SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2r8q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_D_PPFD412_1
(PHOSPHONOACETATE
HYDROLASE)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		4 / 8 THR A 795
ASP A 722
HIS A 681
HIS A 685
 MG  A   2 ( 4.7A)
MG  A   2 ( 2.6A)
IBM  A   3 ( 4.8A)
ZN  A   1 (-3.4A)
 1.00A 1ei6D-2r8qA:
undetectable		 1ei6D-2r8qA:
23.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UDT_A_VIAA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		5 / 12 TYR A 680
HIS A 681
VAL A 853
GLN A 887
PHE A 890
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
IBM  A   3 ( 4.8A)
IBM  A   3 (-3.3A)
IBM  A   3 (-3.6A)
 0.52A 1udtA-2r8qA:
38.2		 1udtA-2r8qA:
30.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		5 / 11 TYR A 680
VAL A 853
PHE A 857
GLN A 887
PHE A 890
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
IBM  A   3 (-4.9A)
IBM  A   3 (-3.3A)
IBM  A   3 (-3.6A)
 0.58A 1uduA-2r8qA:
37.0		 1uduA-2r8qA:
30.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		5 / 12 TYR A 680
VAL A 853
PHE A 857
GLN A 887
PHE A 890
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
IBM  A   3 (-4.9A)
IBM  A   3 (-3.3A)
IBM  A   3 (-3.6A)
 0.58A 1uduB-2r8qA:
37.0		 1uduB-2r8qA:
30.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UHO_A_VDNA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		6 / 10 TYR A 680
HIS A 681
PHE A 857
GLN A 887
GLY A 889
PHE A 890
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
IBM  A   3 (-4.9A)
IBM  A   3 (-3.3A)
None
IBM  A   3 (-3.6A)
 0.63A 1uhoA-2r8qA:
38.1		 1uhoA-2r8qA:
30.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		7 / 12 TYR A 680
HIS A 681
HIS A 725
MET A 797
ASN A 838
GLN A 887
PHE A 890
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
None
None
IBM  A   3 (-4.5A)
IBM  A   3 (-3.3A)
IBM  A   3 (-3.6A)
 0.64A 1xlxA-2r8qA:
39.7		 1xlxA-2r8qA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		5 / 12 TYR A 680
HIS A 681
HIS A 725
MET A 797
THR A 854
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
None
None
None
 1.41A 1xlxA-2r8qA:
39.7		 1xlxA-2r8qA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_B_CIOB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		7 / 12 TYR A 680
HIS A 681
HIS A 725
MET A 797
PHE A 857
GLN A 887
PHE A 890
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
None
None
IBM  A   3 (-4.9A)
IBM  A   3 (-3.3A)
IBM  A   3 (-3.6A)
 0.55A 1xlxB-2r8qA:
39.7		 1xlxB-2r8qA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_B_CIOB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		5 / 12 TYR A 680
HIS A 681
HIS A 725
MET A 797
THR A 854
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
None
None
None
 1.49A 1xlxB-2r8qA:
39.7		 1xlxB-2r8qA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_B_CIOB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		6 / 12 TYR A 680
HIS A 681
MET A 797
MET A 874
GLN A 887
PHE A 890
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
None
IBM  A   3 ( 3.8A)
IBM  A   3 (-3.3A)
IBM  A   3 (-3.6A)
 0.83A 1xlxB-2r8qA:
39.7		 1xlxB-2r8qA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_A_ROFA101_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		6 / 12 TYR A 680
HIS A 681
ASP A 835
TRP A 849
PHE A 857
PHE A 890
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
ZN  A   1 (-2.6A)
None
IBM  A   3 (-4.9A)
IBM  A   3 (-3.6A)
 0.37A 1xmuA-2r8qA:
39.8		 1xmuA-2r8qA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_B_ROFB102_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		6 / 12 TYR A 680
HIS A 681
MET A 797
ASP A 835
TRP A 849
PHE A 857
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
None
ZN  A   1 (-2.6A)
None
IBM  A   3 (-4.9A)
 0.36A 1xmuB-2r8qA:
39.8		 1xmuB-2r8qA:
29.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOM_A_CIOA603_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		8 / 12 TYR A 680
HIS A 681
