SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2r8a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_ACTA421_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 2r8a LONG-CHAIN FATTY
ACID TRANSPORT
PROTEIN
(Escherichia
coli) 		5 / 8 TYR A  17
GLY A 386
GLY A  10
GLY A  12
SER A 388
 None
 1.31A 1qzzA-2r8aA:
undetectable		 1qzzA-2r8aA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2r8a LONG-CHAIN FATTY
ACID TRANSPORT
PROTEIN
(Escherichia
coli) 		3 / 3 SER A 370
GLY A 344
ARG A 326
 None
 0.55A 1t9wA-2r8aA:
undetectable		 1t9wA-2r8aA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_A_ACTA2001_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 2r8a LONG-CHAIN FATTY
ACID TRANSPORT
PROTEIN
(Escherichia
coli) 		4 / 5 SER A  97
SER A  31
THR A  99
ASN A 101
 None
 1.07A 1yvpA-2r8aA:
undetectable		 1yvpA-2r8aA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_B_ACTB2002_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 2r8a LONG-CHAIN FATTY
ACID TRANSPORT
PROTEIN
(Escherichia
coli) 		4 / 6 SER A  97
SER A  31
THR A  99
ASN A 101
 None
 1.03A 1yvpB-2r8aA:
undetectable		 1yvpB-2r8aA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z35_A_2FAA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2r8a LONG-CHAIN FATTY
ACID TRANSPORT
PROTEIN
(Escherichia
coli) 		5 / 10 THR A 121
GLY A 119
THR A 197
GLU A 156
SER A 360
 None
 1.44A 1z35A-2r8aA:
undetectable		 1z35A-2r8aA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2r8a LONG-CHAIN FATTY
ACID TRANSPORT
PROTEIN
(Escherichia
coli) 		4 / 5 LEU A 184
PRO A 174
ALA A 175
ILE A 170
 None
 1.03A 2aofB-2r8aA:
undetectable		 2aofB-2r8aA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_B_ACTB141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 2r8a LONG-CHAIN FATTY
ACID TRANSPORT
PROTEIN
(Escherichia
coli) 		3 / 3 PRO A  34
ASN A 210
ARG A 228
 None
 0.77A 2qeuB-2r8aA:
undetectable		 2qeuB-2r8aA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA606_1
(CHITINASE A)		 2r8a LONG-CHAIN FATTY
ACID TRANSPORT
PROTEIN
(Escherichia
coli) 		4 / 7 GLY A  12
LYS A   9
TYR A  17
ARG A 228
 None
 0.96A 3arrA-2r8aA:
undetectable		 3arrA-2r8aA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA606_1
(CHITINASE A)		 2r8a LONG-CHAIN FATTY
ACID TRANSPORT
PROTEIN
(Escherichia
coli) 		4 / 7 GLY A  12
LYS A   9
TYR A  17
ARG A 228
 None
 0.99A 3aruA-2r8aA:
undetectable		 3aruA-2r8aA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_1
(O-METHYLTRANSFERASE)		 2r8a LONG-CHAIN FATTY
ACID TRANSPORT
PROTEIN
(Escherichia
coli) 		3 / 3 ASP A  26
PHE A  40
SER A  31
 None
 1.01A 3i5uB-2r8aA:
undetectable		 3i5uB-2r8aA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_D_QELD2_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 2r8a LONG-CHAIN FATTY
ACID TRANSPORT
PROTEIN
(Escherichia
coli) 		4 / 5 TYR A 112
THR A 111
PHE A 158
LEU A 162
 None
 1.05A 3qelC-2r8aA:
undetectable		 3qelC-2r8aA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_1
(ADENOSINE KINASE)		 2r8a LONG-CHAIN FATTY
ACID TRANSPORT
PROTEIN
(Escherichia
coli) 		5 / 12 GLY A 119
GLY A 118
LEU A  68
GLU A 399
THR A 197
 None
 1.04A 3uboB-2r8aA:
undetectable		 3uboB-2r8aA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_A_ADNA500_1
(SUGAR KINASE PROTEIN)		 2r8a LONG-CHAIN FATTY
ACID TRANSPORT
PROTEIN
(Escherichia
coli) 		5 / 12 GLY A 119
GLY A 118
LEU A  68
GLU A 399
THR A 197
 None
 1.03A 4e3aA-2r8aA:
