SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2r8w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		 2r8w AGR_C_1641P
(Agrobacterium
fabrum) 		5 / 11 ALA A 321
LEU A 276
LEU A 322
LEU A 296
ALA A 291
 None
 1.17A 1h9zA-2r8wA:
2.5		 1h9zA-2r8wA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_D_SAMD200_0
(METHIONINE REPRESSOR)		 2r8w AGR_C_1641P
(Agrobacterium
fabrum) 		5 / 12 ALA A  40
GLY A  73
LEU A 252
ALA A 244
LEU A  64
 None
 0.97A 1mjqC-2r8wA:
undetectable
1mjqD-2r8wA:
undetectable		 1mjqC-2r8wA:
16.20
1mjqD-2r8wA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_J_SAMJ200_0
(METHIONINE REPRESSOR)		 2r8w AGR_C_1641P
(Agrobacterium
fabrum) 		5 / 12 ALA A  40
GLY A  73
LEU A 252
ALA A 244
LEU A  64
 None
 0.96A 1mjqI-2r8wA:
undetectable
1mjqJ-2r8wA:
undetectable		 1mjqI-2r8wA:
16.20
1mjqJ-2r8wA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2001_1
(SERUM ALBUMIN)		 2r8w AGR_C_1641P
(Agrobacterium
fabrum) 		5 / 11 LEU A 184
ILE A 190
VAL A 155
GLY A 157
LEU A 135
 None
 1.30A 2bxeA-2r8wA:
undetectable		 2bxeA-2r8wA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 2r8w AGR_C_1641P
(Agrobacterium
fabrum) 		4 / 6 ALA A 192
TYR A 240
ILE A 220
ILE A 165
 None
 1.13A 2dcfA-2r8wA:
undetectable		 2dcfA-2r8wA:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WQ5_A_MIYA1120_1
(PHOSPHOLIPASE A2,
ACIDIC)		 2r8w AGR_C_1641P
(Agrobacterium
fabrum) 		5 / 7 LEU A 163
ALA A 118
GLY A 111
ARG A  89
PHE A  35
 None
 1.47A 2wq5A-2r8wA:
undetectable		 2wq5A-2r8wA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM7_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 2r8w AGR_C_1641P
(Agrobacterium
fabrum) 		4 / 7 ALA A 192
TYR A 240
ILE A 220
ILE A 165
 None
 1.13A 2zm7A-2r8wA:
undetectable		 2zm7A-2r8wA:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA601_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 2r8w AGR_C_1641P
(Agrobacterium
fabrum) 		4 / 7 GLY A 109
ALA A 122
ALA A 125
VAL A 155
 None
 0.80A 3a2qA-2r8wA:
undetectable		 3a2qA-2r8wA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_A_SAMA226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2r8w AGR_C_1641P
(Agrobacterium
fabrum) 		5 / 12 GLY A 221
ALA A 204
GLY A 205
LEU A 210
ILE A 220
 None
 0.87A 3ku1A-2r8wA:
undetectable		 3ku1A-2r8wA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_C_SAMC226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2r8w AGR_C_1641P
(Agrobacterium
fabrum) 		5 / 12 GLY A 221
ALA A 204
GLY A 205
LEU A 210
ILE A 220
 None
 0.85A 3ku1C-2r8wA:
undetectable		 3ku1C-2r8wA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_G_SAMG226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2r8w AGR_C_1641P
(Agrobacterium
fabrum) 		5 / 12 GLY A 221
ALA A 204
GLY A 205
LEU A 210
ILE A 220
 None
 0.85A 3ku1G-2r8wA:
undetectable		 3ku1G-2r8wA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE506_1
(HEMOLYTIC LECTIN
CEL-III)		 2r8w AGR_C_1641P
(Agrobacterium
fabrum) 		4 / 6 CYH A 228
THR A 229
GLY A 224
ASP A 225
 None
 1.32A 3w9tE-2r8wA:
undetectable		 3w9tE-2r8wA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_B_GBMB801_1
(PROLINE--TRNA LIGASE)		 2r8w AGR_C_1641P
(Agrobacterium
fabrum) 		5 / 9 TYR A 240
ILE A 165
LEU A 181
ILE A 220
GLY A 221
 None
 1.23A 5ifuB-2r8wA:
undetectable		 5ifuB-2r8wA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2r8w AGR_C_1641P
(Agrobacterium
fabrum) 		5 / 12 ILE A 289
PHE A 273
ILE A 295
ALA A 293
VAL A 318
 None
 1.07A 5n0sA-2r8wA:
undetectable		 5n0sA-2r8wA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2r8w AGR_C_1641P
(Agrobacterium
fabrum) 		5 / 12 ILE A 289
PHE A 273
ILE A 295
ALA A 293
VAL A 318
 None
 1.06A 5n0sB-2r8wA:
undetectable		 5n0sB-2r8wA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2r8w AGR_C_1641P
(Agrobacterium
fabrum) 		5 / 12 ILE A 289
PHE A 273
ILE A 295
ALA A 293
VAL A 318
 None
 1.06A 5n0tA-2r8wA:
undetectable		 5n0tA-2r8wA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2r8w AGR_C_1641P
(Agrobacterium
fabrum) 		5 / 12 ILE A 289
PHE A 273
ILE A 295
ALA A 293
VAL A 318
 None
 1.06A 5n0xA-2r8wA:
undetectable		 5n0xA-2r8wA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2r8w AGR_C_1641P
(Agrobacterium
fabrum) 		5 / 12 ILE A 289
PHE A 273
ILE A 295
ALA A 293
VAL A 318
 None
 1.08A 5n4iA-2r8wA:
undetectable		 5n4iA-2r8wA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W5V_A_ANWA701_0
(SERINE/THREONINE-PRO
TEIN KINASE TBK1)		 2r8w AGR_C_1641P
(Agrobacterium
fabrum) 		5 / 9 LEU A 134
VAL A 138
GLY A  76
THR A  78
THR A 172
 None
None
ACT  A 333 (-3.5A)
ACT  A 333 (-3.5A)
None
 1.47A 5w5vA-2r8wA:
undetectable		 5w5vA-2r8wA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9K_F_ACTF802_0
(UNCHARACTERIZED
PROTEIN)		 2r8w AGR_C_1641P
(Agrobacterium
fabrum) 		3 / 3 TYR A 222
ALA A 234
LEU A 207
 None
 0.76A 6d9kF-2r8wA:
undetectable		 6d9kF-2r8wA:
20.93