  26
LEU A  76
ALA A  64
THR A  69
LEU A  17
 None
 1.46A 5mm4B-2r87A:
2.8		 5mm4B-2r87A:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 2r87 PURP PROTEIN PF1517
(Pyrococcus
furiosus) 		5 / 10 LEU A 329
VAL A 332
PHE A  89
ILE A 316
ALA A 317
 None
 1.33A 6h1lA-2r87A:
undetectable		 6h1lA-2r87A:
23.14