undetectable		 4e3aA-2r8aA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKU_B_ADNB500_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2r8a LONG-CHAIN FATTY
ACID TRANSPORT
PROTEIN
(Escherichia
coli) 		5 / 12 GLY A 119
GLY A 118
LEU A  68
GLU A 399
THR A 197
 None
 1.02A 4jkuB-2r8aA:
undetectable		 4jkuB-2r8aA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8P_A_ADNA401_1
(SUGAR KINASE)		 2r8a LONG-CHAIN FATTY
ACID TRANSPORT
PROTEIN
(Escherichia
coli) 		5 / 12 GLY A 119
GLY A 118
LEU A  68
GLU A 399
THR A 197
 None
 1.04A 4k8pA-2r8aA:
undetectable		 4k8pA-2r8aA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8P_B_ADNB401_1
(SUGAR KINASE)		 2r8a LONG-CHAIN FATTY
ACID TRANSPORT
PROTEIN
(Escherichia
coli) 		5 / 12 GLY A 119
GLY A 118
LEU A  68
GLU A 399
THR A 197
 None
 1.02A 4k8pB-2r8aA:
undetectable		 4k8pB-2r8aA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8T_A_ADNA401_1
(SUGAR KINASE)		 2r8a LONG-CHAIN FATTY
ACID TRANSPORT
PROTEIN
(Escherichia
coli) 		5 / 12 GLY A 119
GLY A 118
LEU A  68
GLU A 399
THR A 197
 None
 1.03A 4k8tA-2r8aA:
undetectable		 4k8tA-2r8aA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8T_B_ADNB401_1
(SUGAR KINASE)		 2r8a LONG-CHAIN FATTY
ACID TRANSPORT
PROTEIN
(Escherichia
coli) 		5 / 12 GLY A 119
GLY A 118
LEU A  68
GLU A 399
THR A 197
 None
 1.02A 4k8tB-2r8aA:
undetectable		 4k8tB-2r8aA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K93_A_ADNA401_1
(SUGAR KINASE)		 2r8a LONG-CHAIN FATTY
ACID TRANSPORT
PROTEIN
(Escherichia
coli) 		5 / 12 GLY A 119
GLY A 118
LEU A  68
GLU A 399
THR A 197
 None
 1.01A 4k93A-2r8aA:
undetectable		 4k93A-2r8aA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K93_B_ADNB402_1
(SUGAR KINASE)		 2r8a LONG-CHAIN FATTY
ACID TRANSPORT
PROTEIN
(Escherichia
coli) 		5 / 12 GLY A 119
GLY A 118
LEU A  68
GLU A 399
THR A 197
 None
 1.01A 4k93B-2r8aA:
undetectable		 4k93B-2r8aA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9C_A_ADNA401_1
(SUGAR KINASE)		 2r8a LONG-CHAIN FATTY
ACID TRANSPORT
PROTEIN
(Escherichia
coli) 		5 / 12 GLY A 119
GLY A 118
LEU A  68
GLU A 399
THR A 197
 None
 1.02A 4k9cA-2r8aA:
undetectable		 4k9cA-2r8aA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9C_B_ADNB401_1
(SUGAR KINASE)		 2r8a LONG-CHAIN FATTY
ACID TRANSPORT
PROTEIN
(Escherichia
coli) 		5 / 12 GLY A 119
GLY A 118
LEU A  68
GLU A 399
THR A 197
 None
 1.03A 4k9cB-2r8aA:
undetectable		 4k9cB-2r8aA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9I_A_ADNA401_1
(SUGAR KINASE)		 2r8a LONG-CHAIN FATTY
ACID TRANSPORT
PROTEIN
(Escherichia
coli) 		5 / 12 GLY A 119
GLY A 118
LEU A  68
GLU A 399
THR A 197
 None
 1.02A 4k9iA-2r8aA:
undetectable		 4k9iA-2r8aA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9I_B_ADNB401_1
(SUGAR KINASE)		 2r8a LONG-CHAIN FATTY
ACID TRANSPORT
PROTEIN
(Escherichia
coli) 		5 / 12 GLY A 119
GLY A 118
LEU A  68
GLU A 399
THR A 197
 None
 1.01A 4k9iB-2r8aA:
undetectable		 4k9iB-2r8aA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAD_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2r8a LONG-CHAIN FATTY
ACID TRANSPORT
PROTEIN
(Escherichia
coli) 		5 / 12 GLY A 119
GLY A 118
LEU A  68
GLU A 399
THR A 197
 None
 1.02A 4kadA-2r8aA:
undetectable		 4kadA-2r8aA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAD_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2r8a LONG-CHAIN FATTY
ACID TRANSPORT
PROTEIN
(Escherichia
coli) 		5 / 12 GLY A 119
GLY A 118
LEU A  68
GLU A 399
THR A 197
 None
 1.02A 4kadB-2r8aA:
