SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2r8u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YDO_A_ADNA400_1
(ADENOSINE RECEPTOR
A2A)		 2r8u MICROTUBULE-ASSOCIAT
ED PROTEIN RP/EB
FAMILY MEMBER 1
(Homo
sapiens) 		5 / 12 LEU A  51
PHE A 111
MET A  20
ILE A  24
SER A  27
 None
 1.49A 2ydoA-2r8uA:
undetectable		 2ydoA-2r8uA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JVL_A_ESTA702_1
(ESTROGEN
SULFOTRANSFERASE)		 2r8u MICROTUBULE-ASSOCIAT
ED PROTEIN RP/EB
FAMILY MEMBER 1
(Homo
sapiens) 		4 / 9 PHE A  75
PHE A 111
ILE A  56
MET A  48
 None
 1.34A 4jvlA-2r8uA:
undetectable		 4jvlA-2r8uA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_C_EF2C151_1
(CEREBLON ISOFORM 4)		 2r8u MICROTUBULE-ASSOCIAT
ED PROTEIN RP/EB
FAMILY MEMBER 1
(Homo
sapiens) 		4 / 7 ASN A 118
PHE A 115
TRP A 110
PHE A 107
 None
 1.38A 4v32C-2r8uA:
undetectable		 4v32C-2r8uA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2r8u MICROTUBULE-ASSOCIAT
ED PROTEIN RP/EB
FAMILY MEMBER 1
(Homo
sapiens) 		4 / 7 ILE A  35
VAL A  61
ASN A  25
PHE A  63
 None
 0.81A 5hieC-2r8uA:
undetectable		 5hieC-2r8uA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Q1S_A_AWYA1103_0
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 2r8u MICROTUBULE-ASSOCIAT
ED PROTEIN RP/EB
FAMILY MEMBER 1
(Homo
sapiens) 		4 / 6 LYS A 100
VAL A  93
LYS A  95
ILE A  72
 None
 1.00A 5q1sA-2r8uA:
undetectable		 5q1sA-2r8uA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_2
(CYTOCHROME P450 2C9)		 2r8u MICROTUBULE-ASSOCIAT
ED PROTEIN RP/EB
FAMILY MEMBER 1
(Homo
sapiens) 		4 / 4 PHE A 114
LEU A  96
LEU A  78
VAL A 108
 None
 1.06A 5xxiA-2r8uA:
undetectable		 5xxiA-2r8uA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2r8u MICROTUBULE-ASSOCIAT
ED PROTEIN RP/EB
FAMILY MEMBER 1
(Homo
sapiens) 		5 / 9 LEU A  51
SER A  55
GLY A  54
ILE A  56
PHE A 114
 None
 1.30A 6ebpA-2r8uA:
undetectable		 6ebpA-2r8uA:
15.12