MET A 797
ASP A 835
PHE A 857
MET A 874
GLN A 887
PHE A 890
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
None
ZN  A   1 (-2.6A)
IBM  A   3 (-4.9A)
IBM  A   3 ( 3.8A)
IBM  A   3 (-3.3A)
IBM  A   3 (-3.6A)
 0.78A 1xomA-2r8qA:
39.4		 1xomA-2r8qA:
30.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		7 / 12 TYR A 680
HIS A 681
MET A 797
PHE A 857
MET A 874
GLN A 887
PHE A 890
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
None
IBM  A   3 (-4.9A)
IBM  A   3 ( 3.8A)
IBM  A   3 (-3.3A)
IBM  A   3 (-3.6A)
 0.83A 1xomB-2r8qA:
39.4		 1xomB-2r8qA:
30.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		5 / 12 TYR A 680
HIS A 681
MET A 797
ASP A 835
PHE A 890
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
None
ZN  A   1 (-2.6A)
IBM  A   3 (-3.6A)
 0.39A 1xoqA-2r8qA:
39.4		 1xoqA-2r8qA:
30.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		5 / 12 TYR A 680
HIS A 681
MET A 797
ASP A 835
THR A 854
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
None
ZN  A   1 (-2.6A)
None
 1.29A 1xoqA-2r8qA:
39.4		 1xoqA-2r8qA:
30.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_A_ROFA502_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		3 / 3 ASN A 838
TRP A 849
GLN A 887
 IBM  A   3 (-4.5A)
None
IBM  A   3 (-3.3A)
 0.36A 1xoqA-2r8qA:
39.4		 1xoqA-2r8qA:
30.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		5 / 12 TYR A 680
HIS A 681
ASP A 835
TRP A 849
PHE A 890
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
ZN  A   1 (-2.6A)
None
IBM  A   3 (-3.6A)
 0.42A 1xoqB-2r8qA:
39.4		 1xoqB-2r8qA:
30.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		3 / 3 MET A 797
ASN A 838
GLN A 887
 None
IBM  A   3 (-4.5A)
IBM  A   3 (-3.3A)
 0.58A 1xoqB-2r8qA:
39.4		 1xoqB-2r8qA:
30.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOS_A_VIAA1_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		7 / 12 TYR A 680
HIS A 681
MET A 797
ASP A 835
MET A 874
GLN A 887
PHE A 890
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
None
ZN  A   1 (-2.6A)
IBM  A   3 ( 3.8A)
IBM  A   3 (-3.3A)
IBM  A   3 (-3.6A)
 0.76A 1xosA-2r8qA:
39.8		 1xosA-2r8qA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOS_A_VIAA1_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		7 / 12 TYR A 680
HIS A 681
MET A 797
ASP A 835
PHE A 857
GLN A 887
PHE A 890
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
None
ZN  A   1 (-2.6A)
IBM  A   3 (-4.9A)
IBM  A   3 (-3.3A)
IBM  A   3 (-3.6A)
 0.52A 1xosA-2r8qA:
39.8		 1xosA-2r8qA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		5 / 12 TYR A 680
HIS A 681
MET A 797
GLN A 887
PHE A 890
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
None
IBM  A   3 (-3.3A)
IBM  A   3 (-3.6A)
 0.50A 1xotA-2r8qA:
39.6		 1xotA-2r8qA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		5 / 12 TYR A 680
MET A 797
MET A 874
GLN A 887
PHE A 890
 IBM  A   3 ( 4.7A)
None
IBM  A   3 ( 3.8A)
IBM  A   3 (-3.3A)
IBM  A   3 (-3.6A)
 0.83A 1xotA-2r8qA:
39.6		 1xotA-2r8qA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_B_VDNB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		7 / 12 TYR A 680
HIS A 681
MET A 797
ASN A 838
MET A 874
GLN A 887
PHE A 890
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
None
IBM  A   3 (-4.5A)
IBM  A   3 ( 3.8A)
IBM  A   3 (-3.3A)
IBM  A   3 (-3.6A)
 0.72A 1xotB-2r8qA:
39.8		 1xotB-2r8qA:
29.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		5 / 12 TYR A 680
VAL A 853
PHE A 857
GLN A 887
PHE A 890
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
IBM  A   3 (-4.9A)
IBM  A   3 (-3.3A)
IBM  A   3 (-3.6A)
 0.49A 1xozA-2r8qA:
40.5		 1xozA-2r8qA:
30.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2H42_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		6 / 11 TYR A 680
HIS A 681
VAL A 853
PHE A 857
GLN A 887
PHE A 890
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
IBM  A   3 ( 4.8A)
IBM  A   3 (-4.9A)
IBM  A   3 (-3.3A)
