SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2r98'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_A_FLPA1650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 2r98 PUTATIVE
ACETYLGLUTAMATE
SYNTHASE
(Neisseria
gonorrhoeae) 		5 / 12 VAL A 203
LEU A  26
ILE A  30
GLY A 261
LEU A 267
 None
 1.06A 1cqeA-2r98A:
undetectable		 1cqeA-2r98A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_A_FLPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 2r98 PUTATIVE
ACETYLGLUTAMATE
SYNTHASE
(Neisseria
gonorrhoeae) 		5 / 12 VAL A 203
LEU A  26
ILE A  30
GLY A 261
LEU A 267
 None
 1.03A 1eqhA-2r98A:
undetectable		 1eqhA-2r98A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_B_FLPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 2r98 PUTATIVE
ACETYLGLUTAMATE
SYNTHASE
(Neisseria
gonorrhoeae) 		5 / 12 VAL A 203
LEU A  26
ILE A  30
GLY A 261
LEU A 267
 None
 1.02A 1eqhB-2r98A:
undetectable		 1eqhB-2r98A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_A_9CRA801_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2r98 PUTATIVE
ACETYLGLUTAMATE
SYNTHASE
(Neisseria
gonorrhoeae) 		6 / 12 ILE A  47
ALA A  44
LEU A  35
LEU A 110
ALA A 109
LEU A 205
 None
 1.48A 1xlsA-2r98A:
undetectable		 1xlsA-2r98A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_B_9CRB802_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2r98 PUTATIVE
ACETYLGLUTAMATE
SYNTHASE
(Neisseria
gonorrhoeae) 		6 / 12 ILE A  47
ALA A  44
LEU A  35
LEU A 110
ALA A 109
LEU A 205
 None
 1.48A 1xlsB-2r98A:
undetectable		 1xlsB-2r98A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_C_9CRC803_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2r98 PUTATIVE
ACETYLGLUTAMATE
SYNTHASE
(Neisseria
gonorrhoeae) 		6 / 12 ILE A  47
ALA A  44
LEU A  35
LEU A 110
ALA A 109
LEU A 205
 None
 1.48A 1xlsC-2r98A:
undetectable		 1xlsC-2r98A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_D_9CRD804_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2r98 PUTATIVE
ACETYLGLUTAMATE
SYNTHASE
(Neisseria
gonorrhoeae) 		6 / 12 ILE A  47
ALA A  44
LEU A  35
LEU A 110
ALA A 109
LEU A 205
 None
 1.48A 1xlsD-2r98A:
undetectable		 1xlsD-2r98A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_B_FLPB2701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2r98 PUTATIVE
ACETYLGLUTAMATE
SYNTHASE
(Neisseria
gonorrhoeae) 		5 / 12 VAL A 203
LEU A  26
ILE A  30
GLY A 261
LEU A 267
 None
 1.08A 2aylB-2r98A:
undetectable		 2aylB-2r98A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 2r98 PUTATIVE
ACETYLGLUTAMATE
SYNTHASE
(Neisseria
gonorrhoeae) 		5 / 9 LEU A  35
LEU A  40
PHE A 106
LEU A  59
ILE A  30
 None
 1.26A 2f78A-2r98A:
undetectable		 2f78A-2r98A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 2r98 PUTATIVE
ACETYLGLUTAMATE
SYNTHASE
(Neisseria
gonorrhoeae) 		5 / 9 LEU A  35
LEU A  34
LEU A  40
PHE A 106
LEU A  59
 None
 1.25A 2f7aB-2r98A:
undetectable		 2f7aB-2r98A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_B_017B203_1
(PROTEASE)		 2r98 PUTATIVE
ACETYLGLUTAMATE
SYNTHASE
(Neisseria
gonorrhoeae) 		4 / 6 TRP A 398
LEU A 388
ARG A 402
GLY A 403
 ACO  A   1 (-3.9A)
None
ACO  A   1 ( 4.0A)
None
 1.24A 2hs2B-2r98A:
undetectable		 2hs2B-2r98A:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2r98 PUTATIVE
ACETYLGLUTAMATE
SYNTHASE
(Neisseria
gonorrhoeae) 		4 / 6 LEU A 222
ARG A 213
ILE A 211
LEU A 205
 None
 0.97A 2xkwB-2r98A:
undetectable		 2xkwB-2r98A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IIZ_A_SAMA1501_0
