SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2r8b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_2
(LIVER
CARBOXYLESTERASE I)		 2r8b UNCHARACTERIZED
PROTEIN ATU2452
(Agrobacterium
fabrum) 		3 / 3 PHE A 164
LEU A 153
MET A 170
 None
 0.82A 1mx1D-2r8bA:
11.6		 1mx1D-2r8bA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2r8b UNCHARACTERIZED
PROTEIN ATU2452
(Agrobacterium
fabrum) 		5 / 12 GLN A  75
HIS A 171
HIS A 224
GLU A 234
PHE A  76
 None
 1.44A 1o86A-2r8bA:
undetectable		 1o86A-2r8bA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		 2r8b UNCHARACTERIZED
PROTEIN ATU2452
(Agrobacterium
fabrum) 		3 / 3 LEU A 242
LEU A 169
PHE A  63
 None
 0.73A 2pgrA-2r8bA:
undetectable		 2pgrA-2r8bA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X8Z_A_X8ZA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2r8b UNCHARACTERIZED
PROTEIN ATU2452
(Agrobacterium
fabrum) 		5 / 11 GLN A  75
HIS A 171
HIS A 224
GLU A 234
PHE A  76
 None
 1.46A 2x8zA-2r8bA:
undetectable		 2x8zA-2r8bA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2r8b UNCHARACTERIZED
PROTEIN ATU2452
(Agrobacterium
fabrum) 		5 / 6 VAL A 189
SER A 211
LEU A 118
ALA A 154
LEU A 169
 None
 1.33A 3kk6B-2r8bA:
undetectable		 3kk6B-2r8bA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_C_T44C128_1
(5-HYDROXYISOURATE
HYDROLASE)		 2r8b UNCHARACTERIZED
PROTEIN ATU2452
(Agrobacterium
fabrum) 		4 / 6 LEU A 212
PRO A 178
PRO A 172
LEU A 204
 None
 1.04A 3q1eA-2r8bA:
undetectable
3q1eC-2r8bA:
undetectable		 3q1eA-2r8bA:
19.68
3q1eC-2r8bA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_C_T44C128_1
(5-HYDROXYISOURATE
HYDROLASE)		 2r8b UNCHARACTERIZED
PROTEIN ATU2452
(Agrobacterium
fabrum) 		4 / 6 PRO A 172
LEU A 204
LEU A 212
PRO A 178
 None
 0.93A 3q1eA-2r8bA:
undetectable
3q1eC-2r8bA:
undetectable		 3q1eA-2r8bA:
19.68
3q1eC-2r8bA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C2P_A_X8ZA709_1
(ANGIOTENSIN-CONVERTI
NG ENZYME)		 2r8b UNCHARACTERIZED
PROTEIN ATU2452
(Agrobacterium
fabrum) 		5 / 11 GLN A  75
HIS A 171
HIS A 224
GLU A 234
PHE A  76
 None
 1.42A 4c2pA-2r8bA:
undetectable		 4c2pA-2r8bA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DXU_A_ACAA711_1
(LACTOTRANSFERRIN)		 2r8b UNCHARACTERIZED
PROTEIN ATU2452
(Agrobacterium
fabrum) 		4 / 6 GLY A  59
VAL A  57
PRO A  61
GLY A 246
 None
 0.87A 4dxuA-2r8bA:
undetectable		 4dxuA-2r8bA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ5_B_ACTB404_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 2r8b UNCHARACTERIZED
PROTEIN ATU2452
(Agrobacterium
fabrum) 		3 / 3 TYR A  49
ARG A 120
LYS A 124
 None
 1.48A 4wq5B-2r8bA:
3.0		 4wq5B-2r8bA:
24.70