IBM  A   3 (-3.6A)
 0.59A 2h42A-2r8qA:
38.4		 2h42A-2r8qA:
31.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2H42_B_VIAB902_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		5 / 12 TYR A 680
HIS A 681
VAL A 853
GLN A 887
PHE A 890
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
IBM  A   3 ( 4.8A)
IBM  A   3 (-3.3A)
IBM  A   3 (-3.6A)
 0.55A 2h42B-2r8qA:
38.1		 2h42B-2r8qA:
31.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2H42_C_VIAC903_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		5 / 12 TYR A 680
VAL A 853
PHE A 857
GLN A 887
PHE A 890
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
IBM  A   3 (-4.9A)
IBM  A   3 (-3.3A)
IBM  A   3 (-3.6A)
 0.56A 2h42C-2r8qA:
38.1		 2h42C-2r8qA:
31.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_A_EV1A1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		6 / 12 TYR A 680
HIS A 681
GLU A 856
PHE A 857
GLN A 887
PHE A 890
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
None
IBM  A   3 (-4.9A)
IBM  A   3 (-3.3A)
IBM  A   3 (-3.6A)
 0.70A 2weyA-2r8qA:
38.9		 2weyA-2r8qA:
28.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_A_EV1A1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		7 / 12 TYR A 680
HIS A 681
VAL A 839
GLU A 856
PHE A 857
MET A 874
PHE A 890
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
None
None
IBM  A   3 (-4.9A)
IBM  A   3 ( 3.8A)
IBM  A   3 (-3.6A)
 0.69A 2weyA-2r8qA:
38.9		 2weyA-2r8qA:
28.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_B_EV1B1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		4 / 8 PHE A 857
MET A 874
GLN A 887
PHE A 890
 IBM  A   3 (-4.9A)
IBM  A   3 ( 3.8A)
IBM  A   3 (-3.3A)
IBM  A   3 (-3.6A)
 0.59A 2weyB-2r8qA:
39.1		 2weyB-2r8qA:
28.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_B_EV1B1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		4 / 8 VAL A 839
PHE A 857
MET A 874
PHE A 890
 None
IBM  A   3 (-4.9A)
IBM  A   3 ( 3.8A)
IBM  A   3 (-3.6A)
 0.63A 2weyB-2r8qA:
39.1		 2weyB-2r8qA:
28.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_1
(UNCHARACTERIZED
PROTEIN PH0793)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		3 / 3 MET A 874
GLU A 856
ASP A 722
 IBM  A   3 ( 3.8A)
None
MG  A   2 ( 2.6A)
 1.04A 3a25A-2r8qA:
undetectable		 3a25A-2r8qA:
20.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		6 / 12 TYR A 680
HIS A 681
VAL A 853
PHE A 857
GLN A 887
PHE A 890
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
IBM  A   3 ( 4.8A)
IBM  A   3 (-4.9A)
IBM  A   3 (-3.3A)
IBM  A   3 (-3.6A)
 0.55A 3b2rA-2r8qA:
33.6		 3b2rA-2r8qA:
30.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		5 / 11 TYR A 680
HIS A 681
VAL A 853
GLN A 887
PHE A 890
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
IBM  A   3 ( 4.8A)
IBM  A   3 (-3.3A)
IBM  A   3 (-3.6A)
 0.41A 3b2rB-2r8qA:
33.4		 3b2rB-2r8qA:
30.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_K_TRPK1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		5 / 9 GLY A 834
VAL A 689
HIS A 685
ASP A 835
VAL A 839
 None
None
ZN  A   1 (-3.4A)
ZN  A   1 (-2.6A)
None
 1.37A 3fi0K-2r8qA:
undetectable		 3fi0K-2r8qA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		6 / 12 TYR A 680
HIS A 681
MET A 797
ASN A 838
TRP A 849
PHE A 890
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
None
IBM  A   3 (-4.5A)
None
IBM  A   3 (-3.6A)
 0.40A 3g4lA-2r8qA:
38.8		 3g4lA-2r8qA:
29.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_B_ROFB902_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		5 / 12 TYR A 680
HIS A 681
MET A 797
ASP A 835
THR A 854
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
None
ZN  A   1 (-2.6A)
None
 1.27A 3g4lB-2r8qA:
38.9		 3g4lB-2r8qA:
29.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_B_ROFB902_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		6 / 12 TYR A 680
HIS A 681
MET A 797
ASP A 835
TRP A 849
PHE A 890
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