undetectable		 4kadB-2r8aA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBX_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2r8a LONG-CHAIN FATTY
ACID TRANSPORT
PROTEIN
(Escherichia
coli) 		5 / 12 GLY A 119
GLY A 118
LEU A  68
GLU A 399
THR A 197
 None
 1.01A 4lbxA-2r8aA:
undetectable		 4lbxA-2r8aA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBX_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2r8a LONG-CHAIN FATTY
ACID TRANSPORT
PROTEIN
(Escherichia
coli) 		5 / 12 GLY A 119
GLY A 118
LEU A  68
GLU A 399
THR A 197
 None
 1.02A 4lbxB-2r8aA:
undetectable		 4lbxB-2r8aA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LC4_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2r8a LONG-CHAIN FATTY
ACID TRANSPORT
PROTEIN
(Escherichia
coli) 		5 / 12 GLY A 119
GLY A 118
LEU A  68
GLU A 399
THR A 197
 None
 1.01A 4lc4A-2r8aA:
undetectable		 4lc4A-2r8aA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LC4_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2r8a LONG-CHAIN FATTY
ACID TRANSPORT
PROTEIN
(Escherichia
coli) 		5 / 12 GLY A 119
GLY A 118
LEU A  68
GLU A 399
THR A 197
 None
 1.01A 4lc4B-2r8aA:
undetectable		 4lc4B-2r8aA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_1
(PROLINE--TRNA LIGASE)		 2r8a LONG-CHAIN FATTY
ACID TRANSPORT
PROTEIN
(Escherichia
coli) 		3 / 3 GLU A  20
THR A 332
HIS A 290
 None
 0.71A 4q15A-2r8aA:
undetectable		 4q15A-2r8aA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_1
(PROLINE--TRNA LIGASE)		 2r8a LONG-CHAIN FATTY
ACID TRANSPORT
PROTEIN
(Escherichia
coli) 		3 / 3 GLU A  20
THR A 332
HIS A 290
 None
 0.70A 4q15B-2r8aA:
undetectable		 4q15B-2r8aA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 2r8a LONG-CHAIN FATTY
ACID TRANSPORT
PROTEIN
(Escherichia
coli) 		4 / 6 ASP A 384
ALA A 376
THR A 374
THR A 340
 None
 1.47A 4w5tA-2r8aA:
undetectable		 4w5tA-2r8aA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_1
(PROLINE--TRNA LIGASE)		 2r8a LONG-CHAIN FATTY
ACID TRANSPORT
PROTEIN
(Escherichia
coli) 		3 / 3 GLU A  20
THR A 332
HIS A 290
 None
 0.73A 4ydqB-2r8aA:
undetectable		 4ydqB-2r8aA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2r8a LONG-CHAIN FATTY
ACID TRANSPORT
PROTEIN
(Escherichia
coli) 		4 / 7 ARG A 282
ARG A 342
ILE A  23
TYR A 280
 None
 1.31A 5a06B-2r8aA:
undetectable		 5a06B-2r8aA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_1
(SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 2r8a LONG-CHAIN FATTY
ACID TRANSPORT
PROTEIN
(Escherichia
coli) 		4 / 6 LEU A  68
SER A 116
PHE A 158
GLU A 156
 None
 1.27A 5b8iA-2r8aA:
undetectable		 5b8iA-2r8aA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_1
(DIHYDROFOLATE
REDUCTASE)		 2r8a LONG-CHAIN FATTY
ACID TRANSPORT
PROTEIN
(Escherichia
coli) 		3 / 3 ASP A  26
ARG A 282
ARG A 222
 None
 0.87A 5eajB-2r8aA:
undetectable		 5eajB-2r8aA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 2r8a LONG-CHAIN FATTY
ACID TRANSPORT
PROTEIN
(Escherichia
coli) 		5 / 12 GLU A 399
ILE A 359
GLY A 119
ILE A  73
ALA A  74
 None
None
None
None
C8E  A 504 (-3.6A)
 1.31A 5j7wC-2r8aA:
undetectable		 5j7wC-2r8aA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2r8a LONG-CHAIN FATTY
ACID TRANSPORT
PROTEIN
(Escherichia
coli) 		3 / 3 TYR A 227
ARG A 228
THR A 296
 None
 0.77A 5z84J-2r8aA:
undetectable		 5z84J-2r8aA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA821_0
(GEPHYRIN)		 2r8a LONG-CHAIN FATTY
ACID TRANSPORT
PROTEIN
(Escherichia
coli) 		3 / 3 ARG A 157
PHE A 158
GLY A 118
 None
 0.78A 6fgdA-2r8aA:
undetectable		 6fgdA-2r8aA:
20.87