(BIOTIN SYNTHETASE,
PUTATIVE)		 2r98 PUTATIVE
ACETYLGLUTAMATE
SYNTHASE
(Neisseria
gonorrhoeae) 		5 / 12 GLN A 257
SER A 280
GLY A 278
ILE A  18
LEU A 271
 None
 1.22A 3iizA-2r98A:
undetectable		 3iizA-2r98A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2r98 PUTATIVE
ACETYLGLUTAMATE
SYNTHASE
(Neisseria
gonorrhoeae) 		4 / 7 ARG A 255
LEU A 267
ILE A  18
PHE A 272
 None
 1.04A 3ln1C-2r98A:
undetectable		 3ln1C-2r98A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2r98 PUTATIVE
ACETYLGLUTAMATE
SYNTHASE
(Neisseria
gonorrhoeae) 		4 / 5 ARG A 255
LEU A 267
ILE A  18
PHE A 272
 None
 1.04A 3ln1D-2r98A:
undetectable		 3ln1D-2r98A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA277_0
(UNIVERSAL STRESS
PROTEIN)		 2r98 PUTATIVE
ACETYLGLUTAMATE
SYNTHASE
(Neisseria
gonorrhoeae) 		3 / 3 ASP A  88
SER A  91
ARG A  85
 None
 1.02A 3loqA-2r98A:
3.9		 3loqA-2r98A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_B_EAAB214_1
(GLUTATHIONE
S-TRANSFERASE P)		 2r98 PUTATIVE
ACETYLGLUTAMATE
SYNTHASE
(Neisseria
gonorrhoeae) 		4 / 8 VAL A 359
GLY A 339
ILE A 289
GLY A 369
 ACO  A   1 (-4.2A)
None
None
ACO  A   1 (-3.2A)
 0.75A 3n9jB-2r98A:
undetectable		 3n9jB-2r98A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2r98 PUTATIVE
ACETYLGLUTAMATE
SYNTHASE
(Neisseria
gonorrhoeae) 		4 / 6 GLU A 327
ARG A 416
ALA A 342
ALA A 355
 None
 1.14A 3ns1C-2r98A:
undetectable		 3ns1C-2r98A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHN_A_ACTA108_0
(PROTEIN P-30)		 2r98 PUTATIVE
ACETYLGLUTAMATE
SYNTHASE
(Neisseria
gonorrhoeae) 		3 / 3 THR A 393
SER A 427
ARG A 425
 None
 0.77A 3phnA-2r98A:
undetectable		 3phnA-2r98A:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROX_A_TEPA266_1
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 2r98 PUTATIVE
ACETYLGLUTAMATE
SYNTHASE
(Neisseria
gonorrhoeae) 		4 / 8 ALA A 190
VAL A 193
LEU A 197
LEU A  59
 None
 0.77A 3roxA-2r98A:
undetectable		 3roxA-2r98A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7V_A_SAMA992_0
(METHYLORNITHINE
SYNTHASE PYLB)		 2r98 PUTATIVE
ACETYLGLUTAMATE
SYNTHASE
(Neisseria
gonorrhoeae) 		5 / 12 GLY A 278
GLY A 276
LEU A  50
VAL A 203
ALA A  28
 None
 1.09A 3t7vA-2r98A:
undetectable		 3t7vA-2r98A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC1_1
(CYTOCHROME P450 2D6)		 2r98 PUTATIVE
ACETYLGLUTAMATE
SYNTHASE
(Neisseria
gonorrhoeae) 		5 / 12 LEU A  59
LEU A  26
LEU A  49
SER A  51
PHE A 272
 None
 1.34A 3tbgC-2r98A:
undetectable		 3tbgC-2r98A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB502_1
(CYTOCHROME P450 2B6)		 2r98 PUTATIVE
ACETYLGLUTAMATE
SYNTHASE
(Neisseria
gonorrhoeae) 		5 / 10 LEU A 434
GLU A 353
LEU A 343
PRO A 413
VAL A 431
 None
 1.36A 3ua5B-2r98A:
undetectable		 3ua5B-2r98A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M48_A_21BA704_1
(TRANSPORTER)		 2r98 PUTATIVE
ACETYLGLUTAMATE
SYNTHASE
(Neisseria
gonorrhoeae) 		4 / 8 ASP A 350
VAL A 431
SER A 386
ALA A 407
 None
 0.81A 4m48A-2r98A:
undetectable		 4m48A-2r98A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA603_1
(SERUM ALBUMIN)		 2r98 PUTATIVE
ACETYLGLUTAMATE
SYNTHASE
(Neisseria
gonorrhoeae) 		5 / 10 LEU A  34
LEU A  43
VAL A 203
LEU A  26
LEU A 271
 None
 1.15A 4po0A-2r98A:
undetectable		 4po0A-2r98A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 2r98 PUTATIVE
ACETYLGLUTAMATE
SYNTHASE
(Neisseria
gonorrhoeae) 		5 / 9 GLN A  20
PHE A 272
GLU A 270
LEU A  50
ILE A  55
 None
 1.34A 5i73A-2r98A:
0.0		 5i73A-2r98A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_1