None
ZN  A   1 (-2.6A)
None
IBM  A   3 (-3.6A)
 0.41A 3g4lB-2r8qA:
38.9		 3g4lB-2r8qA:
29.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		6 / 12 TYR A 680
HIS A 681
MET A 797
ASP A 835
ASN A 838
TRP A 849
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
None
ZN  A   1 (-2.6A)
IBM  A   3 (-4.5A)
None
 0.41A 3g4lC-2r8qA:
38.9		 3g4lC-2r8qA:
29.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		5 / 12 TYR A 680
HIS A 681
MET A 797
ASP A 835
THR A 854
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
None
ZN  A   1 (-2.6A)
None
 1.27A 3g4lC-2r8qA:
38.9		 3g4lC-2r8qA:
29.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		5 / 12 TYR A 680
HIS A 681
MET A 797
ASP A 835
THR A 854
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
None
ZN  A   1 (-2.6A)
None
 1.30A 3g4lD-2r8qA:
39.2		 3g4lD-2r8qA:
29.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		6 / 12 TYR A 680
HIS A 681
MET A 797
ASP A 835
TRP A 849
GLN A 887
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
None
ZN  A   1 (-2.6A)
None
IBM  A   3 (-3.3A)
 0.45A 3g4lD-2r8qA:
39.2		 3g4lD-2r8qA:
29.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IAK_A_EV1A415_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		6 / 9 TYR A 680
MET A 797
ASN A 838
PHE A 857
GLN A 887
PHE A 890
 IBM  A   3 ( 4.7A)
None
IBM  A   3 (-4.5A)
IBM  A   3 (-4.9A)
IBM  A   3 (-3.3A)
IBM  A   3 (-3.6A)
 0.74A 3iakA-2r8qA:
38.9		 3iakA-2r8qA:
30.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IAK_A_EV1A415_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		6 / 9 TYR A 680
MET A 797
ASN A 838
PHE A 857
MET A 874
PHE A 890
 IBM  A   3 ( 4.7A)
None
IBM  A   3 (-4.5A)
IBM  A   3 (-4.9A)
IBM  A   3 ( 3.8A)
IBM  A   3 (-3.6A)
 0.85A 3iakA-2r8qA:
38.9		 3iakA-2r8qA:
30.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JWQ_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		7 / 9 TYR A 680
HIS A 681
VAL A 853
LEU A 883
GLN A 887
PHE A 890
VAL A 894
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
IBM  A   3 ( 4.8A)
None
IBM  A   3 (-3.3A)
IBM  A   3 (-3.6A)
None
 0.66A 3jwqA-2r8qA:
40.5		 3jwqA-2r8qA:
31.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JWQ_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		7 / 9 TYR A 680
HIS A 681
VAL A 853
MET A 874
GLN A 887
PHE A 890
VAL A 894
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
IBM  A   3 ( 4.8A)
IBM  A   3 ( 3.8A)
IBM  A   3 (-3.3A)
IBM  A   3 (-3.6A)
None
 0.67A 3jwqA-2r8qA:
40.5		 3jwqA-2r8qA:
31.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JWQ_B_VIAB901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		6 / 11 HIS A 681
ASN A 729
VAL A 853
MET A 874
GLN A 887
PHE A 890
 IBM  A   3 ( 4.8A)
None
IBM  A   3 ( 4.8A)
IBM  A   3 ( 3.8A)
IBM  A   3 (-3.3A)
IBM  A   3 (-3.6A)
 0.83A 3jwqB-2r8qA:
40.5
3jwqC-2r8qA:
40.3		 3jwqB-2r8qA:
31.58
3jwqC-2r8qA:
31.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JWQ_B_VIAB901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		6 / 11 TYR A 680
HIS A 681
VAL A 853
LEU A 883
GLN A 887
PHE A 890
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
IBM  A   3 ( 4.8A)
None
IBM  A   3 (-3.3A)
IBM  A   3 (-3.6A)
 0.76A 3jwqB-2r8qA:
40.5
3jwqC-2r8qA:
40.3		 3jwqB-2r8qA:
31.58
3jwqC-2r8qA:
31.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JWQ_B_VIAB901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		6 / 11 TYR A 680
HIS A 681
VAL A 853
MET A 874
GLN A 887
PHE A 890
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
IBM  A   3 ( 4.8A)
IBM  A   3 ( 3.8A)
IBM  A   3 (-3.3A)
IBM  A   3 (-3.6A)
 0.67A 3jwqB-2r8qA:
40.5
3jwqC-2r8qA:
40.3		 3jwqB-2r8qA:
31.58
3jwqC-2r8qA:
31.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JWQ_C_VIAC901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		6 / 7 TYR A 680
HIS A 681
LEU A 883
GLN A 887
PHE A 890
VAL A 894
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
None
IBM  A   3 (-3.3A)
IBM  A   3 (-3.6A)
None
 0.62A 3jwqC-2r8qA:
40.3		 3jwqC-2r8qA:
31.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JWQ_C_VIAC901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		6 / 7 TYR A 680
HIS A 681
MET A 874
GLN A 887
PHE A 890
VAL A 894
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
IBM  A   3 ( 3.8A)
IBM  A   3 (-3.3A)
IBM  A   3 (-3.6A)
None
 0.70A 3jwqC-2r8qA:
40.3		 3jwqC-2r8qA:
31.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JWQ_D_VIAD901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		5 / 11 TYR A 680
HIS A 681
LEU A 883
GLN A 887
PHE A 890
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
None
IBM  A   3 (-3.3A)
IBM  A   3 (-3.6A)
 1.14A 3jwqA-2r8qA:
40.5
3jwqD-2r8qA:
40.0		 3jwqA-2r8qA:
31.58
3jwqD-2r8qA:
31.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JWQ_D_VIAD901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		6 / 11 TYR A 680
HIS A 681
PHE A 857
MET A 874
GLN A 887
PHE A 890
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
IBM  A   3 (-4.9A)
IBM  A   3 ( 3.8A)
IBM  A   3 (-3.3A)
IBM  A   3 (-3.6A)
 0.77A 3jwqA-2r8qA:
40.5
3jwqD-2r8qA:
40.0		 3jwqA-2r8qA:
31.58
3jwqD-2r8qA:
31.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_B_4CHB192_0
(DEHALOPEROXIDASE A)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		4 / 6 PHE A 899
TYR A 696
THR A 840
VAL A 839
 None
 1.05A 3lb3B-2r8qA:
undetectable		 3lb3B-2r8qA:
17.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		6 / 7 TYR A 680
ASN A 838
PHE A 857
MET A 874
GLN A 887
PHE A 890
 IBM  A   3 ( 4.7A)
IBM  A   3 (-4.5A)
IBM  A   3 (-4.9A)
IBM  A   3 ( 3.8A)
IBM  A   3 (-3.3A)
IBM  A   3 (-3.6A)
 0.77A 3tvxB-2r8qA:
39.6		 3tvxB-2r8qA:
32.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_2
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		4 / 5 VAL A 644
VAL A 720
TYR A 684
ARG A 660
 None
 0.96A 4r7iA-2r8qA:
undetectable		 4r7iA-2r8qA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_A_QDNA602_1
(CYTOCHROME P450 2D6)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		5 / 11 LEU A 714
GLY A 834
LEU A 697
ALA A 702
PHE A 898
 None
 1.10A 4wnuA-2r8qA:
undetectable		 4wnuA-2r8qA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		4 / 8 LEU A 906
LEU A 830
HIS A 822
LEU A 825
 None
 1.24A 5dxeA-2r8qA:
undetectable		 5dxeA-2r8qA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA202_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		5 / 8 GLU A 856
VAL A 678
HIS A 681
ASP A 722
HIS A 757
 None
None
IBM  A   3 ( 4.8A)
MG  A   2 ( 2.6A)
None
 1.24A 5f8yA-2r8qA:
undetectable		 5f8yA-2r8qA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_B_X6XB201_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		5 / 8 GLU A 856
VAL A 678
HIS A 681
ASP A 722
HIS A 757
 None
None
IBM  A   3 ( 4.8A)
MG  A   2 ( 2.6A)
None
 1.27A 5f8yB-2r8qA:
undetectable		 5f8yB-2r8qA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS1_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		4 / 8 PHE A 898
ILE A 902
LEU A 714
LEU A 697
 None
 0.87A 5hs1A-2r8qA:
undetectable		 5hs1A-2r8qA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS6_A_J3ZA302_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		4 / 8 HIS A 694
TYR A 698
LEU A 715
LEU A 647
 None
 1.15A 5hs6A-2r8qA:
undetectable		 5hs6A-2r8qA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		3 / 3 LEU A 715
TYR A 698
SER A 651
 None
 0.74A 5iktA-2r8qA:
undetectable		 5iktA-2r8qA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC608_1
(ALPHA-AMYLASE)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		3 / 3 TYR A 712
ALA A 718
LEU A 719
 None
 0.44A 6ag0C-2r8qA:
undetectable		 6ag0C-2r8qA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 2r8q CLASS I
PHOSPHODIESTERASE
PDEB1
(Leishmania
major) 		4 / 8 LEU A 906
LEU A 830
HIS A 822
LEU A 825
 None
 1.25A 6cbzA-2r8qA:
3.1		 6cbzA-2r8qA:
12.00