(CDL2.2)		 2r98 PUTATIVE
ACETYLGLUTAMATE
SYNTHASE
(Neisseria
gonorrhoeae) 		6 / 10 ILE A 167
LEU A 125
VAL A 102
ILE A  30
LEU A  35
LEU A  50
 None
 1.49A 5ienB-2r98A:
undetectable		 5ienB-2r98A:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2r98 PUTATIVE
ACETYLGLUTAMATE
SYNTHASE
(Neisseria
gonorrhoeae) 		5 / 12 ILE A  30
GLU A 107
PHE A  98
ALA A  63
SER A 127
 None
 1.17A 5igyA-2r98A:
undetectable		 5igyA-2r98A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 2r98 PUTATIVE
ACETYLGLUTAMATE
SYNTHASE
(Neisseria
gonorrhoeae) 		5 / 12 VAL A 102
GLU A  36
ALA A  63
THR A  90
LEU A  70
 None
 1.31A 5m54B-2r98A:
undetectable		 5m54B-2r98A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_2
(SCRFP-TAG,GP41)		 2r98 PUTATIVE
ACETYLGLUTAMATE
SYNTHASE
(Neisseria
gonorrhoeae) 		4 / 7 GLN A  52
LEU A  49
ASP A  46
LEU A  40
 None
 1.09A 5nwvA-2r98A:
undetectable		 5nwvA-2r98A:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA405_0
(THIOREDOXIN
REDUCTASE)		 2r98 PUTATIVE
ACETYLGLUTAMATE
SYNTHASE
(Neisseria
gonorrhoeae) 		3 / 3 GLY A  32
LEU A  35
HIS A  61
 None
 0.45A 5u63A-2r98A:
undetectable		 5u63A-2r98A:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_B_ACTB405_0
(THIOREDOXIN
REDUCTASE)		 2r98 PUTATIVE
ACETYLGLUTAMATE
SYNTHASE
(Neisseria
gonorrhoeae) 		3 / 3 GLY A  32
LEU A  35
HIS A  61
 None
 0.44A 5u63B-2r98A:
undetectable		 5u63B-2r98A:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA503_1
(CYTOCHROME P450 2C9)		 2r98 PUTATIVE
ACETYLGLUTAMATE
SYNTHASE
(Neisseria
gonorrhoeae) 		4 / 5 GLY A  38
THR A  39
ASN A  41
LYS A  42
 None
 1.23A 5x23A-2r98A:
undetectable		 5x23A-2r98A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2r98 PUTATIVE
ACETYLGLUTAMATE
SYNTHASE
(Neisseria
gonorrhoeae) 		5 / 9 LEU A 162
SER A  51
GLY A  54
ILE A  55
ILE A 167
 None
 1.17A 6ebpA-2r98A:
undetectable		 6ebpA-2r98A:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2r98 PUTATIVE
ACETYLGLUTAMATE
SYNTHASE
(Neisseria
gonorrhoeae) 		5 / 10 LEU A 162
SER A  51
GLY A  54
ILE A  55
ILE A 167
 None
 1.18A 6ebpB-2r98A:
undetectable		 6ebpB-2r98A:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2r98 PUTATIVE
ACETYLGLUTAMATE
SYNTHASE
(Neisseria
gonorrhoeae) 		5 / 10 LEU A 162
SER A  51
GLY A  54
ILE A  55
ILE A 167
 None
 1.13A 6ebpC-2r98A:
undetectable		 6ebpC-2r98A:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_0
(STIE PROTEIN)		 2r98 PUTATIVE
ACETYLGLUTAMATE
SYNTHASE
(Neisseria
gonorrhoeae) 		5 / 12 LEU A 259
GLY A 278
ILE A 281
LEU A 241
ILE A 242
 None
 1.05A 6ectA-2r98A:
2.6		 6ectA-2r98A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F8C_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 2r98 PUTATIVE
ACETYLGLUTAMATE
SYNTHASE
(Neisseria
gonorrhoeae) 		4 / 6 ALA A 234
GLY A 210
THR A 279
ILE A 281
 None
 0.75A 6f8cA-2r98A:
undetectable		 6f8cA-2r98A:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HQB_A_PQNA2001_0
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 2r98 PUTATIVE
ACETYLGLUTAMATE
SYNTHASE
(Neisseria
gonorrhoeae) 		5 / 10 GLY A 216
ARG A 213
ALA A 219
LEU A 218
LEU A  50
 None
 1.43A 6hqbA-2r98A:
undetectable
6hqbJ-2r98A:
undetectable		 6hqbA-2r98A:
10.09
6hqbJ-2r98A:
5.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA605_0
(SERUM ALBUMIN)		 2r98 PUTATIVE
ACETYLGLUTAMATE
SYNTHASE
(Neisseria
gonorrhoeae) 		4 / 8 HIS A  65
GLY A  62
GLY A  29
GLU A 237
 None
 0.87A 6mdqA-2r98A:
undetectable		 6mdqA-2r98A:
10.88